Erratum: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells (Genes and Development DOI: 10.1101/gad.415507);The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Genes and Development

Volumn 21, Issue 5, 2007, Pages 525-530

  Bracken, Adrian P ^a   Kleine Kohlbrecher, Daniela ^a   Dietrich, Nikolaj ^a   Pasini, Diego ^a   Gargiulo, Gaetano ^b   Beekman, Chantal ^c   Theilgaard Mönch, Kim ^d   Minucci, Saverio ^b   Porse, Bo T ^d   Marine, Jean Christophe ^c   Hansen, Klaus H ^a   Helin, Kristian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d Mental Health Services CPH   (Denmark)

Author keywords

ARF; Cancer; INK4A; INK4B; Polycomb; Senescence

Indexed keywords

ARF PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; PROTEIN P16INK4A; PROTEIN POLYCOMB REPRESSIVE COMPLEX 2 COMPLEX; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BMI2 ONCOGENE; CANCER; CELL STRESS; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FIBROBLAST; GENE ACTIVATION; GENE LOCUS; GENE REPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; SENESCENCE; TRANSCRIPTION INITIATION;

EID: 33947134834     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.351178.123     Document Type: Erratum

References (40)

1. Alcorta, D.A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., and Barrett, J.C. 1996. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. 93: 13742-13747.
2. Boyer, L.A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L.A., Lee, T.I., Levine, S.S., Wernig, M., Tajonar, A., Ray, M.K., et al. 2006. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441: 349-353.
3. Bracken, A.P., Pasini, D., Capra, M., Prosperini, E., Colli, E., and Helin, K. 2003. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 22: 5323-5335.
4. Bracken, A.P., Dietrich, N., Pasini, D., Hansen, K.H., and Helin, K. 2006. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Dev. 20: 1123-1136.
5. Bruggeman, S.W., Valk-Lingbeek, M.E., van der Stoop, P.P., Jacobs, J.J., Kieboom, K., Tanger, E., Hulsman, D., Leung, C., Arsenijevic, Y., Marino, S., et al. 2005. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes & Dev. 19: 1438-1443.
6. Cao, R. and Zhang, Y. 2004. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14: 155-164.
7. Dietrich, N., Bracken, A.P., Trinh, E., Schjerling, C.K., Koscki, H., Rappsilber, J., Helin, K., and Hansen, K.H. 2007. Bypass of senescence by the Polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J. (in press).
8. Dimri, G.P. 2005. What has senescence got to do with cancer? Cancer Cell 7: 505-512.
9. Esteller, M., Corn, P.G., Baylin, S.B., and Herman, J.G. 2001. A gene hypermethylation profile of human cancer. Cancer Res. 61: 3225-3229.
10. Gil, J. and Peters, G. 2006. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all. Nat. Rev. Mol. Cell Biol. 7: 667-677.
11. Gil, J., Bernard, D., Martinez, D., and Beach, D. 2004. Polycomb CBX7 has a unifying role in cellular lifespan. Nat. Cell Biol. 6: 67-72.
12. Henikoff, S., Furuyama, T., and Ahmad, K. 2004. Histone variants, nucleosome assembly and epigenetic inheritance. Trends Genet. 20: 320-326.
13. Hernandez-Munoz, I., Taghavi, P., Kuijl, C., Neefjes, J., and van Lohuizen, M. 2005. Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1. Mol. Cell. Biol. 25: 11047-11058.
14. Itahana, K., Zou, Y., Itahana, Y., Martinez, J.L., Beausejour, C., Jacobs, J.J., Van Lohuizen, M., Band, V., Campisi, J., and Dimri, G.P. 2003. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell. Biol. 23: 389-401.
15. Jacobs, J.J., Kieboom, K., Marino, S., DePinho, R.A., and van Lohuizen, M. 1999. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164-168.
16. Janzen, V., Forkert, R., Fleming, H.E., Saito, Y., Waring, M.T., Dombkowski, D.M., Cheng, T., DePinho, R.A., Sharpless, N.E., and Scadden, D.T. 2006. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443: 421-426.
17. Kamminga, L.M., Bystrykh, L.V., de Boer, A., Houwer, S., Douma, J., Weersing, E., Dontje, B., and de Haan, G. 2006. The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood 107: 2170-2179.
18. Kim, W.Y. and Sharpless, N.E. 2006. The regulation of INK4/ARF in cancer and aging. Cell 127: 265-275.
19. Krishnamurthy, J., Ramsey, M.R., Ligon, K.L., Torrice, C., Koh, A., Bonner-Weir, S., and Sharpless, N.E. 2006. p16INK4a induces an agedependent decline in islet regenerative potential. Nature 443: 453-457.
20. Lee, T.I., Jenner, R.G., Boyer, L.A., Guenther, M.G., Levine, S.S., Kumar, R.M., Chevalier, B., Johnstone, S.E., Cole, M.F., Isono, K., et al. 2006. Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125: 301-313.
21. Lessard, J. and Sauvageau, G. 2003. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423: 255-260.
22. Leung, C., Lingbeek, M., Shakhova, O., Liu, J., Tanger, E., Saremaslani, P., Van Lohuizen, M., and Marino, S. 2004. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428: 337-341.
23. Levine, S.S., King, I.F., and Kingston, R.E. 2004. Division of labor in polycomb group repression. Trends Biochem. Sci. 29: 478-485.
24. Lowe, S.W. and Sherr, C.J. 2003. Tumor suppression by Ink4a-Arf: Progress and puzzles. Curr. Opin. Genet. Dev. 13: 77-83.
25. Molofsky, A.V., Pardal, R., Iwashita, T., Park, I.K., Clarke, M.F., and Morrison, S.J. 2003. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425: 962-967.
26. Molofsky, A.V., He, S., Bydon, M., Morrison, S.J., and Pardal, R. 2005. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes & Dev. 19: 1432-1437.
27. Molofsky, A.V., Slutsky, S.G., Joseph, N.M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N.E., and Morrison, S.J. 2006. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443: 448-452.
28. Narita, M. and Lowe, S.W. 2005. Senescence comes of age. Nat. Med. 11: 920-922.
29. Narita, M., Nunez, S., Heard, E., Narita, M., Lin, A.W., Hearn, S.A., Spector, D.L., Hannon, G.J., and Lowe, S.W. 2003. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113: 703-716.
30. Oruetxebarria, I., Venturini, F., Kekarainen, T., Houweling, A., Zuijderduijn, L.M., Mohd-Sarip, A., Vries, R.G., Hoeben, R.C., and Verrijzer, C.P. 2004. P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells. J. Biol. Chem. 279: 3807-3816.
31. Park, I.K., Qian, D., Kiel, M., Becker, M.W., Pihalja, M., Weissman, I.L., Morrison, S.J., and Clarke, M.F. 2003. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423: 302-305.
32. Pasini, D., Bracken, A.P., and Helin, K. 2004a. Polycomb group proteins in cell cycle progression and cancer. Cell Cycle 3: 396-400.
33. Pasini, D., Bracken, A.P., Jensen, M.R., Lazzerini Denchi, E., and Helin, K. 2004b. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23: 4061-4071.
34. Poux, S., Melfi, R., and Pirrotta, V. 2001. Establishment of Polycomb silencing requires a transient interaction between PC and ESC. Genes & Dev. 15: 2509-2514.
35. Raaphorst, F.M. 2005. Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors. Hum. Mol. Genet. 14: R93-R100.
36. Rastelli, L., Chan, C.S., and Pirrotta, V. 1993. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J. 12: 1513-1522.
37. Squazzo, S.L., O'Geen, H., Komashko, V.M., Krig, S.R., Jin, V.X., Jang, S., Margueron, R., Reinberg, D., Green, R., and Farnham, P.J. 2006. Suz12 binds to silenced regions of the genomein a cell-type-specific manner. Genome Res. 16: 890-900.
38. Tang, X., Milyavsky, M., Shats, I., Erez, N., Goldfinger, N., and Rotter, V. 2004. Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene 23: 5759-5769.
39. Trojer, P. and Reinberg, D. 2006. Histone lysine demethylases and their impact on epigenetics. Cell 125: 213-217.
40. Wei, W., Hemmer, R.M., and Sedivy, J.M. 2001. Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Mol. Cell. Biol. 21: 6748-6757.