The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia

Haematologica

Volumn 90, Issue 7, 2005, Pages 982-984

  Voso, Maria Teresa ^a   D'Alò, Francesco ^a   Gumiero, Daniela ^a   Guidi, Francesco ^a   Hohaus, Stefan ^a   Leone, Giuseppe ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Acute myeloid leukemia; CYP1A1; P450; Polymorphisms; Prognosis

Indexed keywords

CYTOCHROME P450 1A1; FLT3 LIGAND;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ALLELE; ARTICLE; BONE MARROW EXAMINATION; CANCER SURVIVAL; CHROMOSOME ANALYSIS; ENZYME POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE; HUMAN; KARYOTYPING; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROGNOSIS; REMISSION; ACUTE DISEASE; CYTOGENETICS; DISEASE FREE SURVIVAL; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; LETTER; MORTALITY; RISK; TREATMENT OUTCOME;

ACUTE DISEASE; ALLELES; CYTOCHROME P-450 CYP1A1; CYTOGENETICS; DISEASE-FREE SURVIVAL; GENETIC PREDISPOSITION TO DISEASE; LEUKEMIA, MYELOCYTIC, ACUTE; POLYMORPHISM, GENETIC; PROGNOSIS; REMISSION INDUCTION; RISK; TREATMENT OUTCOME;

EID: 22544431983     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Ingelman-Sundberg M. Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes. Mutat Res 2001;482:11-9.
2. D'Alo F, Voso MT, Guidi F, Scardocci A, Massini G, Sica S, et al. Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia. Haematologica 2004;89:664-70.
3. Voso MT, D'Alò F, Putzulu R, Mele L, Scardocci A, Chiusolo P, et al. Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia. Blood 2002;100:2703-7.
4. Hohaus S, Massini G, D'Alo' F, Guidi F, Putzulu R, Scardocci A, et al. Association between glutathione S-transferase genotypes and Hodgkin's lymphoma risk and prognosis. Clin Cancer Res 2003;9:3435-40.
5. Hohaus S, Di Ruscio A, Di Febo A, Massini G, D'Alo' F, Guidi F, et al. Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma. Clin Cancer Res 2005;11:2175-9.
6. Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001;98:1752-9.
7. Cascorbi I, Brockmöller J, Roots I. A C4887 A polymorphisim in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Res 1996;56:2965-9.
8. Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood 1998;92:2322-33.
9. Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 1996;10:1911-8.
10. Bowen DT, Frew ME, Rollinson S, Roddam PL, Dring A, Smith MT, et al. Cytochrome P450 1A1 *2B (Val) allele is over-represented in a sub-group of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication. Blood 2003;101:2770-4.