Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

Science

Volumn 303, Issue 5654, 2004, Pages 92-95

  Aten, Jacob A ^a   Stap, Jan ^a   Krawczyk, Przemek M ^a   Van Oven, Carel H ^a   Hoebe, Ron A ^a   Essers, Jeroen ^b   Kanaar, Roland ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; MORPHOLOGY; TUMORS;

TRANSLOCATIONS;

DNA;

CHROMOSOME; DNA;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL CYCLE G1 PHASE; CELL SUBPOPULATION; CHROMOSOME DAMAGE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; GENE INDUCTION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL;

ALPHA PARTICLES; ANIMALS; ATAXIA TELANGIECTASIA; CELL NUCLEUS; CHO CELLS; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN; CHROMOSOMES, MAMMALIAN; CRICETINAE; CRICETULUS; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FIBROBLASTS; G1 PHASE; G2 PHASE; HELA CELLS; HISTONES; HUMANS; PHOSPHORYLATION; RAD51 RECOMBINASE; S PHASE; TRANSLOCATION, GENETIC;

ANIMALIA;

EID: 0347988236     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088845     Document Type: Article

References (25)

1. B. Elliott, H. Jasin, Cell. Mol. Life Sci. 59, 373 (2002).
2. J. R. Savage, Science 290, 62 (2000).
3. A. S. Serebrovski, Am. Nat. 63, 374 (1929).
4. K. Sax, Cold Spring Harbor Symp. Quant. Biol. 9, 93 (1941).
5. B. E. Nelms, R. S. Maser, J. F. MacKay, M. G. Lagally, J. H. Petrini, Science 280, 590 (1998).
6. M. N. Nikiforova, J. R. Stringe, R. Blough, H. Medvedovic, J. A. Fagin, Y. E. Nikiforov, Science 290, 139 (2000).
7. R. M. Anderson, D. L. Stevens, D. T. Goodhead, Proc. Natl. Acad. Sci. U.S.A. 99, 12167 (2002).
8. Materials and Methods are available as supporting material on Science Online.
9. G. W. Barendsen, Nature 193, 1153 (1962).
10. W. R. Holley, I. S. Mian, S. J. Park, B. Rydberg, A. Chatterjee, Radiat. Res. 158, 568 (2002).
11. B. Jakob, M. Scholz, G. Taucher-Scholz, Radiat. Res. 159, 676 (2003).
12. G. L. Dianov, P. O'Neill, D. T. Goodhead, BioEssays 23, 745 (2001).
13. E. P. Rogakou, C. Boon, C. Redon, W. M. Bonner, J. Cell Biol. 146, 905 (1999).
14. O. A. Sedelnikova, E. P. Rogakou, I. G. Panyutin, W. M. Bonner, Radiat. Res. 158, 486 (2002).
15. J. R. Chubb, S. Boyle, P. Berry, W. A. Bickmore, Curr. Biol. 12, 439 (2002).
16. C. Wyman, R. Kanaar, Curr. Biol. 12, R446 (2002).
17. M. de Jager, J. van Noort, D. C. van Gent, C. Dekker, R. Kanaar, C. Wyman, Mol. Cell 8, 1129 (2001).
18. O. K. Mirzoeva, J. H. Petrini, Mol. Cell. Biol. 21, 281 (2001).
19. J. Kobayashi et al., Curr. Biol. 12, 1846, (2002).
20. G. S. Stewart et al., Cell 99, 577 (1999).
21. S. Tashiro, N. Kotomura, A. Shinohara, K. Tanaka, K. Ueda, N. Kamada, Oncogene 12, 2165 (1996).
22. M. Lisby, U. H. Mortensen, R. Rothstein, Nature Cell Biol. 5, 572, 2003.
23. G. Ludwikow et al., Int. J. Radiat. Biol. 78, 239 (2002).
24. O. K. Mirzoeva, J. H. Petrini, Molec. Cancer Res. 1, 217 (2003).
25. We thank G. W. Barendsen and C. Wyman for discussion and N. G. J. Jaspers for cell lines. This work was supported by European Community grants.