BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation

Current Biology

Volumn 14, Issue 23, 2004, Pages 2135-2142

  Turner, James M A ^a   Aprelikova, Olga ^b   Xu, Xiaoling ^c   Wang, Ruihong ^c   Kim, Sangsoo ^c   Chandramouli, Gadisetti V R ^b   Barrett, J Carl ^b   Burgoyne, Paul S ^a   Deng, Chu Xia ^c  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN, MOUSE; CELL CYCLE PROTEIN; HISTONE; PRIMER DNA; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; COMPARATIVE STUDY; DNA MICROARRAY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; METABOLISM; MOUSE; MUTATION; PACHYTENE; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX CHROMOSOME; SPERMATOGENESIS; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA PRIMERS; GENES, BRCA1; HISTONES; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PACHYTENE STAGE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX CHROMOSOMES; SPERMATOGENESIS;

MAMMALIA;

EID: 10344264478     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2004.11.032     Document Type: Article

References (27)

1. Monesi V. Synthetic activities during spermatogenesis in the mouse. Exp. Cell Res. 39:1965;197-224
2. Solari A.J. The behaviour of the XY pair in mammals. Int. Rev. Cytol. 38:1974;273-317
3. McKee B.D., Handel M.A. Sex chromosomes, recombination, and chromatin conformation. Chromosoma. 102:1993;71-80
4. Mahadevaiah S.K., Turner J.M.A., Baudat F., Rogakou E.P., de Boer P., Blanco-Rodriguez J., Jasin M., Keeney S., Bonner W.M., Burgoyne P.S. Recombinational DNA double-strand breaks in mice precede synapsis. Nat. Genet. 27:2001;271-276
5. Fernandez-Capetillo O., Mahadevaiah S.K., Celeste A., Romanienko P.J., Camerini-Otero R.D., Bonner W.M., Manova K., Burgoyne P., Nussenzweig A. H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev. Cell. 4:2003;497-508
6. Scully R., Chen J., Plug A., Xiao Y., Weaver D., Feunteun J., Ashley T., Livingston D.M. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 88:1997;265-275
7. Zabludoff S.D., Wright W.W., Harshman K., Wold B.J. BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells. Oncogene. 13:1996;649-653
8. Xu X., Aprelikova O., Moens P., Deng C.X., Furth P.A. Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development. 130:2003;2001-2012
9. Peters A.H., Plug A.W., van Vugt M.J., de Boer P. A drying-down technique for the spreading of mammalian meiocytes from the male and female germ line. Chromosome Res. 5:1997;66-68
10. Lammers J.H.M., Offenberg H.H., Van Aalderen M., Vink A.C.G., Dietrich A.J.J., Heyting C. The gene encoding a major component of synaptonemal complexes of rat is related to X-linked lymphocyte-regulated genes. Mol. Cell. Biol. 14:1994;1137-1146
11. Xu X., Qiao W., Linke S.P., Cao L., Li W.M., Furth P.A., Harris C.C., Deng C.X. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat. Genet. 28:2001;266-271
12. Keegan K.S., Holtzman D.A., Plug A.W., Christenson E.R., Brainerd E.E., Flaggs G., Bentley N.J., Taylor E.M., Meyn M.S., Moss S.B., et al. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10:1996;2423-2437
13. Moens P.B., Tarsounas M., Morita T., Habu T., Rottinghaus S.T., Freire R., Jackson S.P., Barlow C., Wynshaw-Boris A. The association of ATR protein with mouse meiotic chromosome cores. Chromosoma. 108:1999;95-102
14. Hall L.L., Byron M., Sakai K., Carrel L., Willard H.F., Lawrence J.B. An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells. Proc. Natl. Acad. Sci. USA. 99:2002;8677-8682
15. Huynh K.D., Lee J.T. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature. 426:2003;857-862
16. Ganesan S., Silver D.P., Greenberg R.A., Avni D., Drapkin R., Miron A., Mok S.C., Randrianarison V., Brodie S., Salstrom J., et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 111:2002;393-405
17. Bochar D.A., Wang L., Beniya H., Kinev A., Xue Y., Lane W.S., Wang W., Kashanchi F., Shiekhattar R. BRCA1 is associated with a human SWI/SNF-related complex. linking chromatin remodeling to breast cancer Cell. 102:2000;257-265
18. Cortez D., Wang Y., Qin J., Elledge S.J. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science. 286:1999;1162-1166
19. Ward I.M., Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276:2001;47759-47762
20. Hamer G., Roepers-Gajadien H.L., van Duyn-Goedhart A., Gademan I.S., Kal H.B., van Buul P.P., Ashley T., de Rooij D.G. Function of DNA-protein kinase catalytic subunit during the early meiotic prophase without Ku70 and Ku86. Biol. Reprod. 68:2003;717-721
21. Turner J.M.A., Mahadevaiah S.K., Fernandez-Capetillo O., Nussenzweig A., Xu X., Deng C.-X., Burgoyne P.S. Silencing of unsynapsed meiotic chromosomes in the mouse. Nat. Genet. in press:2004
22. Plug A.W., Peters A.H.F.M., Xu Y., Keegan K.S., Hoekstra M.F., Baltimore D., de Boer P., Ashley T. ATM and RPA in meiotic chromosome synapsis and recombination. Nat. Genet. 17:1997;457-461
23. Barlow C., Liyanage M., Moens P.B., Tarsounas M., Nagashima K., Brown K., Rottinghaus S., Jackson S.P., Tagle D., Ried T. Atm deficiency results in severe meiotic disruption as early as leptonema of prophase 1. Development. 125:1998;4007-4017
24. Hamer G., Kal H.B., Westphal C.H., Ashley T., de Rooij D.G. Ataxia telangiectasia mutated expression and activation in the testis. Biol. Reprod. 70:2004;1206-1212
25. Shiu P.K., Raju N.B., Zickler D., Metzenberg R.L. Meiotic silencing by unpaired DNA. Cell. 107:2001;905-916
26. Van Der Laan R., Uringa E.J., Wassenaar E., Hoogerbrugge J.W., Sleddens E., Odijk H., Roest H.P., De Boer P., Hoeijmakers J.H., Grootegoed J.A., et al. Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase. J. Cell Sci. 117:2004;5023-5033
27. Barlow A.L., Benson F.E., West S.C., Hultén M.A. Distribution of the RAD51 recombinase in human and mouse spermatocytes. EMBO J. 16:1997;5207-5215