Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia

Clinical Cancer Research

Volumn 8, Issue 3, 2002, Pages 802-810

  Krajinovic, Maja ^a   Labuda, Damian ^a   Mathonnet, Geraldine ^a   Labuda, Marcin ^a   Moghrabi, Albert ^a   Champagne, Josette ^a   Sinnett, Daniel ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ASPARAGINASE; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOCHROME P450 1A1; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; DEXAMETHASONE; DOXORUBICIN; DRUG METABOLIZING ENZYME; ETOPOSIDE; GLUTATHIONE TRANSFERASE; HYDROCORTISONE; HYDROXYUREA; MERCAPTOPURINE; METHOTREXATE; METHYLPREDNISOLONE; MYELOPEROXIDASE; NITROSOUREA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PREDNISONE; RAZOXANE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); TENIPOSIDE; TIOGUANINE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CANCER MORTALITY; CANCER RECURRENCE; CANCER RESISTANCE; CANCER RISK; CANCER SUSCEPTIBILITY; CHILD; CHILDHOOD CANCER; DNA POLYMORPHISM; DRUG METABOLISM; FEMALE; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

ACETYLTRANSFERASES; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHILD, PRESCHOOL; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE SUSCEPTIBILITY; DNA REPAIR; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE; NAD(P)H DEHYDROGENASE (QUINONE); POLYMORPHISM, GENETIC; PROGNOSIS; SURVIVAL RATE; TREATMENT OUTCOME; XENOBIOTICS;

EID: 0036304753     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Acute lymphoblastic leukemia in children
2. Biology and treatment of acute lymphocytic leukemia in children
3. Intensification of treatment and survival in all children with lymphoblastic leukaemia: Results of UK Medical Research Council trial UKALL X
4. Treatment of childhood acute lymphoblastic leukemia: Results of Dana-Farber Cancer Institute/Children's Hospital Acute Lymphoblastic Leukemia Consortium Protocol 85-01
5. Cognitive sequelae of treatment in childhood acute lymphoblastic leukemia: Cranial radiation requires an accomplice
6. Health status of long-term survivors after cancer in childhood. Results of an uniinstitutional study in Italy
7. Molecular epidemiology: Insight into cancer susceptibility, risk assessment, and prevention
8. Susceptibility to childhood acute lymphoblastic leukemia: Influence of CYP1A1, CYP2D6, GSTM 1, and GSTT1 genetic polymorphisms
9. Genetic polymorphisms of N-acetyltransferase 1 (NAT1) and 2 (NAT2) and gene-gene interaction in the susceptibility to childhood acute lymphoblastic leukemia
10. The role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia
11. Genetic susceptibility to childhood acute lymphoblastic leukemia
12. Individualization of cancer therapy based on cytochrome P450 polymorphism: A pharmacogenetic approach
13. Molecular mechanisms of genetic polymorphisms of drug metabolism
14. Les arylamine N-acétyltransferases: Génétique à la susceptibilité aux xénobiotiques
15. Genetic determinants of drug responsiveness and drug interactions
16. Relationship between genotype and function of the human CYP1A1 gene
17. Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man
18. Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
19. Genetic polymorphism in the 5′ flanking region change transcriptional regulation of the human cytochrome P450E1 gene
20. An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element
21. Nomenclature for human glutathione transferases
22. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism
23. Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility
24. Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins
25. Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer
26. Characterization of a polymorphism in NAD(P)H: Quinone oxidoreductase (DT-diaphorase)
27. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms
28. A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity
29. Purification of an alpha class glutathione S-transferase from melphalan-resistant Chinese hamster ovary cells and demonstration of its ability to catalyze melphalan-glutathione adduct formation
30. Expression of mu class glutathione S-transferase correlates with event-free survival in childhood acute lymphoblastic leukemia
31. Transfection of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme, mouse GSTA4-4, confers doxorubicin resistance to Chinese hamster ovary cells
32. Glutathione-associated enzymes in anticancer drug resistance
33. NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells
34. The role of NAD(P)H oxidoreductase (DT-diaphorase) in the bioactivation of quinone-containing antitumor agents: A review
35. Anthracyclines and anthracenediones
36. Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells
37. DNA repair: Enzymatic mechanisms and relevance to drug response
38. DNA repair: Counteragent in mutagenesis and carcinogenesis-accomplice in cancer therapy resistance
39. Alterations of DNA repair in melanoma cell lines resistant to cisplatin, fotemustine, or etoposide
40. High resolution deletion mapping reveals frequent allelic losses at the DNA mismatch repair loci hMLH1 and hMSH3 in non-small cell lung cancer
41. Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans
42. Polymorphisms in the human DNA repair gene XPF
43. Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population
44. Inheritance of the 194Trp and the 399G1n variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt
45. Substituting dexamethasone for prednisone complicates remission induction in children with acute lymphoblastic leukemia
46. Rapid detection of CYP1A1, CYP2D6, and NAT variants by multiplex polymerase chain reaction and allele-specific oligonucleotide assay
47. Ethnic differences in drug disposition and response
48. Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): Dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A
49. Glucocorticoid potentiation of cytochrome P4501A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin in porcine and human endothelial cells in culture
50. Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms
51. Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Quebec, Canada)
52. Free radical formation by antitumor quinines
53. Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/myelodysplastic syndrome and de novo acute myeloid leukemia
54. Prevalence of the inactivating 609C→T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia
55. A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions
56. Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents
57. Role of apoptotic response in cellular resistance to cytotoxic agents
58. Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: A case-control study
59. Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia
60. Expression of glutathione transferase pi as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia
61. P-glycoprotein and glutathione S-transferase pi in childhood acute lymphoblastic leukaemia
62. Immunohistochemical expression of glutathione S-transferase pi (GST-pi) and chemotherapy response in malignant ovarian tumors
63. Higher frequency of glutathione S-transferase deletions in black children with acute lymphoblastic leukemia
64. Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia