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Volumn 8, Issue 7, 2008, Pages 512-522

Living on a break: Cellular senescence as a DNA-damage response

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELL CULTURE; CARCINOGENESIS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME; DNA DAMAGE; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; GENE EXPRESSION; HETEROCHROMATIN; HUMAN; IN VITRO STUDY; ONCOGENE; PRIORITY JOURNAL; PROTEIN DNA BINDING; REVIEW; TELOMERE;

EID: 45849099050     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2440     Document Type: Review
Times cited : (837)

References (144)
  • 1
    • 33745823159 scopus 로고    scopus 로고
    • The ATM-mediated DNA-damage response: Taking shape
    • Shiloh, Y. The ATM-mediated DNA-damage response: taking shape. Trends Biochem. Sci. 37, 402-410 (2006).
    • (2006) Trends Biochem. Sci , vol.37 , pp. 402-410
    • Shiloh, Y.1
  • 3
    • 34247251276 scopus 로고    scopus 로고
    • building a trigger of ATR-mediated DNA damage response
    • and double-stranded DNA
    • Zou, L. Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev. 21, 879-885 (2007).
    • (2007) Genes Dev , vol.21 , pp. 879-885
    • Zou, L.S.1
  • 4
    • 0037012845 scopus 로고    scopus 로고
    • Genomic instability in mice lacking histone H2AX
    • Celeste, A. et al. Genomic instability in mice lacking histone H2AX. Science 296, 922-927 (2002).
    • (2002) Science , vol.296 , pp. 922-927
    • Celeste, A.1
  • 5
    • 0037468232 scopus 로고    scopus 로고
    • MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
    • Lou, Z., Minter-Dykhouse, K., Wu, X. & Chen, J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421, 957-961 (2003).
    • (2003) Nature , vol.421 , pp. 957-961
    • Lou, Z.1    Minter-Dykhouse, K.2    Wu, X.3    Chen, J.4
  • 6
    • 0037468169 scopus 로고    scopus 로고
    • MDC1 is required for the intra-S-phase DNA damage checkpoint
    • Goldberg, M. et al. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421, 952-956 (2003).
    • (2003) Nature , vol.421 , pp. 952-956
    • Goldberg, M.1
  • 7
  • 8
    • 0036906303 scopus 로고    scopus 로고
    • Checkpoint signalling: Focusing on 53BP1
    • Abraham, R. T. Checkpoint signalling: focusing on 53BP1. Nature Cell Biol. 4, E277-E279 (2002).
    • (2002) Nature Cell Biol , vol.4
    • Abraham, R.T.1
  • 9
    • 3342915628 scopus 로고    scopus 로고
    • Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
    • Lukas, C. et al. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J. 23, 2674-2683 (2004).
    • (2004) EMBO J , vol.23 , pp. 2674-2683
    • Lukas, C.1
  • 10
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki, M. et al. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123, 1213-1226 (2005).
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1
  • 11
    • 30744465308 scopus 로고    scopus 로고
    • MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
    • Lou, Z. et al. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol. Cell 21, 187-200 (2006).
    • (2006) Mol. Cell , vol.21 , pp. 187-200
    • Lou, Z.1
  • 12
    • 22944462083 scopus 로고    scopus 로고
    • Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
    • Bekker-Jensen, S., Lukas, C., Melander, F., Bartek, J. & Lukas, J. Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J. Cell Biol. 170, 201-211 (2005).
    • (2005) J. Cell Biol , vol.170 , pp. 201-211
    • Bekker-Jensen, S.1    Lukas, C.2    Melander, F.3    Bartek, J.4    Lukas, J.5
  • 13
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • Cortez, D., Guntuku, S., Qin, J. & Elledge, S. J. ATR and ATRIP: partners in checkpoint signaling. Science 294, 1713-1716 (2001).
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 14
    • 0037039165 scopus 로고    scopus 로고
    • Hus1 acts upstream of Chk1 in a mammalian DNA damage response pathway
    • Weiss, R. S., Matsuoka, S., Elledge, S. J. & Leder, P. Hus1 acts upstream of Chk1 in a mammalian DNA damage response pathway. Curr. Biol. 12, 73-77 (2002).
    • (2002) Curr. Biol , vol.12 , pp. 73-77
    • Weiss, R.S.1    Matsuoka, S.2    Elledge, S.J.3    Leder, P.4
  • 15
    • 33644757806 scopus 로고    scopus 로고
    • TopBP1 activates the ATR-ATRIP complex
    • Kumagai, A., Lee, J., Yoo, H. Y. & Dunphy, W. G. TopBP1 activates the ATR-ATRIP complex. Cell 124, 943-955 (2006).
    • (2006) Cell , vol.124 , pp. 943-955
    • Kumagai, A.1    Lee, J.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 16
    • 33746948393 scopus 로고    scopus 로고
    • Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
    • Liu, S. et al. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol. Cell. Biol. 26, 6056-6064 (2006).
    • (2006) Mol. Cell. Biol , vol.26 , pp. 6056-6064
    • Liu, S.1
  • 17
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • Jazayeri, A. et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nature Cell Biol. 8, 37-45 (2006).
    • (2006) Nature Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1
  • 18
    • 7044260304 scopus 로고    scopus 로고
    • Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks
    • Buscemi, G. et al. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene 23, 7691-7700 (2004).
    • (2004) Oncogene , vol.23 , pp. 7691-7700
    • Buscemi, G.1
  • 19
    • 0037341599 scopus 로고    scopus 로고
    • Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
    • Lukas, C., Falck, J., Bartkova, J., Bartek, J. & Lukas, J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nature Cell Biol. 5, 255-260 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 255-260
    • Lukas, C.1    Falck, J.2    Bartkova, J.3    Bartek, J.4    Lukas, J.5
  • 20
    • 33646117239 scopus 로고    scopus 로고
    • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
    • Bekker-Jensen, S. et al. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173, 195-206 (2006).
    • (2006) J. Cell Biol , vol.173 , pp. 195-206
    • Bekker-Jensen, S.1
  • 21
    • 0034717309 scopus 로고    scopus 로고
    • Rapid destruction of human Cdc25A in response to DNA damage
    • Mailand, N. et al. Rapid destruction of human Cdc25A in response to DNA damage. Science 288, 1425-1429 (2000).
    • (2000) Science , vol.288 , pp. 1425-1429
    • Mailand, N.1
  • 22
    • 0035939844 scopus 로고    scopus 로고
    • Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53
    • Turenne, G. A., Paul, P., Laflair, L. & Price, B. D. Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53. Oncogene 20, 5100-5110 (2001).
    • (2001) Oncogene , vol.20 , pp. 5100-5110
    • Turenne, G.A.1    Paul, P.2    Laflair, L.3    Price, B.D.4
  • 23
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • Deng, C., Zhang, P., Harper, J. W., Elledge, S. J. & Leder, P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684 (1995).
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 24
    • 33746618049 scopus 로고    scopus 로고
    • γH2AX as a checkpoint maintenance signal
    • Downey, M. & Durocher, D. γH2AX as a checkpoint maintenance signal. Cell Cycle 5, 1376-1381 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 1376-1381
    • Downey, M.1    Durocher, D.2
  • 25
    • 39149122177 scopus 로고    scopus 로고
    • Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling
    • Yamauchi, M. et al. Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling. DNA Repair 7, 405-417 (2008).
    • (2008) DNA Repair , vol.7 , pp. 405-417
    • Yamauchi, M.1
  • 26
  • 27
    • 0347988236 scopus 로고    scopus 로고
    • Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains
    • Aten, J. A. et al. Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science 303, 92-95 (2004).
    • (2004) Science , vol.303 , pp. 92-95
    • Aten, J.A.1
  • 28
    • 34447574977 scopus 로고    scopus 로고
    • Positional stability of single double-strand breaks in mammalian cells
    • Soutoglou, E. et al. Positional stability of single double-strand breaks in mammalian cells. Nature Cell Biol. 9, 675-682 (2007).
    • (2007) Nature Cell Biol , vol.9 , pp. 675-682
    • Soutoglou, E.1
  • 29
    • 33644905252 scopus 로고    scopus 로고
    • Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
    • Kruhlak, M. J. et al. Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J. Cell. Biochem. 172, 823-834 (2006).
    • (2006) J. Cell. Biochem , vol.172 , pp. 823-834
    • Kruhlak, M.J.1
  • 30
    • 42949130159 scopus 로고    scopus 로고
    • Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
    • Bonilla, C. Y., Melo, J. A. & Toczyski, D. P. Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol. Cell 30, 267-276 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 267-276
    • Bonilla, C.Y.1    Melo, J.A.2    Toczyski, D.P.3
  • 31
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo, A., Linke, S. P., Clarkin, K. & Wahl, G. M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540-2551 (1994).
    • (1994) Genes Dev , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 32
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi, J. & d'Adda di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nature Rev. Mol. Cell Biol. 8, 729-740 (2007).
    • (2007) Nature Rev. Mol. Cell Biol , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 33
    • 0344622606 scopus 로고    scopus 로고
    • Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961). How it all started.
    • Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961). How it all started.
  • 34
    • 50549218525 scopus 로고
    • The limited in vitro proliferation of human diploid cell strains
    • Hayflick, L. The limited in vitro proliferation of human diploid cell strains. Exp. Cell Res. 37, 614-636 (1965).
    • (1965) Exp. Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 35
    • 38349073475 scopus 로고    scopus 로고
    • DNA damage response at functional and dysfunctional telomeres
    • Longhese, M. P. DNA damage response at functional and dysfunctional telomeres. Genes Dev. 22, 125-140 (2008).
    • (2008) Genes Dev , vol.22 , pp. 125-140
    • Longhese, M.P.1
  • 36
    • 3543056880 scopus 로고    scopus 로고
    • Functional links between telomeres and proteins of the DNA-damage response
    • d'Adda di Fagagna, F., Teo, S.-H. & Jackson, S. P. Functional links between telomeres and proteins of the DNA-damage response. Genes Dev. 18, 1781-1799 (2004).
    • (2004) Genes Dev , vol.18 , pp. 1781-1799
    • d'Adda di Fagagna, F.1    Teo, S.-H.2    Jackson, S.P.3
  • 37
    • 19344374569 scopus 로고    scopus 로고
    • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response
    • Karlseder, J. et al. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol. 2, e240 (2004).
    • (2004) PLoS Biol , vol.2
    • Karlseder, J.1
  • 38
    • 34548317418 scopus 로고    scopus 로고
    • Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    • Denchi, E. L. & de Lange, T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448, 1068-1071 (2007).
    • (2007) Nature , vol.448 , pp. 1068-1071
    • Denchi, E.L.1    de Lange, T.2
  • 39
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • First article to suggest that telomere shortening dictates replicative senescence
    • Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460 (1990). First article to suggest that telomere shortening dictates replicative senescence.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 40
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 41
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198 (2003).
    • (2003) Nature , vol.426 , pp. 194-198
    • d'Adda di Fagagna, F.1
  • 42
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    • References 41 and 42 were the first to show DDR activation at critically short telomeres in senescent cells
    • Herbig, U., Jobling, W. A., Chen, B. P., Chen, D. J. & Sedivy, J. M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14, 501-513 (2004). References 41 and 42 were the first to show DDR activation at critically short telomeres in senescent cells.
    • (2004) Mol. Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.3    Chen, D.J.4    Sedivy, J.M.5
  • 43
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann, M. T., Strong, M. A., Hao, L. Y. & Greider, C. W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67-77 (2001).
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 44
    • 0030609861 scopus 로고    scopus 로고
    • CIP1/WAF1 gene in normal diploid human fibroblasts
    • CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277, 831-834 (1997).
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 45
    • 3342929538 scopus 로고    scopus 로고
    • DNA damage checkpoint kinase Chk2 triggers replicative senescence
    • Gire, V., Roux, P., Wynford-Thomas, D., Brondello, J. M. & Dulic, V. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J. 23, 2554-2563 (2004).
    • (2004) EMBO J , vol.23 , pp. 2554-2563
    • Gire, V.1    Roux, P.2    Wynford-Thomas, D.3    Brondello, J.M.4    Dulic, V.5
  • 46
    • 0028261160 scopus 로고
    • Escape from senescence in human diploid fibroblasts induced directly by mutant p53
    • Bond, J. A., Wyllie, F. S. & Wynford-Thomas, D. Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 9, 1885-1889 (1994).
    • (1994) Oncogene , vol.9 , pp. 1885-1889
    • Bond, J.A.1    Wyllie, F.S.2    Wynford-Thomas, D.3
  • 47
    • 0037452888 scopus 로고    scopus 로고
    • Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of upregulated chromosomal loci
    • Zhang, H., Pan, K.-H. & Cohen, S. N. Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of upregulated chromosomal loci. Proc. Natl Acad. Sci. USA 100, 3251-3256 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 3251-3256
    • Zhang, H.1    Pan, K.-H.2    Cohen, S.N.3
  • 48
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov, V. L., Hirose, Y. & Langmore, J. P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88, 657-666 (1997).
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 49
    • 33947204449 scopus 로고    scopus 로고
    • Chromosome breakage after G2 checkpoint release
    • Deckbar, D. et al. Chromosome breakage after G2 checkpoint release. J. Cell Biol. 176, 749-755 (2007).
    • (2007) J. Cell Biol , vol.176 , pp. 749-755
    • Deckbar, D.1
  • 50
    • 0029897210 scopus 로고    scopus 로고
    • Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest
    • Huang, L. C., Clarkin, K. C. & Wahl, G. M. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc. Natl Acad. Sci. USA 93, 4827-4832 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 4827-4832
    • Huang, L.C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 51
    • 34249989400 scopus 로고    scopus 로고
    • Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres
    • Meier, A. et al. Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres. EMBO J. 26, 2707-2718 (2007).
    • (2007) EMBO J , vol.26 , pp. 2707-2718
    • Meier, A.1
  • 52
    • 0037313185 scopus 로고    scopus 로고
    • Extensive allelic variation and ultrashort telomeres in senescent human cells
    • Baird, D. M., Rowson, J., Wynford-Thomas, D. & Kipling, D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nature Genet. 33, 203-207 (2003).
    • (2003) Nature Genet , vol.33 , pp. 203-207
    • Baird, D.M.1    Rowson, J.2    Wynford-Thomas, D.3    Kipling, D.4
  • 53
    • 0031984598 scopus 로고    scopus 로고
    • Short telomeres on human chromosome 17p
    • Martens, U. M. et al. Short telomeres on human chromosome 17p. Nature Genet. 18, 76-80 (1998).
    • (1998) Nature Genet , vol.18 , pp. 76-80
    • Martens, U.M.1
  • 55
    • 33846090789 scopus 로고    scopus 로고
    • Accumulation of senescent cells in mitotic tissue of aging primates
    • References 54 and 55 provide the first evidence of telomere-associated DDR activation in ageing primates
    • Jeyapalan, J. C., Ferreira, M., Sedivy, J. M. & Herbig, U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 128, 36-44 (2006). References 54 and 55 provide the first evidence of telomere-associated DDR activation in ageing primates.
    • (2006) Mech. Ageing Dev , vol.128 , pp. 36-44
    • Jeyapalan, J.C.1    Ferreira, M.2    Sedivy, J.M.3    Herbig, U.4
  • 56
    • 0036510162 scopus 로고    scopus 로고
    • Molecular characterization of intertelomere and intra-telomere mutations in human ALT cells
    • Varley, H., Pickett, H. A., Foxon, J. L., Reddel, R. R. & Royle, N. J. Molecular characterization of intertelomere and intra-telomere mutations in human ALT cells. Nature Genet. 30, 301-305 (2002).
    • (2002) Nature Genet , vol.30 , pp. 301-305
    • Varley, H.1    Pickett, H.A.2    Foxon, J.L.3    Reddel, R.R.4    Royle, N.J.5
  • 57
    • 33746644257 scopus 로고    scopus 로고
    • Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination
    • Celli, G. B., Denchi, E. L. & de Lange, T. Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biol. 8, 855-890 (2006).
    • (2006) Nature Cell Biol , vol.8 , pp. 855-890
    • Celli, G.B.1    Denchi, E.L.2    de Lange, T.3
  • 58
    • 22144490491 scopus 로고    scopus 로고
    • DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
    • Celli, G. B. & de Lange, T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nature Cell Biol. 7, 712-718 (2005).
    • (2005) Nature Cell Biol , vol.7 , pp. 712-718
    • Celli, G.B.1    de Lange, T.2
  • 59
    • 34247600494 scopus 로고    scopus 로고
    • A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends
    • Bae, N. S. & Baumann, P. A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol. Cell 26, 323-334 (2007).
    • (2007) Mol. Cell , vol.26 , pp. 323-334
    • Bae, N.S.1    Baumann, P.2
  • 60
    • 3342972121 scopus 로고    scopus 로고
    • Does a sentinel or a subset of short telomeres determine replicative senescence?
    • Zou, Y., Sfeir, A., Gryaznov, S. M., Shay, J. W. & Wright, W. E. Does a sentinel or a subset of short telomeres determine replicative senescence? Mol. Biol. Cell 15, 3709-3718 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 3709-3718
    • Zou, Y.1    Sfeir, A.2    Gryaznov, S.M.3    Shay, J.W.4    Wright, W.E.5
  • 61
    • 34948816005 scopus 로고    scopus 로고
    • The nature of telomere fusion and a definition of the critical telomere length in human cells
    • Capper, R. et al. The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev. 21, 2495-2508 (2007).
    • (2007) Genes Dev , vol.21 , pp. 2495-2508
    • Capper, R.1
  • 62
    • 41549149451 scopus 로고    scopus 로고
    • Cellular senescence in vivo: A barrier to tumorigenesis
    • Prieur, A. & Peeper, D. S. Cellular senescence in vivo: a barrier to tumorigenesis. Curr. Opin. Cell Biol. 20, 150-155 (2008).
    • (2008) Curr. Opin. Cell Biol , vol.20 , pp. 150-155
    • Prieur, A.1    Peeper, D.S.2
  • 63
    • 0033941559 scopus 로고    scopus 로고
    • Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells
    • Jones, C. J. et al. Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells. Mol. Cell. Biol. 20, 5690-5699 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 5690-5699
    • Jones, C.J.1
  • 64
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    • Di Micco, R. et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444, 638-642 (2006).
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1
  • 65
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • References 64 and 65 demonstrate that oncogene activation leads to DDR activation and consequent senescence establishment
    • Bartkova, J. et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444, 633-637 (2006). References 64 and 65 demonstrate that oncogene activation leads to DDR activation and consequent senescence establishment.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1
  • 66
    • 33845970597 scopus 로고    scopus 로고
    • Rac1 GTPase regulates cell genomic stability and senescence
    • Debidda, M., Williams, D. A. & Zheng, Y. Rac1 GTPase regulates cell genomic stability and senescence. J. Biol. Chem. 281, 38519-38528 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 38519-38528
    • Debidda, M.1    Williams, D.A.2    Zheng, Y.3
  • 67
    • 40749092119 scopus 로고    scopus 로고
    • β-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo
    • Xu, M. et al. β-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol. Cell. Biol. 28, 1713-1723 (2008).
    • (2008) Mol. Cell. Biol , vol.28 , pp. 1713-1723
    • Xu, M.1
  • 68
    • 34548312368 scopus 로고    scopus 로고
    • Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
    • Gorrini, C. et al. Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature 448, 1063-1067 (2007).
    • (2007) Nature , vol.448 , pp. 1063-1067
    • Gorrini, C.1
  • 69
    • 33745363911 scopus 로고    scopus 로고
    • DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation
    • Moiseeva, O., Mallette, F. A., Mukhopadhyay, U. K., Moores, A. & Ferbeyre, G. DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation. Mol. Biol. Cell 17, 1583-1592 (2006).
    • (2006) Mol. Biol. Cell , vol.17 , pp. 1583-1592
    • Moiseeva, O.1    Mallette, F.A.2    Mukhopadhyay, U.K.3    Moores, A.4    Ferbeyre, G.5
  • 70
    • 33846128155 scopus 로고    scopus 로고
    • The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
    • Mallette, F. A., Gaumont-Leclerc, M.-F. & Ferbeyre, G. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev. 21, 43-48 (2007).
    • (2007) Genes Dev , vol.21 , pp. 43-48
    • Mallette, F.A.1    Gaumont-Leclerc, M.-F.2    Ferbeyre, G.3
  • 71
    • 0037663490 scopus 로고    scopus 로고
    • Werner syndrome protein limits MYC-induced cellular senescence
    • Grandori, C. et al. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev. 17, 1569-1574 (2003).
    • (2003) Genes Dev , vol.17 , pp. 1569-1574
    • Grandori, C.1
  • 72
    • 36048965126 scopus 로고    scopus 로고
    • Breaking news: High-speed race ends in arrest - how oncogenes induce senescence
    • Di Micco, R., Fumagalli, M. & d'Adda di Fagagna, F. Breaking news: high-speed race ends in arrest - how oncogenes induce senescence. Trends Cell Biol. 17, 529-536 (2007).
    • (2007) Trends Cell Biol , vol.17 , pp. 529-536
    • Di Micco, R.1    Fumagalli, M.2    d'Adda di Fagagna, F.3
  • 73
    • 23244447037 scopus 로고    scopus 로고
    • E600-associated senescence-like cell cycle arrest of human naevi, Reports that skin naevi are senescent melanocytes
    • E600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724 (2005). Reports that skin naevi are senescent melanocytes.
    • (2005) Nature , vol.436 , pp. 720-724
    • Michaloglou, C.1
  • 74
    • 33847201454 scopus 로고    scopus 로고
    • V600E-induced lung tumors
    • V600E-induced lung tumors. Genes Dev. 21, 379-384 (2007).
    • (2007) Genes Dev , vol.21 , pp. 379-384
    • Dankort, D.1
  • 75
    • 15044351968 scopus 로고    scopus 로고
    • Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland
    • Denchi, E. L., Attwooll, C., Pasini, D. & Helin, K. Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol. Cell. Biol. 25, 2660-2672 (2005).
    • (2005) Mol. Cell. Biol , vol.25 , pp. 2660-2672
    • Denchi, E.L.1    Attwooll, C.2    Pasini, D.3    Helin, K.4
  • 76
    • 85164625764 scopus 로고    scopus 로고
    • Dominguez-Sola, D. et al. Non-transcriptional control of DNA replication by c-Myc. Nature 448, 445-451 (2007). Reports that the MYC proto-oncogene is a direct regulator of DNA replication.
    • Dominguez-Sola, D. et al. Non-transcriptional control of DNA replication by c-Myc. Nature 448, 445-451 (2007). Reports that the MYC proto-oncogene is a direct regulator of DNA replication.
  • 77
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan, M. B. & Bartek, J. Cell-cycle checkpoints and cancer. Nature 432, 316-323 (2004).
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 78
    • 37249025795 scopus 로고    scopus 로고
    • Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
    • Ge, X. Q., Jackson, D. A. & Blow, J. J. Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev. 21, 3331-3341 (2007).
    • (2007) Genes Dev , vol.21 , pp. 3331-3341
    • Ge, X.Q.1    Jackson, D.A.2    Blow, J.J.3
  • 79
    • 0037623356 scopus 로고    scopus 로고
    • A p53-dependent checkpoint pathway prevents rereplication
    • Vaziri, C. et al. A p53-dependent checkpoint pathway prevents rereplication. Mol. Cell 11, 997-1008 (2003).
    • (2003) Mol. Cell , vol.11 , pp. 997-1008
    • Vaziri, C.1
  • 80
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913 (2005).
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1
  • 81
    • 44349119351 scopus 로고    scopus 로고
    • Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study
    • Tsantoulis, P. K. et al. Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study. Oncogene 27, 3256-3264 (2007).
    • (2007) Oncogene , vol.27 , pp. 3256-3264
    • Tsantoulis, P.K.1
  • 82
    • 34147110423 scopus 로고    scopus 로고
    • Heterochromatin and its relationship to cell senescence and cancer therapy
    • Zhang, R. & Adams, P. D. Heterochromatin and its relationship to cell senescence and cancer therapy. Cell Cycle 6, 784-789 (2007).
    • (2007) Cell Cycle , vol.6 , pp. 784-789
    • Zhang, R.1    Adams, P.D.2
  • 83
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • The first report to describe global heterochromatinization of senescent nuclei
    • Narita, M. et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716 (2003). The first report to describe global heterochromatinization of senescent nuclei.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1
  • 84
    • 38649118240 scopus 로고    scopus 로고
    • Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression
    • Shimada, M. et al. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 132, 221-232 (2008).
    • (2008) Cell , vol.132 , pp. 221-232
    • Shimada, M.1
  • 85
    • 34250820438 scopus 로고    scopus 로고
    • Chromatin dynamics and the preservation of genetic information
    • Downs, J. A., Nussenzweig, M. C. & Nussenzweig, A. Chromatin dynamics and the preservation of genetic information. Nature 447, 951-958 (2007).
    • (2007) Nature , vol.447 , pp. 951-958
    • Downs, J.A.1    Nussenzweig, M.C.2    Nussenzweig, A.3
  • 86
    • 33746601439 scopus 로고    scopus 로고
    • Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway
    • Ziv, Y. et al. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway. Nature Cell Biol. 8, 870-876 (2006).
    • (2006) Nature Cell Biol , vol.8 , pp. 870-876
    • Ziv, Y.1
  • 87
    • 30344444484 scopus 로고    scopus 로고
    • Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
    • Murr, R. et al. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nature Cell Biol. 8, 91-99 (2006).
    • (2006) Nature Cell Biol , vol.8 , pp. 91-99
    • Murr, R.1
  • 88
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 89
    • 33646946746 scopus 로고    scopus 로고
    • Senescence-associated beta-galactosidase is lysosomal β-galactosidase
    • Lee, B. Y. et al. Senescence-associated beta-galactosidase is lysosomal β-galactosidase. Aging Cell 5, 187-195 (2006).
    • (2006) Aging Cell , vol.5 , pp. 187-195
    • Lee, B.Y.1
  • 90
    • 0035059672 scopus 로고    scopus 로고
    • From cells to organisms: Can we learn about aging from cells in culture?
    • Campisi, J. From cells to organisms: can we learn about aging from cells in culture? Exp. Gerontol. 36, 607-618 (2001).
    • (2001) Exp. Gerontol , vol.36 , pp. 607-618
    • Campisi, J.1
  • 91
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • Rossi, D. J. et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447, 725-729 (2007).
    • (2007) Nature , vol.447 , pp. 725-729
    • Rossi, D.J.1
  • 92
    • 34250001450 scopus 로고    scopus 로고
    • DNA repair is limiting for haematopoietic stem cells during ageing
    • References 91 and 92 demonstrate that stem cells accumulate DDR markers during normal ageing
    • Nijnik, A. et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447, 686-690 (2007). References 91 and 92 demonstrate that stem cells accumulate DDR markers during normal ageing.
    • (2007) Nature , vol.447 , pp. 686-690
    • Nijnik, A.1
  • 93
    • 34447565003 scopus 로고    scopus 로고
    • Replication in context: Dynamic regulation of DNA replication patterns in metazoans
    • Aladjem, M. I. Replication in context: dynamic regulation of DNA replication patterns in metazoans. Nature Rev. Genet. 8, 588-600 (2007).
    • (2007) Nature Rev. Genet , vol.8 , pp. 588-600
    • Aladjem, M.I.1
  • 94
    • 5144231886 scopus 로고    scopus 로고
    • Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation
    • Hong, Y. & Stambrook, P. J. Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proc. Natl Acad. Sci. USA 101, 14443-14448 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 14443-14448
    • Hong, Y.1    Stambrook, P.J.2
  • 95
    • 0041966056 scopus 로고    scopus 로고
    • Reversal of human cellular senescence: Roles of the p53 and p16 pathways
    • Beausejour, C. M. et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 22, 4212-4222 (2003).
    • (2003) EMBO J , vol.22 , pp. 4212-4222
    • Beausejour, C.M.1
  • 96
    • 33749172559 scopus 로고    scopus 로고
    • Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
    • Janzen, V. et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443, 421-426 (2006).
    • (2006) Nature , vol.443 , pp. 421-426
    • Janzen, V.1
  • 97
    • 33749187810 scopus 로고    scopus 로고
    • p16INK4a induces an age-dependent decline in islet regenerative potential
    • Krishnamurthy, J. et al. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443, 453-457 (2006).
    • (2006) Nature , vol.443 , pp. 453-457
    • Krishnamurthy, J.1
  • 98
    • 33749171885 scopus 로고    scopus 로고
    • Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
    • Molofsky, A. V. et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443, 448-452 (2006).
    • (2006) Nature , vol.443 , pp. 448-452
    • Molofsky, A.V.1
  • 99
    • 33947134834 scopus 로고    scopus 로고
    • The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    • Bracken, A. P. et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 21, 525-530 (2007).
    • (2007) Genes Dev , vol.21 , pp. 525-530
    • Bracken, A.P.1
  • 100
    • 23244461708 scopus 로고    scopus 로고
    • Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005). Shows that heterochromatin formation is an in vivo barrier to cancer development.
    • Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005). Shows that heterochromatin formation is an in vivo barrier to cancer development.
  • 101
    • 23244447893 scopus 로고    scopus 로고
    • Tumour biology: Senescence in premalignant tumours
    • Collado, M. et al. Tumour biology: senescence in premalignant tumours. Nature 436, 642 (2005).
    • (2005) Nature , vol.436 , pp. 642
    • Collado, M.1
  • 102
    • 23244460597 scopus 로고    scopus 로고
    • Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (2005). References 101 and 102 demonstrate that senescent cells accumulate in vivo in mouse models of oncogene activation.
    • Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (2005). References 101 and 102 demonstrate that senescent cells accumulate in vivo in mouse models of oncogene activation.
  • 103
    • 35148812601 scopus 로고    scopus 로고
    • Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression
    • Nuciforo, P. G., Luise, C., Capra, M., Pelosi, G. & d'Adda di Fagagna, F. Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression. Carcinogenesis 28, 2082-2088 (2007).
    • (2007) Carcinogenesis , vol.28 , pp. 2082-2088
    • Nuciforo, P.G.1    Luise, C.2    Capra, M.3    Pelosi, G.4    d'Adda di Fagagna, F.5
  • 104
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • References 80 and 104 are landmark papers that report that DDR signalling is activated in early preneoplastic lesions in humans
    • Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864-870 (2005). References 80 and 104 are landmark papers that report that DDR signalling is activated in early preneoplastic lesions in humans.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1
  • 105
    • 33947101019 scopus 로고    scopus 로고
    • Patterns of somatic mutation in human cancer genomes
    • Greenman, C. et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158 (2007).
    • (2007) Nature , vol.446 , pp. 153-158
    • Greenman, C.1
  • 106
    • 39449096135 scopus 로고    scopus 로고
    • Genome instability: A mechanistic view of its causes and consequences
    • Aguilera, A. & Gomez-Gonzalez, B. Genome instability: a mechanistic view of its causes and consequences. Nature Rev. Genet. 9, 204-217 (2008).
    • (2008) Nature Rev. Genet , vol.9 , pp. 204-217
    • Aguilera, A.1    Gomez-Gonzalez, B.2
  • 107
    • 33751293168 scopus 로고    scopus 로고
    • Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis
    • Tort, F. et al. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res. 66, 10258-10263 (2006).
    • (2006) Cancer Res , vol.66 , pp. 10258-10263
    • Tort, F.1
  • 108
    • 33846899456 scopus 로고    scopus 로고
    • Restoration of p53 function leads to tumour regression in vivo
    • Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo. Nature 445, 661-665 (2007).
    • (2007) Nature , vol.445 , pp. 661-665
    • Ventura, A.1
  • 109
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660 (2007).
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1
  • 111
    • 44649120132 scopus 로고    scopus 로고
    • Chemokine signaling via the CXCR2 receptor reinforces senescence
    • Acosta, J. C. et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133, 1006-1018 (2008).
    • (2008) Cell , vol.133 , pp. 1006-1018
    • Acosta, J.C.1
  • 112
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced cellular senescence relayed by a cell-autonomous interleukin-dependent network
    • Kuilman, T. et al. Oncogene-induced cellular senescence relayed by a cell-autonomous interleukin-dependent network. Cell 133, 1019-1031 (2008).
    • (2008) Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1
  • 113
    • 2542536710 scopus 로고    scopus 로고
    • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells
    • Bakkenist, C. J., Drissi, R., Wu, J., Kastan, M. B. & Dome, J. S. Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. Cancer Res. 64, 3748-3752 (2004).
    • (2004) Cancer Res , vol.64 , pp. 3748-3752
    • Bakkenist, C.J.1    Drissi, R.2    Wu, J.3    Kastan, M.B.4    Dome, J.S.5
  • 114
    • 9744220428 scopus 로고    scopus 로고
    • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to γ-H2AX foci
    • Riballo, E. et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to γ-H2AX foci. Mol. Cell 16, 715-724 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 715-724
    • Riballo, E.1
  • 115
    • 33746816108 scopus 로고    scopus 로고
    • The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation
    • Branzei, D. & Foiani, M. The Rad53 signal transduction pathway: replication fork stabilization, DNA repair, and adaptation. Exp. Cell Res. 312, 2654-2659 (2006).
    • (2006) Exp. Cell Res , vol.312 , pp. 2654-2659
    • Branzei, D.1    Foiani, M.2
  • 116
    • 34247860915 scopus 로고    scopus 로고
    • Cosme-Blanco, W. et al. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 8, 497-503 (2007).
    • Cosme-Blanco, W. et al. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 8, 497-503 (2007).
  • 117
    • 34247581288 scopus 로고    scopus 로고
    • Short telomeres limit tumor progression in vivo by inducing senescence
    • Feldser, D. M. & Greider, C. W. Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11, 461-469 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 461-469
    • Feldser, D.M.1    Greider, C.W.2
  • 118
    • 34447517413 scopus 로고    scopus 로고
    • Delayed ageing through damage protection by the Arf/p53 pathway
    • Matheu, A. et al. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448, 375-379 (2007).
    • (2007) Nature , vol.448 , pp. 375-379
    • Matheu, A.1
  • 119
    • 33747819484 scopus 로고    scopus 로고
    • Sherr, C. J. Divorcing ARF and p53: an unsettled case. Nature Rev. Cancer 6, 663-673 (2006).
    • Sherr, C. J. Divorcing ARF and p53: an unsettled case. Nature Rev. Cancer 6, 663-673 (2006).
  • 120
    • 0036237039 scopus 로고    scopus 로고
    • Oncogenic ras and p53 cooperate to induce cellular senescence
    • Ferbeyre, G. et al. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol. Cell. Biol. 22, 3497-3508 (2002).
    • (2002) Mol. Cell. Biol , vol.22 , pp. 3497-3508
    • Ferbeyre, G.1
  • 123
    • 0037711771 scopus 로고    scopus 로고
    • Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
    • Celeste, A. et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nature Cell Biol. 5, 675-679 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 675-679
    • Celeste, A.1
  • 124
    • 0034749425 scopus 로고    scopus 로고
    • DNA damage-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva, O. K. & Petrini, J. H. J. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell. Biol. 21, 281-288 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 281-288
    • Mirzoeva, O.K.1    Petrini, J.H.J.2
  • 125
    • 10344264478 scopus 로고    scopus 로고
    • BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation
    • Turner, J. M. A. et al. BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr. Biol. 14, 2135-2142 (2004).
    • (2004) Curr. Biol , vol.14 , pp. 2135-2142
    • Turner, J.M.A.1
  • 126
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Conclusive evidence that telomere maintenance is the limiting factor that restrains cell proliferation of normal human fibroblasts
    • Bodnar, A. G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352 (1998). Conclusive evidence that telomere maintenance is the limiting factor that restrains cell proliferation of normal human fibroblasts.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 127
    • 2142666372 scopus 로고    scopus 로고
    • Developmental differences in the immortalization of lung fibroblasts by telomerase
    • Forsyth, N. R., Evans, A. P., Shay, J. W. & Wright, W. E. Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell 2, 235-243 (2003).
    • (2003) Aging Cell , vol.2 , pp. 235-243
    • Forsyth, N.R.1    Evans, A.P.2    Shay, J.W.3    Wright, W.E.4
  • 128
    • 0035114576 scopus 로고    scopus 로고
    • Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
    • Ramirez, R. D. et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15, 398-403 (2001).
    • (2001) Genes Dev , vol.15 , pp. 398-403
    • Ramirez, R.D.1
  • 129
    • 0042195820 scopus 로고    scopus 로고
    • Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
    • Parrinello, S. et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nature Cell Biol. 5, 741-747 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 741-747
    • Parrinello, S.1
  • 130
    • 0036276388 scopus 로고    scopus 로고
    • The MRE11 complex: At the crossroads of DNA repair and checkpoint signalling
    • D'Amours, D. & Jackson, S. P. The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling. Nature Rev. Mol. Cell Biol. 3, 317-327 (2002).
    • (2002) Nature Rev. Mol. Cell Biol , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 131
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck, J., Coates, J. & Jackson, S. P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434, 605-611 (2005).
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 132
    • 9244252580 scopus 로고    scopus 로고
    • Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
    • Huyen, Y. et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432, 406-411 (2004).
    • (2004) Nature , vol.432 , pp. 406-411
    • Huyen, Y.1
  • 133
    • 30944435598 scopus 로고    scopus 로고
    • Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
    • Smits, V. A., Reaper, P. M. & Jackson, S. P. Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr. Biol. 16, 150-159 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 150-159
    • Smits, V.A.1    Reaper, P.M.2    Jackson, S.P.3
  • 134
    • 33846691378 scopus 로고    scopus 로고
    • The POT1-TPP1 telomere complex is a telomerase processivity factor
    • Wang, F. et al. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445, 506-510 (2007).
    • (2007) Nature , vol.445 , pp. 506-510
    • Wang, F.1
  • 135
    • 33745713451 scopus 로고    scopus 로고
    • Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres
    • Wu, L. et al. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126, 49-62 (2006).
    • (2006) Cell , vol.126 , pp. 49-62
    • Wu, L.1
  • 136
    • 34548317418 scopus 로고    scopus 로고
    • Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    • Denchi, E. L. & de Lange, T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448, 1068-1071 (2007).
    • (2007) Nature , vol.448 , pp. 1068-1071
    • Denchi, E.L.1    de Lange, T.2
  • 137
    • 33845292259 scopus 로고    scopus 로고
    • A negative feedback signaling network underlies oncogene-induced senescence
    • Courtois-Cox, S. et al. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 10, 459-472 (2006).
    • (2006) Cancer Cell , vol.10 , pp. 459-472
    • Courtois-Cox, S.1
  • 139
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu, J., Woods, D., McMahon, M. & Bishop, J. M. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 12, 2997-3007 (1998).
    • (1998) Genes Dev , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 140
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin, A. W. et al. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12, 3008-3019 (1998).
    • (1998) Genes Dev , vol.12 , pp. 3008-3019
    • Lin, A.W.1
  • 141
    • 0033525019 scopus 로고    scopus 로고
    • Transforming growth factor β triggers two independent-senescence programs in cancer cells
    • Katakura, Y., Nakata, E., Miura, T. & Shirahata, S. Transforming growth factor β triggers two independent-senescence programs in cancer cells. Biochem. Biophys Res. Commun. 255, 110-115 (1999).
    • (1999) Biochem. Biophys Res. Commun , vol.255 , pp. 110-115
    • Katakura, Y.1    Nakata, E.2    Miura, T.3    Shirahata, S.4
  • 142
    • 10644263286 scopus 로고    scopus 로고
    • Smurf2 up-regulation activates telomere-dependent senescence
    • Zhang, H. & Cohen, S. N. Smurf2 up-regulation activates telomere-dependent senescence. Genes Dev. 18, 3028-3040 (2004).
    • (2004) Genes Dev , vol.18 , pp. 3028-3040
    • Zhang, H.1    Cohen, S.N.2
  • 143
    • 0034644274 scopus 로고    scopus 로고
    • PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
    • Pearson, M. et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207-210 (2000).
    • (2000) Nature , vol.406 , pp. 207-210
    • Pearson, M.1
  • 144
    • 36348944160 scopus 로고    scopus 로고
    • Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior
    • Liontos, M. et al. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res. 67, 10899-10909 (2007).
    • (2007) Cancer Res , vol.67 , pp. 10899-10909
    • Liontos, M.1


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