A p53-dependent checkpoint pathway prevents rereplication

Molecular Cell

Volumn 11, Issue 4, 2003, Pages 997-1008

  Vaziri, Cyrus ^b   Saxena, Sandeep ^a   Jeon, Yesu ^a,c   Lee, Charles ^a   Murata, Kazutaka ^a   Machida, Yuichi ^a   Wagle, Nikhil ^a   Hwang, Deog Su ^a,c   Dutta, Anindya ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CYCLIN A; INITIATION FACTOR; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA REPLICATION; DNA REPLICATION ORIGIN; EUKARYOTIC CELL; GENETIC STABILITY; GENOME; MAMMAL CELL; NONHUMAN; PROTEIN FUNCTION; PROTEIN INDUCTION; TUMOR GROWTH;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 0037623356     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00099-6     Document Type: Article

References (56)

1. Bates S., Ryan K.M., Phillips A.C., Vousden K.H. Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression. Oncogene. 17:1998;1691-1703.
2. Becker T.C., Noel R.J., Coats W.S., Gomez-Foix A.M., Alam T., Gerard R.D., Newgard C.B. Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol. 43:1994;161-189.
3. Bell S.P., Dutta A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71:2002;333-374.
4. Blegen H., Ghadimi B.M., Jauho A., Zetterberg A., Eriksson E., Auer G., Ried T. Genetic instability promotes the acquisition of chromosomal imbalances in T1b and T1c breast adenocarcinomas. Anal. Cell. Pathol. 22:2001;123-131.
5. Bukholm I.R., Bukholm G., Nesland J.M. Coexpression of cyclin A and beta-catenin and survival in breast cancer patients. Int. J. Cancer. 94:2001;148-149. a.
6. Bukholm I.R., Bukholm G., Nesland J.M. Over-expression of cyclin A is highly associated with early relapse and reduced survival in patients with primary breast carcinomas. Int. J. Cancer. 93:2001;283-287. b.
7. Canman C.E., Lim D.S., Cimprich K.A., Taya Y., Tamai K., Sakaguchi K., Appella E., Kastan M.B., Siliciano J.D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 281:1998;1677-1679.
8. Chen J., Jackson P.K., Kirschner M.W., Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature. 374:1995;386-388.
9. Chen J., Saha P., Kornbluth S., Dynlacht B.D., Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Mol. Cell. Biol. 16:1996;4673-4682.
10. Correa-Bordes J., Nurse P. p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Cell. 83:1995;1001-1009.
11. Dahmann C., Diffley J.F., Nasmyth K.A. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol. 5:1995;1257-1269.
12. Delmolino L.M., Saha P., Dutta A. Multiple mechanisms regulate subcellular localization of human CDC6. J. Biol. Chem. 276:2001;26947-26954.
13. Dhar S.K., Dutta A. Identification and characterization of the human ORC6 homolog. J. Biol. Chem. 275:2000;34983-34988.
14. Diffley J.F. DNA replication. building the perfect switch Curr. Biol. 11:2001;R367-R370.
15. Dutta A., Bell S.P. Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell Dev. Biol. 13:1997;293-332.
16. Fetni R., Drouin R., Richer C.L., Lemieux N. Complementary replication R- and G-band patterns induced by cell blocking at the R-band/G-band transition, a possible regulatory checkpoint within the S phase of the cell cycle. Cytogenet. Cell Genet. 75:1996;172-179.
17. Findeisen M., El-Denary M., Kapitza T., Graf R., Strausfeld U. Cyclin A-dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis. Eur. J. Biochem. 264:1999;415-426.
18. Florenes V.A., Maelandsmo G.M., Faye R., Nesland J.M., Holm R. Cyclin A expression in superficial spreading malignant melanomas correlates with clinical outcome. J. Pathol. 195:2001;530-536.
19. Gopalakrishnan V., Simancek P., Houchens C., Snaith H.A., Frattini M.G., Sazer S., Kelly T.J. Redundant control of rereplication in fission yeast. Proc. Natl. Acad. Sci. USA. 98:2001;13114-13119.
20. Hall I.J., Gioeli D., Weissman B.E., Tlsty T.D. Identification of additional complementation groups that regulate genomic instability. Genes Chromosomes Cancer. 20:1997;103-112.
21. Herbig U., Griffith J.W., Fanning E. Mutation of cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cells. Mol. Biol. Cell. 11:2000;4117-4130.
22. Hirao A., Kong Y.Y., Matsuoka S., Wakeham A., Ruland J., Yoshida H., Liu D., Elledge S.J., Mak T.W. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science. 287:2000;1824-1827.
23. Hua X.H., Yan H., Newport J. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle. J. Cell Biol. 137:1997;183-192.
24. Ishimi Y., Komamura-Kohno Y. Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity. J. Biol. Chem. 276:2001;34428-34433.
25. Ishimi Y., Komamura-Kohno Y., You Z., Omori A., Kitagawa M. Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2. J. Biol. Chem. 275:2000;16235-16241.
26. Itzhaki J.E., Gilbert C.S., Porter A.C. Construction by gene targeting in human cells of a "conditional" CDC2 mutant that rereplicates its DNA. Nat. Genet. 15:1997;258-265.
27. Jallepalli P.V., Kelly T.J. Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe. Genes Dev. 10:1996;541-552.
28. Jiang W., Wells N.J., Hunter T. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc. Natl. Acad. Sci. USA. 96:1999;6193-6198.
29. Kelly T.J., Brown G.W. Regulation of chromosome replication. Annu. Rev. Biochem. 69:2000;829-880.
30. Labib K., Diffley J.F. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Curr. Opin. Genet. Dev. 11:2001;64-70.
31. Lei M., Tye B.K. Initiating DNA synthesis. from recruiting to activating the MCM complex J. Cell Sci. 114:2001;1447-1454.
32. Lengauer C., Kinzler K.W., Vogelstein B. Genetic instabilities in human cancers. Nature. 396:1998;643-649.
33. Li C.J., DePamphilis M.L. Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle. Mol. Cell. Biol. 22:2002;105-116.
34. Masumoto H., Muramatsu S., Kamimura Y., Araki H. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature. 415:2002;651-655.
35. McGarry T.J., Kirschner M.W. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell. 93:1998;1043-1053.
36. Mendez J., Zou-Yang X.H., Kim S.Y., Hidaka M., Tansey W.P., Stillman B. Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol. Cell. 9:2002;481-491.
37. Michalides R., van Tinteren H., Balkenende A., Vermorken J.B., Benraadt J., Huldij J., van Diest P. Cyclin A is a prognostic indicator in early stage breast cancer with and without tamoxifen treatment. Br. J. Cancer. 86:2002;402-408.
38. Mihaylov I.S., Kondo T., Jones L., Ryzhikov S., Tanaka J., Zheng J., Higa L.A., Minamino N., Cooley L., Zhang H. Control of DNA replication and chromosome ploidy by geminin and cyclin A. Mol. Cell. Biol. 22:2002;1868-1880.
39. Nguyen V.Q., Co C., Li J.J. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature. 411:2001;1068-1073.
40. Noton E., Diffley J.F. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. Mol. Cell. 5:2000;85-95.
41. Petersen B.O., Lukas J., Sorensen C.S., Bartek J., Helin K. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J. 18:1999;396-410.
42. Prives C., Hall P.A. The p53 pathway. J. Pathol. 187:1999;112-126.
43. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273:1998;5858-5868.
44. Saha P., Chen J., Thome K.C., Lawlis S.J., Hou Z.H., Hendricks M., Parvin J.D., Dutta A. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol. Cell. Biol. 18:1998;2758-2767.
45. Shao C., Deng L., Henegariu O., Liang L., Stambrook P.J., Tischfield J.A. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proc. Natl. Acad. Sci. USA. 97:2000;7405-7410.
46. Singer M.J., Mesner L.D., Friedman C.L., Trask B.J., Hamlin J.L. Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks. Proc. Natl. Acad. Sci. USA. 97:2000;7921-7926.
47. Tada S., Li A., Maiorano D., Mechali M., Blow J.J. Repression of origin assembly in metaphase depends on inhibition of RLF- B/Cdt1 by geminin. Nat. Cell Biol. 3:2001;107-113.
48. Takeda D.Y., Wohlschlegel J.A., Dutta A. A bipartite substrate recognition motif for cyclin-dependent kinases. J. Biol. Chem. 276:2001;1993-1997.
49. Takisawa H., Mimura S., Kubota Y. Eukaryotic DNA replication. from pre-replication complex to initiation complex Curr. Opin. Cell Biol. 12:2000;690-696.
50. Telenius H., Pelmear A.H., Tunnacliffe A., Carter N.P., Behmel A., Ferguson-Smith M.A., Nordenskjold M., Pfragner R., Ponder B.A. Cytogenetic analysis by chromosome painting using DOP-PCR amplified flow-sorted chromosomes. Genes Chromosomes Cancer. 4:1992;257-263.
51. Thome K.C., Dhar S.K., Quintana D.G., Delmolino L., Shahsafaei A., Dutta A. Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins. J. Biol. Chem. 275:2000;35233-35241.
52. Vas A., Mok W., Leatherwood J. Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex. Mol. Cell. Biol. 21:2001;5767-5777.
53. Vogelstein B., Lane D., Levine A.J. Surfing the p53 network. Nature. 408:2000;307-310.
54. Waga S., Stillman B. The DNA replication fork in eukaryotic cells. Annu. Rev. Biochem. 67:1998;721-751.
55. Wohlschlegel J.A., Dwyer B.T., Dhar S.K., Cvetic C., Walter J.C., Dutta A. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science. 290:2000;2309-2312.
56. Yanow S.K., Lygerou Z., Nurse P. Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication. EMBO J. 20:2001;4648-4656.