Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole

Drug Metabolism and Disposition

Volumn 30, Issue 11, 2002, Pages 1240-1245

  Matsumoto, Shigeki ^a   Hirama, Tomoe ^a   Matsubara, Tsutomu ^a   Nagata, Kiyoshi ^a   Yamazoe, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; ARACHIDONIC ACID; ASTEMIZOLE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 2J2; EBASTINE; O DEMETHYLASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ARACHIDONATE EPOXYGENASE; BLOCKING ANTIBODY; BUTYROPHENONE DERIVATIVE; ENZYME INHIBITOR; HISTAMINE H1 RECEPTOR ANTAGONIST; OXYGENASE; PIPERIDINE DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA LIBRARY; DRUG ABSORPTION; DRUG ELIMINATION; FIRST PASS EFFECT; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMALL INTESTINE; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; DEALKYLATION; DRUG ANTAGONISM; GENE LIBRARY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE; MASS SPECTROMETRY; METABOLISM; MOLECULAR CLONING; WESTERN BLOTTING;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ANIMALS; ANTIBODIES, BLOCKING; ARACHIDONIC ACID; ASTEMIZOLE; BLOTTING, WESTERN; BUTYROPHENONES; CERCOPITHECUS AETHIOPS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; COS CELLS; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; DNA, COMPLEMENTARY; ENZYME INHIBITORS; GENE LIBRARY; HISTAMINE H1 ANTAGONISTS; HUMANS; INTESTINES; MASS SPECTROMETRY; MICROSOMES, LIVER; OXYGENASES; PIPERIDINES; RABBITS; RECOMBINANT PROTEINS;

EID: 0036842039     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.11.1240     Document Type: Article

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