Does a sentinel or a subset of short telomeres determine replicative senescence?

Molecular Biology of the Cell

Volumn 15, Issue 8, 2004, Pages 3709-3718

  Zou, Ying ^a   Sfeir, Agnel ^a   Gryaznov, Sergei M ^b   Shay, Jerry W ^a   Wright, Woodring E ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b GERON CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL SUBPOPULATION; DNA DAMAGE; FIBROBLAST; GENE INDUCTION; IN SITU HYBRIDIZATION; INTERPHASE; KARYOTYPE; LIFESPAN; METAPHASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SENESCENCE; TELOMERE; TISSUE SPECIFICITY;

CELL AGING; CHROMOSOMES, HUMAN; DNA; DNA DAMAGE; DNA REPLICATION; FIBROBLASTS; HISTONES; HUMANS; IN SITU HYBRIDIZATION; TELOMERE;

ANIMALIA;

EID: 3342972121     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E04-03-0207     Document Type: Article

References (46)

1. Allshire, R.C., Dempster, M., and Hastie, N.D. (1989). Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res. 17, 4611-4627.
2. Atamna, H., Paler-Martinez, A., and Ames, B.N. (2000). N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts. J. Biol. Chem. 275, 6741-6748.
3. Baird, D.M., Coleman, J., Rosser, Z.H., and Royle, N.J. (2000). High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution. Am. J. Hum. Genet. 66, 235-250.
4. Baird, D.M., Rowson, J., Wynford-Thomas, D., and Kipling, D. (2003). Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat. Genet. 33, 203-207.
5. Barbosa, M.S., Vass, W.C., Lowy, D.R., and Schiller, J.T. (1991). In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential. J. Virol. 65, 292-298.
6. Benn, P.A. (1976). Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos. Am. J. Hum. Genet. 28, 465-473.
7. Bodnar, A.G. et al. (1998). Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
8. Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S., and Reddel, R.R. (1995). Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240-4248.
9. d'Adda di Fagagna, F., Reaper, P.M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzk, G., Carter, N.P., and Jackson, S.P. (2003). A DNA damage checkpoint-mediated response in telomere-initiated senescence. Nature 426, 194-198.
10. de Lange, T. (2002). Protection of mammalian telomeres. Oncogene 21, 532-540.
11. der-Sarkissian, H., Bacchetti, S., Cazes, L., and Londono-Vallejo, J.A. (2004). The shortest telomeres drive karyotype evolution in transformed cells. Oncogene 23, 1221-1228.
12. Drayton, S., and Peters, G. (2002). Immortalisation and transformation revisited. Curr. Opin. Genet. Dev. 12, 98-104.
13. Dunham, M.A., Neumann, A.A., Fasching, C.L., and Reddel, R.R. (2000). Telomere maintenance by recombination in human cells. Nat. Genet. 26, 447-450.
14. Forsyth, N.R., Evans, A.P., Shay, J.W., and Wright, W.E. (2003). Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell 2, 235-243.
15. Graakjaer, J., Bischoff, C., Korsholm, L., Holstebroe, S., Vach, W., Bohr, V.A., Christensen, K., and Kolvraa, S. (2003). The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life. Mech. Ageing Dev. 124, 629-640.
16. Greider, C.W. (1990). Telomeres, telomerase and senescence. Bioessays 12, 363-369.
17. Gustashaw, K.M. (1997). Chromsome Stains. Philadelphia: Lippincott-Raven.
18. Halbert, C.L., Demers, G.W., and Galloway, D.A. (1992). The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells. J. Virol. 66, 2125-2134.
19. Hara, E., Tsurui, H., Shinozaki, A., Nakada, S., and Oda, K. (1991). Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun. 179, 528-534.
20. Harley, C.B. (1991). Telomere loss: mitotic clock or genetic time bomb? Mutat. Res. 256, 271-282.
21. Harley, C.B., Futcher, A.B., and Greider, C.W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460.
22. Hayflick, L., and Moorhead, P.S. (1961). The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621.
23. Hemann, M.T., Strong, M.A., Hao, L.Y., and Greider, C.W. (2001). The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67-77.
24. Kim, N.W. et al. (1994). Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015.
25. Levy, M.Z., Allsopp, R.C., Futcher, A.B., Greider, C.W., and Harley, C.B. (1992). Telomere end-replication problem and cell aging. J. Mol. Biol. 225, 951-960.
26. Lingner, J., Cooper, J.P., and Cech, T.R. (1995). Telomerase and DNA end replication: no longer a lagging strand problem? Science 269, 1533-1534.
27. Londono-Vallejo, J.A., DerSarkissian, H., Cazes, L., and Thomas, G. (2001). Differences in telomere length between homologous chromosomes in humans. Nucleic Acids Res. 29, 3164-3171.
28. Lorenz, M., Saretzki, G., Sitte, N., Metzkow, S., and von Zglinicki, T. (2001). BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic. Biol. Med. 31, 824-831.
29. Martens, U.M., Chavez, E.A., Poon, S.S., Schmoor, C., and Lansdorp, P.M. (2000). Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp. Cell Res. 256, 291-299.
30. Masutomi, K. et al. (2003). Telomerase maintains telomere structure in normal human cells. Cell 114, 241-253.
31. Ouellette, M.M., Liao, M., Herbert, B.S., Johnson, M., Holt, S.E., Liss, H.S., Shay, J.W., and Wright, W.E. (2000). Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J. Biol. Chem. 275, 10072-10076.
32. Ramirez, R.D., Morales, C.P., Herbert, B.S., Rohde, J.M., Passons, C., Shay, J.W., and Wright, W.E. (2001). Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15, 398-403.
33. Saksela, E., and Moorhead, P.S. (1963). Aneuploidy in the degenerative phase of serial cultivation of human cell strains. Proc. Natl. Acad. Sci. USA 50, 390-395.
34. Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J., and Howley, P.M. (1990). The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63, 1129-1136.
35. Shay, J.W., and Bacchetti, S. (1997). A survey of telomerase activity in human cancer. Eur. J. Cancer 5, 787-791.
36. Shay, J.W., Pereira-Smith, O.M., and Wright, W.E. (1991). A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196, 33-39.
37. Sherwood, S.W., Rush, D., Ellsworth, J.L., and Schimke, R.T. (1988). Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc. Natl. Acad. Sci. USA 85, 9086-9090.
38. Steinert, S., Shay, J.W., and Wright, W.E. (2000). Transient expression of human telomerase extends the life span of normal human fibroblasts. Biochem. Biophys. Res. Commun. 273, 1095-1098.
39. Stewart, S.A., Ben-Porath, I., Carey, V.J., O'Connor, B.F., Hahn, W.C., and Weinberg, R.A. (2003). Erosion of the telomeric single-strand overhang at replicative senescence. Nat. Genet. 33, 492-496.
40. Suda, T., Fujiyama, A., Takimoto, M., Igarashi, M., Kuroiwa, T., Waguri, N., Kawai, H., Mita, Y., and Aoyagi, Y. (2002). Interchromosomal telomere length variation. Biochem. Biophys. Res. Commun. 291, 210-214.
41. Takai, H., Smogorzewska, A., and de Lange, T. (2003). DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556.
42. Thompson, K.V., and Holliday, R. (1975). Chromosome changes during the in vitro ageing of MRC-5 human fibroblasts. Exp. Cell Res. 96, 1-6.
43. von Zglinicki, T. (2002). Oxidative stress shortens telomeres. Trends Biochem. Sci. 27, 339-344.
44. von Zglinicki, T., Saretzki, G., Docke, W., and Lotze, C. (1995). Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp. Cell Res. 220, 186-193.
45. Werness, B.A., Levine, A.J., and Howley, P.M. (1990). Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248, 76-79.
46. Wright, W.E., and Shay, J.W. (2002). Historical claims and current interpretations of replicative aging. Nat. Biotechnol. 20, 682-688.