Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Genes and Development

Volumn 12, Issue 19, 1998, Pages 3008-3019

  Lin, Athena W ^a   Barradas, Marta ^b   Stone, James C ^c   Van Aelst, Linda ^a   Serrano, Manuel ^b   Lowe, Scott W ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

MAPK signaling; MEK; P16; P53; Premature senescence; Tumor suppression

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P16; PROTEIN P53;

ARTICLE; CELL AGING; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL TRANSFORMATION; DNA DAMAGE; EFFECTOR CELL; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MITOGENICITY; PREMATURE AGING; PRIORITY JOURNAL; SENESCENCE; TUMOR SUPPRESSOR GENE;

MURINAE; RODENTIA;

EID: 0032190629     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.19.3008     Document Type: Article

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