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Volumn 7, Issue 7, 2005, Pages 712-718

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DOUBLE STRANDED DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN P53; TELOMERIC REPEAT BINDING FACTOR 2;

EID: 22144490491     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1275     Document Type: Article
Times cited : (499)

References (36)
  • 1
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413 (1998).
    • (1998) Cell , vol.92 , pp. 401-413
    • van Steensel, B.1    Smogorzewska, A.2    de Lange, T.3
  • 2
    • 0037382414 scopus 로고    scopus 로고
    • Erosion of the telomeric single-strand overhang at replicative senescence
    • Stewart, S. A. et al. Erosion of the telomeric single-strand overhang at replicative senescence. Nature Genet. 33, 492-496 (2003).
    • (2003) Nature Genet. , vol.33 , pp. 492-496
    • Stewart, S.A.1
  • 3
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith, J. D. et al. Mammalian telomeres end in a large duplex loop. Cell 97, 503-514 (1999).
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1
  • 4
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198 (2003).
    • (2003) Nature , vol.426 , pp. 194-198
    • d'Adda di Fagagna, F.1
  • 5
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 7
    • 0028822203 scopus 로고
    • Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
    • Garvik, B., Carson, M. & Hartwell, L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol. 15, 6128-6138 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6128-6138
    • Garvik, B.1    Carson, M.2    Hartwell, L.3
  • 8
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou, L. & Elledge, S. J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548 (2003).
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 9
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003).
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 10
    • 0041689966 scopus 로고    scopus 로고
    • Targeted deletion reveals an essential function for the telomere length regulator Trf1
    • Karlseder, J. et al. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol. 23, 6533-6541 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6533-6541
    • Karlseder, J.1
  • 11
    • 3242709415 scopus 로고    scopus 로고
    • Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway
    • Chiang, Y. J., Kim, S. H., Tessarollo, L., Campisi, J. & Hodes, R. J. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol. Cell. Biol. 24, 6631-6634 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 6631-6634
    • Chiang, Y.J.1    Kim, S.H.2    Tessarollo, L.3    Campisi, J.4    Hodes, R.J.5
  • 12
    • 10944240539 scopus 로고    scopus 로고
    • Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
    • Liu, D., O'Connor, M. S., Qin, J. & Songyang, Z. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279, 51338-51342 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 51338-51342
    • Liu, D.1    O'Connor, M.S.2    Qin, J.3    Songyang, Z.4
  • 13
    • 6944232071 scopus 로고    scopus 로고
    • TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
    • Ye, J. Z. et al. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279, 47264-47271 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 47264-47271
    • Ye, J.Z.1
  • 14
    • 6344289975 scopus 로고    scopus 로고
    • TIN2 mediates functions of TRF2 at human telomeres
    • Kim, S. H. et al. TIN2 mediates functions of TRF2 at human telomeres. J. Biol. Chem. 279, 43799-43804 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 43799-43804
    • Kim, S.H.1
  • 15
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin, L. et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97, 527-538 (1999).
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1
  • 16
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska, A. & de Lange, T. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21, 4338-4348 (2002).
    • (2002) EMBO J. , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    de Lange, T.2
  • 17
    • 0033605145 scopus 로고    scopus 로고
    • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. & de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 1321-1325 (1999).
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    de Lange, T.5
  • 18
    • 0347416975 scopus 로고    scopus 로고
    • ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes
    • Zhu, X. D. et al. ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol. Cell 12, 1489-1498 (2003).
    • (2003) Mol. Cell. , vol.12 , pp. 1489-1498
    • Zhu, X.D.1
  • 19
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • Ma, Y., Pannicke, U., Schwarz, K. & Lieber, M. R. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108, 781-794 (2002).
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 20
    • 0033961281 scopus 로고    scopus 로고
    • Control of human telomere length by TRF1 and TRF2
    • Smogorzewska, A. et al. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20, 1659-1668 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1659-1668
    • Smogorzewska, A.1
  • 21
    • 2542536710 scopus 로고    scopus 로고
    • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells
    • Bakkenist, C. J., Drissi, R., Wu, J., Kastan, M. B. & Dome, J. S. Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. Cancer Res. 64, 3748-3752 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3748-3752
    • Bakkenist, C.J.1    Drissi, R.2    Wu, J.3    Kastan, M.B.4    Dome, J.S.5
  • 22
    • 19344374569 scopus 로고    scopus 로고
    • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response
    • Karlseder, J. et al. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol. 2, E240 (2004).
    • (2004) PLoS Biol. , vol.2
    • Karlseder, J.1
  • 23
    • 0027212790 scopus 로고
    • Nucleosomal organization of telomere-specific chromatin in rat
    • Makarov, V. L., Lejnine, S., Bedoyan, J. & Langmore, J. P. Nucleosomal organization of telomere-specific chromatin in rat. Cell 73, 775-787 (1993).
    • (1993) Cell , vol.73 , pp. 775-787
    • Makarov, V.L.1    Lejnine, S.2    Bedoyan, J.3    Langmore, J.P.4
  • 24
    • 9244252580 scopus 로고    scopus 로고
    • Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
    • Huyen, Y. et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432, 406-411 (2004).
    • (2004) Nature , vol.432 , pp. 406-411
    • Huyen, Y.1
  • 25
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • Wong, K. K. et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421, 643-648 (2003).
    • (2003) Nature , vol.421 , pp. 643-648
    • Wong, K.K.1
  • 26
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    • Herbig, U., Jobling, W. A., Chen, B. P., Chen, D. J. & Sedivy, J. M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14, 501-513 (2004).
    • (2004) Mol. Cell. , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.3    Chen, D.J.4    Sedivy, J.M.5
  • 27
    • 0032511976 scopus 로고    scopus 로고
    • Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
    • Frank, K. M. et al. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396, 173-177 (1998).
    • (1998) Nature , vol.396 , pp. 173-177
    • Frank, K.M.1
  • 28
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7 (1994).
    • (1994) Curr. Biol. , vol.4 , pp. 1-7
    • Jacks, T.1
  • 29
    • 0034888424 scopus 로고    scopus 로고
    • Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity
    • Silver, D. P. & Livingston, D. M. Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol. Cell 8, 233-243 (2001).
    • (2001) Mol. Cell. , vol.8 , pp. 233-243
    • Silver, D.P.1    Livingston, D.M.2
  • 30
    • 11144268164 scopus 로고    scopus 로고
    • Significant role for p16(INK4a) in p53-independent telomere-directed senescence
    • Jacobs, J. J. & de Lange, T. Significant role for p16(INK4a) in p53-independent telomere-directed senescence. Curr. Biol. 14, 2302-2308 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 2302-2308
    • Jacobs, J.J.1    de Lange, T.2
  • 31
    • 0029939848 scopus 로고    scopus 로고
    • Heterogeneity in telomere length of human chromosomes
    • Lansdorp, P. M. et al. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5, 685-691 (1996).
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 685-691
    • Lansdorp, P.M.1
  • 32
    • 7044232011 scopus 로고    scopus 로고
    • Homologous recombination generates T-loop-sized deletions at human telomeres
    • Wang, R. C., Smogorzewska, A. & de Lange, T. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 119, 355-368 (2004).
    • (2004) Cell , vol.119 , pp. 355-368
    • Wang, R.C.1    Smogorzewska, A.2    de Lange, T.3
  • 33
    • 0037192462 scopus 로고    scopus 로고
    • Senescence induced by altered telomere state, not telomere loss
    • Karlseder, J., Smogorzewska, A. & de Lange, T. Senescence induced by altered telomere state, not telomere loss. Science 295, 2446-2449 (2002).
    • (2002) Science , vol.295 , pp. 2446-2449
    • Karlseder, J.1    Smogorzewska, A.2    de Lange, T.3
  • 34
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 35
    • 0342561644 scopus 로고    scopus 로고
    • Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
    • Zhu, X. D., Kuster, B., Mann, M., Petrini, J. H. & de Lange, T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genet. 25, 347-352 (2000).
    • (2000) Nature Genet. , vol.25 , pp. 347-352
    • Zhu, X.D.1    Kuster, B.2    Mann, M.3    Petrini, J.H.4    de Lange, T.5
  • 36
    • 0034716904 scopus 로고    scopus 로고
    • Identification of human Rap1: Implications for telomere evolution
    • Li, B., Oestreich, S. & de Lange, T. Identification of human Rap1: implications for telomere evolution. Cell 101, 471-483 (2000).
    • (2000) Cell , vol.101 , pp. 471-483
    • Li, B.1    Oestreich, S.2    de Lange, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.