Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

Genes and Development

Volumn 15, Issue 4, 2001, Pages 398-403

  Ramirez, Ruben D ^a,b   Morales, Carmela P ^a,b   Herbert, Brittney Shea ^a   Rohde, Jeffrey M ^a   Passons, Christina ^a   Shay, Jerry W ^a   Wright, Woodring E ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Dallas VA   (United States)

Author keywords

Aging; Cancer; Cellular senescence; P161NK4a; Replicative aging; Telomeres

Indexed keywords

MITOMYCIN; PROTEIN P16; RETINOBLASTOMA PROTEIN; TELOMERASE;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CELL AGING; CELL IMMORTALIZATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; TELOMERE; TUMOR CELL; TUMOR SUPPRESSOR GENE;

3T3 CELLS; ANIMALS; CELL AGING; CELL DIVISION; CELL LINE, TRANSFORMED; CULTURE MEDIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; HUMANS; KERATINOCYTES; MAMMARY GLANDS, ANIMAL; MICE; SKIN; TELOMERASE; TELOMERE;

ANIMALIA;

EID: 0035114576     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.859201     Document Type: Article

References (40)

1. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
2. Extension of life-span by introduction of telomerase into normal human cells
3. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
4. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
5. Genetic and epigenetic changes in human epithelial cells immortalized by telomerase
6. Inactivation of p16 in human mammary epithelial cells by CpG island methylation
7. Properties of an epithelial cell type in culture: The epidermal keratinocyte and its dependence on products of the fibroblast
8. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
9. Telomere loss: Mitotic clock or genetic time bomb?
10. Telomeres shorten during aging
11. Cell Aging
12. The limited in vitro lifetime of human diploid cell strains
13. Telomere shortening is proportional to the size of the G-rich telomeric 3′-overhang
14. P16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells
15. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
16. Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells
17. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
18. Positive correlation between mammalian life span and cellular resistance to stress
19. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
20. Extended culture of mouse embryo cells without senescence: Inhibition by serum
21. The p53 tumor suppressor protein does not regulate expression of its own inhibitor. MDM2, except under conditions of stress
22. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
23. The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes
24. Serum amine oxidase activity contributes to crisis in mouse embryo cell lines
25. Methods for clonal growth and serial cultivation of normal human epidermal keratinocytes and mesothelial cells
26. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
27. Cell aging in vivo and in vitro
28. Telomerase and cellular life span: Ending the debate?
29. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
30. Microarray analysis of replicative senescence
31. Cellular senescence: Mitotic clock or culture shock?
32. Growth of normal human mammary cells in culture
33. TRF2 protects human telomeres from end-to-end fusions
34. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
35. Evidence for a new step in telomere maintenance
36. The two-stage mechanism controlling cellular senescence and immortalization
37. Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology
38. Telomerase activity in human germline and embryonic tissues and cells
39. Human endothelial cell life extension by telomerase expression
40. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging