-
1
-
-
0033565561
-
The biology of chronic myeloid leukemia
-
Faderl S., Talpaz M., Estrov Z., O'Brien S., Kurzrock R., and Kantarjian H.M. The biology of chronic myeloid leukemia. N Engl J Med 341 (1999) 164-172
-
(1999)
N Engl J Med
, vol.341
, pp. 164-172
-
-
Faderl, S.1
Talpaz, M.2
Estrov, Z.3
O'Brien, S.4
Kurzrock, R.5
Kantarjian, H.M.6
-
2
-
-
0141528828
-
Chronic myeloid leukemia-Advances in biology and new approaches to treatment
-
Goldman J.M., and Melo J.V. Chronic myeloid leukemia-Advances in biology and new approaches to treatment. N Engl J Med 349 (2003) 1451-1464
-
(2003)
N Engl J Med
, vol.349
, pp. 1451-1464
-
-
Goldman, J.M.1
Melo, J.V.2
-
3
-
-
4644359704
-
Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-α
-
Kantarjian H.M., Cortes J.E., O'Brien S., et al. Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-α. Blood 104 (2004) 1979-1988
-
(2004)
Blood
, vol.104
, pp. 1979-1988
-
-
Kantarjian, H.M.1
Cortes, J.E.2
O'Brien, S.3
-
4
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
International STI571 CML Study Group
-
Kantarjian H., Sawyers C., Hochhaus A., et al., International STI571 CML Study Group. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 346 (2002) 645-652
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
5
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
IRIS Investigators
-
O'Brien S.G., Guilhot F., Larson R.A., et al., IRIS Investigators. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 348 (2003) 994-1004
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
6
-
-
11144354274
-
High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia
-
Kantarjian H., Talpaz M., O'Brien S., et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood 103 (2004) 2873-2878
-
(2004)
Blood
, vol.103
, pp. 2873-2878
-
-
Kantarjian, H.1
Talpaz, M.2
O'Brien, S.3
-
7
-
-
20944442975
-
Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate
-
Cortes J., Talpaz M., O'Brien S., et al. Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate. Clin Cancer Res 11 (2005) 3425-3432
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3425-3432
-
-
Cortes, J.1
Talpaz, M.2
O'Brien, S.3
-
8
-
-
10744229080
-
Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
-
International Randomised Study of Interferon versus STI571 Study Group
-
Hughes T.P., Kaeda J., Branford S., et al., International Randomised Study of Interferon versus STI571 Study Group. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 349 (2003) 1423-1432
-
(2003)
N Engl J Med
, vol.349
, pp. 1423-1432
-
-
Hughes, T.P.1
Kaeda, J.2
Branford, S.3
-
9
-
-
79959308232
-
Loss of response to imatinib: Mechanisms and management
-
Shah N.P. Loss of response to imatinib: Mechanisms and management. Hematol Am Soc Hematol Educ Program (2005) 183-187
-
(2005)
Hematol Am Soc Hematol Educ Program
, pp. 183-187
-
-
Shah, N.P.1
-
10
-
-
0036850514
-
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
-
Hochhaus A., Kreil S., Corbin A.S., et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 16 (2002) 2190-2196
-
(2002)
Leukemia
, vol.16
, pp. 2190-2196
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.S.3
-
11
-
-
29144464371
-
Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
-
Manley P.W., Cowan-Jacob S.W., and Mestan J. Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia. Biochim Biophys Acta 1754 (2005) 3-13
-
(2005)
Biochim Biophys Acta
, vol.1754
, pp. 3-13
-
-
Manley, P.W.1
Cowan-Jacob, S.W.2
Mestan, J.3
-
12
-
-
0037315281
-
Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias
-
Gambacorti-Passerini C.B., Gunby R.H., Piazza R., Galietta A., Rostagno R., and Scapozza L. Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias. Lancet Oncol 4 (2003) 75-85
-
(2003)
Lancet Oncol
, vol.4
, pp. 75-85
-
-
Gambacorti-Passerini, C.B.1
Gunby, R.H.2
Piazza, R.3
Galietta, A.4
Rostagno, R.5
Scapozza, L.6
-
13
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre M.E., Mohammed M., Ellwood K., et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293 (2001) 876-880
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
14
-
-
10744232328
-
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
-
Branford S., Rudzki Z., Walsh S., et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 102 (2003) 276-283
-
(2003)
Blood
, vol.102
, pp. 276-283
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
15
-
-
0042305479
-
Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients
-
Gambacorti-Passerini C., Zucchetti M., Russo D., et al. Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients. Clin Cancer Res 9 (2003) 625-632
-
(2003)
Clin Cancer Res
, vol.9
, pp. 625-632
-
-
Gambacorti-Passerini, C.1
Zucchetti, M.2
Russo, D.3
-
16
-
-
9144234689
-
Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia
-
Donato N.J., Wu J.Y., Stapley J., et al. Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia. Cancer Res 64 (2004) 672-677
-
(2004)
Cancer Res
, vol.64
, pp. 672-677
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
-
17
-
-
0037438640
-
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
-
Donato N.J., Wu J.Y., Stapley J., et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 101 (2003) 690-698
-
(2003)
Blood
, vol.101
, pp. 690-698
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
-
18
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
Branford S., Rudzki Z., Walsh S., et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99 (2002) 3472-3475
-
(2002)
Blood
, vol.99
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
19
-
-
23044458596
-
ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
-
Soverini S., Martinelli G., Rosti G., et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 23 (2005) 4100-4109
-
(2005)
J Clin Oncol
, vol.23
, pp. 4100-4109
-
-
Soverini, S.1
Martinelli, G.2
Rosti, G.3
-
20
-
-
33750077276
-
Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
-
Jabbour E., Kantarjian H., Jones D., et al. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia 20 (2006) 1767-1773
-
(2006)
Leukemia
, vol.20
, pp. 1767-1773
-
-
Jabbour, E.1
Kantarjian, H.2
Jones, D.3
-
21
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
-
O'Hare T., Walters D.K., Stoffregen E.P., et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 65 (2005) 4500-4505
-
(2005)
Cancer Res
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
-
22
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah N.P., Tran C., Lee F.Y., Chen P., Norris D., and Sawyers C.L. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305 (2004) 399-401
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
23
-
-
33745283618
-
The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
-
Tokarski J.S., Newitt J.A., Chang C.Y., et al. The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. Cancer Res 66 (2006) 5790-5797
-
(2006)
Cancer Res
, vol.66
, pp. 5790-5797
-
-
Tokarski, J.S.1
Newitt, J.A.2
Chang, C.Y.3
-
24
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
Talpaz M., Shah N.P., Kantarjian H., et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 354 (2006) 2531-2541
-
(2006)
N Engl J Med
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
-
25
-
-
34247465126
-
Efficacy of dasatinib (SPRYCEL) in patients (pts) with chronic phase chronic myelogenous leukemia (CP-CML) resistant or intolerant of imatinib: Updated results of the CA180013 'START-C' phase II study
-
(abstr 164)
-
Baccarani M., Kantarjian H.M., Apperley J.F., et al. Efficacy of dasatinib (SPRYCEL) in patients (pts) with chronic phase chronic myelogenous leukemia (CP-CML) resistant or intolerant of imatinib: Updated results of the CA180013 'START-C' phase II study. Blood 108 (2006) (abstr 164)
-
(2006)
Blood
, vol.108
-
-
Baccarani, M.1
Kantarjian, H.M.2
Apperley, J.F.3
-
26
-
-
34247543905
-
Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in accelerated phase (AP-CML) that is imatinib-resistant (im-r) or -intolerant (im-i): Updated results of the CA180-005 'START-A' phase II study
-
(abstr 2160)
-
Cortes J., Kim D.W., Guilhot F., et al. Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in accelerated phase (AP-CML) that is imatinib-resistant (im-r) or -intolerant (im-i): Updated results of the CA180-005 'START-A' phase II study. Blood 108 (2006) (abstr 2160)
-
(2006)
Blood
, vol.108
-
-
Cortes, J.1
Kim, D.W.2
Guilhot, F.3
-
27
-
-
33846819360
-
Dasatinib (SPRYCEL) efficacy and safety in patients (pts) with chronic myelogenous leukemia in lymphoid (CML-LB) or myeloid blast (CML-MB) phase who are imatinib-resistant (im-r) or -intolerant (im-i)
-
(abstr 745)
-
Martinelli G., Hochhaus A., Coutre S., et al. Dasatinib (SPRYCEL) efficacy and safety in patients (pts) with chronic myelogenous leukemia in lymphoid (CML-LB) or myeloid blast (CML-MB) phase who are imatinib-resistant (im-r) or -intolerant (im-i). Blood 108 (2006) (abstr 745)
-
(2006)
Blood
, vol.108
-
-
Martinelli, G.1
Hochhaus, A.2
Coutre, S.3
-
28
-
-
33846801845
-
Dasatinib (SPRYCEL) in patients (pts) with Philadelphia chromosome-positive acute lymphoblastic leukemia who are imatinib-resistant (im-r) or -intolerant (im-i): Updated results from the CA180-015 'START-L' study
-
(abstr 286)
-
Dombret H., Ottmann O.G., Rosti G., et al. Dasatinib (SPRYCEL) in patients (pts) with Philadelphia chromosome-positive acute lymphoblastic leukemia who are imatinib-resistant (im-r) or -intolerant (im-i): Updated results from the CA180-015 'START-L' study. Blood 108 (2006) (abstr 286)
-
(2006)
Blood
, vol.108
-
-
Dombret, H.1
Ottmann, O.G.2
Rosti, G.3
-
29
-
-
33846815854
-
Dasatinib (SPRYCEL) vs escalated dose of imatinib (im) in patients (pts) with chronic phase chronic myeloid leukemia (CP-CML) resistant to imatinib: Results of the CA180-017 START-R randomized study
-
(abstr 167)
-
Shah N., Pasquini R., Rousselot P., et al. Dasatinib (SPRYCEL) vs escalated dose of imatinib (im) in patients (pts) with chronic phase chronic myeloid leukemia (CP-CML) resistant to imatinib: Results of the CA180-017 START-R randomized study. Blood 108 (2006) (abstr 167)
-
(2006)
Blood
, vol.108
-
-
Shah, N.1
Pasquini, R.2
Rousselot, P.3
-
30
-
-
33846849919
-
-
Bristol-Myers Squibb Company, Princeton, NJ [package insert].
-
Sprycel (2006), Bristol-Myers Squibb Company, Princeton, NJ [package insert].
-
(2006)
Sprycel
-
-
-
31
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg E., Manley P.W., Breitenstein W., et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 7 (2005) 129-141
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
-
32
-
-
24644464172
-
AMN107, a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute lymphoblastic leukemia cells
-
Verstovsek S., Golemovic M., Kantarjian H., et al. AMN107, a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute lymphoblastic leukemia cells. Cancer 104 (2005) 1230-1236
-
(2005)
Cancer
, vol.104
, pp. 1230-1236
-
-
Verstovsek, S.1
Golemovic, M.2
Kantarjian, H.3
-
33
-
-
33846848412
-
AMN107 (nilotinib): A novel and selective inhibitor Bcr-Abl
-
Weisberg E., Manley P., Mestan J., Cowan-Jacob S., Ray A., and Griffin J.D. AMN107 (nilotinib): A novel and selective inhibitor Bcr-Abl. Br J Cancer 7 (2006) 129-141
-
(2006)
Br J Cancer
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.2
Mestan, J.3
Cowan-Jacob, S.4
Ray, A.5
Griffin, J.D.6
-
34
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
Kantarjian H., Giles F., Wunderle L., et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 354 (2006) 2542-2551
-
(2006)
N Engl J Med
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
-
35
-
-
33846814283
-
A phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant and -intolerant patients with chronic myelogenous leukemia (CML) in chronic phase (CP)
-
(abstr 165)
-
Le Coutre P., Bhalla K., Giles F., et al. A phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant and -intolerant patients with chronic myelogenous leukemia (CML) in chronic phase (CP). Blood 108 (2006) (abstr 165)
-
(2006)
Blood
, vol.108
-
-
Le Coutre, P.1
Bhalla, K.2
Giles, F.3
-
36
-
-
33846812048
-
A phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant or -intolerant patients with chronic myelogenous leukemia (CML) in accelerated phase (AP)
-
(abstr 2169)
-
Kantarjian H.M., Gattermann N., Hochhaus A., et al. A phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant or -intolerant patients with chronic myelogenous leukemia (CML) in accelerated phase (AP). Blood 108 (2006) (abstr 2169)
-
(2006)
Blood
, vol.108
-
-
Kantarjian, H.M.1
Gattermann, N.2
Hochhaus, A.3
-
37
-
-
33750089041
-
A phase II study of AMN107, a novel inhibitor of Bcr-Abl, administered to imatinib-resistant or intolerant patients (pts) with Ph+ chronic myelogenous leukemia (CML) in blast crisis (BC) or relapsed/refractory Ph+ acute lymphoblastic leukemia (ALL)
-
(abstr 6536)
-
Giles F.J., Larson R., Le Coutre P., et al. A phase II study of AMN107, a novel inhibitor of Bcr-Abl, administered to imatinib-resistant or intolerant patients (pts) with Ph+ chronic myelogenous leukemia (CML) in blast crisis (BC) or relapsed/refractory Ph+ acute lymphoblastic leukemia (ALL). Proc Am Soc Clin Oncol 24 (2006) (abstr 6536)
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
Giles, F.J.1
Larson, R.2
Le Coutre, P.3
-
38
-
-
33846839963
-
Preliminary activity of AMN107, a novel potent oral selective Bcr-Abl tyrosine kinase inhibitor, in newly diagnosed Philadelphia chromosome (Ph)-positive chronic phase chronic myelogenous leukemia (CML-CP)
-
(abstr 6591)
-
Jabbour E., Giles F., Cortes J., et al. Preliminary activity of AMN107, a novel potent oral selective Bcr-Abl tyrosine kinase inhibitor, in newly diagnosed Philadelphia chromosome (Ph)-positive chronic phase chronic myelogenous leukemia (CML-CP). Proc Am Soc Clin Oncol 24 (2006) (abstr 6591)
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
Jabbour, E.1
Giles, F.2
Cortes, J.3
-
39
-
-
0037439689
-
SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
-
Golas J.M., Arndt K., Etienne C., et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res 63 (2003) 375-381
-
(2003)
Cancer Res
, vol.63
, pp. 375-381
-
-
Golas, J.M.1
Arndt, K.2
Etienne, C.3
-
40
-
-
28444479480
-
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
-
Kimura S., Naito H., Segawa H., et al. NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia. Blood 106 (2005) 3948-3954
-
(2005)
Blood
, vol.106
, pp. 3948-3954
-
-
Kimura, S.1
Naito, H.2
Segawa, H.3
-
41
-
-
4644368478
-
Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML
-
O'Hare T., Pollock R., Stoffregen E.P., et al. Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood 104 (2004) 2532-2539
-
(2004)
Blood
, vol.104
, pp. 2532-2539
-
-
O'Hare, T.1
Pollock, R.2
Stoffregen, E.P.3
-
42
-
-
0037438513
-
Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases
-
Warmuth M., Simon N., Mitina O., et al. Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases. Blood 101 (2003) 664-672
-
(2003)
Blood
, vol.101
, pp. 664-672
-
-
Warmuth, M.1
Simon, N.2
Mitina, O.3
-
43
-
-
13844261144
-
A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance
-
Gumireddy K., Baker S.J., Cosenza S.C., et al. A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc Natl Acad Sci U S A 102 (2005) 1992-1997
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1992-1997
-
-
Gumireddy, K.1
Baker, S.J.2
Cosenza, S.C.3
-
44
-
-
17644368237
-
ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent
-
Gumireddy K., Reddy M.V., Cosenza S.C., et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell 7 (2005) 275-286
-
(2005)
Cancer Cell
, vol.7
, pp. 275-286
-
-
Gumireddy, K.1
Reddy, M.V.2
Cosenza, S.C.3
-
45
-
-
23344440655
-
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
-
Carter T.A., Wodicka L.M., Shah N.P., et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A 102 (2005) 11011-11016
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 11011-11016
-
-
Carter, T.A.1
Wodicka, L.M.2
Shah, N.P.3
-
46
-
-
0037255789
-
Allogeneic stem cell transplantation for chronic myeloid leukemia
-
Barrett J. Allogeneic stem cell transplantation for chronic myeloid leukemia. Semin Hematol 40 (2003) 59-71
-
(2003)
Semin Hematol
, vol.40
, pp. 59-71
-
-
Barrett, J.1
-
47
-
-
0031796063
-
Interferon-alpha: mechanisms of action in chronic myelogenous leukemia in chronic phase
-
Guilhot F., and Lacotte-Thierry L. Interferon-alpha: mechanisms of action in chronic myelogenous leukemia in chronic phase. Hematol Cell Ther 40 (1998) 237-239
-
(1998)
Hematol Cell Ther
, vol.40
, pp. 237-239
-
-
Guilhot, F.1
Lacotte-Thierry, L.2
-
48
-
-
0034161533
-
Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses
-
Pinilla-Ibarz J., Cathcart K., Korontsvit T., et al. Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses. Blood 95 (2000) 1781-1787
-
(2000)
Blood
, vol.95
, pp. 1781-1787
-
-
Pinilla-Ibarz, J.1
Cathcart, K.2
Korontsvit, T.3
-
49
-
-
1642500316
-
A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia
-
Cathcart K., Pinilla-Ibarz J., Korontsvit T., et al. A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia. Blood 103 (2004) 1037-1042
-
(2004)
Blood
, vol.103
, pp. 1037-1042
-
-
Cathcart, K.1
Pinilla-Ibarz, J.2
Korontsvit, T.3
-
50
-
-
13844312036
-
Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: A multicentre observational trial
-
Bocchia M., Gentili S., Abruzzese E., et al. Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: A multicentre observational trial. Lancet 365 (2005) 657-662
-
(2005)
Lancet
, vol.365
, pp. 657-662
-
-
Bocchia, M.1
Gentili, S.2
Abruzzese, E.3
-
51
-
-
29844437061
-
Vaccination with the PR1 leukemia-associated antigen can induce complete remission in patients with myeloid leukemia
-
(abstr 259)
-
Qazilbash M.H., Weider E., Rios R., et al. Vaccination with the PR1 leukemia-associated antigen can induce complete remission in patients with myeloid leukemia. Blood 104 (2004) 77a (abstr 259)
-
(2004)
Blood
, vol.104
-
-
Qazilbash, M.H.1
Weider, E.2
Rios, R.3
-
52
-
-
3242732550
-
Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein 70 vaccine for chronic myelogenous leukemia
-
(abstr 664)
-
Li Z., Qiao Y., Laska E., et al. Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein 70 vaccine for chronic myelogenous leukemia. Proc Am Soc Clin Oncol 22 (2003) 166 (abstr 664)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 166
-
-
Li, Z.1
Qiao, Y.2
Laska, E.3
-
53
-
-
0037372488
-
Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
-
Cortes J., Albitar M., Thomas D., et al. Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies. Blood 101 (2003) 1692-1697
-
(2003)
Blood
, vol.101
, pp. 1692-1697
-
-
Cortes, J.1
Albitar, M.2
Thomas, D.3
-
54
-
-
30744446226
-
Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy
-
Borthakur G., Kantarjian H., Daley G., et al. Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy. Cancer 106 (2006) 346-352
-
(2006)
Cancer
, vol.106
, pp. 346-352
-
-
Borthakur, G.1
Kantarjian, H.2
Daley, G.3
-
55
-
-
28444434844
-
A phase I study of tipifarnib in combination with imatinib mesylate for patients with chronic myeloid leukemia in chronic phase who failed imatinib therapy
-
(abstr1011)
-
Cortes J., Garcia-Manero G., O'Brien S., et al. A phase I study of tipifarnib in combination with imatinib mesylate for patients with chronic myeloid leukemia in chronic phase who failed imatinib therapy. Blood 104 (2004) 289a (abstr1011)
-
(2004)
Blood
, vol.104
-
-
Cortes, J.1
Garcia-Manero, G.2
O'Brien, S.3
-
56
-
-
28444434844
-
Phase I study of lonafarnib in combination with imatinib mesylate for patients with chronic myeloid leukemia after failure to imatinib
-
(abstr 1009)
-
Cortes J., O'Brien S., Verstovsek S., et al. Phase I study of lonafarnib in combination with imatinib mesylate for patients with chronic myeloid leukemia after failure to imatinib. Blood 104 (2004) 288a (abstr 1009)
-
(2004)
Blood
, vol.104
-
-
Cortes, J.1
O'Brien, S.2
Verstovsek, S.3
-
57
-
-
21244431605
-
Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
-
Issa J.P., Gharibyan V., Cortes J., et al. Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol 23 (2005) 3948-3956
-
(2005)
J Clin Oncol
, vol.23
, pp. 3948-3956
-
-
Issa, J.P.1
Gharibyan, V.2
Cortes, J.3
-
58
-
-
33845301827
-
Subcutaneous (SC) homoharringtonine (HHT) for patients (pts) with chronic myelogenous leukemia (CML) in chronic phase (CP) after imatinib mesylate failure
-
(abstr 4839)
-
Quintas-Cardama A., Cortes J., Verstovsek S., Laddie N., Estrov Z., and Kantarjian H. Subcutaneous (SC) homoharringtonine (HHT) for patients (pts) with chronic myelogenous leukemia (CML) in chronic phase (CP) after imatinib mesylate failure. Blood 106 (2005) (abstr 4839)
-
(2005)
Blood
, vol.106
-
-
Quintas-Cardama, A.1
Cortes, J.2
Verstovsek, S.3
Laddie, N.4
Estrov, Z.5
Kantarjian, H.6
-
59
-
-
33747156914
-
Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure
-
Jabbour E., Cortes J., Kantarjian H.M., et al. Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure. Blood 108 (2006) 1421-1423
-
(2006)
Blood
, vol.108
, pp. 1421-1423
-
-
Jabbour, E.1
Cortes, J.2
Kantarjian, H.M.3
-
60
-
-
33846815853
-
Novel tyrosine kinase inhibitor therapy (NTKI) prior to allogeneic stem cell transplantation (ASCT) in patients (pts) with chronic myeloid leukemia: No evidence for increased transplant-related toxicity
-
(abstr 16515)
-
De Lima M., Jabbour E., Cortes J., et al. Novel tyrosine kinase inhibitor therapy (NTKI) prior to allogeneic stem cell transplantation (ASCT) in patients (pts) with chronic myeloid leukemia: No evidence for increased transplant-related toxicity. Proc Am Soc Clin Oncol 24 (2006) (abstr 16515)
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
De Lima, M.1
Jabbour, E.2
Cortes, J.3
|