-
1
-
-
33750632169
-
The Biochemistry of Drug Metabolism - An Introduction. Part 1: Principles and Overview
-
B. Testa, S. D. Krämer, 'The Biochemistry of Drug Metabolism - An Introduction. Part 1: Principles and Overview', Chem. Biodiv. 2006, 3, 1053-1101.
-
(2006)
Chem. Biodiv
, vol.3
, pp. 1053-1101
-
-
Testa, B.1
Krämer, S.D.2
-
2
-
-
0030834058
-
Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
-
S. Rendic, F. J. Di Carlo, 'Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors', Drug Metab. Rev. 1997, 29, 413-580;
-
(1997)
Drug Metab. Rev
, vol.29
, pp. 413-580
-
-
Rendic, S.1
Di Carlo, F.J.2
-
3
-
-
0036223831
-
Summary of information on human CYP enzymes: Human P450 metabolism data
-
S. Rendic, 'Summary of information on human CYP enzymes: Human P450 metabolism data', Drug Metab. Rev. 2002, 34, 83-448.
-
(2002)
Drug Metab. Rev
, vol.34
, pp. 83-448
-
-
Rendic, S.1
-
4
-
-
0036226275
-
Human CYPs: In vivo and clinical aspects
-
O. Pelkonen, 'Human CYPs: in vivo and clinical aspects', Drug Metab. Rev. 2002, 34, 37-46.
-
(2002)
Drug Metab. Rev
, vol.34
, pp. 37-46
-
-
Pelkonen, O.1
-
6
-
-
34250649432
-
-
'Cytochrome P450. Structure, Mechanism, and Biochemistry', 2nd edn., Ed. P. R. Ortiz de Montellano, Plenum Press, New York, 1996.
-
'Cytochrome P450. Structure, Mechanism, and Biochemistry', 2nd edn., Ed. P. R. Ortiz de Montellano, Plenum Press, New York, 1996.
-
-
-
-
7
-
-
34250642466
-
-
'Handbook of Drug Metabolism', Ed. T. F. Woolf, Dekker, New York, 1999.
-
'Handbook of Drug Metabolism', Ed. T. F. Woolf, Dekker, New York, 1999.
-
-
-
-
8
-
-
34250638036
-
-
'Enzyme Systems that Metabolise Drugs and Other Xenobiotics', Ed. C. Ioannides, Wiley, Chichester, 2002.
-
'Enzyme Systems that Metabolise Drugs and Other Xenobiotics', Ed. C. Ioannides, Wiley, Chichester, 2002.
-
-
-
-
9
-
-
34250677387
-
-
'Drug-Drug Interactions', Ed. A. D. Rodrigues, Dekker, New York, 2002.
-
'Drug-Drug Interactions', Ed. A. D. Rodrigues, Dekker, New York, 2002.
-
-
-
-
10
-
-
2442601735
-
Principles of drug metabolism
-
6th edn, Ed. D. J. Abraham, Wiley-Interscience, Hoboken
-
B. Testa, W. Soine, 'Principles of drug metabolism', in 'Burger's Medicinal Chemistry and Drug Discovery', 6th edn., Ed. D. J. Abraham, Wiley-Interscience, Hoboken, 2003, Vol. 2, p. 431-498.
-
(2003)
Burger's Medicinal Chemistry and Drug Discovery
, vol.2
, pp. 431-498
-
-
Testa, B.1
Soine, W.2
-
11
-
-
34250649843
-
-
'Cytochrome P450 Protocols', Eds. I. R. Phillips, E. A. Shephard, Humana Press, Totowa, 2006.
-
'Cytochrome P450 Protocols', Eds. I. R. Phillips, E. A. Shephard, Humana Press, Totowa, 2006.
-
-
-
-
12
-
-
0003450992
-
-
Nomenclature Committee of the International Union of Biochemistry and Molecular Biology IUBMB
-
Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB), 'Enzyme Nomenclature', www.chem.qmul.ac.uk/ iubmb/enzyme.
-
Enzyme Nomenclature
-
-
-
13
-
-
0025067462
-
Molecular genetics of the P-450 superfamily
-
F. J. Gonzalez, 'Molecular genetics of the P-450 superfamily', Pharmacol. Ther. 1990, 45, 1-38.
-
(1990)
Pharmacol. Ther
, vol.45
, pp. 1-38
-
-
Gonzalez, F.J.1
-
14
-
-
0842312531
-
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative splice variants
-
D. R. Nelson, D. C. Zeldin, S. M. G. Hoffman, L. J. Maltais, H. M. Wain, D. W. Nebert, 'Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative splice variants', Pharmacogenetics 2004, 14, 1-18.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 1-18
-
-
Nelson, D.R.1
Zeldin, D.C.2
Hoffman, S.M.G.3
Maltais, L.J.4
Wain, H.M.5
Nebert, D.W.6
-
15
-
-
42549103742
-
-
homepage
-
a) D. R. Nelson, 'Cytochrome P450 homepage', http://drnelson.utmem.edu/ CytochromeP450.html;
-
Cytochrome
-
-
Nelson, D.R.1
-
16
-
-
34250649844
-
-
b) http://drnelson.utmem.edu/Nomenclature.html;
-
-
-
-
17
-
-
34250613202
-
-
c) http://drnelson.utmem.edu/hum.html;
-
-
-
-
18
-
-
34250688048
-
-
d) http://drnelson.utmem.edu/P450lect.html;
-
-
-
-
19
-
-
34250646753
-
-
e) http://drnelson.utmem.edu/P450trees.html.
-
-
-
-
20
-
-
84901167119
-
Directory of P450-containing Systems
-
'Directory of P450-containing Systems', http://www.icgeb.org/~p450srv/.
-
-
-
-
21
-
-
84872269269
-
Brenda: The Comprehensive Enzyme Information System
-
'Brenda: The Comprehensive Enzyme Information System', www.brenda.uni-koeln.de;
-
-
-
-
22
-
-
27844519588
-
ExPASy Proteomics Server
-
'ExPASy Proteomics Server', www.expasy.org.
-
-
-
-
23
-
-
0027495277
-
Cloning and expression of cytochrome P450 genes controlling flower colour
-
T. A. Holton, F. Brugliera, D. R. Lester, Y. Tanaka, C. D. Hyland, J. G. T. Menting, C. Y. Lu, E. Fracy, T. W. Stevenson, E. C. Cornish, 'Cloning and expression of cytochrome P450 genes controlling flower colour', Nature 1993, 366, 276-279.
-
(1993)
Nature
, vol.366
, pp. 276-279
-
-
Holton, T.A.1
Brugliera, F.2
Lester, D.R.3
Tanaka, Y.4
Hyland, C.D.5
Menting, J.G.T.6
Lu, C.Y.7
Fracy, E.8
Stevenson, T.W.9
Cornish, E.C.10
-
24
-
-
0024363541
-
Xenobiotic metabolism in helminths
-
W. Y. Precious, J. Barrett, 'Xenobiotic metabolism in helminths', Parasitol. Today 1989, 5, 156-160.
-
(1989)
Parasitol. Today
, vol.5
, pp. 156-160
-
-
Precious, W.Y.1
Barrett, J.2
-
25
-
-
0037478407
-
Human extrahepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts
-
X. Ding, L. S. Kaminsky, 'Human extrahepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts', Annu. Rev. Pharmacol. Toxicol. 2003, 43, 149-173.
-
(2003)
Annu. Rev. Pharmacol. Toxicol
, vol.43
, pp. 149-173
-
-
Ding, X.1
Kaminsky, L.S.2
-
26
-
-
26444529021
-
The endoplasmic reticulum in xenobiotic toxicity
-
A. E. Cribb, M. Peyron, S. Muruganandan, L. Schneider, 'The endoplasmic reticulum in xenobiotic toxicity', Drug Metab. Rev. 2005, 37, 405-442.
-
(2005)
Drug Metab. Rev
, vol.37
, pp. 405-442
-
-
Cribb, A.E.1
Peyron, M.2
Muruganandan, S.3
Schneider, L.4
-
27
-
-
33646701679
-
Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells
-
I. Hanukoglu, 'Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells', Drug Metab. Rev. 2006, 38, 171-196.
-
(2006)
Drug Metab. Rev
, vol.38
, pp. 171-196
-
-
Hanukoglu, I.1
-
28
-
-
0023918714
-
On the membrane topology of vertebrate cytochrome P-450 proteins
-
D. R. Nelson, H. W. Strobel, 'On the membrane topology of vertebrate cytochrome P-450 proteins', J. Biol. Chem. 1988, 263, 6038-6050.
-
(1988)
J. Biol. Chem
, vol.263
, pp. 6038-6050
-
-
Nelson, D.R.1
Strobel, H.W.2
-
29
-
-
0026011648
-
Orientation of cytochromes P450 in the endoplasmic reticulum
-
R. J. Edwards, B. P. Murray, A. M. Singleton, A. R. Boobis, 'Orientation of cytochromes P450 in the endoplasmic reticulum', Biochemistry 1991, 30, 71-76.
-
(1991)
Biochemistry
, vol.30
, pp. 71-76
-
-
Edwards, R.J.1
Murray, B.P.2
Singleton, A.M.3
Boobis, A.R.4
-
30
-
-
0026757684
-
Location of functional centers in the microsomal cytochrome P450 system
-
F. Centero, C. Gutiérrez-Merino, 'Location of functional centers in the microsomal cytochrome P450 system', Biochemistry 1992, 31, 8473-8481.
-
(1992)
Biochemistry
, vol.31
, pp. 8473-8481
-
-
Centero, F.1
Gutiérrez-Merino, C.2
-
31
-
-
33646681244
-
Cytochromes P450 - a family of proteins and scientists - understanding their relationships
-
B. S. Masters, C. C. Marohnic, 'Cytochromes P450 - a family of proteins and scientists - understanding their relationships', Drug Metab. Rev. 2006, 38, 209-225.
-
(2006)
Drug Metab. Rev
, vol.38
, pp. 209-225
-
-
Masters, B.S.1
Marohnic, C.C.2
-
32
-
-
0042265520
-
Crystal structure of human cytochrome P450 2C9 with bound warfarin
-
a) P. A. Williams, J. Cosme, A. Ward, H. C. Angove, D. M. Vinkovic, H. Jhoti, 'Crystal structure of human cytochrome P450 2C9 with bound warfarin', Nature 2003, 424, 464-468;
-
(2003)
Nature
, vol.424
, pp. 464-468
-
-
Williams, P.A.1
Cosme, J.2
Ward, A.3
Angove, H.C.4
Vinkovic, D.M.5
Jhoti, H.6
-
33
-
-
3442896773
-
Crystal structure of human cytochrome P450 3A4 bound to metarypone and progesterone
-
b) P. A. Williams, J. Cosme, D. M. Vinkovic, A. Ward, H. C. Angove, P. J. Day, C. Vonrhein, I. J. Tickle, H. Jhoti, 'Crystal structure of human cytochrome P450 3A4 bound to metarypone and progesterone', Science 2004, 305, 683-686.
-
(2004)
Science
, vol.305
, pp. 683-686
-
-
Williams, P.A.1
Cosme, J.2
Vinkovic, D.M.3
Ward, A.4
Angove, H.C.5
Day, P.J.6
Vonrhein, C.7
Tickle, I.J.8
Jhoti, H.9
-
34
-
-
0025333289
-
Evolution of the P450 gene superfamily: Animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation
-
F. J. Gonzalez, D. W. Nebert, 'Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation', Trends Genet. 1990, 6, 182-186;
-
(1990)
Trends Genet
, vol.6
, pp. 182-186
-
-
Gonzalez, F.J.1
Nebert, D.W.2
-
35
-
-
8944256082
-
-
A. K. Daly, J. Brockmöller, F. Broly, M. Eichelbaum, W. E. Evans, F. J. Gonzalez, J. D. Huang, J. R. Idle, M. Ingelman-Sundberg, T. Ishizaki, E. Jacqz-Aigrain, U. A. Meyer, D. W. Nebert, V. M. Steen, C. R. Wolf, U. M. Zanger, 'Nomenclature for human CYP2D6 alleles', Pharmacogenetics 1996, 6, 193-201; homepage of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee, www.cypalleles.ki.se.
-
A. K. Daly, J. Brockmöller, F. Broly, M. Eichelbaum, W. E. Evans, F. J. Gonzalez, J. D. Huang, J. R. Idle, M. Ingelman-Sundberg, T. Ishizaki, E. Jacqz-Aigrain, U. A. Meyer, D. W. Nebert, V. M. Steen, C. R. Wolf, U. M. Zanger, 'Nomenclature for human CYP2D6 alleles', Pharmacogenetics 1996, 6, 193-201; homepage of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee, www.cypalleles.ki.se.
-
-
-
-
36
-
-
84906428924
-
-
B. Oesch-Bartlomowicz, F. Oesch, 'Mechanisms of toxification and detoxification that challenge drug candidates and drugs', in 'ADME-Tox Approaches', Eds. B. Testa, H. van de Waterbeemd, 5 in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, 2007, p. 193-214.
-
B. Oesch-Bartlomowicz, F. Oesch, 'Mechanisms of toxification and detoxification that challenge drug candidates and drugs', in 'ADME-Tox Approaches', Eds. B. Testa, H. van de Waterbeemd, Vol. 5 in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, 2007, p. 193-214.
-
-
-
-
37
-
-
0035062413
-
Implications of polymorphic cytochrome P450-dependent drug metabolism for drug development
-
M. Ingelman-Sundberg,'Implications of polymorphic cytochrome P450-dependent drug metabolism for drug development', Drug Metab. Dispos. 2001, 29, 570-573.
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 570-573
-
-
Ingelman-Sundberg, M.1
-
38
-
-
33646442004
-
Pharmacogenetics and drug development
-
H. Reiser, 'Pharmacogenetics and drug development', Annu. Rep. Med. Chem. 2005, 40, 414-427.
-
(2005)
Annu. Rep. Med. Chem
, vol.40
, pp. 414-427
-
-
Reiser, H.1
-
39
-
-
84906428688
-
-
R. A. Totah, A. E. Rettie, 'Principles of drug metabolism 3: Enzymes and tissues', in 'ADME-Tox Approaches', Eds. B. Testa, H. van de Waterbeemd, 5 in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, 2007, p. 167-191.
-
R. A. Totah, A. E. Rettie, 'Principles of drug metabolism 3: Enzymes and tissues', in 'ADME-Tox Approaches', Eds. B. Testa, H. van de Waterbeemd, Vol. 5 in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, 2007, p. 167-191.
-
-
-
-
40
-
-
0030924503
-
Properties of cytochrome P450 isoenzymes and their substrates. Part 1: Active site characteristics
-
D. A. Smith, M. J. Ackland, B. C. Jones, 'Properties of cytochrome P450 isoenzymes and their substrates. Part 1: active site characteristics', Drug Discov. Today 1997, 2, 406-414;
-
(1997)
Drug Discov. Today
, vol.2
, pp. 406-414
-
-
Smith, D.A.1
Ackland, M.J.2
Jones, B.C.3
-
41
-
-
0030763355
-
Properties of cytochrome P450 isoenzymes and their substrates. Part 2: Properties of cytochrome P450 substrates
-
D. A. Smith, M. J. Ackland, B. C. Jones, 'Properties of cytochrome P450 isoenzymes and their substrates. Part 2: properties of cytochrome P450 substrates', Drug Discov. Today 1997, 2, 479-486.
-
(1997)
Drug Discov. Today
, vol.2
, pp. 479-486
-
-
Smith, D.A.1
Ackland, M.J.2
Jones, B.C.3
-
42
-
-
0032444641
-
Human cytochrome P450s: Selectivity and measurement in vivo
-
D. A. Smith, S. M. Abel, R. Hyland, B. C. Jones, 'Human cytochrome P450s: selectivity and measurement in vivo', Xenobiotica 1998, 28, 1095-1128.
-
(1998)
Xenobiotica
, vol.28
, pp. 1095-1128
-
-
Smith, D.A.1
Abel, S.M.2
Hyland, R.3
Jones, B.C.4
-
43
-
-
0032985950
-
Cytochrome P450 substrate specificities, substrate structural templates and enzyme active site geometries
-
D. F. V. Lewis, M. Dickins, P. J. Eddershaw, M. H. Tarbit, P. S. Goldfarb, 'Cytochrome P450 substrate specificities, substrate structural templates and enzyme active site geometries', Drug Metab. Drug Interact. 1999, 15, 1-49.
-
(1999)
Drug Metab. Drug Interact
, vol.15
, pp. 1-49
-
-
Lewis, D.F.V.1
Dickins, M.2
Eddershaw, P.J.3
Tarbit, M.H.4
Goldfarb, P.S.5
-
44
-
-
0034256965
-
On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics
-
D. F. V. Lewis, 'On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics', Biochem. Pharmacol. 2000, 60, 293-306.
-
(2000)
Biochem. Pharmacol
, vol.60
, pp. 293-306
-
-
Lewis, D.F.V.1
-
45
-
-
0034541821
-
The human CYP3A subfamily: Practical considerations
-
S. A. Wrighton, E. G. Schuetz, K. E. Thummel, D. D. Shen, K. R. Korzekwa, P. B. Watkins, 'The human CYP3A subfamily: practical considerations', Drug Metab. Rev. 2000, 32, 339-361.
-
(2000)
Drug Metab. Rev
, vol.32
, pp. 339-361
-
-
Wrighton, S.A.1
Schuetz, E.G.2
Thummel, K.E.3
Shen, D.D.4
Korzekwa, K.R.5
Watkins, P.B.6
-
46
-
-
11644292682
-
Spin-state/stereochemical relationships in iron porphyrins: Implications for the hemoproteins
-
W. R. Scheidt, C. A. Reed, 'Spin-state/stereochemical relationships in iron porphyrins: implications for the hemoproteins', Chem. Rev. 1981, 81, 543-555.
-
(1981)
Chem. Rev
, vol.81
, pp. 543-555
-
-
Scheidt, W.R.1
Reed, C.A.2
-
47
-
-
0023023246
-
Physical methods in the study of the active site geometry of cytochromes P-450
-
D.F.V. Lewis, 'Physical methods in the study of the active site geometry of cytochromes P-450', Drug Metab. Rev. 1986, 17, 1-66.
-
(1986)
Drug Metab. Rev
, vol.17
, pp. 1-66
-
-
Lewis, D.F.V.1
-
48
-
-
0019931441
-
The postenzymatic chemistry of activated oxygen
-
W. F. Trager, 'The postenzymatic chemistry of activated oxygen', Drug Metab. Rev. 1982, 13, 51-69.
-
(1982)
Drug Metab. Rev
, vol.13
, pp. 51-69
-
-
Trager, W.F.1
-
49
-
-
0032430067
-
Multiple activated oxygen species in P450 catalysis. Contributions to specificity in drug metabolism
-
M. J. Coon, A. D. N. Vaz, D. F. McGinnity, H. M. Peng. 'Multiple activated oxygen species in P450 catalysis. Contributions to specificity in drug metabolism', Drug Metab. Dispos. 1998, 26, 1190-1193.
-
(1998)
Drug Metab. Dispos
, vol.26
, pp. 1190-1193
-
-
Coon, M.J.1
Vaz, A.D.N.2
McGinnity, D.F.3
Peng, H.M.4
-
50
-
-
1842842895
-
Mechanistic enzymology of oxygen activation by the cytochromes P450
-
T. M. Makris, R. Davydov, I. G. Denisov, B. M. Hoffman, S. G. Sligar, 'Mechanistic enzymology of oxygen activation by the cytochromes P450', Drug Metab. Rev. 2002, 34, 691-708.
-
(2002)
Drug Metab. Rev
, vol.34
, pp. 691-708
-
-
Makris, T.M.1
Davydov, R.2
Denisov, I.G.3
Hoffman, B.M.4
Sligar, S.G.5
-
51
-
-
0025885546
-
NADPH-Cytochrome P450 oxidoreductase. The role of cysteine 566 in catalysis and cofactor binding
-
A. L. Shen, M. J. Christensen, C. B. Kasper, 'NADPH-Cytochrome P450 oxidoreductase. The role of cysteine 566 in catalysis and cofactor binding', J. Biol. Chem. 1991, 266, 19976-19980.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 19976-19980
-
-
Shen, A.L.1
Christensen, M.J.2
Kasper, C.B.3
-
52
-
-
0025773635
-
Role of cysteine residues in human NADH-cytochrome b5 reductase studied by site-directed mutagenesis
-
K. Shirabe, T. Yubisui, T. Nishino, M. Takeshita, 'Role of cysteine residues in human NADH-cytochrome b5 reductase studied by site-directed mutagenesis', J. Biol. Chem. 1991, 266, 7531-7536.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 7531-7536
-
-
Shirabe, K.1
Yubisui, T.2
Nishino, T.3
Takeshita, M.4
-
53
-
-
0032954374
-
Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism
-
D. N. Li, M. P. Pritchard, S. T. Hanlon, B. Burchell, C. R. Wolf, T. Friedberg, 'Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism', J. Pharmacol. Exp. Ther. 1999, 289, 661-667.
-
(1999)
J. Pharmacol. Exp. Ther
, vol.289
, pp. 661-667
-
-
Li, D.N.1
Pritchard, M.P.2
Hanlon, S.T.3
Burchell, B.4
Wolf, C.R.5
Friedberg, T.6
-
54
-
-
0036041419
-
Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase
-
C. R. Nishida, G. Knudsen, W. Straub, P. R. Ortiz de Montellano, 'Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase', Drug Metab. Rev. 2002, 34, 479-501.
-
(2002)
Drug Metab. Rev
, vol.34
, pp. 479-501
-
-
Nishida, C.R.1
Knudsen, G.2
Straub, W.3
Ortiz de Montellano, P.R.4
-
55
-
-
10044230408
-
5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans
-
5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans', J. Pharmacol. Exp. Ther. 2004, 311, 1171-1178.
-
(2004)
J. Pharmacol. Exp. Ther
, vol.311
, pp. 1171-1178
-
-
Kurian, J.R.1
Bajad, S.U.2
Miller, J.L.3
Chin, N.A.4
Trepanier, L.A.5
-
56
-
-
0024429854
-
Cytochrome P-450 catalysis: Radical intermediates and dehydrogenation reaction
-
P. R. Ortiz de Montellano, 'Cytochrome P-450 catalysis: radical intermediates and dehydrogenation reaction', Trends Pharmacol. Sci. 1989, 10, 354-359.
-
(1989)
Trends Pharmacol. Sci
, vol.10
, pp. 354-359
-
-
Ortiz de Montellano, P.R.1
-
57
-
-
0027321139
-
Cytochromes P450: Their active-site structure and mechanism of oxidation
-
L. Koymans, G. M. Donné-Op den Kelder, J. M. te Koppele, N. P. E. Vermeulen, 'Cytochromes P450: Their active-site structure and mechanism of oxidation', Drug Metab. Rev. 1993, 25, 325-387.
-
(1993)
Drug Metab. Rev
, vol.25
, pp. 325-387
-
-
Koymans, L.1
Donné-Op den Kelder, G.M.2
te Koppele, J.M.3
Vermeulen, N.P.E.4
-
58
-
-
0032076871
-
The structure of heme proteins compounds I and II: Some misconceptions
-
J. Everse, 'The structure of heme proteins compounds I and II: some misconceptions', Free Radical Biol. Med. 1998, 24, 1338-1346.
-
(1998)
Free Radical Biol. Med
, vol.24
, pp. 1338-1346
-
-
Everse, J.1
-
59
-
-
0032924934
-
Cytochrome P450 3A4: Regulation and role in drug metabolism
-
F. P. Guengerich, 'Cytochrome P450 3A4: Regulation and role in drug metabolism', Annu. Rev. Pharmacol. Toxicol. 1999, 39, 1-17.
-
(1999)
Annu. Rev. Pharmacol. Toxicol
, vol.39
, pp. 1-17
-
-
Guengerich, F.P.1
-
60
-
-
0034088779
-
The catalytic pathway of cytochrome P450 cam at atomic resolution
-
I. Schlichting, J. Berendzen, K. Chu, A. M. Stock, S. A. Maves, D. E. Benson, R. M. Sweet, D. Ringe, G. A. Petsko, S. G. Sligar, 'The catalytic pathway of cytochrome P450 cam at atomic resolution', Science 2000, 287, 1615-1622.
-
(2000)
Science
, vol.287
, pp. 1615-1622
-
-
Schlichting, I.1
Berendzen, J.2
Chu, K.3
Stock, A.M.4
Maves, S.A.5
Benson, D.E.6
Sweet, R.M.7
Ringe, D.8
Petsko, G.A.9
Sligar, S.G.10
-
61
-
-
0034973773
-
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
-
F. P. Guengerich, 'Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity', Chem. Res. Toxicol. 2001, 14, 611-650.
-
(2001)
Chem. Res. Toxicol
, vol.14
, pp. 611-650
-
-
Guengerich, F.P.1
-
62
-
-
2942679678
-
Oxoiron(IV) in chloroperoxidase compound II is basic: Implications for P450 chemistry
-
M. T. Green, J. H. Dawson, H. B. Gray, 'Oxoiron(IV) in chloroperoxidase compound II is basic: Implications for P450 chemistry', Science 2004, 304, 1653-1656.
-
(2004)
Science
, vol.304
, pp. 1653-1656
-
-
Green, M.T.1
Dawson, J.H.2
Gray, H.B.3
-
63
-
-
77957561475
-
-
W. F. Trager, 'Principles of drug metabolism 1: Redox reactions', in 'ADME-Tox Approaches', Eds. B. Testa, H. van de Waterbeemd, 5 in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, 2007, p. 87-132.
-
W. F. Trager, 'Principles of drug metabolism 1: Redox reactions', in 'ADME-Tox Approaches', Eds. B. Testa, H. van de Waterbeemd, Vol. 5 in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, 2007, p. 87-132.
-
-
-
-
64
-
-
0023894686
-
Flavin-containing monooxygenases: Catalytic mechanism and substrate specificities
-
D. M. Ziegler, 'Flavin-containing monooxygenases: catalytic mechanism and substrate specificities', Drug Metab. Rev. 1988, 19, 1-32.
-
(1988)
Drug Metab. Rev
, vol.19
, pp. 1-32
-
-
Ziegler, D.M.1
-
65
-
-
0028945438
-
Structural and catalytic properties of the mammalian flavin-containing monooxygenases
-
J. R. Cashman, 'Structural and catalytic properties of the mammalian flavin-containing monooxygenases', Chem. Res. Toxicol. 1995, 8, 165-181.
-
(1995)
Chem. Res. Toxicol
, vol.8
, pp. 165-181
-
-
Cashman, J.R.1
-
66
-
-
0028917419
-
The molecular biology of flavin-containing monooxygenases of man
-
I. R. Phillips, C. T. Dolphin, P. Clair, M. R. Hadley, A. J. Hutt, R. R. McCombie, R. L. Smith, E. A. Shephard, 'The molecular biology of flavin-containing monooxygenases of man', Chem.-Biol. Interact. 1995, 96, 17-32.
-
(1995)
Chem.-Biol. Interact
, vol.96
, pp. 17-32
-
-
Phillips, I.R.1
Dolphin, C.T.2
Clair, P.3
Hadley, M.R.4
Hutt, A.J.5
McCombie, R.R.6
Smith, R.L.7
Shephard, E.A.8
-
67
-
-
0028987973
-
Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compounds
-
A. A. Elfarra, 'Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compounds', Chem.-Biol. Interact. 1995, 96, 47-55.
-
(1995)
Chem.-Biol. Interact
, vol.96
, pp. 47-55
-
-
Elfarra, A.A.1
-
68
-
-
0028935832
-
Multisubstrate flavin-containing monooxygenases: Applications of mechanism to specificity
-
L. L. Poulsen, D. M. Ziegler, 'Multisubstrate flavin-containing monooxygenases: applications of mechanism to specificity', Chem.-Biol. Interact. 1995, 96, 57-73.
-
(1995)
Chem.-Biol. Interact
, vol.96
, pp. 57-73
-
-
Poulsen, L.L.1
Ziegler, D.M.2
-
69
-
-
0034280122
-
Human flavin-containing monooxygenase: Substrate specificity and role in drug metabolism
-
J. R. Cashman, 'Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism', Curr. Drug Metab. 2000, 1, 181-191.
-
(2000)
Curr. Drug Metab
, vol.1
, pp. 181-191
-
-
Cashman, J.R.1
-
70
-
-
0036036854
-
An overview of the mechanism, substrate specificities, and structure of FMOs
-
D. M. Ziegler, 'An overview of the mechanism, substrate specificities, and structure of FMOs', Drug Metab. Rev. 2002, 34, 503-511.
-
(2002)
Drug Metab. Rev
, vol.34
, pp. 503-511
-
-
Ziegler, D.M.1
-
71
-
-
0042029629
-
The role of flavin-containing monooxygenases in drug metabolism and development
-
J. R. Cashman, 'The role of flavin-containing monooxygenases in drug metabolism and development', Curr. Opin. Drug Discov. Dev. 2003, 6, 486-493.
-
(2003)
Curr. Opin. Drug Discov. Dev
, vol.6
, pp. 486-493
-
-
Cashman, J.R.1
-
72
-
-
2942530688
-
The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development
-
J. R. Cashman, 'The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development', Drug Discov. Today 2004, 9, 574-581.
-
(2004)
Drug Discov. Today
, vol.9
, pp. 574-581
-
-
Cashman, J.R.1
-
73
-
-
19444375492
-
Mammalian flavin-containing monooxygenases: Structure/function, genetic polymorphisms and role in drug metabolism
-
S. K. Krueger, D. E. Williams, 'Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism', Pharmacol. Ther. 2005, 106, 357-387.
-
(2005)
Pharmacol. Ther
, vol.106
, pp. 357-387
-
-
Krueger, S.K.1
Williams, D.E.2
-
74
-
-
27544496636
-
Some distinctions between flavin-containing and cytochrome P450 monooxygenases
-
J. R. Cashman, 'Some distinctions between flavin-containing and cytochrome P450 monooxygenases', Biochem. Biophys. Res. Commun. 2005, 338, 599-604;
-
(2005)
Biochem. Biophys. Res. Commun
, vol.338
, pp. 599-604
-
-
Cashman, J.R.1
-
76
-
-
0036076899
-
Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase
-
R. N. Hines, K. A. Hopp, J. Franco, K. Saeian, F. P. Begun, 'Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase', Mol. Pharmacol. 2002, 62, 320-325.
-
(2002)
Mol. Pharmacol
, vol.62
, pp. 320-325
-
-
Hines, R.N.1
Hopp, K.A.2
Franco, J.3
Saeian, K.4
Begun, F.P.5
-
77
-
-
0021326691
-
Bio-organic chemistry and cytochrome P450-dependent catalysis
-
S. G. Sligar, M. H. Gelb, D. C. Heimbrook, 'Bio-organic chemistry and cytochrome P450-dependent catalysis', Xenobiotica 1984, 14, 63-86.
-
(1984)
Xenobiotica
, vol.14
, pp. 63-86
-
-
Sligar, S.G.1
Gelb, M.H.2
Heimbrook, D.C.3
-
78
-
-
33845469510
-
Chemical mechanisms of catalysis by cytochromes P-450: A unified view
-
F. P. Guengerich, T. L. Macdonald, 'Chemical mechanisms of catalysis by cytochromes P-450: a unified view', Acc. Chem. Res. 1984, 17, 9-16.
-
(1984)
Acc. Chem. Res
, vol.17
, pp. 9-16
-
-
Guengerich, F.P.1
Macdonald, T.L.2
-
79
-
-
33845377490
-
Key elements of the chemistry of cytochrome P-450. The oxygen rebound mechanism
-
J. T. Groves, 'Key elements of the chemistry of cytochrome P-450. The oxygen rebound mechanism', J. Chem. Educ. 1985, 62, 928-931.
-
(1985)
J. Chem. Educ
, vol.62
, pp. 928-931
-
-
Groves, J.T.1
-
80
-
-
0001382112
-
Stereochemical dynamics of aliphatic hydroxylation by cytochrome P-450
-
R. E. White, J. P. Miller, L. V. Favreau, A. Bhattacharyya, 'Stereochemical dynamics of aliphatic hydroxylation by cytochrome P-450', J. Am. Chem. Soc. 1986, 108, 6024-6031.
-
(1986)
J. Am. Chem. Soc
, vol.108
, pp. 6024-6031
-
-
White, R.E.1
Miller, J.P.2
Favreau, L.V.3
Bhattacharyya, A.4
-
81
-
-
0027852254
-
Cytochrome P450 hydroxylation of hydrocarbons: Variation in the rate of oxygen rebound using cyclopropyl radical clocks including two new ultrafast probes
-
J. K. Atkinson, K. U. Ingold, 'Cytochrome P450 hydroxylation of hydrocarbons: variation in the rate of oxygen rebound using cyclopropyl radical clocks including two new ultrafast probes', Biochemistry 1993, 32, 9209-9214.
-
(1993)
Biochemistry
, vol.32
, pp. 9209-9214
-
-
Atkinson, J.K.1
Ingold, K.U.2
-
82
-
-
0021382681
-
Regioselectivity in the cytochrome P-450: Control by protein constraints and by chemical reactivity
-
R. E. White, M. B. McCarthy, K. D. Egeberg, S. G. Sligar, 'Regioselectivity in the cytochrome P-450: control by protein constraints and by chemical reactivity', Arch. Biochem. Biophys. 1984, 228, 493-502.
-
(1984)
Arch. Biochem. Biophys
, vol.228
, pp. 493-502
-
-
White, R.E.1
McCarthy, M.B.2
Egeberg, K.D.3
Sligar, S.G.4
-
83
-
-
0022522989
-
Identification of the n-heptane metabolites in rat and human urine
-
L. Perbellini, F. Brugnone, V. Cocheo, E. De Rosa, G. B. Bartolucci, 'Identification of the n-heptane metabolites in rat and human urine', Arch. Toxicol. 1986, 58, 229-234.
-
(1986)
Arch. Toxicol
, vol.58
, pp. 229-234
-
-
Perbellini, L.1
Brugnone, F.2
Cocheo, V.3
De Rosa, E.4
Bartolucci, G.B.5
-
84
-
-
20344402771
-
Biotransformation of terpinoids by mammals, microorganisms, and plant-cultured cells
-
T. Ishida, 'Biotransformation of terpinoids by mammals, microorganisms, and plant-cultured cells', Chem. Biodiv. 2005, 2, 569-590.
-
(2005)
Chem. Biodiv
, vol.2
, pp. 569-590
-
-
Ishida, T.1
-
85
-
-
0036151380
-
Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome P450 enzymes in rat liver microsomes
-
M. Miyazawa, M. Shinto, T. Shimada, 'Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome P450 enzymes in rat liver microsomes', Chem. Res. Toxicol. 2002, 15, 15-20.
-
(2002)
Chem. Res. Toxicol
, vol.15
, pp. 15-20
-
-
Miyazawa, M.1
Shinto, M.2
Shimada, T.3
-
86
-
-
0014543919
-
The microsomal oxygenation of ethylbenzene: Isotopic, stereochemical, and induction studies
-
R. E. McMahon, H. R. Sullivan, J. C. Craig, W. E. Pereira Jr., 'The microsomal oxygenation of ethylbenzene: isotopic, stereochemical, and induction studies', Arch. Biochem. Biophys. 1969, 132, 575-577.
-
(1969)
Arch. Biochem. Biophys
, vol.132
, pp. 575-577
-
-
McMahon, R.E.1
Sullivan, H.R.2
Craig, J.C.3
Pereira Jr., W.E.4
-
87
-
-
0024576994
-
The metabolism of ethylbenzene and styrene to mandelic acid: Stereochemical considerations
-
L. Drummond, J. Caldwell, H. K. Wilson, 'The metabolism of ethylbenzene and styrene to mandelic acid: stereochemical considerations', Xenobiotica 1989, 19, 199-207.
-
(1989)
Xenobiotica
, vol.19
, pp. 199-207
-
-
Drummond, L.1
Caldwell, J.2
Wilson, H.K.3
-
88
-
-
0034052783
-
Pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats
-
S. K. Paulson, J. Y. Zhang, A. P. Breau, J. D. Hribar, N. W. K. Liu, S. M. Jessen, Y. M. Lawal, J. N. Cogburn, C. J. Gresk, C. S. Markos, T. J. Maziasz, G. L. Schoenhard, E. G. Burton, 'Pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats', Drug Metab. Dispos. 2000, 28, 514-521.
-
(2000)
Drug Metab. Dispos
, vol.28
, pp. 514-521
-
-
Paulson, S.K.1
Zhang, J.Y.2
Breau, A.P.3
Hribar, J.D.4
Liu, N.W.K.5
Jessen, S.M.6
Lawal, Y.M.7
Cogburn, J.N.8
Gresk, C.J.9
Markos, C.S.10
Maziasz, T.J.11
Schoenhard, G.L.12
Burton, E.G.13
-
89
-
-
0033621712
-
14C]celecoxib in healthy male volunteers
-
14C]celecoxib in healthy male volunteers', Drug Metab. Dispos. 2000, 28, 308-314.
-
(2000)
Drug Metab. Dispos
, vol.28
, pp. 308-314
-
-
Paulson, S.K.1
Hribar, J.D.2
Liu, N.W.K.3
Hajdu, E.4
Bible Jr., R.H.5
Piergies, A.6
Karim, A.7
-
90
-
-
0031739606
-
1- and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans
-
B. Eiermann, P. O. Edlund, A. Tjernberg, P. Dalén, M. L. Dahl, L. Bertilsson, '1- and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans', Drug Metab. Dispos. 1998, 26, 1096-1101.
-
(1998)
Drug Metab. Dispos
, vol.26
, pp. 1096-1101
-
-
Eiermann, B.1
Edlund, P.O.2
Tjernberg, A.3
Dalén, P.4
Dahl, M.L.5
Bertilsson, L.6
-
91
-
-
33745083308
-
Species differences in the pharmacokinetics and metabolism of reparixin in rat and dog
-
I. Midgley, K. Fitzpatrick, S. J. Wright, B. A. John, A. J. Peard, R. M. Major, J. D. Major, J. D. Holding, A. McBurney, R. Anacardio, R. Novellini, M. P. Ferrari, 'Species differences in the pharmacokinetics and metabolism of reparixin in rat and dog', Xenobiotica 2006, 36, 419-440.
-
(2006)
Xenobiotica
, vol.36
, pp. 419-440
-
-
Midgley, I.1
Fitzpatrick, K.2
Wright, S.J.3
John, B.A.4
Peard, A.J.5
Major, R.M.6
Major, J.D.7
Holding, J.D.8
McBurney, A.9
Anacardio, R.10
Novellini, R.11
Ferrari, M.P.12
-
92
-
-
0019980059
-
14C]caffeine after oral administration
-
14C]caffeine after oral administration', Drug Metab. Dispos. 1982, 10, 417-423.
-
(1982)
Drug Metab. Dispos
, vol.10
, pp. 417-423
-
-
Callahan, M.M.1
Robertson, R.S.2
Arnaud, M.J.3
Branfman, A.R.4
McComish, M.F.5
Yesair, D.W.6
-
93
-
-
0026646696
-
Interspecies variations in caffeine metabolism related to cytochrome P4501A
-
F. Berthou, B. Guillois, C. Riche, Y. Dreano, E. Jacqz-Aigrain, P. H. Beaune, 'Interspecies variations in caffeine metabolism related to cytochrome P4501A', Xenobiotica 1992, 22, 671-680.
-
(1992)
Xenobiotica
, vol.22
, pp. 671-680
-
-
Berthou, F.1
Guillois, B.2
Riche, C.3
Dreano, Y.4
Jacqz-Aigrain, E.5
Beaune, P.H.6
-
94
-
-
0029981725
-
The use of caffeine as a metabolic probe for human drug metabolizing enzymes
-
J. O. Miners, D. J. Birkett, 'The use of caffeine as a metabolic probe for human drug metabolizing enzymes', Gen. Pharmacol. 1996, 27, 245-249.
-
(1996)
Gen. Pharmacol
, vol.27
, pp. 245-249
-
-
Miners, J.O.1
Birkett, D.J.2
-
95
-
-
1042300334
-
Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: Implications for assessing children's risks from environmental agents
-
G. Ginsberg, D. Hattis, A. Russ, B. Sonawane, 'Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents', J. Toxicol. Environ. Health A 2004, 67, 297-329.
-
(2004)
J. Toxicol. Environ. Health A
, vol.67
, pp. 297-329
-
-
Ginsberg, G.1
Hattis, D.2
Russ, A.3
Sonawane, B.4
-
96
-
-
0025347457
-
Pathways of gallopamil metabolism. Regiochemistry and enantioselectivity of the N-dealkylation processes
-
A. E. Mutlib, W. L. Nelson, 'Pathways of gallopamil metabolism. Regiochemistry and enantioselectivity of the N-dealkylation processes', Drug Metab. Dispos. 1990, 18, 331-337.
-
(1990)
Drug Metab. Dispos
, vol.18
, pp. 331-337
-
-
Mutlib, A.E.1
Nelson, W.L.2
-
97
-
-
0025278986
-
Pathways of gallopamil metabolism. Regiochemistry and enantioselectivity of the O-demethylation processes
-
A. E. Mutlib, W. L. Nelson, 'Pathways of gallopamil metabolism. Regiochemistry and enantioselectivity of the O-demethylation processes', Drug Metab. Dispos. 1990, 18, 309-314.
-
(1990)
Drug Metab. Dispos
, vol.18
, pp. 309-314
-
-
Mutlib, A.E.1
Nelson, W.L.2
-
98
-
-
0018333325
-
The metabolism of DL-[14C]verapamil in man
-
M. Eichelbaum, M. Ende, G. Remberg, M. Schomerus, H. J. Dengler, 'The metabolism of DL-[14C]verapamil in man', Drug Metab. Dispos. 1979, 7, 145-148.
-
(1979)
Drug Metab. Dispos
, vol.7
, pp. 145-148
-
-
Eichelbaum, M.1
Ende, M.2
Remberg, G.3
Schomerus, M.4
Dengler, H.J.5
-
99
-
-
0842347425
-
Differential enantioselectivity and product-dependent activation and inhibition in metabolism of verapamil by human CYP3As
-
L. Shen, J. F. Fitzloff, C. S. Cook, 'Differential enantioselectivity and product-dependent activation and inhibition in metabolism of verapamil by human CYP3As', Drug Metab. Dispos. 2004, 32, 186-196.
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 186-196
-
-
Shen, L.1
Fitzloff, J.F.2
Cook, C.S.3
-
100
-
-
0034575202
-
The biotransformation of nitrogen-containing xenobiotics to lactams
-
S. Vickers, S. L. Polsky, 'The biotransformation of nitrogen-containing xenobiotics to lactams', Curr. Drug Metab. 2000, 1, 357-389.
-
(2000)
Curr. Drug Metab
, vol.1
, pp. 357-389
-
-
Vickers, S.1
Polsky, S.L.2
-
101
-
-
14144253640
-
Metabolism and disposition of nicotine
-
J. Hukkanen, P. Jacob III, N. L. Benowitz, 'Metabolism and disposition of nicotine', Pharmacol. Rev. 2005, 57, 79-115.
-
(2005)
Pharmacol. Rev
, vol.57
, pp. 79-115
-
-
Hukkanen, J.1
Jacob III, P.2
Benowitz, N.L.3
-
102
-
-
1942532837
-
Nicotine, its metabolism and an overview of its biological effects
-
D. Yildiz, 'Nicotine, its metabolism and an overview of its biological effects', Toxicon 2004, 43, 619-632.
-
(2004)
Toxicon
, vol.43
, pp. 619-632
-
-
Yildiz, D.1
-
103
-
-
11244347797
-
In vitro metabolism of gefitinib in human liver microsomes
-
D. McKillop, A. D. McCormick, G. S. Miles, P. J. Phillips, K. J. Pickup, N. Bushby, M. Hutchison, 'In vitro metabolism of gefitinib in human liver microsomes', Xenobiotica 2004, 34, 983-1000.
-
(2004)
Xenobiotica
, vol.34
, pp. 983-1000
-
-
McKillop, D.1
McCormick, A.D.2
Miles, G.S.3
Phillips, P.J.4
Pickup, K.J.5
Bushby, N.6
Hutchison, M.7
-
104
-
-
16244394037
-
Cytochrome P450-dependent metabolism of gefitinib
-
D. McKillop, A. D. McCormick, A. Millar, G. S. Miles, P. J. Phillips, M. Hutchison, 'Cytochrome P450-dependent metabolism of gefitinib', Xenobiotica 2005, 35, 39-50.
-
(2005)
Xenobiotica
, vol.35
, pp. 39-50
-
-
McKillop, D.1
McCormick, A.D.2
Millar, A.3
Miles, G.S.4
Phillips, P.J.5
Hutchison, M.6
-
105
-
-
0028933006
-
Oxidative cleavage of esters and amides to carbonyl products by cyrochrome P450
-
H. M. Peng, G. M. Raner, A. D. N. Vaz, M. J. Coon, 'Oxidative cleavage of esters and amides to carbonyl products by cyrochrome P450', Arch. Biochem. Biophys. 1995, 318, 333-339.
-
(1995)
Arch. Biochem. Biophys
, vol.318
, pp. 333-339
-
-
Peng, H.M.1
Raner, G.M.2
Vaz, A.D.N.3
Coon, M.J.4
-
106
-
-
0030048830
-
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedative antihistamine loratadine. Formation of descarboxyethoxyloratadine by CYP3A4 and CYP2D6
-
N. Yumibe, K. Huie, K. J. Chen, M. Snow, R. P. Clement, M. N. Cayen, 'Identification of human liver cytochrome P450 enzymes that metabolize the nonsedative antihistamine loratadine. Formation of descarboxyethoxyloratadine by CYP3A4 and CYP2D6', Biochem. Pharmacol. 1996, 51, 165-172.
-
(1996)
Biochem. Pharmacol
, vol.51
, pp. 165-172
-
-
Yumibe, N.1
Huie, K.2
Chen, K.J.3
Snow, M.4
Clement, R.P.5
Cayen, M.N.6
-
107
-
-
20044364020
-
Metabolism and excretion of loratadine in male and female mice, rats and monkeys
-
R. Ramanathan, N. Alvarez, A. D. Su, S. Chowdhury, K. Alton, K. Stauber, J. Patrick, 'Metabolism and excretion of loratadine in male and female mice, rats and monkeys', Xenobiotica 2005, 35, 155-189.
-
(2005)
Xenobiotica
, vol.35
, pp. 155-189
-
-
Ramanathan, R.1
Alvarez, N.2
Su, A.D.3
Chowdhury, S.4
Alton, K.5
Stauber, K.6
Patrick, J.7
-
108
-
-
0014962167
-
Hepatic microsomal ethanol-oxidizing system
-
C. S. Lieber, L. M. DeCarli, 'Hepatic microsomal ethanol-oxidizing system', J. Biol. Chem. 1970, 245, 2505-2512.
-
(1970)
J. Biol. Chem
, vol.245
, pp. 2505-2512
-
-
Lieber, C.S.1
DeCarli, L.M.2
-
109
-
-
0030431698
-
Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s
-
H. Asai, S. Imaoka, T. Kuroki, T. Monna, Y. Funae, 'Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s', J. Pharmacol. Exp. Ther. 1996, 277, 1004-1009.
-
(1996)
J. Pharmacol. Exp. Ther
, vol.277
, pp. 1004-1009
-
-
Asai, H.1
Imaoka, S.2
Kuroki, T.3
Monna, T.4
Funae, Y.5
-
110
-
-
0031752988
-
Major cytochrome P450 enzyme responsible for oxidation of secondary alcohols to the corresponding ketones in mouse hepatic microsomes
-
T. Matsunaga, N. Kishi, H. Tanaka, K. Watanabe, H. Yoshimura, I. Yamamoto, 'Major cytochrome P450 enzyme responsible for oxidation of secondary alcohols to the corresponding ketones in mouse hepatic microsomes', Drug Metab. Dispos. 1998, 26, 1045-1047.
-
(1998)
Drug Metab. Dispos
, vol.26
, pp. 1045-1047
-
-
Matsunaga, T.1
Kishi, N.2
Tanaka, H.3
Watanabe, K.4
Yoshimura, H.5
Yamamoto, I.6
-
111
-
-
0030933914
-
Acetaldehyde as well as ethanol is metabolized by human CYP2E1
-
S. Kunitoh, S. Imaoka, T. Hiroi, Y. Yabusaki, T. Monna, Y. Funae, 'Acetaldehyde as well as ethanol is metabolized by human CYP2E1, J. Pharmacol. Exp. Ther. 1997, 280, 527-532.
-
(1997)
J. Pharmacol. Exp. Ther
, vol.280
, pp. 527-532
-
-
Kunitoh, S.1
Imaoka, S.2
Hiroi, T.3
Yabusaki, Y.4
Monna, T.5
Funae, Y.6
-
112
-
-
0030924897
-
Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro
-
D. K. Spracklin, D. C. Hankins, J. M. Fisher, K. E. Thummel, E. D. Kharasch, 'Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro', J. Pharmacol. Exp. Ther. 1997, 281, 400-411.
-
(1997)
J. Pharmacol. Exp. Ther
, vol.281
, pp. 400-411
-
-
Spracklin, D.K.1
Hankins, D.C.2
Fisher, J.M.3
Thummel, K.E.4
Kharasch, E.D.5
-
113
-
-
0027220076
-
Mechanisms of halothane toxicity: Novel insights
-
J. Gut, U. Christen, J. Huwyler, 'Mechanisms of halothane toxicity: novel insights', Pharmacol. Ther. 1993, 58, 133-155.
-
(1993)
Pharmacol. Ther
, vol.58
, pp. 133-155
-
-
Gut, J.1
Christen, U.2
Huwyler, J.3
-
114
-
-
0029609131
-
Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1
-
K. J. Garton, P. Yuen, J. Meinwald, K. E. Thummel, E. D. Kharasch, 'Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1', Drug Metab. Dispos. 1995, 23, 1426-1430.
-
(1995)
Drug Metab. Dispos
, vol.23
, pp. 1426-1430
-
-
Garton, K.J.1
Yuen, P.2
Meinwald, J.3
Thummel, K.E.4
Kharasch, E.D.5
-
115
-
-
0019509069
-
Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P450 by chloramphenicol
-
J. Halpert, 'Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P450 by chloramphenicol', Biochem. Pharmacol. 1981, 30, 875-881.
-
(1981)
Biochem. Pharmacol
, vol.30
, pp. 875-881
-
-
Halpert, J.1
-
116
-
-
0025139064
-
Hepatic microsomal oxygenation of aldehydes to carboxylic acids
-
K. Watanabe, S. Narimatsu, I. Yamamoto, H. Yoshimura, 'Hepatic microsomal oxygenation of aldehydes to carboxylic acids', Biochem. Biophys. Res. Commun. 1990, 166, 1308-1312.
-
(1990)
Biochem. Biophys. Res. Commun
, vol.166
, pp. 1308-1312
-
-
Watanabe, K.1
Narimatsu, S.2
Yamamoto, I.3
Yoshimura, H.4
-
117
-
-
0025907945
-
Oxygenation mechanism of aldehyde to carboxylic acid catalyzed by a cytochrome P450 isozyme
-
K. Watanabe, S. Narimatsu, I. Yamamoto, H. Yoshimura, 'Oxygenation mechanism of aldehyde to carboxylic acid catalyzed by a cytochrome P450 isozyme', J. Biol. Chem. 1991, 266, 2709-2711.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 2709-2711
-
-
Watanabe, K.1
Narimatsu, S.2
Yamamoto, I.3
Yoshimura, H.4
-
118
-
-
0028894286
-
Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes
-
R. A. Stearns, P. K. Chakravarty, R. Chen, S. H. Chiu, 'Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes', Drug Metab. Dispos. 1995, 23, 207-215.
-
(1995)
Drug Metab. Dispos
, vol.23
, pp. 207-215
-
-
Stearns, R.A.1
Chakravarty, P.K.2
Chen, R.3
Chiu, S.H.4
-
119
-
-
34250632903
-
-
M. Bartók, K. L. Láng, 'Oxiranes', in 'Small Ring Heterocycles, Part 3', Ed. A. Hassner, Wiley, New York, 1985, p. 1-196.
-
M. Bartók, K. L. Láng, 'Oxiranes', in 'Small Ring Heterocycles, Part 3', Ed. A. Hassner, Wiley, New York, 1985, p. 1-196.
-
-
-
-
120
-
-
0032441633
-
Stereochemistry of the biotransformation of 1-hexene and 2-methyl-1-hexene with rat liver microsomes and purified P450s of rats and humans
-
C. Chiappe, A. De Rubertis, G. Amato, P. G. Gervasi, 'Stereochemistry of the biotransformation of 1-hexene and 2-methyl-1-hexene with rat liver microsomes and purified P450s of rats and humans', Chem. Res. Toxicol. 1998, 11, 1487-1493.
-
(1998)
Chem. Res. Toxicol
, vol.11
, pp. 1487-1493
-
-
Chiappe, C.1
De Rubertis, A.2
Amato, G.3
Gervasi, P.G.4
-
121
-
-
0034999950
-
Stereochemial aspects in the 4-vinylcyclohexene biotransformation with rat liver microsomes and purified P450s. Monoepoxides and diols
-
C. Chiappe, A. De Rubertis, M. De Carlo, G. Amato, P. G. Gervasi, 'Stereochemial aspects in the 4-vinylcyclohexene biotransformation with rat liver microsomes and purified P450s. Monoepoxides and diols', Chem. Res. Toxicol. 2001, 14, 492-499.
-
(2001)
Chem. Res. Toxicol
, vol.14
, pp. 492-499
-
-
Chiappe, C.1
De Rubertis, A.2
De Carlo, M.3
Amato, G.4
Gervasi, P.G.5
-
122
-
-
0020473257
-
Oxidation of trichloroethylene by liver microsomal cytochrome P450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide
-
R. E. Miller, F. P. Guengerich, 'Oxidation of trichloroethylene by liver microsomal cytochrome P450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide', Biochemistry 1982, 21, 1090-1097.
-
(1982)
Biochemistry
, vol.21
, pp. 1090-1097
-
-
Miller, R.E.1
Guengerich, F.P.2
-
124
-
-
0023269873
-
Serum concentrations of carbamazepine and its epoxide and diol metabolites in epileptic patients: The influence of dose and comedication
-
B. Rambeck, T. May, U. Juergens, 'Serum concentrations of carbamazepine and its epoxide and diol metabolites in epileptic patients: the influence of dose and comedication', Ther. Drug Monit. 1987, 9, 298-303.
-
(1987)
Ther. Drug Monit
, vol.9
, pp. 298-303
-
-
Rambeck, B.1
May, T.2
Juergens, U.3
-
125
-
-
0036841947
-
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites
-
R. E. Pearce, G. R. Vakkalagadda, J. S. Leeder, 'Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites', Drug Metab. Dispos. 2002, 30, 1170-1179.
-
(2002)
Drug Metab. Dispos
, vol.30
, pp. 1170-1179
-
-
Pearce, R.E.1
Vakkalagadda, G.R.2
Leeder, J.S.3
-
126
-
-
0021115233
-
Microsomal epoxide hydrolase. Properties, regulation and function
-
J. Seidegard, J. W. DePierre, 'Microsomal epoxide hydrolase. Properties, regulation and function', Biochim. Biophys. Acta 1983, 695, 251-270.
-
(1983)
Biochim. Biophys. Acta
, vol.695
, pp. 251-270
-
-
Seidegard, J.1
DePierre, J.W.2
-
127
-
-
77957557296
-
-
B. Testa, 'Principles of drug metabolism 2: Hydrolysis and conjugation reactions', in 'ADME-Tox Approaches', Eds. B. Testa, H. van de Waterbeemd, 5 in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, 2007, p. 133-166.
-
B. Testa, 'Principles of drug metabolism 2: Hydrolysis and conjugation reactions', in 'ADME-Tox Approaches', Eds. B. Testa, H. van de Waterbeemd, Vol. 5 in 'Comprehensive Medicinal Chemistry', 2nd edn., Eds. D. J. Triggle, J. Taylor, Elsevier, Oxford, 2007, p. 133-166.
-
-
-
-
128
-
-
18444418834
-
The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects
-
R. A. Halpin, A. G. Porras, L. A. Geer, M. R. Davis, D. Cui, G. A. Doss, E. Woolf, D. Musson, C. Matthews, R. Mazenko, J. I. Schwartz, K. C. Lasseter, K. P. Vyas, T. A. Baillie, 'The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects', Drug Metab. Dispos. 2002, 30, 684-693.
-
(2002)
Drug Metab. Dispos
, vol.30
, pp. 684-693
-
-
Halpin, R.A.1
Porras, A.G.2
Geer, L.A.3
Davis, M.R.4
Cui, D.5
Doss, G.A.6
Woolf, E.7
Musson, D.8
Matthews, C.9
Mazenko, R.10
Schwartz, J.I.11
Lasseter, K.C.12
Vyas, K.P.13
Baillie, T.A.14
-
129
-
-
1342323500
-
An analysis of the regioselectivity of aromatic hydroxylation and N-oxygenation by cytochrome P450 enzymes
-
T. S. Dowers, D. A. Rock, D. A. Rock, B. N. S. Perkins, J. P. Jones, 'An analysis of the regioselectivity of aromatic hydroxylation and N-oxygenation by cytochrome P450 enzymes', Drug Metab. Dispos. 2004, 32, 328-332.
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 328-332
-
-
Dowers, T.S.1
Rock, D.A.2
Rock, D.A.3
Perkins, B.N.S.4
Jones, J.P.5
-
130
-
-
0036127307
-
Biotransformation reactions of five-membered aromatic heterocyclic rings
-
D. K. Dalvie, A. S. Katgutkar, S. C. Khojasteh-Bakht, R. S. Obach, J. P. O'Donnell, 'Biotransformation reactions of five-membered aromatic heterocyclic rings', Chem. Res. Toxicol. 2002, 15, 269-299.
-
(2002)
Chem. Res. Toxicol
, vol.15
, pp. 269-299
-
-
Dalvie, D.K.1
Katgutkar, A.S.2
Khojasteh-Bakht, S.C.3
Obach, R.S.4
O'Donnell, J.P.5
-
131
-
-
0026457779
-
Oxidative dehalogenation of 2-fluoro-17α-ethynylestradiol in vivo. A distal structure-metabolism relationship of 17α-ethynylation
-
P. Morgan, J. L. Maggs, P. C. B. Page, B. K. Park, 'Oxidative dehalogenation of 2-fluoro-17α-ethynylestradiol in vivo. A distal structure-metabolism relationship of 17α-ethynylation', Biochem. Pharmacol. 1992, 44, 1717-1724.
-
(1992)
Biochem. Pharmacol
, vol.44
, pp. 1717-1724
-
-
Morgan, P.1
Maggs, J.L.2
Page, P.C.B.3
Park, B.K.4
-
132
-
-
0031012608
-
Substituent elimination from p-substituted phenols by cytochrome P450. ipso-substitution by the oxygen atom of the active species
-
T. Ohe, T. Mashino, M. Hirobe, 'Substituent elimination from p-substituted phenols by cytochrome P450. ipso-substitution by the oxygen atom of the active species', Drug Metab. Dispos. 1997, 25, 116-122.
-
(1997)
Drug Metab. Dispos
, vol.25
, pp. 116-122
-
-
Ohe, T.1
Mashino, T.2
Hirobe, M.3
-
133
-
-
0016872299
-
Metabolism of 4,4′-dihalogenobiphenyls
-
S. Safe, D. Jones, O. Hutzinger, 'Metabolism of 4,4′-dihalogenobiphenyls', J. Chem. Soc., Perkin Trans. 1 1976, 357-359.
-
(1976)
J. Chem. Soc., Perkin Trans. 1
, pp. 357-359
-
-
Safe, S.1
Jones, D.2
Hutzinger, O.3
-
134
-
-
0020033909
-
New ring-hydroxylated metabolites of propranolol
-
T. Walle, J. E. Oatis Jr., U. K. Walle, D. R. Knapp, 'New ring-hydroxylated metabolites of propranolol', Drug Metab. Dispos. 1982, 10, 122-127.
-
(1982)
Drug Metab. Dispos
, vol.10
, pp. 122-127
-
-
Walle, T.1
Oatis Jr., J.E.2
Walle, U.K.3
Knapp, D.R.4
-
135
-
-
0021672722
-
Stereoselectivity in the aromatic hydroxylation of propranolol in rats
-
W. L. Nelson, M. J. Bartels, 'Stereoselectivity in the aromatic hydroxylation of propranolol in rats', Drug Metab. Dispos. 1984, 12, 382-384.
-
(1984)
Drug Metab. Dispos
, vol.12
, pp. 382-384
-
-
Nelson, W.L.1
Bartels, M.J.2
-
136
-
-
0021278470
-
The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite
-
W. L. Nelson, M. J. Bartels, P. J. Bednarski, S. Zhang, K. Messick, J. S. Horng, R. R. Ruffolo Jr., 'The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite', J. Med. Chem. 1984, 27, 857-861.
-
(1984)
J. Med. Chem
, vol.27
, pp. 857-861
-
-
Nelson, W.L.1
Bartels, M.J.2
Bednarski, P.J.3
Zhang, S.4
Messick, K.5
Horng, J.S.6
Ruffolo Jr., R.R.7
-
137
-
-
0023821244
-
Regioisomeric aromatic dihydroxylation of propranolol
-
R. E. Talaat, W. L. Nelson, 'Regioisomeric aromatic dihydroxylation of propranolol', Drug Metab. Dispos. 1988, 16, 207-211, 212-216.
-
(1988)
Drug Metab. Dispos
, vol.16
-
-
Talaat, R.E.1
Nelson, W.L.2
-
138
-
-
0024534047
-
Propranolol metabolism is determined by both mephenytoin and debrisoquine hydroxylase activities
-
S. A. Ward, T. Walle, U. K. Walle, G. R. Wilkinson, R. A. Branch, 'Propranolol metabolism is determined by both mephenytoin and debrisoquine hydroxylase activities', Clin. Pharmacol. Ther. 1989, 45, 72-79.
-
(1989)
Clin. Pharmacol. Ther
, vol.45
, pp. 72-79
-
-
Ward, S.A.1
Walle, T.2
Walle, U.K.3
Wilkinson, G.R.4
Branch, R.A.5
-
139
-
-
0018187388
-
-
M. J. Fasco, P. P. Dymerski, J. D. Wos, L. S. Kaminsky, 'A new warfarin metabolite: structure and function', J. Med. Chem. 1978, 21, 1054-1059.
-
M. J. Fasco, P. P. Dymerski, J. D. Wos, L. S. Kaminsky, 'A new warfarin metabolite: structure and function', J. Med. Chem. 1978, 21, 1054-1059.
-
-
-
-
140
-
-
0024439393
-
Warfarin as a probe of cytochromes P450 function
-
L. S. Kaminsky, 'Warfarin as a probe of cytochromes P450 function', Drug Metab. Rev. 1989, 20, 479-487.
-
(1989)
Drug Metab. Rev
, vol.20
, pp. 479-487
-
-
Kaminsky, L.S.1
-
141
-
-
0026519541
-
Hydroxylation of warfarin by cDNA-expressed cytochromes P450: A role for P4502C9 in the etiology of (S)-warfarin-drug interactions
-
A. E. Rettie, K. R. Korzekwa, K. L. Kunze, R. F. Lawrence, A. C. Eddy, T. Aoyama, H. V. Gelboin, F. J. Gonzalez, W. F. Trager, 'Hydroxylation of warfarin by cDNA-expressed cytochromes P450: A role for P4502C9 in the etiology of (S)-warfarin-drug interactions', Chem. Res. Toxicol. 1992, 5, 54-59.
-
(1992)
Chem. Res. Toxicol
, vol.5
, pp. 54-59
-
-
Rettie, A.E.1
Korzekwa, K.R.2
Kunze, K.L.3
Lawrence, R.F.4
Eddy, A.C.5
Aoyama, T.6
Gelboin, H.V.7
Gonzalez, F.J.8
Trager, W.F.9
-
142
-
-
0029559028
-
Human cytochromes P4501A1 and P4501A2: R-Warfarin metabolism as a probe
-
Z. Zhang, M. J. Fasco, Z. Huang, F. P. Guengerich, L. S. Kaminsky, 'Human cytochromes P4501A1 and P4501A2: R-Warfarin metabolism as a probe', Drug Metab. Dispos. 1995, 23, 1339-1345.
-
(1995)
Drug Metab. Dispos
, vol.23
, pp. 1339-1345
-
-
Zhang, Z.1
Fasco, M.J.2
Huang, Z.3
Guengerich, F.P.4
Kaminsky, L.S.5
-
143
-
-
0035015062
-
In vitro stimulation of warfarin metabolism by quinidine: Increases in the formation of 4′- and 10-hydroxywarfarin
-
J. S. Ngui, Q. Chen, M. Shou, R. W. Wang, R. A. Stearns, T. A. Baillie, W. Tang, 'In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4′- and 10-hydroxywarfarin', Drug Metab. Dispos. 2001, 29, 877-886.
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 877-886
-
-
Ngui, J.S.1
Chen, Q.2
Shou, M.3
Wang, R.W.4
Stearns, R.A.5
Baillie, T.A.6
Tang, W.7
-
144
-
-
0021280575
-
Suicidal destruction of cytochrome P-450 by ethynyl substituted compounds
-
I. N. H. White, 'Suicidal destruction of cytochrome P-450 by ethynyl substituted compounds', Pharm. Res. 1984, 1, 141-148.
-
(1984)
Pharm. Res
, vol.1
, pp. 141-148
-
-
White, I.N.H.1
-
145
-
-
0021018789
-
Cytochrome P450-dependent oxidation of the 17a-ethynyl group of synthetic steroids
-
S. E. Schmid, W. Y. W. Au, D. E. Hill, F. F. Kadlubar, W. Slikker Jr., 'Cytochrome P450-dependent oxidation of the 17a-ethynyl group of synthetic steroids', Drug Metab. Dispos. 1983, 11, 531-536.
-
(1983)
Drug Metab. Dispos
, vol.11
, pp. 531-536
-
-
Schmid, S.E.1
Au, W.Y.W.2
Hill, D.E.3
Kadlubar, F.F.4
Slikker Jr., W.5
-
146
-
-
0027275796
-
Mechanism-based inactivation of cytochrome P450 2B1 by 2-ethynylnaphthalene: Identification of an active-site peptide
-
E. S. Roberts, N. E. Hopkins, W. L. Alworth, P. F. Hollenberg, 'Mechanism-based inactivation of cytochrome P450 2B1 by 2-ethynylnaphthalene: Identification of an active-site peptide', Chem. Res. Toxicol. 1993, 6, 470-479.
-
(1993)
Chem. Res. Toxicol
, vol.6
, pp. 470-479
-
-
Roberts, E.S.1
Hopkins, N.E.2
Alworth, W.L.3
Hollenberg, P.F.4
-
147
-
-
0018601716
-
Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl
-
A. Wade, A. M. Symons, L. Martin, D. V. Parke, 'Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl', Biochem. J. 1979, 184, 509-517.
-
(1979)
Biochem. J
, vol.184
, pp. 509-517
-
-
Wade, A.1
Symons, A.M.2
Martin, L.3
Parke, D.V.4
-
148
-
-
0018947737
-
The metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl in vitro
-
A. Wade, A. M. Symons, L. Martin, D. V. Parke, 'The metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl in vitro', Biochem. J. 1980, 188, 867-872.
-
(1980)
Biochem. J
, vol.188
, pp. 867-872
-
-
Wade, A.1
Symons, A.M.2
Martin, L.3
Parke, D.V.4
-
149
-
-
0019179887
-
Structure-activity relationships in the destruction of cytochrome P450 mediated by certain ethynyl-substituted compounds in rats
-
I. N. H. White, 'Structure-activity relationships in the destruction of cytochrome P450 mediated by certain ethynyl-substituted compounds in rats', Biochem. Pharmacol. 1980, 29, 3253-3255.
-
(1980)
Biochem. Pharmacol
, vol.29
, pp. 3253-3255
-
-
White, I.N.H.1
-
150
-
-
0037671388
-
Mechanism-based inactivation of cytochrome P450 2B6 by a novel terminal acetylene inhibitor
-
P. W. Fan, C. Gu, S. A. Marsh, J. C. Stevens, 'Mechanism-based inactivation of cytochrome P450 2B6 by a novel terminal acetylene inhibitor', Drug Metab. Dispos. 2003, 31, 28-36.
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 28-36
-
-
Fan, P.W.1
Gu, C.2
Marsh, S.A.3
Stevens, J.C.4
-
151
-
-
0036707616
-
Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: Selective inactivation of P450 3A4
-
K. K. Khan, Y. Q. He, M. A. Correia, J. R. Halpert, 'Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: Selective inactivation of P450 3A4', Drug Metab. Dispos. 2002, 30, 985-990.
-
(2002)
Drug Metab. Dispos
, vol.30
, pp. 985-990
-
-
Khan, K.K.1
He, Y.Q.2
Correia, M.A.3
Halpert, J.R.4
-
152
-
-
0015760480
-
Differentiation of various types of biological oxidation of nitrogen in organic compounds
-
J. W. Gorrod, 'Differentiation of various types of biological oxidation of nitrogen in organic compounds', Chem.-Biol. Interact. 1973, 7, 289-303.
-
(1973)
Chem.-Biol. Interact
, vol.7
, pp. 289-303
-
-
Gorrod, J.W.1
-
153
-
-
0032531915
-
Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes
-
D. H. Lang, C. K. Yeung, R. M. Peter, C. Ibarra, R. Gasser, K. Itagaki, R. M. Philpot, A. E. Rettie, 'Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes', Biochem. Pharmacol. 1998, 56, 1005-1012.
-
(1998)
Biochem. Pharmacol
, vol.56
, pp. 1005-1012
-
-
Lang, D.H.1
Yeung, C.K.2
Peter, R.M.3
Ibarra, C.4
Gasser, R.5
Itagaki, K.6
Philpot, R.M.7
Rettie, A.E.8
-
154
-
-
0032862884
-
Structure-property relations in the basicity and lipophilicity of arylalkylamine oxides
-
G. Caron, G. Ermondi, D. Boschi, P. A. Carrupt, R. Fruttero, B. Testa, A. Gasco, 'Structure-property relations in the basicity and lipophilicity of arylalkylamine oxides', Helv. Chim. Acta 1999, 82, 1630-1639.
-
(1999)
Helv. Chim. Acta
, vol.82
, pp. 1630-1639
-
-
Caron, G.1
Ermondi, G.2
Boschi, D.3
Carrupt, P.A.4
Fruttero, R.5
Testa, B.6
Gasco, A.7
-
155
-
-
34250647153
-
-
E. M. Hawes, T. J. Jawoeski, K. K. Midha, G. McKay, J. W. Hubbard, E. D. Korchinski, 'In vivo metabolism of N-oxides', in 'N-Oxidation of Drugs: Biochemistry, Pharmacology, Toxicology', Eds. P. Hlavida, L. A. Damani, Chapman and Hall, London, 1991, p. 263-286.
-
E. M. Hawes, T. J. Jawoeski, K. K. Midha, G. McKay, J. W. Hubbard, E. D. Korchinski, 'In vivo metabolism of N-oxides', in 'N-Oxidation of Drugs: Biochemistry, Pharmacology, Toxicology', Eds. P. Hlavida, L. A. Damani, Chapman and Hall, London, 1991, p. 263-286.
-
-
-
-
156
-
-
7544225874
-
The metabolic fate of amitriptyline, nortriptyline and amitryptylinoxide in man
-
U. Breyer-Pfaff, 'The metabolic fate of amitriptyline, nortriptyline and amitryptylinoxide in man', Drug Metab. Rev. 2004, 36, 723-746.
-
(2004)
Drug Metab. Rev
, vol.36
, pp. 723-746
-
-
Breyer-Pfaff, U.1
-
157
-
-
0028954243
-
Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans
-
J. R. Cashman, S. B. Park, C. E. Berkman, L. E. Cashman, 'Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans', Chem.-Biol. Interact. 1995, 96, 33-46.
-
(1995)
Chem.-Biol. Interact
, vol.96
, pp. 33-46
-
-
Cashman, J.R.1
Park, S.B.2
Berkman, C.E.3
Cashman, L.E.4
-
158
-
-
0026514338
-
Pharmacokinetics of moclobemide in male, virgin female, pregnant and nursing rats
-
S. Øie, T. W. Guentert, L. Tolentino, G. Hermodsson, 'Pharmacokinetics of moclobemide in male, virgin female, pregnant and nursing rats', J. Pharm. Pharmacol. 1992, 44, 413-418.
-
(1992)
J. Pharm. Pharmacol
, vol.44
, pp. 413-418
-
-
Øie, S.1
Guentert, T.W.2
Tolentino, L.3
Hermodsson, G.4
-
159
-
-
0032981915
-
N-Oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (Form 3): Role in bioactivation and detoxication
-
J. R. Cashman, Y. N. Xiong, L. Xu, A. Janowsky, 'N-Oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (Form 3): Role in bioactivation and detoxication', J. Pharmacol. Exp. Ther. 1999, 288, 1251-1260.
-
(1999)
J. Pharmacol. Exp. Ther
, vol.288
, pp. 1251-1260
-
-
Cashman, J.R.1
Xiong, Y.N.2
Xu, L.3
Janowsky, A.4
-
160
-
-
0029959134
-
N-Oxygenation of primary amines and hydroxylamines and retroreduction of hydroxylamines by adult human liver microsomes and adult human flavin-containing monooxygenase 3
-
J. Lin, C. E. Berkman, J. R. Cashman, 'N-Oxygenation of primary amines and hydroxylamines and retroreduction of hydroxylamines by adult human liver microsomes and adult human flavin-containing monooxygenase 3', Chem. Res. Toxicol. 1996, 9, 1183-1193.
-
(1996)
Chem. Res. Toxicol
, vol.9
, pp. 1183-1193
-
-
Lin, J.1
Berkman, C.E.2
Cashman, J.R.3
-
161
-
-
0030886020
-
N-Oxygenation of phenylethylamine to the trans-oxime by adult human liver flavin-containing monooxygenase and retroreduction of phenylethylamine hydroxylamine by human liver microsomes
-
J. Lin, J. R. Cashman, 'N-Oxygenation of phenylethylamine to the trans-oxime by adult human liver flavin-containing monooxygenase and retroreduction of phenylethylamine hydroxylamine by human liver microsomes', J. Pharmacol. Exp. Ther. 1997, 282, 1269-1279.
-
(1997)
J. Pharmacol. Exp. Ther
, vol.282
, pp. 1269-1279
-
-
Lin, J.1
Cashman, J.R.2
-
162
-
-
0020579326
-
Reductive drug metabolism
-
K. E. Mc Lane, J. Fisher, K. Ramakrishnan, 'Reductive drug metabolism', Drug Metab. Rev. 1983, 14, 741-799.
-
(1983)
Drug Metab. Rev
, vol.14
, pp. 741-799
-
-
Mc Lane, K.E.1
Fisher, J.2
Ramakrishnan, K.3
-
163
-
-
0023928052
-
Cytochrome P450-catalyzed dehydrogenation of 1,4-dihydropyridines
-
F. P. Guengerich, R. H. Böcker, 'Cytochrome P450-catalyzed dehydrogenation of 1,4-dihydropyridines', J. Biol. Chem. 1988, 263, 8168-8175.
-
(1988)
J. Biol. Chem
, vol.263
, pp. 8168-8175
-
-
Guengerich, F.P.1
Böcker, R.H.2
-
164
-
-
0025860978
-
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P450 IIIA4
-
F. P. Guengerich, W. R. Brian, M. Iwasaki, M. A. Sari, C. Bäärnhielm, P. Berntsson, 'Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P450 IIIA4', J. Med. Chem. 1991, 34, 1838-1844.
-
(1991)
J. Med. Chem
, vol.34
, pp. 1838-1844
-
-
Guengerich, F.P.1
Brian, W.R.2
Iwasaki, M.3
Sari, M.A.4
Bäärnhielm, C.5
Berntsson, P.6
-
165
-
-
0036041122
-
N-Hydroxylarylamines
-
F. P. Guengerich, 'N-Hydroxylarylamines', Drug Metab. Rev. 2002, 34, 607-623;
-
(2002)
Drug Metab. Rev
, vol.34
, pp. 607-623
-
-
Guengerich, F.P.1
-
166
-
-
13844316753
-
Cytochrome P450 activation of arylamines and heterocyclic amines
-
D. Kim, F. P. Guengerich, 'Cytochrome P450 activation of arylamines and heterocyclic amines', Annu. Rev. Pharmacol. Toxicol. 2005, 45, 27-49.
-
(2005)
Annu. Rev. Pharmacol. Toxicol
, vol.45
, pp. 27-49
-
-
Kim, D.1
Guengerich, F.P.2
-
167
-
-
0032913756
-
Regiochemistry of nucleophilic attack by the guanine 2-amino group at the ring positions of nitrenium ions derived from carcinogenic polycyclic arylamines and nitroarenes: Molecular orbital calculations and simple models
-
G. P. Ford, J. W. Thompson, 'Regiochemistry of nucleophilic attack by the guanine 2-amino group at the ring positions of nitrenium ions derived from carcinogenic polycyclic arylamines and nitroarenes: Molecular orbital calculations and simple models', Chem. Res. Toxicol. 1999, 12, 53-59;
-
(1999)
Chem. Res. Toxicol
, vol.12
, pp. 53-59
-
-
Ford, G.P.1
Thompson, J.W.2
-
168
-
-
0026584188
-
Relative stability of nitrenium ions derived from polycyclic aromatic amines. Relationship to mutagenicity
-
G. P. Ford, P. S. Herman, 'Relative stability of nitrenium ions derived from polycyclic aromatic amines. Relationship to mutagenicity', Chem.-Biol. Interact. 1992, 81, 1-18;
-
(1992)
Chem.-Biol. Interact
, vol.81
, pp. 1-18
-
-
Ford, G.P.1
Herman, P.S.2
-
169
-
-
0026512204
-
Relative stability of nitrenium ions derived from heterocyclic amine food carcinogens. Relationship to mutagenicity
-
G. P. Ford, G. R. Griffin, 'Relative stability of nitrenium ions derived from heterocyclic amine food carcinogens. Relationship to mutagenicity', Chem.-Biol. Interact. 1992, 81, 19-33;
-
(1992)
Chem.-Biol. Interact
, vol.81
, pp. 19-33
-
-
Ford, G.P.1
Griffin, G.R.2
-
170
-
-
0027474794
-
Reactivity and genotoxicity of arylnitrenium ions in bacterial and mammalian cells
-
R. S. Kerdar, D. Dehner, D. Wild, 'Reactivity and genotoxicity of arylnitrenium ions in bacterial and mammalian cells', Toxicol. Lett. 1993, 67, 73-85.
-
(1993)
Toxicol. Lett
, vol.67
, pp. 73-85
-
-
Kerdar, R.S.1
Dehner, D.2
Wild, D.3
-
171
-
-
0030815886
-
Comparison of the metabolism and toxicity of dapsone in rat, mouse and man
-
M. D. Tingle, R. Mahmud, J. L. Maggs, M. Pirmohamed, B. K. Park, 'Comparison of the metabolism and toxicity of dapsone in rat, mouse and man', J. Pharmacol. Exp. Ther. 1997, 283, 817-823.
-
(1997)
J. Pharmacol. Exp. Ther
, vol.283
, pp. 817-823
-
-
Tingle, M.D.1
Mahmud, R.2
Maggs, J.L.3
Pirmohamed, M.4
Park, B.K.5
-
172
-
-
0032520749
-
Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone
-
R. P. Reilly, F. H. Bellevue III, P. M. Woster, C. K. Svensson, 'Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone', Biochem. Pharmacol. 1998, 55, 803-810.
-
(1998)
Biochem. Pharmacol
, vol.55
, pp. 803-810
-
-
Reilly, R.P.1
Bellevue III, F.H.2
Woster, P.M.3
Svensson, C.K.4
-
173
-
-
0025947068
-
Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione
-
A. E. Cribb, M. Miller, J. S. Leeder, J. Hill, S. P. Spielberg, 'Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione', Drug Metab. Dispos. 1991, 19, 900-906.
-
(1991)
Drug Metab. Dispos
, vol.19
, pp. 900-906
-
-
Cribb, A.E.1
Miller, M.2
Leeder, J.S.3
Hill, J.4
Spielberg, S.P.5
-
174
-
-
0026552198
-
Sulfamethoxazole is metabolized to the hydroxylamine in humans
-
A. E. Cribb, S. P. Spielberg, 'Sulfamethoxazole is metabolized to the hydroxylamine in humans', Clin. Pharmacol. Ther. 1992, 51, 522-526.
-
(1992)
Clin. Pharmacol. Ther
, vol.51
, pp. 522-526
-
-
Cribb, A.E.1
Spielberg, S.P.2
-
175
-
-
0031815379
-
Activation of heterocyclic aromatic amines by rat and human microsomes and by purified rat and human cytochrome P450 1A2
-
R. J. Turesky, A. Constable, J. Richoz, N. Varga, J. Markovic, M. V. Martin, F. P. Guengerich, 'Activation of heterocyclic aromatic amines by rat and human microsomes and by purified rat and human cytochrome P450 1A2', Chem. Res. Toxicol. 1998, 11, 925-936.
-
(1998)
Chem. Res. Toxicol
, vol.11
, pp. 925-936
-
-
Turesky, R.J.1
Constable, A.2
Richoz, J.3
Varga, N.4
Markovic, J.5
Martin, M.V.6
Guengerich, F.P.7
-
176
-
-
0027260697
-
Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents
-
L. Koymans, G. M. Donné-Op den Kelder, J. M. te Koppele, N. P. E. Vermeulen, 'Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents', Xenobiotica 1993, 23, 633-648.
-
(1993)
Xenobiotica
, vol.23
, pp. 633-648
-
-
Koymans, L.1
Donné-Op den Kelder, G.M.2
te Koppele, J.M.3
Vermeulen, N.P.E.4
-
177
-
-
0021831945
-
Metabolism of chemical carcinogens
-
A. Dipple, C. J. Michejda, E. K. Weisburger, 'Metabolism of chemical carcinogens', Pharmacol. Ther. 1985, 27, 265-296.
-
(1985)
Pharmacol. Ther
, vol.27
, pp. 265-296
-
-
Dipple, A.1
Michejda, C.J.2
Weisburger, E.K.3
-
178
-
-
0005719341
-
Arylamines and arylamides: Oxidation mechanisms
-
Ed. M. W. Anders, Academic Press, Orlando
-
S. D. Nelson, 'Arylamines and arylamides: Oxidation mechanisms', in 'Bioactivation of Foreign Compounds', Ed. M. W. Anders, Academic Press, Orlando, 1985, p. 349-374.
-
(1985)
Bioactivation of Foreign Compounds
, pp. 349-374
-
-
Nelson, S.D.1
-
179
-
-
0019919026
-
The non- and postenzymatic chemistry of N-oxygenated molecules
-
B. Lindeke, 'The non- and postenzymatic chemistry of N-oxygenated molecules', Drug Metab. Rev. 1982, 13, 71-121.
-
(1982)
Drug Metab. Rev
, vol.13
, pp. 71-121
-
-
Lindeke, B.1
-
180
-
-
0025216230
-
Mechanisms of oxidation of phenacetin to reactive metabolites by cytochrome P450: A theoretical study involving radical intermediates
-
L. Koymans, J. H. Van Lenthe, G. M. Donné-Op den Kelder, N. P. E. Vermeulen, 'Mechanisms of oxidation of phenacetin to reactive metabolites by cytochrome P450: A theoretical study involving radical intermediates', Mol. Pharmacol. 1990, 37, 452-460.
-
(1990)
Mol. Pharmacol
, vol.37
, pp. 452-460
-
-
Koymans, L.1
Van Lenthe, J.H.2
Donné-Op den Kelder, G.M.3
Vermeulen, N.P.E.4
-
181
-
-
33746792830
-
3: Measurement of futile metabolic deacetylation vis HPLC/MS-SPE-NMR and HPLC-ToF MS
-
3: Measurement of futile metabolic deacetylation vis HPLC/MS-SPE-NMR and HPLC-ToF MS', Xenobiotica 2006, 36, 615-629.
-
(2006)
Xenobiotica
, vol.36
, pp. 615-629
-
-
Nichols, A.W.1
Wilson, I.D.2
Godejohann, M.3
Nicholson, I.K.4
Stockcor, J.P.5
-
182
-
-
0025196912
-
Metabolism of nitro-polycyclic aromatic hydrocarbons
-
P. P. Fu, 'Metabolism of nitro-polycyclic aromatic hydrocarbons', Drug Metab. Rev. 1990, 22, 209-268.
-
(1990)
Drug Metab. Rev
, vol.22
, pp. 209-268
-
-
Fu, P.P.1
-
183
-
-
0022392309
-
The early history of xenobiotic sulfoxidation
-
S. C. Mitchell, R. H. Waring, 'The early history of xenobiotic sulfoxidation', Drug Metab. Rev. 1985, 16, 255-284.
-
(1985)
Drug Metab. Rev
, vol.16
, pp. 255-284
-
-
Mitchell, S.C.1
Waring, R.H.2
-
184
-
-
0022408102
-
Comparison of sulfide oxygenation mechanism for liver microsomal FAD-containing mono-oxygenase with that for cytochrome P-450
-
S. Oae, A. Mikami, T. Matsuura, K. Ogawa-Asada, Y. Watanabe, K. Fujimori, T. Iyanagi, 'Comparison of sulfide oxygenation mechanism for liver microsomal FAD-containing mono-oxygenase with that for cytochrome P-450', Biochem. Biophys. Res. Commun. 1985, 131, 567-573.
-
(1985)
Biochem. Biophys. Res. Commun
, vol.131
, pp. 567-573
-
-
Oae, S.1
Mikami, A.2
Matsuura, T.3
Ogawa-Asada, K.4
Watanabe, Y.5
Fujimori, K.6
Iyanagi, T.7
-
185
-
-
1342323499
-
In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily
-
K. A. Usmani, E. D. Karoly, E. Hodgson, R. L. Rose, 'In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily', Drug Metab. Dispos. 2004, 32, 333-339.
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 333-339
-
-
Usmani, K.A.1
Karoly, E.D.2
Hodgson, E.3
Rose, R.L.4
-
186
-
-
0030890218
-
Lipophilicity behavior of model and medicinal compounds containing a sulfide, sulfoxide, or sulfone moiety
-
G. Caron, P. Gaillard, P. A. Carrupt, B. Testa, 'Lipophilicity behavior of model and medicinal compounds containing a sulfide, sulfoxide, or sulfone moiety', Helv. Chim. Acta 1997, 80, 449-462.
-
(1997)
Helv. Chim. Acta
, vol.80
, pp. 449-462
-
-
Caron, G.1
Gaillard, P.2
Carrupt, P.A.3
Testa, B.4
-
187
-
-
0032697030
-
Clinical pharmacokinetics and drug metabolism of tazarotene
-
D. D. S. Tang-Liu, R. M. Matsumoto, J. I. Usansky, 'Clinical pharmacokinetics and drug metabolism of tazarotene', Clin. Pharmacokinet. 1999, 37, 273-287.
-
(1999)
Clin. Pharmacokinet
, vol.37
, pp. 273-287
-
-
Tang-Liu, D.D.S.1
Matsumoto, R.M.2
Usansky, J.I.3
-
188
-
-
0037378805
-
Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotene acid in humans
-
M. Attar, D. Dong, K. H. J. Ling, D. D. S. Tang-Liu, 'Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotene acid in humans', Drug Metab. Dispos. 2003, 31, 476-481.
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 476-481
-
-
Attar, M.1
Dong, D.2
Ling, K.H.J.3
Tang-Liu, D.D.S.4
-
189
-
-
0028343305
-
Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: Studies with rabbit FMO1, FMO2, FMO3 and FMO5 expressed in Escherichia coli
-
A. E. Rettie, M. P. Lawton, A. Jafar, M. Sadeque, G. P. Meier, R. M. Philpot,'Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: Studies with rabbit FMO1, FMO2, FMO3 and FMO5 expressed in Escherichia coli', Arch. Biochem. Biophys. 1994, 311, 369-377.
-
(1994)
Arch. Biochem. Biophys
, vol.311
, pp. 369-377
-
-
Rettie, A.E.1
Lawton, M.P.2
Jafar, A.3
Sadeque, M.4
Meier, G.P.5
Philpot, R.M.6
-
190
-
-
0031756449
-
Stereoselectivity in S- and N-oxygenation by the mammalian flavin-containing and cytochrome P450 monooxygenases
-
J. R. Cashman, 'Stereoselectivity in S- and N-oxygenation by the mammalian flavin-containing and cytochrome P450 monooxygenases', Drug Metab. Rev. 1998, 30, 675-707.
-
(1998)
Drug Metab. Rev
, vol.30
, pp. 675-707
-
-
Cashman, J.R.1
-
191
-
-
0015773336
-
Physiologic disposition and metabolic fate of a new anti-inflammatory agent, sulindac in the rat, dog, rhesus monkey, and man
-
H. B. Hucker, S. C. Stauffer, S. D. White, R. E. Rhodes, B. H. Arison, E. R. Umbenhauer, R. J. Bower, F. G. McMahon, 'Physiologic disposition and metabolic fate of a new anti-inflammatory agent, sulindac in the rat, dog, rhesus monkey, and man', Drug Metab. Dispos. 1973, 1, 721-736.
-
(1973)
Drug Metab. Dispos
, vol.1
, pp. 721-736
-
-
Hucker, H.B.1
Stauffer, S.C.2
White, S.D.3
Rhodes, R.E.4
Arison, B.H.5
Umbenhauer, E.R.6
Bower, R.J.7
McMahon, F.G.8
-
192
-
-
0034097599
-
Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases
-
M. A. Hamman, B. D. Haehner-Daniels, S. A. Wrighton, A. E. Rettie, S. D. Hall, 'Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases', Biochem. Pharmacol. 2000, 60, 7-17.
-
(2000)
Biochem. Pharmacol
, vol.60
, pp. 7-17
-
-
Hamman, M.A.1
Haehner-Daniels, B.D.2
Wrighton, S.A.3
Rettie, A.E.4
Hall, S.D.5
-
193
-
-
0027462628
-
Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases
-
D. M. Ziegler, 'Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases', Annu. Rev. Pharmacol. Toxicol. 1993, 33, 179-199.
-
(1993)
Annu. Rev. Pharmacol. Toxicol
, vol.33
, pp. 179-199
-
-
Ziegler, D.M.1
-
194
-
-
0023119493
-
Studies on substrate specificity of the hog liver flavin-containing monooxygenase. Anionic organic sulfur compounds
-
K. L. Taylor, D. M. Ziegler, 'Studies on substrate specificity of the hog liver flavin-containing monooxygenase. Anionic organic sulfur compounds', Biochem. Pharmacol. 1987, 36, 141-146.
-
(1987)
Biochem. Pharmacol
, vol.36
, pp. 141-146
-
-
Taylor, K.L.1
Ziegler, D.M.2
-
195
-
-
0024397272
-
Oxidative metabolism of spironolactone: Evidence for the involvement of electrophilic thiosteroid species in drug-mediated destruction of rat hepatic cytochrome P450
-
C. J. Decker, M. S. Rashed, T. A. Baillie, D. Maltby, M. A. Correia, 'Oxidative metabolism of spironolactone: evidence for the involvement of electrophilic thiosteroid species in drug-mediated destruction of rat hepatic cytochrome P450', Biochemistry 1989, 28, 5128-5136.
-
(1989)
Biochemistry
, vol.28
, pp. 5128-5136
-
-
Decker, C.J.1
Rashed, M.S.2
Baillie, T.A.3
Maltby, D.4
Correia, M.A.5
-
196
-
-
0025880860
-
Formation of glutathionyl-spironolactone disulfide by rat liver cytochromes P450 or hog liver flavin-containing monooxygenases: A functional probe of two-electron oxidations of the thiosteroid
-
C. J. Decker, J. R. Cashman, K. Sugiyama, D. Maltby, M. A. Correia, 'Formation of glutathionyl-spironolactone disulfide by rat liver cytochromes P450 or hog liver flavin-containing monooxygenases: a functional probe of two-electron oxidations of the thiosteroid', Chem. Res. Toxicol. 1991, 4, 669-677.
-
(1991)
Chem. Res. Toxicol
, vol.4
, pp. 669-677
-
-
Decker, C.J.1
Cashman, J.R.2
Sugiyama, K.3
Maltby, D.4
Correia, M.A.5
-
197
-
-
0033064615
-
Metabolism of diallyl disulfide by human liver microsomal cytochromes P450 and flavin-containing monooxygenases
-
C. Teyssier, L. Guenot, M. Suschetet, M. H. Siess, 'Metabolism of diallyl disulfide by human liver microsomal cytochromes P450 and flavin-containing monooxygenases', Drug Metab. Dispos. 1999, 27, 835-841.
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 835-841
-
-
Teyssier, C.1
Guenot, L.2
Suschetet, M.3
Siess, M.H.4
-
198
-
-
1642498338
-
Hepatic metabolism of diallyl disulfide in rat and man
-
E. Germain, J. Chevalier, M. H. Siess, C. Teyssier, 'Hepatic metabolism of diallyl disulfide in rat and man', Xenobiotica 2003, 33, 1185-1199.
-
(2003)
Xenobiotica
, vol.33
, pp. 1185-1199
-
-
Germain, E.1
Chevalier, J.2
Siess, M.H.3
Teyssier, C.4
-
199
-
-
0026611401
-
35S-labeled thiocarbamides in rat hepatic microsomes
-
35S-labeled thiocarbamides in rat hepatic microsomes', Biochem. Pharmacol. 1992, 43, 881-888.
-
(1992)
Biochem. Pharmacol
, vol.43
, pp. 881-888
-
-
Decker, C.J.1
Doerge, D.R.2
-
200
-
-
0020678413
-
Studies of the mechanism of metabolism of thioacetamide S-oxide by rat liver microsomes
-
M. C. Dyroff, R. A. Neal, 'Studies of the mechanism of metabolism of thioacetamide S-oxide by rat liver microsomes', Mol. Pharmacol. 1983, 23, 219-227.
-
(1983)
Mol. Pharmacol
, vol.23
, pp. 219-227
-
-
Dyroff, M.C.1
Neal, R.A.2
-
201
-
-
0037066702
-
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
-
T. A. Vannelli, A. Dykman, P. R. Ortiz de Montellano, 'The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase', J. Biol. Chem. 2002, 277, 12824-12829.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 12824-12829
-
-
Vannelli, T.A.1
Dykman, A.2
Ortiz de Montellano, P.R.3
-
202
-
-
0018884625
-
Inactivation of purified rat liver cytochrome P450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate)
-
J. Halpert, D. Hammond, R. A. Neal, 'Inactivation of purified rat liver cytochrome P450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate)', J. Biol. Chem. 1980, 255, 1080-1089.
-
(1980)
J. Biol. Chem
, vol.255
, pp. 1080-1089
-
-
Halpert, J.1
Hammond, D.2
Neal, R.A.3
-
203
-
-
0026691008
-
Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention
-
N. P. E. Vermeulen, J. G. M. Bessems, R. van de Straat, 'Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention', Drug Metab. Rev. 1992, 24, 367-407.
-
(1992)
Drug Metab. Rev
, vol.24
, pp. 367-407
-
-
Vermeulen, N.P.E.1
Bessems, J.G.M.2
van de Straat, R.3
-
204
-
-
0027304762
-
Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics
-
C. J. Patten, P. E. Thomas, R. L. Guy, M. Lee, F. J. Gonzalez, F. P. Guengerich, C. S. Yang, 'Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics', Chem. Res. Toxicol. 1993, 6, 511-518.
-
(1993)
Chem. Res. Toxicol
, vol.6
, pp. 511-518
-
-
Patten, C.J.1
Thomas, P.E.2
Guy, R.L.3
Lee, M.4
Gonzalez, F.J.5
Guengerich, F.P.6
Yang, C.S.7
-
205
-
-
15844419997
-
-
S. S. T Lee, J. T. M: Buters, T. Pineau, P. Fernandez Alguero, F. J. Gonzalez, 'Role of CYP2E1 in the hepatotoxicity of acetaminophen', J. Biol. Chem. 1996, 271, 12063-12067.
-
S. S. T Lee, J. T. M: Buters, T. Pineau, P. Fernandez Alguero, F. J. Gonzalez, 'Role of CYP2E1 in the hepatotoxicity of acetaminophen', J. Biol. Chem. 1996, 271, 12063-12067.
-
-
-
-
206
-
-
0031710907
-
Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450
-
J. G. M. Bessems, M. J. de Groot, E. J. Baede, J. M. te Koppele, N. P. E. Vermeulen, 'Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450', Xenobiotica 1998, 28, 855-875.
-
(1998)
Xenobiotica
, vol.28
, pp. 855-875
-
-
Bessems, J.G.M.1
de Groot, M.J.2
Baede, E.J.3
te Koppele, J.M.4
Vermeulen, N.P.E.5
-
207
-
-
0027410978
-
Biological and toxicological consequences of quinone methide formation
-
D. C. Thompson, J. A. Thompson, M. Sugumaran, P. Moldéus, 'Biological and toxicological consequences of quinone methide formation', Chem.-Biol. Interact. 1992, 86, 129-162.
-
(1992)
Chem.-Biol. Interact
, vol.86
, pp. 129-162
-
-
Thompson, D.C.1
Thompson, J.A.2
Sugumaran, M.3
Moldéus, P.4
-
208
-
-
0023585268
-
Oxidative metabolism of butylated hydroxytoluene by hepatic and pulmonary microsomes from rats and mice
-
J. A. Thompson, A. M. Malkinson, M. D. Wand, S. L. Mastovich, E. W. Mead, K. M. Schullek, W. G. Laudenschlager, 'Oxidative metabolism of butylated hydroxytoluene by hepatic and pulmonary microsomes from rats and mice', Drug Metab. Dispos. 1987, 15, 833-840.
-
(1987)
Drug Metab. Dispos
, vol.15
, pp. 833-840
-
-
Thompson, J.A.1
Malkinson, A.M.2
Wand, M.D.3
Mastovich, S.L.4
Mead, E.W.5
Schullek, K.M.6
Laudenschlager, W.G.7
-
209
-
-
33646539102
-
Metabolism, pharmacokinetic and excretion of a potent tachykinin NK1 receptor antagonist (CP-122,721) in rat: Characterization of a novel oxidative pathway
-
A. Kamel, J. Davis, M. J. Potchoiba, C. Prakash, 'Metabolism, pharmacokinetic and excretion of a potent tachykinin NK1 receptor antagonist (CP-122,721) in rat: Characterization of a novel oxidative pathway', Xenobiotica 2006, 36, 235-258.
-
(2006)
Xenobiotica
, vol.36
, pp. 235-258
-
-
Kamel, A.1
Davis, J.2
Potchoiba, M.J.3
Prakash, C.4
-
210
-
-
0031422710
-
Cytochrome P450-dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes
-
M. R. Anari, S. Khan, S. D. Jatoe, P. J. O'Brien, 'Cytochrome P450-dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes', Eur. J. Drug Metab. Pharmacokinet. 1997, 22, 305-310.
-
(1997)
Eur. J. Drug Metab. Pharmacokinet
, vol.22
, pp. 305-310
-
-
Anari, M.R.1
Khan, S.2
Jatoe, S.D.3
O'Brien, P.J.4
-
211
-
-
0028010806
-
Identification of fatty acid hydroperoxide cofactors in the cytochrome P450-mediated oxidation of estrogens to quinone metabolites
-
M. Y. Wang, J. G. Liehr, 'Identification of fatty acid hydroperoxide cofactors in the cytochrome P450-mediated oxidation of estrogens to quinone metabolites', J. Biol. Chem. 1994, 269, 284-291.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 284-291
-
-
Wang, M.Y.1
Liehr, J.G.2
-
212
-
-
0030917089
-
Hydrogen peroxide supports human and rat cytochrome P450 1A2-catalyzed 2-amino-3-methylimidazo[4,5-f]quinoline bioactivation to mutagenic metabolites: Significance of cytochrome P450 peroxidase
-
M. R. Anari, R D. Josephy, T. Henry, P. J. O'Brien, 'Hydrogen peroxide supports human and rat cytochrome P450 1A2-catalyzed 2-amino-3-methylimidazo[4,5-f]quinoline bioactivation to mutagenic metabolites: Significance of cytochrome P450 peroxidase', Chem. Res. Toxicol. 1997, 10, 582-588.
-
(1997)
Chem. Res. Toxicol
, vol.10
, pp. 582-588
-
-
Anari, M.R.1
Josephy, R.D.2
Henry, T.3
O'Brien, P.J.4
-
213
-
-
0026463538
-
-
R. W. Chadwick, S. E. George, L. D. Claxton, 'Role of the gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens', Drug Metab. Rev. 1992, 24, 425-492.
-
R. W. Chadwick, S. E. George, L. D. Claxton, 'Role of the gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens', Drug Metab. Rev. 1992, 24, 425-492.
-
-
-
-
214
-
-
0026567713
-
Oxidative and reductive metabolism by cytochrome P450 2E1
-
D. R. Koop, 'Oxidative and reductive metabolism by cytochrome P450 2E1', FASEB J. 1992, 6, 724-730.
-
(1992)
FASEB J
, vol.6
, pp. 724-730
-
-
Koop, D.R.1
-
215
-
-
0028876897
-
Oxygen and xenobiotic reductase activities by cytochrome P450
-
A. R. Goeptar, H. Scheerens, N. P. E. Vermeulen, 'Oxygen and xenobiotic reductase activities by cytochrome P450', Crit. Rev. Toxicol. 1995, 25, 25-65.
-
(1995)
Crit. Rev. Toxicol
, vol.25
, pp. 25-65
-
-
Goeptar, A.R.1
Scheerens, H.2
Vermeulen, N.P.E.3
-
216
-
-
0022505086
-
Inhibiting or potentiating effects of flavonoids on carbon tetrachloride-induced toxicity in isolated rat hepatocytes
-
D. Perrissoud, B. Testa, 'Inhibiting or potentiating effects of flavonoids on carbon tetrachloride-induced toxicity in isolated rat hepatocytes', Arzneim.-Forsch. (Drug Res.) 1986, 36, 1249-1253.
-
(1986)
Arzneim.-Forsch. (Drug Res.)
, vol.36
, pp. 1249-1253
-
-
Perrissoud, D.1
Testa, B.2
-
217
-
-
27144524217
-
Drug metabolism and drug toxicity: Some evolutionary considerations
-
Part B, Eds. P. Jenner, B. Testa, Dekker, New York
-
W. R. Jondorf, 'Drug metabolism and drug toxicity: Some evolutionary considerations', in 'Concepts in Drug Metabolism, Part B', Eds. P. Jenner, B. Testa, Dekker, New York, 1981, p. 307-376.
-
(1981)
Concepts in Drug Metabolism
, pp. 307-376
-
-
Jondorf, W.R.1
-
218
-
-
0029047149
-
Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist
-
W. R. Kelce, C. R. Stone, S. C. Laws, L. E. Gray, J. A. Kemppainen, E. M. Wilson, 'Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist', Nature 1995, 375, 581-585.
-
(1995)
Nature
, vol.375
, pp. 581-585
-
-
Kelce, W.R.1
Stone, C.R.2
Laws, S.C.3
Gray, L.E.4
Kemppainen, J.A.5
Wilson, E.M.6
-
219
-
-
0025974665
-
The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane
-
M. Manno, S. Cazzaro, M. Rezzadore, 'The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane', Arch. Toxicol. 1991, 65, 191-198.
-
(1991)
Arch. Toxicol
, vol.65
, pp. 191-198
-
-
Manno, M.1
Cazzaro, S.2
Rezzadore, M.3
-
220
-
-
0029809856
-
Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4′
-
D. K. Spracklin, K. E. Thummel, E. D. Kharasch, 'Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4′, Drug Metab. Dispos. 1991, 24, 976-983.
-
(1991)
Drug Metab. Dispos
, vol.24
, pp. 976-983
-
-
Spracklin, D.K.1
Thummel, K.E.2
Kharasch, E.D.3
-
221
-
-
16244387932
-
Metabolism of benzamidoxime (N-hydroxyamidine) in human hepatocytes and role of UDP-glucuronosyltransferases
-
A. K. Fröhlich, U. Girreser, B. Clement, 'Metabolism of benzamidoxime (N-hydroxyamidine) in human hepatocytes and role of UDP-glucuronosyltransferases', Xenobiotica 2005, 35, 17-25.
-
(2005)
Xenobiotica
, vol.35
, pp. 17-25
-
-
Fröhlich, A.K.1
Girreser, U.2
Clement, B.3
-
222
-
-
29144492135
-
Oxygen-insensitive enzymatic reduction of oximes to imines
-
S. Heberling, U. Girreser, S. Wolf, B. Clement, 'Oxygen-insensitive enzymatic reduction of oximes to imines', Biochem. Pharmacol. 2006, 71, 354-365.
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 354-365
-
-
Heberling, S.1
Girreser, U.2
Wolf, S.3
Clement, B.4
-
223
-
-
0036038490
-
Reduction of N-hydroxylated compounds: Amidoximes (N-hydroxyamidines) as prodrugs of amidines
-
B. Clement, 'Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as prodrugs of amidines', Drug Metab. Rev. 2002, 34, 565-579.
-
(2002)
Drug Metab. Rev
, vol.34
, pp. 565-579
-
-
Clement, B.1
-
224
-
-
0026498205
-
Substrates for microsomal azoreductase. Hammett substituent effects, NMR studies and response to inhibitors
-
S. Zbaida, C. F. Brewer, W. G. Levine. 'Substrates for microsomal azoreductase. Hammett substituent effects, NMR studies and response to inhibitors', Drug Metab. Dispos. 1992, 20, 902-908.
-
(1992)
Drug Metab. Dispos
, vol.20
, pp. 902-908
-
-
Zbaida, S.1
Brewer, C.F.2
Levine, W.G.3
-
225
-
-
0026768273
-
Multiple mechanisms in hepatic microsomal azoreduction
-
W. G. Levine, A. Stoddart, S. Zbaida, 'Multiple mechanisms in hepatic microsomal azoreduction', Xenobiotica 1992, 22, 1111-1120.
-
(1992)
Xenobiotica
, vol.22
, pp. 1111-1120
-
-
Levine, W.G.1
Stoddart, A.2
Zbaida, S.3
-
226
-
-
0029143024
-
The mechanism of microsomal azoreduction: Predictions based on electronic aspects of structure-activity relationships
-
S. Zbaida, 'The mechanism of microsomal azoreduction: predictions based on electronic aspects of structure-activity relationships', Drug Metab. Rev. 1995, 27, 497-516.
-
(1995)
Drug Metab. Rev
, vol.27
, pp. 497-516
-
-
Zbaida, S.1
-
227
-
-
0027451533
-
Reduction of 3′-azido-2′,3′-dideoxynucleosides to their 3′-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes
-
E. M. Cretton, J. P. Sommadossi, 'Reduction of 3′-azido-2′,3′-dideoxynucleosides to their 3′-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes', Drug Metab. Dispos. 1993, 21, 946-950.
-
(1993)
Drug Metab. Dispos
, vol.21
, pp. 946-950
-
-
Cretton, E.M.1
Sommadossi, J.P.2
-
228
-
-
0032520707
-
5 in the reductive metabolism of 3′-azido-3′-deoxythymidine (AZT) to 3′-amino-3′-deoxythymidine
-
5 in the reductive metabolism of 3′-azido-3′-deoxythymidine (AZT) to 3′-amino-3′-deoxythymidine', Biochem. Pharmacol. 1998, 55, 757-766.
-
(1998)
Biochem. Pharmacol
, vol.55
, pp. 757-766
-
-
Pan-Zhou, X.R.1
Cretton-Scott, E.2
Zhou, X.J.3
Yang, M.X.4
Lasker, J.M.5
Sommadossi, J.P.6
-
229
-
-
0022580542
-
Biochemistry of reduction of nitro heterocycles
-
J. E. Biaglow, M. E. Varnes, L. Roizen-Towle, E. P. Clark, E. R. Epp, M. B. Astor, E. J. Hall, 'Biochemistry of reduction of nitro heterocycles', Biochem. Pharmacol. 1986, 35, 77-90.
-
(1986)
Biochem. Pharmacol
, vol.35
, pp. 77-90
-
-
Biaglow, J.E.1
Varnes, M.E.2
Roizen-Towle, L.3
Clark, E.P.4
Epp, E.R.5
Astor, M.B.6
Hall, E.J.7
-
230
-
-
0033841374
-
Mutagenicity of nitroaromatic compounds
-
V. Purohit, A. K. Basu, 'Mutagenicity of nitroaromatic compounds', Chem. Res. Toxicol. 2000, 13, 673-692.
-
(2000)
Chem. Res. Toxicol
, vol.13
, pp. 673-692
-
-
Purohit, V.1
Basu, A.K.2
-
231
-
-
0027390265
-
The one-electron reduction potential of several substrates can be related to their reduction rates by cytochrome P-450 reductase
-
J. Butler, B. M. Hoey, 'The one-electron reduction potential of several substrates can be related to their reduction rates by cytochrome P-450 reductase', Biochim. Biophys. Acta 1993, 1161, 73-78.
-
(1993)
Biochim. Biophys. Acta
, vol.1161
, pp. 73-78
-
-
Butler, J.1
Hoey, B.M.2
-
232
-
-
0026033301
-
Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4′-nitrowarfarin (acenocoumarol)
-
J. J. R. Hermans, H. H. W. Thijssen, 'Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4′-nitrowarfarin (acenocoumarol)', Xenobiotica 1991, 21, 295-307.
-
(1991)
Xenobiotica
, vol.21
, pp. 295-307
-
-
Hermans, J.J.R.1
Thijssen, H.H.W.2
-
233
-
-
29144463259
-
Metabolism of nilutamide in rat lung
-
K. Ask, N. Décologne, C. Ginies, M. Låg, J. L. Boucher, J. A. Holme, H. Pelczar, P. Camus, 'Metabolism of nilutamide in rat lung', Biochem. Pharmacol. 2006, 71, 377-395.
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 377-395
-
-
Ask, K.1
Décologne, N.2
Ginies, C.3
Låg, M.4
Boucher, J.L.5
Holme, J.A.6
Pelczar, H.7
Camus, P.8
-
234
-
-
0036276786
-
Metabolism of the analgesic drug ULTRAM® (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites
-
W. N. Wu, L. A. McKown, S. Liao, 'Metabolism of the analgesic drug ULTRAM® (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites', Xenobiotica 2002, 32, 411-425.
-
(2002)
Xenobiotica
, vol.32
, pp. 411-425
-
-
Wu, W.N.1
McKown, L.A.2
Liao, S.3
-
235
-
-
33745138542
-
Metabolism of two analgesic agents, tramadol N-oxide and tramadol, in specific pathogen-free and axenic mice
-
W. N. Wu, L. A. McKown, E. E. Codd, R. B. Raffa, 'Metabolism of two analgesic agents, tramadol N-oxide and tramadol, in specific pathogen-free and axenic mice', Xenobiotica 2006, 36, 551-565.
-
(2006)
Xenobiotica
, vol.36
, pp. 551-565
-
-
Wu, W.N.1
McKown, L.A.2
Codd, E.E.3
Raffa, R.B.4
-
236
-
-
0032717495
-
Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug
-
S. M. Raleigh, E. Wanogho, M. D. Burke, L. H. Patterson, 'Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug', Xenobiotica 1999, 29, 1115-1122.
-
(1999)
Xenobiotica
, vol.29
, pp. 1115-1122
-
-
Raleigh, S.M.1
Wanogho, E.2
Burke, M.D.3
Patterson, L.H.4
-
237
-
-
0035065004
-
A preclinical pharmacokinetic study of the bioreductive drug AQ4N
-
P. M. Loadman, D. J. Swaine, M. C. Bibby, K. J. Welham, L. H. Patterson, 'A preclinical pharmacokinetic study of the bioreductive drug AQ4N', Drug Metab. Dispos. 2001, 29, 422-426.
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 422-426
-
-
Loadman, P.M.1
Swaine, D.J.2
Bibby, M.C.3
Welham, K.J.4
Patterson, L.H.5
-
238
-
-
19944393436
-
Non-P450 mediated oxidative metabolism of xenobiotics
-
J. Lee, R. S. Obach, M. B. Fisher, Eds. Dekker, New York
-
D. Lang, A. S. Kalgutkar, 'Non-P450 mediated oxidative metabolism of xenobiotics', In 'Drug Metabolizing Enzymes. Cytochrome P450 and Other Enzymes in Drug Discovery and Development', J. Lee, R. S. Obach, M. B. Fisher, Eds. Dekker, New York, 2003, p. 483-540.
-
(2003)
Drug Metabolizing Enzymes. Cytochrome P450 and Other Enzymes in Drug Discovery and Development
, pp. 483-540
-
-
Lang, D.1
Kalgutkar, A.S.2
-
239
-
-
0026085336
-
New directions in monoamine oxidase A and B selective inhibitors and substrates
-
M. B. H. Youdim, J. P. M. Finberg, 'New directions in monoamine oxidase A and B selective inhibitors and substrates', Biochem. Pharmacol. 1991, 41, 155-162.
-
(1991)
Biochem. Pharmacol
, vol.41
, pp. 155-162
-
-
Youdim, M.B.H.1
Finberg, J.P.M.2
-
240
-
-
0025147290
-
The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism
-
G. Maret, B. Testa, P. Jenner, N. El Tayar, P. A. Carrupt, 'The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism', Drug Metab. Rev. 1990, 22, 291-332.
-
(1990)
Drug Metab. Rev
, vol.22
, pp. 291-332
-
-
Maret, G.1
Testa, B.2
Jenner, P.3
El Tayar, N.4
Carrupt, P.A.5
-
241
-
-
34250680679
-
Amine oxidases: Structure, function and expression
-
T. J. Mantle, K. F. Tipton Eds
-
T. J. Mantle, K. F. Tipton (Eds.), 'Amine oxidases: structure, function and expression', Biochem. Trans. 1991, 19, 199-233.
-
(1991)
Biochem. Trans
, vol.19
, pp. 199-233
-
-
-
242
-
-
0028023851
-
Contribution of amine oxidases to the metabolism of xenobiotics
-
M. Strolin Benedetti, P. Dostert, 'Contribution of amine oxidases to the metabolism of xenobiotics', Drug Metab. Rev. 1994, 26, 507-535.
-
(1994)
Drug Metab. Rev
, vol.26
, pp. 507-535
-
-
Strolin Benedetti, M.1
Dostert, P.2
-
243
-
-
0031627541
-
Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics
-
M. Strolin Benedetti, K. F. Tipton, 'Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics', J. Neural Transm. 1998, 52(Suppl.), 149-171.
-
(1998)
J. Neural Transm
, vol.52
, Issue.SUPPL.
, pp. 149-171
-
-
Strolin Benedetti, M.1
Tipton, K.F.2
-
244
-
-
0035740329
-
Biotransformation of xenobiotics by amine oxidases
-
M. Strolin Benedetti, 'Biotransformation of xenobiotics by amine oxidases', Fundam. Clin. Pharmacol. 2001, 15, 75-84.
-
(2001)
Fundam. Clin. Pharmacol
, vol.15
, pp. 75-84
-
-
Strolin Benedetti, M.1
-
245
-
-
28144464890
-
Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health
-
P. J. O'Brien, A. G. Siraki, N. Shangari, 'Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health', Crit. Rev. Toxicol. 2005, 35, 609-662.
-
(2005)
Crit. Rev. Toxicol
, vol.35
, pp. 609-662
-
-
O'Brien, P.J.1
Siraki, A.G.2
Shangari, N.3
-
246
-
-
33747845619
-
The role of amine oxidases in xenobiotic metabolism
-
B. Gong, P. J. Boor, 'The role of amine oxidases in xenobiotic metabolism', Expert Opin. Drug Metab. Toxicol. 2006, 2, 559-571.
-
(2006)
Expert Opin. Drug Metab. Toxicol
, vol.2
, pp. 559-571
-
-
Gong, B.1
Boor, P.J.2
-
248
-
-
0029613840
-
The reaction mechanism of copper amine oxidase: Detection of intermediates by the use of substrates and inhibitors
-
R. Medda, A. Padiglia, J. Z. Pedersen, G. Rotilio, A. Finazzi Agrò, G. Floris, 'The reaction mechanism of copper amine oxidase: detection of intermediates by the use of substrates and inhibitors', Biochemistry 1995, 34, 16375-16381.
-
(1995)
Biochemistry
, vol.34
, pp. 16375-16381
-
-
Medda, R.1
Padiglia, A.2
Pedersen, J.Z.3
Rotilio, G.4
Finazzi Agrò, A.5
Floris, G.6
-
249
-
-
0033030240
-
Probing the 'active site' of diamine oxidase: Structure - activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium
-
A. High, T. Prior, R. A. Bell, P. K. Rangachari, 'Probing the 'active site' of diamine oxidase: structure - activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium', J. Pharmacol. Exp. Ther. 1999, 288, 490-501.
-
(1999)
J. Pharmacol. Exp. Ther
, vol.288
, pp. 490-501
-
-
High, A.1
Prior, T.2
Bell, R.A.3
Rangachari, P.K.4
-
250
-
-
33645671406
-
Design, synthesis, and biological evaluation of semicarbazide-sensitive amine oxidase (SSAO) inhibitors with anti-inflammatory activity
-
F. Y. Wang, H. Gao, L. Salter-Cid, J. Zhang, L. Huang, E. M. Podar, A. Miller, J. Zhao, A. O'Rourke, M. D. Linnik, 'Design, synthesis, and biological evaluation of semicarbazide-sensitive amine oxidase (SSAO) inhibitors with anti-inflammatory activity', J. Med. Chem. 2006, 49, 2166-2173.
-
(2006)
J. Med. Chem
, vol.49
, pp. 2166-2173
-
-
Wang, F.Y.1
Gao, H.2
Salter-Cid, L.3
Zhang, J.4
Huang, L.5
Podar, E.M.6
Miller, A.7
Zhao, J.8
O'Rourke, A.9
Linnik, M.D.10
-
251
-
-
0001319451
-
Radical ideas about monoamine oxidase
-
R. B. Silverman, 'Radical ideas about monoamine oxidase', Acc. Chem. Res. 1995, 28, 335-342.
-
(1995)
Acc. Chem. Res
, vol.28
, pp. 335-342
-
-
Silverman, R.B.1
-
252
-
-
0025074333
-
Biochemistry and genetics of monoamine oxidase
-
W. Weyler, Y. P. P. Hsu, X. O. Breakefield, 'Biochemistry and genetics of monoamine oxidase', Pharmacol. Ther. 1990, 47, 391-417.
-
(1990)
Pharmacol. Ther
, vol.47
, pp. 391-417
-
-
Weyler, W.1
Hsu, Y.P.P.2
Breakefield, X.O.3
-
253
-
-
0037310739
-
The relative contribution of monoamine oxidase and cytochrome P450 isozymes to the metabolic deamination of the trace amine tryptamine
-
A. M. Yu, C. P. Granvil, R. L. Haining, K. W. Krausz, J. Corchero, A. Küpfer, J. R. Idle, F. J. Gonzalez, 'The relative contribution of monoamine oxidase and cytochrome P450 isozymes to the metabolic deamination of the trace amine tryptamine', J. Pharmacol. Exp. Ther. 2003, 304, 539-546.
-
(2003)
J. Pharmacol. Exp. Ther
, vol.304
, pp. 539-546
-
-
Yu, A.M.1
Granvil, C.P.2
Haining, R.L.3
Krausz, K.W.4
Corchero, J.5
Küpfer, A.6
Idle, J.R.7
Gonzalez, F.J.8
-
254
-
-
0030869610
-
Potential metabolic bioactivation pathways involving cyclic tertiary amines and azaarenes
-
N. Castagnoli Jr., J. M. Rimoldi, J. Bloomquist, K. P. Castagnoli, 'Potential metabolic bioactivation pathways involving cyclic tertiary amines and azaarenes', Chem. Res. Toxicol. 1997, 10, 924-940.
-
(1997)
Chem. Res. Toxicol
, vol.10
, pp. 924-940
-
-
Castagnoli Jr., N.1
Rimoldi, J.M.2
Bloomquist, J.3
Castagnoli, K.P.4
-
255
-
-
0034814085
-
Interactions of nitrogen-containing xenobiotics with MAO-A and MAO-B: SAR studies on MAO substrates and inhibitors
-
A. S. Kalgutkar, D. K. Dalvie, N. Castagnoli Jr., T. J. Taylor, 'Interactions of nitrogen-containing xenobiotics with MAO-A and MAO-B: SAR studies on MAO substrates and inhibitors', Chem. Res. Toxicol. 2001, 14, 1139-1162.
-
(2001)
Chem. Res. Toxicol
, vol.14
, pp. 1139-1162
-
-
Kalgutkar, A.S.1
Dalvie, D.K.2
Castagnoli Jr., N.3
Taylor, T.J.4
-
256
-
-
0036038993
-
-
N. Castagnoli Jr., K. P. Castagnoli, G. Magnin, S. Kuttab, J. Shang, 'Studies on the oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines'. Drug Metab. Rev. 2002, 34, 533-547.
-
N. Castagnoli Jr., K. P. Castagnoli, G. Magnin, S. Kuttab, J. Shang, 'Studies on the oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines'. Drug Metab. Rev. 2002, 34, 533-547.
-
-
-
-
257
-
-
0031751079
-
Stereoselective biotransformation of the SSRI citalopram and its demethylated metabolites by monoamine oxidases in human liver
-
B. Rochat, M. Kossel, G. Boss, B. Testa, M. Gillet, P. Baumann, 'Stereoselective biotransformation of the SSRI citalopram and its demethylated metabolites by monoamine oxidases in human liver', Biochem. Pharmacol. 1998, 56, 15-23.
-
(1998)
Biochem. Pharmacol
, vol.56
, pp. 15-23
-
-
Rochat, B.1
Kossel, M.2
Boss, G.3
Testa, B.4
Gillet, M.5
Baumann, P.6
-
258
-
-
85047695626
-
In vitro biotransformation of the selective serotonin reuptake inhibitor citalopram, its enantiomers and demethylated metabolites by monoamine oxidase in rat and human brain preparations
-
M. Kossel, C. Gnerre, P. Voirol, M. Amey, B. Rochat, C. Bouras, B. Testa, P. Baumann, 'In vitro biotransformation of the selective serotonin reuptake inhibitor citalopram, its enantiomers and demethylated metabolites by monoamine oxidase in rat and human brain preparations', Mol. Psychiat. 2002, 7, 181-188.
-
(2002)
Mol. Psychiat
, vol.7
, pp. 181-188
-
-
Kossel, M.1
Gnerre, C.2
Voirol, P.3
Amey, M.4
Rochat, B.5
Bouras, C.6
Testa, B.7
Baumann, P.8
-
259
-
-
0037382092
-
Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan
-
M. Salva, J. M. Jansat, A. Martinez-Tobed, J. M. Palacios, 'Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan', Drug Metab. Dispos. 2003, 31, 404-411.
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 404-411
-
-
Salva, M.1
Jansat, J.M.2
Martinez-Tobed, A.3
Palacios, J.M.4
-
260
-
-
0026655680
-
Aliphatic propargylamines: Potent, selective, irreversible monoamine oxidase B inhibitors
-
P. H. Yu, B. A. Davis, A. A. Boulton. 'Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors', J. Med. Chem. 1992, 35, 3705-3713.
-
(1992)
J. Med. Chem
, vol.35
, pp. 3705-3713
-
-
Yu, P.H.1
Davis, B.A.2
Boulton, A.A.3
-
261
-
-
0024206480
-
Stereospecific deamination of benzylamine catalyzed by different amine oxidases
-
P. H. Yu, B. A. Davis, 'Stereospecific deamination of benzylamine catalyzed by different amine oxidases', Int. J. Biochem. 1988, 20, 1197-1201.
-
(1988)
Int. J. Biochem
, vol.20
, pp. 1197-1201
-
-
Yu, P.H.1
Davis, B.A.2
-
262
-
-
0028889017
-
Stereochemistry of benzylamine oxidation by copper amine oxidases
-
G. Alton, T. H. Taher, R. J. Beever, M. M. Palcic, 'Stereochemistry of benzylamine oxidation by copper amine oxidases', Arch. Biochem. Biophys. 1995, 316, 353-361.
-
(1995)
Arch. Biochem. Biophys
, vol.316
, pp. 353-361
-
-
Alton, G.1
Taher, T.H.2
Beever, R.J.3
Palcic, M.M.4
-
263
-
-
33750138764
-
New efficient substrates for SSAO/VAP-1 enzyme: Analysis by SARs and computational docking
-
F. Yraola, S. Garcia-Vicente, J. Fernandez-Reccio, F. Albericio, A. Zorzano, L. Marti, M. Royo, 'New efficient substrates for SSAO/VAP-1 enzyme: analysis by SARs and computational docking', J. Med. Chem. 2006, 49, 6197-6208.
-
(2006)
J. Med. Chem
, vol.49
, pp. 6197-6208
-
-
Yraola, F.1
Garcia-Vicente, S.2
Fernandez-Reccio, J.3
Albericio, F.4
Zorzano, A.5
Marti, L.6
Royo, M.7
-
264
-
-
0023881292
-
Metabolism of amlodipine in the rat and dog: A species difference
-
A. P. Beresford, P. V. Macrae, D. A. Stopher, 'Metabolism of amlodipine in the rat and dog: a species difference', Xenobiotica 1988, 18, 169-182.
-
(1988)
Xenobiotica
, vol.18
, pp. 169-182
-
-
Beresford, A.P.1
Macrae, P.V.2
Stopher, D.A.3
-
265
-
-
9944248111
-
Molybdenum-containing hydroxylases
-
R. Hille, 'Molybdenum-containing hydroxylases', Arch. Biochem. Biophys. 2005, 433, 107-116.
-
(2005)
Arch. Biochem. Biophys
, vol.433
, pp. 107-116
-
-
Hille, R.1
-
266
-
-
0037954564
-
Mammalian molybdo-flavoenzymes, an expanding family of proteins: Structure, genetics, regulation, function and pathophysiology
-
E. Garattini, R. Mendel, M. J. Romao, R. Wright, M. Terao, 'Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology', Biochem. J. 2003, 372, 15-32.
-
(2003)
Biochem. J
, vol.372
, pp. 15-32
-
-
Garattini, E.1
Mendel, R.2
Romao, M.J.3
Wright, R.4
Terao, M.5
-
267
-
-
2542612969
-
The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition
-
K. Okamoto, K. Matsumoto, R. Hille, B. T. Eger, E. F. Pai, T. Nishino, 'The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition', Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 7931-7936.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 7931-7936
-
-
Okamoto, K.1
Matsumoto, K.2
Hille, R.3
Eger, B.T.4
Pai, E.F.5
Nishino, T.6
-
268
-
-
33745871580
-
Avian and canine aldehyde oxidases: Novel insights into the biology and evolution of molybdo-flavoenzymes
-
M. Terao, M. Kurosaki, M. M. Barzago, E. Varasano, A. Boldetti, A. Bastone, M. Fratelli, E. Garattini, 'Avian and canine aldehyde oxidases: Novel insights into the biology and evolution of molybdo-flavoenzymes', J. Biol. Chem. 2006, 281, 19748-19761.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 19748-19761
-
-
Terao, M.1
Kurosaki, M.2
Barzago, M.M.3
Varasano, E.4
Boldetti, A.5
Bastone, A.6
Fratelli, M.7
Garattini, E.8
-
269
-
-
3042660859
-
Physiological roles of xanthine oxidoreductase
-
R. Harrison, 'Physiological roles of xanthine oxidoreductase', Drug Metab. Rev. 2004, 36, 363-375.
-
(2004)
Drug Metab. Rev
, vol.36
, pp. 363-375
-
-
Harrison, R.1
-
270
-
-
0028202893
-
The reaction mechanism of oxomolybdenum enzymes
-
R. Hille, 'The reaction mechanism of oxomolybdenum enzymes', Biochim. Biophys. Acta 1994, 1184, 143-169.
-
(1994)
Biochim. Biophys. Acta
, vol.1184
, pp. 143-169
-
-
Hille, R.1
-
271
-
-
33744979094
-
Drug-metabolizing ability of molybdenum hydroxylases
-
S. Kitamura, K. Sugihara, S. Ohta, 'Drug-metabolizing ability of molybdenum hydroxylases', Drug Metab. Pharmacokinet. 2006, 21, 83-96.
-
(2006)
Drug Metab. Pharmacokinet
, vol.21
, pp. 83-96
-
-
Kitamura, S.1
Sugihara, K.2
Ohta, S.3
-
272
-
-
0032189723
-
Role of xanthine oxidase in hydrogen peroxide production
-
F. Lacy, D. A. Gough, G. W. Schmid-Schönbein, 'Role of xanthine oxidase in hydrogen peroxide production', Free Radical Biol. Med. 1998, 25, 720-727.
-
(1998)
Free Radical Biol. Med
, vol.25
, pp. 720-727
-
-
Lacy, F.1
Gough, D.A.2
Schmid-Schönbein, G.W.3
-
273
-
-
33646499185
-
Superoxide radical production by allopurinol and xanthine oxidase
-
C. Galbusera, P. Orth, D. Fedida, T. Spector, 'Superoxide radical production by allopurinol and xanthine oxidase', Biochem. Pharmacol. 2006, 71, 1747-1752.
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 1747-1752
-
-
Galbusera, C.1
Orth, P.2
Fedida, D.3
Spector, T.4
-
274
-
-
0022343014
-
Molybdenum hydroxylases as drug-metabolizing enzymes
-
C. Beedham, 'Molybdenum hydroxylases as drug-metabolizing enzymes', Drug Metab. Rev. 1985, 16, 119-156.
-
(1985)
Drug Metab. Rev
, vol.16
, pp. 119-156
-
-
Beedham, C.1
-
275
-
-
0030772328
-
The role of non-P450 enzymes in drug oxidation
-
C. Beedham, 'The role of non-P450 enzymes in drug oxidation', Pharm. World Sci. 1997, 19, 255-263.
-
(1997)
Pharm. World Sci
, vol.19
, pp. 255-263
-
-
Beedham, C.1
-
276
-
-
0030954581
-
A model of the interaction of substrates and inhibitors with xanthine oxidase
-
G. Rastelli, L. Costantino, A. Albasini, 'A model of the interaction of substrates and inhibitors with xanthine oxidase', J. Am. Chem. Soc. 1997, 119, 3007-3016.
-
(1997)
J. Am. Chem. Soc
, vol.119
, pp. 3007-3016
-
-
Rastelli, G.1
Costantino, L.2
Albasini, A.3
-
277
-
-
33646808612
-
A, α5-subtype inverse agonist
-
A, α5-subtype inverse agonist', Xenobiotica 2006, 36, 315-330.
-
(2006)
Xenobiotica
, vol.36
, pp. 315-330
-
-
O'Connor, D.1
Jones, P.2
Chambers, M.S.3
Maxey, R.4
Szekeres, H.J.5
Szeto, N.6
Scott-Stevens, P.7
Macleod, A.M.8
Braun, M.9
Cato, B.10
-
278
-
-
31344433975
-
1-methylnicotinamide to pyridones, and interspecies variation of the enzyme activity in rats
-
1-methylnicotinamide to pyridones, and interspecies variation of the enzyme activity in rats', Drug Metab. Dispos. 2006, 34, 208-212.
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 208-212
-
-
Sugihara, K.1
Tayama, Y.2
Shimomiya, K.3
Yoshimoto, D.4
Ohta, S.5
Kitamura, S.6
-
279
-
-
0027305791
-
In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase
-
Y. Moriwaki, T. Yamamoto, Y. Nasako, S. Takahashi, M. Suda, K. Hiroishi, T. Hada, K Higashino, 'In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase', Biochem. Pharmacol. 1993, 46, 975-981.
-
(1993)
Biochem. Pharmacol
, vol.46
, pp. 975-981
-
-
Moriwaki, Y.1
Yamamoto, T.2
Nasako, Y.3
Takahashi, S.4
Suda, M.5
Hiroishi, K.6
Hada, T.7
Higashino, K.8
-
280
-
-
6344270255
-
Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes
-
G. I. Panoutsopoulos, D. Kouretas, C. Beedham, 'Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes', Chem. Res. Toxicol. 2004, 17, 1368-1376.
-
(2004)
Chem. Res. Toxicol
, vol.17
, pp. 1368-1376
-
-
Panoutsopoulos, G.I.1
Kouretas, D.2
Beedham, C.3
-
281
-
-
0024458029
-
Relative metabolism of quinones to semiquinone radicals in xanthine oxidase system
-
D. C. Lewis, T. Shibamoto, 'Relative metabolism of quinones to semiquinone radicals in xanthine oxidase system', J. Appl. Toxicol. 1989, 9, 291-295.
-
(1989)
J. Appl. Toxicol
, vol.9
, pp. 291-295
-
-
Lewis, D.C.1
Shibamoto, T.2
-
282
-
-
0025813582
-
Xanthine oxidase-catalyzed reduction of estrogen quinones to semiquinones and hydroquinones
-
D. Roy, B. Kalyanaraman, J. G. Liehr, 'Xanthine oxidase-catalyzed reduction of estrogen quinones to semiquinones and hydroquinones', Biochem. Pharmacol. 1991, 42, 1627-1631.
-
(1991)
Biochem. Pharmacol
, vol.42
, pp. 1627-1631
-
-
Roy, D.1
Kalyanaraman, B.2
Liehr, J.G.3
-
283
-
-
0037379962
-
Xanthine oxidase-catalyzed metabolism of 2-nitrofluorene, a carcinogenic air pollutant, in rat skin
-
O. Ueda, S. Kitamura, K. Ohashi, K. Sugihara, S. Ohta, 'Xanthine oxidase-catalyzed metabolism of 2-nitrofluorene, a carcinogenic air pollutant, in rat skin', Drug Metab. Dispos. 2003, 31, 367-372.
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 367-372
-
-
Ueda, O.1
Kitamura, S.2
Ohashi, K.3
Sugihara, K.4
Ohta, S.5
-
284
-
-
0035342143
-
Challenges of cancer drug design: A drug metabolism perspective
-
R. I. Sanchez, S. Mesia-Vela, F. C. Kauffman, 'Challenges of cancer drug design: a drug metabolism perspective', Curr. Cancer Drug Targets 2001, 1, 1-32.
-
(2001)
Curr. Cancer Drug Targets
, vol.1
, pp. 1-32
-
-
Sanchez, R.I.1
Mesia-Vela, S.2
Kauffman, F.C.3
-
285
-
-
19944432264
-
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bireductive nitroimidazolyl prodrugs
-
P. Reigan, P. N. Edwards, A. Gbaj, C. Cole, S. T. Barry, K. M. Page, S. E. Ashton, R. W. A. Luke, K. T. Douglas, I. J. Stratford, M. Jaffar, R. A. Bryce, S. Freeman, 'Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bireductive nitroimidazolyl prodrugs', J. Med. Chem. 2005, 48, 392-402.
-
(2005)
J. Med. Chem
, vol.48
, pp. 392-402
-
-
Reigan, P.1
Edwards, P.N.2
Gbaj, A.3
Cole, C.4
Barry, S.T.5
Page, K.M.6
Ashton, S.E.7
Luke, R.W.A.8
Douglas, K.T.9
Stratford, I.J.10
Jaffar, M.11
Bryce, R.A.12
Freeman, S.13
-
286
-
-
0038722339
-
Ziprasidone metabolism, aldehyde oxidase, and clinical implications
-
C. Beedham, J. Miceli, R. S. Obach, 'Ziprasidone metabolism, aldehyde oxidase, and clinical implications', J. Clin. Psychopharmacol. 2003, 23, 229-232.
-
(2003)
J. Clin. Psychopharmacol
, vol.23
, pp. 229-232
-
-
Beedham, C.1
Miceli, J.2
Obach, R.S.3
-
287
-
-
0034527729
-
Peroxidases', Chem.-Biol
-
P. J. O'Brien, 'Peroxidases', Chem.-Biol. Interact. 2000, 129, 113-139.
-
(2000)
Interact
, vol.129
, pp. 113-139
-
-
O'Brien, P.J.1
-
288
-
-
18944406318
-
Peroxidases: A role in the metabolism and side effects of drugs
-
S. Tafazoli, P. J. O'Brien, 'Peroxidases: a role in the metabolism and side effects of drugs', Drug Discov. Today 2005, 10, 617-625.
-
(2005)
Drug Discov. Today
, vol.10
, pp. 617-625
-
-
Tafazoli, S.1
O'Brien, P.J.2
-
289
-
-
0029152919
-
One-electron oxidations by peroxidases
-
H. B. Dunford, 'One-electron oxidations by peroxidases', Xenobiotica 1995, 25, 725-733.
-
(1995)
Xenobiotica
, vol.25
, pp. 725-733
-
-
Dunford, H.B.1
-
290
-
-
0026645711
-
The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions
-
J. P. Uetrecht, 'The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions', Drug Metab. Rev. 1992, 24, 299-366.
-
(1992)
Drug Metab. Rev
, vol.24
, pp. 299-366
-
-
Uetrecht, J.P.1
-
291
-
-
0031777185
-
Cyclooxygenases 1 and 2
-
J. R. Vane, Y. S. Bakhle, R. M. Botting, 'Cyclooxygenases 1 and 2', Annu. Rev. Pharmacol. Toxicol. 1998, 38, 97-120.
-
(1998)
Annu. Rev. Pharmacol. Toxicol
, vol.38
, pp. 97-120
-
-
Vane, J.R.1
Bakhle, Y.S.2
Botting, R.M.3
-
292
-
-
16744369033
-
Structural insights into the stereochemistry of the cyclooxygenase reaction
-
J. R. Kiefer, J. L. Pawlitz, K. T. Moreland, R. A. Stegeman, W. F. Hood, J. K. Glerse, A. M. Stevens, D. C. Goodwin, S. W. Rowlinson, L. J. Marnett, W. C. Stallings, R. G. Kurumball, 'Structural insights into the stereochemistry of the cyclooxygenase reaction', Nature 2000, 405, 97-101.
-
(2000)
Nature
, vol.405
, pp. 97-101
-
-
Kiefer, J.R.1
Pawlitz, J.L.2
Moreland, K.T.3
Stegeman, R.A.4
Hood, W.F.5
Glerse, J.K.6
Stevens, A.M.7
Goodwin, D.C.8
Rowlinson, S.W.9
Marnett, L.J.10
Stallings, W.C.11
Kurumball, R.G.12
-
293
-
-
0026655549
-
Xenobiotic metabolism by prostaglandin H synthase
-
T. E. Eling, J. F. Curtis, 'Xenobiotic metabolism by prostaglandin H synthase', Pharmacol. Ther. 1992, 53, 261-273.
-
(1992)
Pharmacol. Ther
, vol.53
, pp. 261-273
-
-
Eling, T.E.1
Curtis, J.F.2
-
294
-
-
0025319526
-
Prostaglandin H synthase and xenobiotic oxidation
-
T. E. Eling, D. C. Thompson, G. L. Foureman, J. F. Curtis, M. F. Hughes, 'Prostaglandin H synthase and xenobiotic oxidation', Annu. Rev. Pharmacol. Toxicol. 1990, 30, 1-45.
-
(1990)
Annu. Rev. Pharmacol. Toxicol
, vol.30
, pp. 1-45
-
-
Eling, T.E.1
Thompson, D.C.2
Foureman, G.L.3
Curtis, J.F.4
Hughes, M.F.5
-
295
-
-
0033231439
-
Myeloperoxidase-catalyzed redox-cycling of phenol promotes lipid peroxidation and thiol oxidation in HL-60 cells
-
R. Goldman, G. H. Claycamp, M. A. Sweetland, A. V. Sedlov, V. A. Tyurin, E. R. Kisin, Y. Y. Tyurnina, V. B. Ritov, S. L. Wenger, S. G. Grant, V E. Kagan, 'Myeloperoxidase-catalyzed redox-cycling of phenol promotes lipid peroxidation and thiol oxidation in HL-60 cells', Free Radical Biol. Med. 1999, 27, 1050-1063.
-
(1999)
Free Radical Biol. Med
, vol.27
, pp. 1050-1063
-
-
Goldman, R.1
Claycamp, G.H.2
Sweetland, M.A.3
Sedlov, A.V.4
Tyurin, V.A.5
Kisin, E.R.6
Tyurnina, Y.Y.7
Ritov, V.B.8
Wenger, S.L.9
Grant, S.G.10
Kagan, V.E.11
-
296
-
-
0022862720
-
Metabolic activation of phenol by human myeloperoxidase and horseradish peroxidase
-
D. A. Eastmond, M. T. Smith, L. O. Ruzo, D. Ross, 'Metabolic activation of phenol by human myeloperoxidase and horseradish peroxidase', Mol. Pharmacol. 1986, 30, 674-679.
-
(1986)
Mol. Pharmacol
, vol.30
, pp. 674-679
-
-
Eastmond, D.A.1
Smith, M.T.2
Ruzo, L.O.3
Ross, D.4
-
297
-
-
17644405444
-
Role of phenoxyl radicals in DNA adduction by chlorophenol xenobiotics following peroxidase activation
-
J. Dai, A. L. Sloat, M. W. Wright, R. A. Manderville, 'Role of phenoxyl radicals in DNA adduction by chlorophenol xenobiotics following peroxidase activation', Chem. Res. Toxicol. 2005, 18, 771-779.
-
(2005)
Chem. Res. Toxicol
, vol.18
, pp. 771-779
-
-
Dai, J.1
Sloat, A.L.2
Wright, M.W.3
Manderville, R.A.4
-
298
-
-
0027055783
-
Cell-specific metabolism in mouse bone marrow stroma: Studies of activation and detoxification of benzene metabolites
-
L. G. Ganousis, D. Goon, T. Zyglewska, K. K. Wu, D. Ross, 'Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites', Mol. Pharmacol. 1992, 42, 1118-1125
-
(1992)
Mol. Pharmacol
, vol.42
, pp. 1118-1125
-
-
Ganousis, L.G.1
Goon, D.2
Zyglewska, T.3
Wu, K.K.4
Ross, D.5
-
299
-
-
0030445486
-
An overview of benzene metabolism
-
R. Snyder, C. C. Hedli, 'An overview of benzene metabolism', Environ. Health Perspect. 1996, 104, 1165-1171.
-
(1996)
Environ. Health Perspect
, vol.104
, pp. 1165-1171
-
-
Snyder, R.1
Hedli, C.C.2
-
300
-
-
0023751257
-
Bioactivation of catechol in rat and human bone marrow cells
-
R. V. Bhat, V. V. Subrahmanyam, A. Sadler, D. Ross, 'Bioactivation of catechol in rat and human bone marrow cells', Toxicol. Appl. Pharmacol. 1988, 94, 297-304
-
(1988)
Toxicol. Appl. Pharmacol
, vol.94
, pp. 297-304
-
-
Bhat, R.V.1
Subrahmanyam, V.V.2
Sadler, A.3
Ross, D.4
-
301
-
-
0033796253
-
Covalent protein adducts of hydroquinone in tissues from rats: Identification of quantification of sulfhydryl-bound forms
-
R. J. Boatman, J. C. English, L. G. Perry, L. A. Fiorica, 'Covalent protein adducts of hydroquinone in tissues from rats: identification of quantification of sulfhydryl-bound forms', Chem. Res. Toxicol. 2000, 13, 853-860.
-
(2000)
Chem. Res. Toxicol
, vol.13
, pp. 853-860
-
-
Boatman, R.J.1
English, J.C.2
Perry, L.G.3
Fiorica, L.A.4
-
302
-
-
0035996573
-
On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics
-
A. S. Kalgutkar, D. K. Dalvie, J. P. O'Donnell, T. J. Taylor, D. C. Sahakian, 'On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics', Curr. Drug Metab. 2002, 3, 379-424.
-
(2002)
Curr. Drug Metab
, vol.3
, pp. 379-424
-
-
Kalgutkar, A.S.1
Dalvie, D.K.2
O'Donnell, J.P.3
Taylor, T.J.4
Sahakian, D.C.5
-
303
-
-
0029416850
-
The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man
-
J. L. Maggs, D. Williams, M. Pirmohamed, B. K. Park, 'The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man', J. Pharmacol. Exp. Ther. 1995, 275, 1463-1475.
-
(1995)
J. Pharmacol. Exp. Ther
, vol.275
, pp. 1463-1475
-
-
Maggs, J.L.1
Williams, D.2
Pirmohamed, M.3
Park, B.K.4
-
304
-
-
0037325276
-
In vitro metabolism of tolcapone to reactive intermediates: Relevance to tolcapone liver toxicity
-
K. S. Smith, P. L. Smith, T. N. Heady, J. M. Trugman, W. D. Harman, T. L. Macdonald, 'In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity', Chem. Res. Toxicol. 2003, 16, 123-128.
-
(2003)
Chem. Res. Toxicol
, vol.16
, pp. 123-128
-
-
Smith, K.S.1
Smith, P.L.2
Heady, T.N.3
Trugman, J.M.4
Harman, W.D.5
Macdonald, T.L.6
-
305
-
-
0016836753
-
Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland
-
L. J. Marnett, P. Wlodawer, B. Samuelsson, 'Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland', J. Biol. Chem. 1975, 250, 8510-8517.
-
(1975)
J. Biol. Chem
, vol.250
, pp. 8510-8517
-
-
Marnett, L.J.1
Wlodawer, P.2
Samuelsson, B.3
-
306
-
-
0023838739
-
Acetaminophen and analogs as cosubstrates and inhibitors of prostaglandin H synthase
-
P. J. Harvison, R. W. Egan, P. H. Gale, G. D. Christian, B. S. Hill, S. D. Nelson, 'Acetaminophen and analogs as cosubstrates and inhibitors of prostaglandin H synthase', Chem.-Biol. Interact. 1988, 64, 251-266.
-
(1988)
Chem.-Biol. Interact
, vol.64
, pp. 251-266
-
-
Harvison, P.J.1
Egan, R.W.2
Gale, P.H.3
Christian, G.D.4
Hill, B.S.5
Nelson, S.D.6
-
307
-
-
0029096479
-
Prostaglandin H synthase-catalyzed ring oxygenation of 2-naphthylamine: Evidence for two distinct oxidation pathways
-
J. F. Curtis, K. Tomer, S. McGown, T. E. Eling, 'Prostaglandin H synthase-catalyzed ring oxygenation of 2-naphthylamine: evidence for two distinct oxidation pathways', Chem. Res. Toxicol. 1995, 8, 875-883.
-
(1995)
Chem. Res. Toxicol
, vol.8
, pp. 875-883
-
-
Curtis, J.F.1
Tomer, K.2
McGown, S.3
Eling, T.E.4
-
308
-
-
0031036750
-
Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis
-
L. M. Winn, P. G. Wells, 'Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis', Free Radical Biol. Med. 1997, 22, 607-621.
-
(1997)
Free Radical Biol. Med
, vol.22
, pp. 607-621
-
-
Winn, L.M.1
Wells, P.G.2
-
309
-
-
0032920883
-
Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity
-
T. Patman, M. J. Wiley, P. G. Wells,'Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity', Nature Med. 1999, 5, 582-585.
-
(1999)
Nature Med
, vol.5
, pp. 582-585
-
-
Patman, T.1
Wiley, M.J.2
Wells, P.G.3
-
310
-
-
3042595713
-
Human carbonyl reduction pathways and a strategy for their study in vitro
-
M. J. Cox Rosemond, J. S. Walsh, 'Human carbonyl reduction pathways and a strategy for their study in vitro', Drug Metab. Rev. 2004, 36, 335-361.
-
(2004)
Drug Metab. Rev
, vol.36
, pp. 335-361
-
-
Cox Rosemond, M.J.1
Walsh, J.S.2
-
311
-
-
0034600004
-
Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions
-
U. C. T. Oppermann, E. Maser, 'Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions', Toxicology 2000, 144, 71-81.
-
(2000)
Toxicology
, vol.144
, pp. 71-81
-
-
Oppermann, U.C.T.1
Maser, E.2
-
312
-
-
0028797794
-
Xenobiotic carbonyl reduction and physiological steroid oxidoreduction. The pluripotency of several hydroxysteroid dehydrogenases
-
E. Maser, 'Xenobiotic carbonyl reduction and physiological steroid oxidoreduction. The pluripotency of several hydroxysteroid dehydrogenases', Biochem. Pharmacol. 1995, 49, 421-440.
-
(1995)
Biochem. Pharmacol
, vol.49
, pp. 421-440
-
-
Maser, E.1
-
313
-
-
0033173362
-
Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family
-
G. Duester, J. Farrés, M. R. Felder, R. S. Holmes, J. O. Höög, X. Parés, B. V. Plapp, S. J. Yin, H. Jörnvall, 'Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family', Biochem. Pharmacol. 1999, 58, 389-395.
-
(1999)
Biochem. Pharmacol
, vol.58
, pp. 389-395
-
-
Duester, G.1
Farrés, J.2
Felder, M.R.3
Holmes, R.S.4
Höög, J.O.5
Parés, X.6
Plapp, B.V.7
Yin, S.J.8
Jörnvall, H.9
-
314
-
-
0033911401
-
Families of retinoid dehydrogenases regulating vitamin A function
-
G. Duester, 'Families of retinoid dehydrogenases regulating vitamin A function', Eur. J. Biochem. 2000, 267, 4315-4324.
-
(2000)
Eur. J. Biochem
, vol.267
, pp. 4315-4324
-
-
Duester, G.1
-
315
-
-
0037330515
-
Multiplicity of eukaryotic ADH and other forms
-
H. Jörnvall, E. Nordling, B. Persson, 'Multiplicity of eukaryotic ADH and other forms', Chem.-Biol. Interact. 2003, 143-144, 255-261.
-
(2003)
Chem.-Biol. Interact
, vol.143-144
, pp. 255-261
-
-
Jörnvall, H.1
Nordling, E.2
Persson, B.3
-
316
-
-
0025303335
-
Zinc coordination, function and structure of zinc enzymes and other proteins
-
B. L. Vallee, D. S. Auld, 'Zinc coordination, function and structure of zinc enzymes and other proteins', Biochemistry 1990, 29, 5647-5659.
-
(1990)
Biochemistry
, vol.29
, pp. 5647-5659
-
-
Vallee, B.L.1
Auld, D.S.2
-
317
-
-
0042342591
-
Influence of outer-shell metal ligands on the structural and electronic properties of horse liver alcohol dehydrogenase zinc active site
-
F. L. Gervasio, V. Schettino, S. Mangani, M. Krack, P. Carloni, M. Parrinello, 'Influence of outer-shell metal ligands on the structural and electronic properties of horse liver alcohol dehydrogenase zinc active site', J. Phys. Chem. 2003, 107, 6886-6892.
-
(2003)
J. Phys. Chem
, vol.107
, pp. 6886-6892
-
-
Gervasio, F.L.1
Schettino, V.2
Mangani, S.3
Krack, M.4
Carloni, P.5
Parrinello, M.6
-
318
-
-
0025105234
-
High blood alcohol levels in women
-
M. Frezza, C. di Padova, G. Pozzato, M. Terpin, E. Baraona, C. S. Lieber,'High blood alcohol levels in women', N. Engl. J. Med. 1990, 322, 95-99.
-
(1990)
N. Engl. J. Med
, vol.322
, pp. 95-99
-
-
Frezza, M.1
di Padova, C.2
Pozzato, G.3
Terpin, M.4
Baraona, E.5
Lieber, C.S.6
-
319
-
-
0035060492
-
Pharmacogenetics of alcohol response and alcoholism: The interplay of genes and environmental factors in thresholds for alcoholism
-
M. Radel, D. Goldman, 'Pharmacogenetics of alcohol response and alcoholism: the interplay of genes and environmental factors in thresholds for alcoholism', Drug Metab. Dispos. 2001, 29, 489-494.
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 489-494
-
-
Radel, M.1
Goldman, D.2
-
320
-
-
3042551383
-
Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
-
V. Vasiliou, A. Pappa, T. Estey, 'Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism', Drug Metab. Rev. 2004, 36, 279-299.
-
(2004)
Drug Metab. Rev
, vol.36
, pp. 279-299
-
-
Vasiliou, V.1
Pappa, A.2
Estey, T.3
-
321
-
-
0032859206
-
Eukaryotic aldehyde dehydrogenase (ALDH) genes: Human polymorphism, and recommended nomenclature based on divergent evolution and chromosomal mapping
-
V. Vasiliou, A. Bairoch, K. F. Tipton, D. W. Nebert,'Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphism, and recommended nomenclature based on divergent evolution and chromosomal mapping', Pharmacogenetics 1999, 9, 421-434; www.aldh.org.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 421-434
-
-
Vasiliou, V.1
Bairoch, A.2
Tipton, K.F.3
Nebert, D.W.4
-
322
-
-
0033824324
-
Polymorphisms of human aldehyde dehydrogenases
-
V. Vasiliou, A. Pappa,'Polymorphisms of human aldehyde dehydrogenases', Pharmacology 2000, 61, 192-198.
-
(2000)
Pharmacology
, vol.61
, pp. 192-198
-
-
Vasiliou, V.1
Pappa, A.2
-
323
-
-
0037008089
-
Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation
-
J. S. Rodriguez-Zavala, H. Weiner, 'Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation', Biochemistry 2002, 41, 8229-8237.
-
(2002)
Biochemistry
, vol.41
, pp. 8229-8237
-
-
Rodriguez-Zavala, J.S.1
Weiner, H.2
-
324
-
-
0030876351
-
A new nomenclature for the aldo-keto reductase superfamily
-
J. M. Jez, T. G. Flynn, T. M. Penning, 'A new nomenclature for the aldo-keto reductase superfamily', Biochem. Pharmacol. 1997, 54, 639-647;
-
(1997)
Biochem. Pharmacol
, vol.54
, pp. 639-647
-
-
Jez, J.M.1
Flynn, T.G.2
Penning, T.M.3
-
325
-
-
0037328450
-
The aldo-keto reductase superfamily homepage
-
D. Hyndman, D. R. Bauman, V. V. Heredia, T. M. Penning, The aldo-keto reductase superfamily homepage', Chem.-Biol. Interact. 2003, 143-144, 621-631; www.med.upenn.edu/akr/.
-
(2003)
Chem.-Biol. Interact
, vol.143-144
, pp. 621-631
-
-
Hyndman, D.1
Bauman, D.R.2
Heredia, V.V.3
Penning, T.M.4
-
326
-
-
1542725957
-
Structure-function of human 3α-hydroxy steroid dehydrogenases: Genes and proteins
-
T. M. Penning, Y. Jin, S. Steckelbroeck, T. Lanisnik Rizner, M. Lewis, 'Structure-function of human 3α-hydroxy steroid dehydrogenases: genes and proteins', Mol. Cell. Endocrinol. 2004, 215, 63-72.
-
(2004)
Mol. Cell. Endocrinol
, vol.215
, pp. 63-72
-
-
Penning, T.M.1
Jin, Y.2
Steckelbroeck, S.3
Lanisnik Rizner, T.4
Lewis, M.5
-
327
-
-
0032712029
-
Genomic structure of rat 3α-hydroxysteroid/dihydrodiol dehydrogenase (3α-HSD/ DD, AKRIC9)
-
H. K. Lin, C. F. Hung, M. Moore, T. M. Penning, 'Genomic structure of rat 3α-hydroxysteroid/dihydrodiol dehydrogenase (3α-HSD/ DD, AKRIC9)', J. Steroid Biochem. Mol. Biol. 1999, 71, 29-39.
-
(1999)
J. Steroid Biochem. Mol. Biol
, vol.71
, pp. 29-39
-
-
Lin, H.K.1
Hung, C.F.2
Moore, M.3
Penning, T.M.4
-
328
-
-
0035870894
-
Cooperative regulation of the transcription of human dihydrodiol dehydrogenase DD4/aldo-keto reductase AKR1C4 gene by hepatocyte nuclear factor (HNF)-4α/γ and HNF-1α
-
T. Ozeki, Y. Takahashi, T. Kume, K. Nakayama, T. Yokoi, K. I. Nunoya, A. Hara, T. Kamataki, 'Cooperative regulation of the transcription of human dihydrodiol dehydrogenase DD4/aldo-keto reductase AKR1C4 gene by hepatocyte nuclear factor (HNF)-4α/γ and HNF-1α', Biochem. J. 2001, 355, 537-544.
-
(2001)
Biochem. J
, vol.355
, pp. 537-544
-
-
Ozeki, T.1
Takahashi, Y.2
Kume, T.3
Nakayama, K.4
Yokoi, T.5
Nunoya, K.I.6
Hara, A.7
Kamataki, T.8
-
329
-
-
0034743625
-
Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases
-
F. P. Guengerich, H. Cai, M. McMahon, J. D. Hayesm T. R. Sutter, J. D. Groopman, Z. Deng, T. M. Harris, 'Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases', Chem. Res. Toxicol. 2001, 14, 727-737.
-
(2001)
Chem. Res. Toxicol
, vol.14
, pp. 727-737
-
-
Guengerich, F.P.1
Cai, H.2
McMahon, M.3
Hayesm, J.D.4
Sutter, T.R.5
Groopman, J.D.6
Deng, Z.7
Harris, T.M.8
-
331
-
-
17044442683
-
Human 11β-hydroxysteroid dehydrogenase 1/carbonyl reductase: Additional domains for membrane attachment
-
A. Blum, A. Raum, H. J. Martin, E. Maser, 'Human 11β-hydroxysteroid dehydrogenase 1/carbonyl reductase: additional domains for membrane attachment', Chem.-Biol. Interact. 2001, 130-132, 749-759.
-
(2001)
Chem.-Biol. Interact
, vol.130-132
, pp. 749-759
-
-
Blum, A.1
Raum, A.2
Martin, H.J.3
Maser, E.4
-
332
-
-
33645532261
-
Rat 3α-hydroxysteroid dehydrogenase: To oxidize or reduce, that is the question
-
M. E. Baker, 'Rat 3α-hydroxysteroid dehydrogenase: to oxidize or reduce, that is the question', Endocrinology 2006, 147, 1589-1590.
-
(2006)
Endocrinology
, vol.147
, pp. 1589-1590
-
-
Baker, M.E.1
-
333
-
-
13544253732
-
Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)
-
S. S. Lakhman, D. Ghosh, J. B. Blanco, 'Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)', Drug Metab. Dispos. 2005, 33, 254-257.
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 254-257
-
-
Lakhman, S.S.1
Ghosh, D.2
Blanco, J.B.3
-
334
-
-
7544236965
-
Quinone reductases multitasking in the metabolic world
-
D. Ross, 'Quinone reductases multitasking in the metabolic world', Drug Metab. Rev. 2004, 36, 639-654.
-
(2004)
Drug Metab. Rev
, vol.36
, pp. 639-654
-
-
Ross, D.1
-
335
-
-
0033800872
-
Structures of mammalian cytosolic quinone reductases
-
C. E. Foster, M. A. Bianchet, P. Talalay, M. Faig, L. M. Amzel, 'Structures of mammalian cytosolic quinone reductases', Free Radical Biol. Med. 2000, 29, 241-245.
-
(2000)
Free Radical Biol. Med
, vol.29
, pp. 241-245
-
-
Foster, C.E.1
Bianchet, M.A.2
Talalay, P.3
Faig, M.4
Amzel, L.M.5
-
336
-
-
0033805383
-
Structure-function studies of DT-diaphorase (NQO1) and NRH:quinone oxidoreductase (NQO2)
-
S. Chen, K. Wu, R. Knox, 'Structure-function studies of DT-diaphorase (NQO1) and NRH:quinone oxidoreductase (NQO2)', Free Radical Biol. Med. 2000, 29, 276-284.
-
(2000)
Free Radical Biol. Med
, vol.29
, pp. 276-284
-
-
Chen, S.1
Wu, K.2
Knox, R.3
-
338
-
-
28344433705
-
NRH: Quinone reductase 2: an enzyme of surprises and mysteries
-
F. Vella, G. Ferry, P. Delagrange, J. A. Boutin, 'NRH: quinone reductase 2: an enzyme of surprises and mysteries', Biochem. Pharmacol. 2005, 71, 1-12.
-
(2005)
Biochem. Pharmacol
, vol.71
, pp. 1-12
-
-
Vella, F.1
Ferry, G.2
Delagrange, P.3
Boutin, J.A.4
-
339
-
-
0029785756
-
Mechanism of aldehyde oxidation catalyzed by horse liver alcohol dehydrogenase
-
L. P. Olson, J. Luo, Ö. Almarsson, T. C. Bruice, 'Mechanism of aldehyde oxidation catalyzed by horse liver alcohol dehydrogenase', Biochemistry 1996. 35, 9782-9791.
-
(1996)
Biochemistry
, vol.35
, pp. 9782-9791
-
-
Olson, L.P.1
Luo, J.2
Almarsson, O.3
Bruice, T.C.4
-
340
-
-
0028300618
-
Structures of horse live alcohol dehydrogenase complexed with NAD and substituted benzyl alcohols
-
S. Ramaswamy, H. Eklund, B. V. Plapp, 'Structures of horse live alcohol dehydrogenase complexed with NAD and substituted benzyl alcohols', Biochemistry 1994, 33, 5230-5237.
-
(1994)
Biochemistry
, vol.33
, pp. 5230-5237
-
-
Ramaswamy, S.1
Eklund, H.2
Plapp, B.V.3
-
341
-
-
0034679001
-
Computational studies on the mechanism for proton and hydride transfer in liver alcohol dehydrogenase
-
P. K. Agarwal, S. P. Webb, S. Hammes-Schiffer, 'Computational studies on the mechanism for proton and hydride transfer in liver alcohol dehydrogenase', J. Am. Chem. Soc. 2000, 122, 4803-4812.
-
(2000)
J. Am. Chem. Soc
, vol.122
, pp. 4803-4812
-
-
Agarwal, P.K.1
Webb, S.P.2
Hammes-Schiffer, S.3
-
342
-
-
1542743968
-
Participation of histidine-51 in catalysis by horse liver alcohol dehydrogenase
-
L. A. LeBrun, D. H. Park, S. Ramaswamy., B. V. Plapp, Participation of histidine-51 in catalysis by horse liver alcohol dehydrogenase', Biochemistry 2004, 43, 3014-3026.
-
(2004)
Biochemistry
, vol.43
, pp. 3014-3026
-
-
LeBrun, L.A.1
Park, D.H.2
Ramaswamy, S.3
Plapp, B.V.4
-
343
-
-
0029863799
-
Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes
-
A. A. Klyosov, 'Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes', Biochemistry 1996, 35, 4457-4467.
-
(1996)
Biochemistry
, vol.35
, pp. 4457-4467
-
-
Klyosov, A.A.1
-
344
-
-
0029935028
-
Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism
-
A. A. Klyosov, L. G. Rashkovetsky, M. K. Tahir, W. M. Keung, 'Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism', Biochemistry 1996, 35, 4445-4456.
-
(1996)
Biochemistry
, vol.35
, pp. 4445-4456
-
-
Klyosov, A.A.1
Rashkovetsky, L.G.2
Tahir, M.K.3
Keung, W.M.4
-
345
-
-
0036667460
-
Oxidative bioactivation of crotyt alcohol to the toxic endogenous aldehyde crotonaldehyde: Association of protein carbonylation with toxicity in mouse hepatocytes
-
F. R. Fontaine, R. A. Dunlop, D. R. Petersen, P. C. Burcham, 'Oxidative bioactivation of crotyt alcohol to the toxic endogenous aldehyde crotonaldehyde: association of protein carbonylation with toxicity in mouse hepatocytes', Chem. Res. Toxicol. 2002, 15, 1051-1058.
-
(2002)
Chem. Res. Toxicol
, vol.15
, pp. 1051-1058
-
-
Fontaine, F.R.1
Dunlop, R.A.2
Petersen, D.R.3
Burcham, P.C.4
-
346
-
-
0026655335
-
Aldehyde dehydrogenases and their role in carcinogenesis
-
R. Lindahl, 'Aldehyde dehydrogenases and their role in carcinogenesis', Crit. Rev. Biochem. Mol. Biol. 1992, 27, 283-335.
-
(1992)
Crit. Rev. Biochem. Mol. Biol
, vol.27
, pp. 283-335
-
-
Lindahl, R.1
-
347
-
-
0026443015
-
Oxidation of carbovir, a carbocyclic nucleoside, by rat liver cytosolic enzymes
-
J. E. Patanella, J. S. Walsh, 'Oxidation of carbovir, a carbocyclic nucleoside, by rat liver cytosolic enzymes', Drug Metab. Dispos. 1992, 20, 912-919.
-
(1992)
Drug Metab. Dispos
, vol.20
, pp. 912-919
-
-
Patanella, J.E.1
Walsh, J.S.2
-
348
-
-
0024459789
-
Pharmacokinetics and biotransformation of diethylene glycol and ethylene glycol in the rat
-
W. Lenk, D. Löhr, J. Sonnenbichler, 'Pharmacokinetics and biotransformation of diethylene glycol and ethylene glycol in the rat', Xenobiotica 1989, 19, 961-979.
-
(1989)
Xenobiotica
, vol.19
, pp. 961-979
-
-
Lenk, W.1
Löhr, D.2
Sonnenbichler, J.3
-
349
-
-
0442282107
-
Comparison of the metabolism of ethylene glycol and glycolic acid in vitro by precision-cut tissue slices from female rat, rabbit and human liver
-
E. D. Booth, O. Dofferhoff, P. J. Boogaard, W. P. Watson, 'Comparison of the metabolism of ethylene glycol and glycolic acid in vitro by precision-cut tissue slices from female rat, rabbit and human liver', Xenobiotica 2004, 34, 31-48.
-
(2004)
Xenobiotica
, vol.34
, pp. 31-48
-
-
Booth, E.D.1
Dofferhoff, O.2
Boogaard, P.J.3
Watson, W.P.4
-
350
-
-
0034129835
-
Metabolism of sameridine to monocarboxylated products by hepatocytes isolated from the male rat
-
A. K. Sohlenius-Sternbeck, H. von Euler Chelpin, A. Orzechowski, M. M. Halldin, 'Metabolism of sameridine to monocarboxylated products by hepatocytes isolated from the male rat', Drug Metab. Dispos. 2000, 28, 695-700.
-
(2000)
Drug Metab. Dispos
, vol.28
, pp. 695-700
-
-
Sohlenius-Sternbeck, A.K.1
von Euler Chelpin, H.2
Orzechowski, A.3
Halldin, M.M.4
-
351
-
-
0026568286
-
Stereoselective acetonyl side chain reduction of warfarin and analogs
-
J. J. R. Hermans, H. H. W. Thijssen, 'Stereoselective acetonyl side chain reduction of warfarin and analogs', Drug Metab. Dispos. 1992, 20, 268-274.
-
(1992)
Drug Metab. Dispos
, vol.20
, pp. 268-274
-
-
Hermans, J.J.R.1
Thijssen, H.H.W.2
-
352
-
-
0033738822
-
Kinetics and inhibition of the formation of 6β-naltrexol from naltrexone in human liver cytosol
-
S. J. Porter, A. A. Somogyi, J. M. White. 'Kinetics and inhibition of the formation of 6β-naltrexol from naltrexone in human liver cytosol', Br. J. Clin. Pharmacol. 2000, 50, 465-471.
-
(2000)
Br. J. Clin. Pharmacol
, vol.50
, pp. 465-471
-
-
Porter, S.J.1
Somogyi, A.A.2
White, J.M.3
-
353
-
-
10044298325
-
Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol
-
U. Breyer-Pfaff, K. Nill, 'Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol', J. Pharm. Pharmacol. 2004, 56, 1601-1606.
-
(2004)
J. Pharm. Pharmacol
, vol.56
, pp. 1601-1606
-
-
Breyer-Pfaff, U.1
Nill, K.2
-
354
-
-
0032729617
-
Purification and characterization of two major forms of naloxone reductase from rabbit liver cytosol, new members of aldo-keto reductase superfamily
-
S. Yamano, F. Ichinose, T. Todaka, S. Toki, 'Purification and characterization of two major forms of naloxone reductase from rabbit liver cytosol, new members of aldo-keto reductase superfamily', Biol. Pharm. Bull. 1999, 22, 1038-1046.
-
(1999)
Biol. Pharm. Bull
, vol.22
, pp. 1038-1046
-
-
Yamano, S.1
Ichinose, F.2
Todaka, T.3
Toki, S.4
-
355
-
-
4143102749
-
Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat liver and by enzymes isolated from human liver
-
U. Breyer-Pfaff, H. J. Martin, M. Ernst, E. Maser, 'Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat liver and by enzymes isolated from human liver', Drug Metab. Dispos. 2004, 32, 915-922.
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 915-922
-
-
Breyer-Pfaff, U.1
Martin, H.J.2
Ernst, M.3
Maser, E.4
-
356
-
-
33344470911
-
Purification and characterization of AKR1B10 from human liver: Role in carbonyl reduction of xenobiotics
-
H. J. Martin, U. Breyer-Pfaff, V. Wsol, S. Venz, S. Block, E. Maser, 'Purification and characterization of AKR1B10 from human liver: role in carbonyl reduction of xenobiotics', Drug Metab. Dispos. 2006, 34, 464-470;
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 464-470
-
-
Martin, H.J.1
Breyer-Pfaff, U.2
Wsol, V.3
Venz, S.4
Block, S.5
Maser, E.6
-
357
-
-
0029086806
-
Stereoselectivity of the carbonyl reduction of dolasetron in rats, dogs and humans
-
J. Dow, C. Berg, 'Stereoselectivity of the carbonyl reduction of dolasetron in rats, dogs and humans', Chirality 1995, 7, 342-348.
-
(1995)
Chirality
, vol.7
, pp. 342-348
-
-
Dow, J.1
Berg, C.2
-
358
-
-
0015719942
-
Some chemical and stereochemical aspects of diethylpropion metabolism in man
-
B. Testa, 'Some chemical and stereochemical aspects of diethylpropion metabolism in man', Acta Pharm. Suec. 1973, 10, 441-454;
-
(1973)
Acta Pharm. Suec
, vol.10
, pp. 441-454
-
-
Testa, B.1
-
359
-
-
0028784530
-
Low configurational stability of amfepramone and cathinone: Mechanism and kinetics of chiral inversion
-
M. Reist, L. H. Christiansen, P. Christoffersen, P. A. Carrupt, B. Testa, 'Low configurational stability of amfepramone and cathinone: Mechanism and kinetics of chiral inversion', Chirality 1995, 7, 469-473.
-
(1995)
Chirality
, vol.7
, pp. 469-473
-
-
Reist, M.1
Christiansen, L.H.2
Christoffersen, P.3
Carrupt, P.A.4
Testa, B.5
-
360
-
-
0027363349
-
Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism
-
T. M. Penning, 'Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism', Chem.-Biol. Interact. 1993. 89, 1-34.
-
(1993)
Chem.-Biol. Interact
, vol.89
, pp. 1-34
-
-
Penning, T.M.1
-
361
-
-
0032937593
-
Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: Generation of reactive and redox active o-quinones
-
T. M. Penning, M. E. Burczynski, C. F. Hung, K. D. McCoull, N. T. Palackal, L. S. Tsuruda, 'Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones', Chem. Res. Toxicol. 1999, 12, 1-18.
-
(1999)
Chem. Res. Toxicol
, vol.12
, pp. 1-18
-
-
Penning, T.M.1
Burczynski, M.E.2
Hung, C.F.3
McCoull, K.D.4
Palackal, N.T.5
Tsuruda, L.S.6
-
362
-
-
0037025386
-
Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells
-
N. T. Palackal, S. H. Lee, R. G. Harvey, I. A. Blair, T. M. Penning, 'Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells', J. Biol. Chem. 2002, 277, 24799-24808.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 24799-24808
-
-
Palackal, N.T.1
Lee, S.H.2
Harvey, R.G.3
Blair, I.A.4
Penning, T.M.5
-
363
-
-
0035845684
-
The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: Potential role in polycyclic aromatic hydrocarbon activation
-
N. T. Palackal, M. E. Burczynski, R. G. Harvey, T. M. Penning, 'The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation', Biochemistry 2001, 40, 10901-10910.
-
(2001)
Biochemistry
, vol.40
, pp. 10901-10910
-
-
Palackal, N.T.1
Burczynski, M.E.2
Harvey, R.G.3
Penning, T.M.4
-
364
-
-
29944447220
-
In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes
-
T. M. Cho, R. L. Rose, E. Hodgson, 'In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes', Drug Metab. Dispos. 2006, 34, 176-183.
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 176-183
-
-
Cho, T.M.1
Rose, R.L.2
Hodgson, E.3
-
365
-
-
0032969410
-
Aldose reductase catalyzes the oxidation of naphthalene- 1,2-dihydrodiol for the formation of ortho-naphthoquinone
-
K. Sugiyama, T. C. Lin Wang, J. T. Simpson, L. Rodriguez, P. F. Kador, S. Sato, 'Aldose reductase catalyzes the oxidation of naphthalene- 1,2-dihydrodiol for the formation of ortho-naphthoquinone', Drug Metab. Dispos. 1999, 27, 60-67.
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 60-67
-
-
Sugiyama, K.1
Lin Wang, T.C.2
Simpson, J.T.3
Rodriguez, L.4
Kador, P.F.5
Sato, S.6
-
366
-
-
20444412643
-
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: A review
-
W. Xue, D. Warshawsky, 'Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review', Toxicol. Appl. Pharmacol. 2005, 206, 73-93.
-
(2005)
Toxicol. Appl. Pharmacol
, vol.206
, pp. 73-93
-
-
Xue, W.1
Warshawsky, D.2
-
367
-
-
0030065647
-
Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbons trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase
-
T. M. Penning, S. T. Ohnishi, T. Ohnishi, R. G. Harvey, 'Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbons trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase', Chem. Res. Toxicol 1996, 9, 84-92.
-
(1996)
Chem. Res. Toxicol
, vol.9
, pp. 84-92
-
-
Penning, T.M.1
Ohnishi, S.T.2
Ohnishi, T.3
Harvey, R.G.4
-
368
-
-
0026515757
-
Quinone chemistry and toxicity
-
T. J. Monks, R. P. Hanzlik, G. M. Cohen, D. Ross, D. G. Graham, 'Quinone chemistry and toxicity', Toxicol Appl. Pharmacol. 1992, 112, 2-16;
-
(1992)
Toxicol Appl. Pharmacol
, vol.112
, pp. 2-16
-
-
Monks, T.J.1
Hanzlik, R.P.2
Cohen, G.M.3
Ross, D.4
Graham, D.G.5
-
369
-
-
0034068228
-
Role of quinones in toxicology
-
J. L. Bolton, M. A. Trush, T. M. Penning, G. Dryherst, T. J. Monks, 'Role of quinones in toxicology', Chem. Res. Toxicol. 2000, 13, 135-160.
-
(2000)
Chem. Res. Toxicol
, vol.13
, pp. 135-160
-
-
Bolton, J.L.1
Trush, M.A.2
Penning, T.M.3
Dryherst, G.4
Monks, T.J.5
-
370
-
-
0033024560
-
Synthesis and characterization of polycyclic aromatic hydrocarbons o-quinone depurinating N7-guanine adducts
-
K. D. McCoull, D. Rindgen, I. A. Blair, T. M. Penning, 'Synthesis and characterization of polycyclic aromatic hydrocarbons o-quinone depurinating N7-guanine adducts', Chem. Res. Toxicol. 1999, 12, 237-246.
-
(1999)
Chem. Res. Toxicol
, vol.12
, pp. 237-246
-
-
McCoull, K.D.1
Rindgen, D.2
Blair, I.A.3
Penning, T.M.4
-
371
-
-
8844283286
-
Oxidative DNA damage induced by benz[a]anthracene dihydrodiols in the presence of dihydrodiol dehydrogenase
-
K. Seite, M. Murata, K. Hirakawa, Y. Deyashiki, S. Kawanishi, 'Oxidative DNA damage induced by benz[a]anthracene dihydrodiols in the presence of dihydrodiol dehydrogenase', Chem. Res. Toxicol. 2004, 17, 1445-1451.
-
(2004)
Chem. Res. Toxicol
, vol.17
, pp. 1445-1451
-
-
Seite, K.1
Murata, M.2
Hirakawa, K.3
Deyashiki, Y.4
Kawanishi, S.5
-
372
-
-
0027207716
-
Studies on three reductases which have polycyclic aromatic hydrocarbon quinones as substrates
-
J. Jarabak, R. G. Harvey, 'Studies on three reductases which have polycyclic aromatic hydrocarbon quinones as substrates', Arch. Biochem. Biophys. 1993, 303, 394-401.
-
(1993)
Arch. Biochem. Biophys
, vol.303
, pp. 394-401
-
-
Jarabak, J.1
Harvey, R.G.2
-
373
-
-
0024498044
-
DT-Diaphorase-catalyzed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates
-
G.D. Buffinton, K. Öllinger, A. Brunmark, E. Cadenas, 'DT-Diaphorase-catalyzed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates', Biochem. J. 1989, 257, 561-571.
-
(1989)
Biochem. J
, vol.257
, pp. 561-571
-
-
Buffinton, G.D.1
Öllinger, K.2
Brunmark, A.3
Cadenas, E.4
-
374
-
-
0027102766
-
Toxicology of quinone-thioethers
-
T. J. Monks, S. S. Lau, 'Toxicology of quinone-thioethers', Crit. Rev. Toxicol. 1992, 22, 243-270.
-
(1992)
Crit. Rev. Toxicol
, vol.22
, pp. 243-270
-
-
Monks, T.J.1
Lau, S.S.2
-
375
-
-
0034662467
-
Role of NAD(P)H: Quinone oxidoreductase I (DT diaphorase) in protection against quinone toxicity
-
P. Joseph, D. J. Long II, A. J. P. Klein-Szanto, A. K. Jaiswal, 'Role of NAD(P)H: quinone oxidoreductase I (DT diaphorase) in protection against quinone toxicity', Biochem. Pharmacol. 2000, 60, 207-214.
-
(2000)
Biochem. Pharmacol
, vol.60
, pp. 207-214
-
-
Joseph, P.1
Long II, D.J.2
Klein-Szanto, A.J.P.3
Jaiswal, A.K.4
-
376
-
-
1242297068
-
Activation and detoxification of naphthoquinones by NAD(P)H:quinone oxidoreductase
-
R. Munday, 'Activation and detoxification of naphthoquinones by NAD(P)H:quinone oxidoreductase', Methods Enzymol. 2004, 382, 364-380.
-
(2004)
Methods Enzymol
, vol.382
, pp. 364-380
-
-
Munday, R.1
-
377
-
-
30344440376
-
Metabolism and disposition of juglone in male F 344 rats
-
L. J. Chen, E. H. Lebetkin, L. T. Burka, 'Metabolism and disposition of juglone in male F 344 rats', Xenobiotica 2005, 35, 1019-1034.
-
(2005)
Xenobiotica
, vol.35
, pp. 1019-1034
-
-
Chen, L.J.1
Lebetkin, E.H.2
Burka, L.T.3
-
378
-
-
0026612119
-
DT-Diaphorase and cancer chemotherapy
-
R. J. Riley, P. Workman, 'DT-Diaphorase and cancer chemotherapy', Biochem. Pharmacol. 1992, 43, 1657-1669.
-
(1992)
Biochem. Pharmacol
, vol.43
, pp. 1657-1669
-
-
Riley, R.J.1
Workman, P.2
-
379
-
-
0032168217
-
Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: A detailed kinetic study and analysis of metabolites
-
S. M. Bailey, A. D. Lewis, R. J. Knox, L. H. Patterson, G. R. Fisher, P. Workman, 'Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites', Biochem. Pharmacol. 1998, 56, 613-621.
-
(1998)
Biochem. Pharmacol
, vol.56
, pp. 613-621
-
-
Bailey, S.M.1
Lewis, A.D.2
Knox, R.J.3
Patterson, L.H.4
Fisher, G.R.5
Workman, P.6
-
380
-
-
0026567982
-
NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based agents and generation of hydroxyl radicals
-
G. R. Fisher, P. L. Gutierrez, M. A. Oldcorne, L. H. Patterson, 'NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based agents and generation of hydroxyl radicals', Biochem. Pharmacol. 1992, 43, 575-585.
-
(1992)
Biochem. Pharmacol
, vol.43
, pp. 575-585
-
-
Fisher, G.R.1
Gutierrez, P.L.2
Oldcorne, M.A.3
Patterson, L.H.4
-
381
-
-
28144450802
-
Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex
-
M. AbuKhader, J. Heap, C. De Matteis, B. Kellam, S. W. Doughty, N. Minton, M. Paoli,'Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex', J. Med. Chem. 2005, 48, 7714-7719.
-
(2005)
J. Med. Chem
, vol.48
, pp. 7714-7719
-
-
AbuKhader, M.1
Heap, J.2
De Matteis, C.3
Kellam, B.4
Doughty, S.W.5
Minton, N.6
Paoli, M.7
-
382
-
-
0026669225
-
Bioreductive activation of mitomycin C by DT-diaphorase
-
D. Siegel, H. Beall, C. Senekowitsch, M. Kasai, H. Arai, N. W. Gibson, D. Ross, 'Bioreductive activation of mitomycin C by DT-diaphorase', Biochemistry 1992, 31, 7879-7885.
-
(1992)
Biochemistry
, vol.31
, pp. 7879-7885
-
-
Siegel, D.1
Beall, H.2
Senekowitsch, C.3
Kasai, M.4
Arai, H.5
Gibson, N.W.6
Ross, D.7
-
383
-
-
0033533801
-
Bioreductive activation of a series of indolquinones by human DT-diaphorase: Structure-activity relationships
-
R. M. Phillips, M. A. Naylor, M. Jaffar, S. W. Doughty, S. A. Everett, A. G. Breen, G. A. Choudry, I. J. Stratford, 'Bioreductive activation of a series of indolquinones by human DT-diaphorase: structure-activity relationships', J. Med. Chem. 1999, 42, 4071-4080.
-
(1999)
J. Med. Chem
, vol.42
, pp. 4071-4080
-
-
Phillips, R.M.1
Naylor, M.A.2
Jaffar, M.3
Doughty, S.W.4
Everett, S.A.5
Breen, A.G.6
Choudry, G.A.7
Stratford, I.J.8
-
384
-
-
0033981669
-
Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-aziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice
-
P. M. Loadman, R. M. Phillips, L. E. Lim, M. C. Bibby, 'Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-aziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice', Biochem. Pharmacol. 2000, 59, 831-837.
-
(2000)
Biochem. Pharmacol
, vol.59
, pp. 831-837
-
-
Loadman, P.M.1
Phillips, R.M.2
Lim, L.E.3
Bibby, M.C.4
-
385
-
-
7444258436
-
Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs
-
R. M. Phillips, M. Jaffar, D. J. Maitland, P. M. Loadman, S. D. Shnyder, G. Steabs, P. A. Cooper, A. Race, A. V. Patterson, I. J. Stratford, 'Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs', Biochem. Pharmacol. 2004, 68, 2107-2116.
-
(2004)
Biochem. Pharmacol
, vol.68
, pp. 2107-2116
-
-
Phillips, R.M.1
Jaffar, M.2
Maitland, D.J.3
Loadman, P.M.4
Shnyder, S.D.5
Steabs, G.6
Cooper, P.A.7
Race, A.8
Patterson, A.V.9
Stratford, I.J.10
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