Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

Nature Genetics

Volumn 30, Issue 3, 2002, Pages 301-305

  Varley, Helen ^a   Pickett, Hilda A ^a   Foxon, Jennifer L ^a   Reddel, Roger R ^b   Royle, Nicola J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

RAD50 PROTEIN; RAD51 PROTEIN; RAD52 PROTEIN; TELOMERASE; UNCLASSIFIED DRUG;

ALLELISM; ARTICLE; CELL DIVISION; CELL IMMORTALIZATION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TELOMERE;

CELL LINE; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; TELOMERE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036510162     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng834     Document Type: Article

References (28)

1. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
2. Specific association of human telomerase activity with immortal cells and cancer
3. Telomerase activity in human germline and embryonic-tissues and cells
4. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
5. Telomere elongation in immortal human cells without detectable telomerase activity
6. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
7. An alternative pathway for yeast telomere maintenance rescues est1 - Senescence
8. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
9. Telomere dynamics in an immortal human cell line
10. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
11. Telomere maintenance by recombination in human cells
12. Telomere length predicts replicative capacity of human fibroblasts
13. Evidence for a critical telomere length in senescent human fibroblasts
14. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
15. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
16. Telomere dynamics and telomerase activity in in vitro immortalised human cells
17. Human telomeres contain at least three types of G-rich repeat distributed non-randomly
18. Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human X/Yp telomere
19. High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: Implications for telomere biology and human evolution
20. The plasticity of human telomeres demonstrated by a hypervariable telomere repeat array that is located on some copies of 16p and 16q
21. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body
22. Defects in mismatch repair promote telomerase-independent proliferation
23. Germ-line splicing mutation of the p53 gene in a cancer-prone family
24. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
25. Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells
26. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
27. Minisatellite repeat coding as a digital approach to DNA typing
28. Sequences from higher primates orthologous to the human Xp/Yp telomere junction region reveal gross rearrangements and high levels of divergence