-
1
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
Harris, S. L. & Levine, A. J. The p53 pathway: positive and negative feedback loops. Oncogene 24, 2899-2908 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
2
-
-
0842346437
-
Principles of tumor suppression
-
Sherr, C. J. Principles of tumor suppression. Cell 116, 235-246 (2004).
-
(2004)
Cell
, vol.116
, pp. 235-246
-
-
Sherr, C.J.1
-
3
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe, S. W., Cepero, E. & Evan, G. Intrinsic tumour suppression. Nature 432, 307-315 (2004).
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
4
-
-
33746441453
-
Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors
-
Zender, L. et al. Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors. Cold Spring Harb. Symp. Quant. Biol. 70, 251-261 (2005).
-
(2005)
Cold Spring Harb. Symp. Quant. Biol
, vol.70
, pp. 251-261
-
-
Zender, L.1
-
5
-
-
33745253109
-
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
-
Zender, L. et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125, 1253-1267 (2006).
-
(2006)
Cell
, vol.125
, pp. 1253-1267
-
-
Zender, L.1
-
6
-
-
0037222429
-
-
Staib, F., Hussain, S. P., Hofseth, L. J., Wang, X. W. & Harris, C. C. TP53 and liver carcinogenesis. Hum. Mutat. 21, 201-216 (2003).
-
Staib, F., Hussain, S. P., Hofseth, L. J., Wang, X. W. & Harris, C. C. TP53 and liver carcinogenesis. Hum. Mutat. 21, 201-216 (2003).
-
-
-
-
7
-
-
27644582893
-
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
-
Dickins, R. A. et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nature Genet. 37, 1289-1295 (2005).
-
(2005)
Nature Genet
, vol.37
, pp. 1289-1295
-
-
Dickins, R.A.1
-
8
-
-
27644436787
-
Second-generation shRNA libraries covering the mouse and human genomes
-
Silva, J. M. et al. Second-generation shRNA libraries covering the mouse and human genomes. Nature Genet. 37, 1281-1288 (2005).
-
(2005)
Nature Genet
, vol.37
, pp. 1281-1288
-
-
Silva, J.M.1
-
9
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
Chin, L. et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468-472 (1999).
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
-
10
-
-
0037025201
-
Sustained loss of a neoplastic phenotype by brief inactivation of MYC
-
Jain, M. et al. Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science 297, 102-104 (2002).
-
(2002)
Science
, vol.297
, pp. 102-104
-
-
Jain, M.1
-
11
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005).
-
(2005)
Nature
, vol.436
, pp. 660-665
-
-
Braig, M.1
-
12
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (2005).
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
-
13
-
-
23244447893
-
Tumour biology: Senescence in premalignant tumours
-
Collado, M. et al. Tumour biology: senescence in premalignant tumours. Nature 436, 642 (2005).
-
(2005)
Nature
, vol.436
, pp. 642
-
-
Collado, M.1
-
14
-
-
23244447037
-
E600-associated senescence-like cell cycle arrest of human naevi
-
E600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724 (2005).
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
-
16
-
-
0242361641
-
Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis
-
Minamino, T. et al. Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis. Circulation 108, 2264-2269 (2003).
-
(2003)
Circulation
, vol.108
, pp. 2264-2269
-
-
Minamino, T.1
-
17
-
-
0033539169
-
Microarray analysis of replicative senescence
-
Shelton, D. N., Chang, E., Whittier, P. S., Choi, D. & Funk, W. D. Microarray analysis of replicative senescence. Curr. Biol. 9, 939-945 (1999).
-
(1999)
Curr. Biol
, vol.9
, pp. 939-945
-
-
Shelton, D.N.1
Chang, E.2
Whittier, P.S.3
Choi, D.4
Funk, W.D.5
-
18
-
-
17144400369
-
p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions
-
Gorgoulis, V. G. et al. p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions. Lab. Invest. 85, 502-511 (2005).
-
(2005)
Lab. Invest
, vol.85
, pp. 502-511
-
-
Gorgoulis, V.G.1
-
19
-
-
21244472975
-
IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
-
Maeda, S., Kamata, H., Luo, J. L., Leffert, H. & Karin, M. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121, 977-990 (2005).
-
(2005)
Cell
, vol.121
, pp. 977-990
-
-
Maeda, S.1
Kamata, H.2
Luo, J.L.3
Leffert, H.4
Karin, M.5
-
20
-
-
0037268529
-
Involvement of TRAIL and its receptors in viral hepatitis
-
Mundt, B. et al. Involvement of TRAIL and its receptors in viral hepatitis. FASEB J. 17, 94-96 (2003).
-
(2003)
FASEB J
, vol.17
, pp. 94-96
-
-
Mundt, B.1
-
21
-
-
0346690258
-
β-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells
-
Hong, F. et al. β-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res. 63, 9023-9031 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 9023-9031
-
-
Hong, F.1
-
22
-
-
0028869986
-
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
-
Shultz, L. D. et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 154, 180-191 (1995).
-
(1995)
J. Immunol
, vol.154
, pp. 180-191
-
-
Shultz, L.D.1
-
23
-
-
33750691006
-
The role of regulatory T cells in the control of natural killer cells: Relevance during tumor progression
-
Ghiringhelli, F., Menard, C., Martin, F. & Zitvogel, L. The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression. Immunol. Rev. 214, 229-238 (2006).
-
(2006)
Immunol. Rev
, vol.214
, pp. 229-238
-
-
Ghiringhelli, F.1
Menard, C.2
Martin, F.3
Zitvogel, L.4
-
24
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
publication, doi:10.1038/nature05541 24 January
-
Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo. Nature advance online publication, doi:10.1038/nature05541 (24 January 2007).
-
(2007)
Nature advance online
-
-
Ventura, A.1
-
25
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B. & Evan, G. I. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 443, 214-217 (2006).
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
26
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov, V. J. et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nature Med. 8, 282-288 (2002).
-
(2002)
Nature Med
, vol.8
, pp. 282-288
-
-
Bykov, V.J.1
-
27
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
28
-
-
33747192833
-
Cellular senescence in naevi and immortalisation in melanoma: A role for p16?
-
Gray-Schopfer, V. C. et al. Cellular senescence in naevi and immortalisation in melanoma: a role for p16? Br. J. Cancer 95, 496-505 (2006).
-
(2006)
Br. J. Cancer
, vol.95
, pp. 496-505
-
-
Gray-Schopfer, V.C.1
-
29
-
-
0038277105
-
Tumor cell senescence in cancer treatment
-
Roninson, I. B. Tumor cell senescence in cancer treatment. Cancer Res. 63, 2705-2715 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 2705-2715
-
-
Roninson, I.B.1
-
30
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
-
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P. Y. & Campisi, J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl Acad. Sci. USA 98, 12072-12077 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.Y.4
Campisi, J.5
|