Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide: Contributions of glutathione, glutathione S-transferase, and MRP1

Biochemistry

Volumn 44, Issue 11, 2005, Pages 4426-4433

  Peklak Scott, Christina ^a   Townsend, Alan J ^a   Morrow, Charles S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENES; REACTION KINETICS; SUBSTRATES; TOXIC MATERIALS; TRANSPORT PROPERTIES;

4-NITROQUINOLINE 1-OXIDE (NQO); ELECTROPHILES; GENOTOXICITIES; RATE ENHANCEMENT FACTOR;

CARCINOGENS;

4 NITROQUINOLINE 1 OXIDE; CARCINOGEN; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; ISOENZYME; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; RECOMBINANT ENZYME; S METHYLGLUTATHIONE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; GENE EXPRESSION; GENOTOXICITY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MEMBRANE VESICLE; PRIORITY JOURNAL; TRANSPORT KINETICS;

4-NITROQUINOLINE-1-OXIDE; CARCINOGENS; CATALYSIS; CELL LINE, TUMOR; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; HYDROGEN-ION CONCENTRATION; ISOENZYMES; KINETICS; METABOLIC DETOXICATION, DRUG; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; SUBSTRATE SPECIFICITY; TEMPERATURE; THERMODYNAMICS; TRANSPORT VESICLES;

EID: 15544376626     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047810y     Document Type: Article

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