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Volumn 25, Issue 3, 2005, Pages 161-182

The granule pathway of programmed cell death

Author keywords

Apoptosis; Cytotoxic lymphocytes; Granzymes; Serine protease inhibitors

Indexed keywords

CAD PROTEIN; CALCIUM ION; CASPASE; DNA FRAGMENT; GRANULYSIN; GRANZYME A; GRANZYME B; LYSOSOME ENZYME; PERFORIN; PROTEOGLYCAN; SERINE PROTEINASE INHIBITOR;

EID: 26844508372     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevImmunol.v25.i3.10     Document Type: Review
Times cited : (35)

References (178)
  • 1
    • 2042425747 scopus 로고
    • Experimental necrobiosis - A venture in cytobiology
    • Kidd J. Experimental necrobiosis-a venture in cytobiology. Proc Inst Med Chicago 1950; 18:50-60.
    • (1950) Proc Inst Med Chicago , vol.18 , pp. 50-60
    • Kidd, J.1
  • 2
    • 0020020694 scopus 로고
    • Lymphocyte mediated cytolysis as a secretory phenomenon
    • Henkart MP, Henkart PA. Lymphocyte mediated cytolysis as a secretory phenomenon. Adv Exp Med Biol 1982; 146:227-47.
    • (1982) Adv Exp Med Biol , vol.146 , pp. 227-247
    • Henkart, M.P.1    Henkart, P.A.2
  • 3
    • 0018940829 scopus 로고
    • Cell surface DNA in immunosuppression in AKR leukemia
    • Russell JL, Golub ES. Cell surface DNA in immunosuppression in AKR leukemia. J Immunol 1980; 125(5):2328-33.
    • (1980) J Immunol , vol.125 , Issue.5 , pp. 2328-2333
    • Russell, J.L.1    Golub, E.S.2
  • 4
    • 0018972855 scopus 로고
    • Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact
    • Russell JH, Dobos CB. Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact. J Immunol 1980; 125(3):1256-61.
    • (1980) J Immunol , vol.125 , Issue.3 , pp. 1256-1261
    • Russell, J.H.1    Dobos, C.B.2
  • 5
    • 0021273768 scopus 로고
    • Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors
    • Millard PJ, Henkart MP, Reynolds CW, Henkart PA. Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors. J Immunol 1984; 132(6):3197-204.
    • (1984) J Immunol , vol.132 , Issue.6 , pp. 3197-3204
    • Millard, P.J.1    Henkart, M.P.2    Reynolds, C.W.3    Henkart, P.A.4
  • 6
    • 0001041396 scopus 로고
    • Isolation and biochemical and functional characterization of perform 1 from cytolytic T-cell granules
    • Podack ER, Young JD, Cohn ZA. Isolation and biochemical and functional characterization of perform 1 from cytolytic T-cell granules. Proc Natl Acad Sci U S A 1985; 82(24):8629-33.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , Issue.24 , pp. 8629-8633
    • Podack, E.R.1    Young, J.D.2    Cohn, Z.A.3
  • 8
    • 0026532606 scopus 로고
    • A natural killer cell granule protein that induces DNA fragmentation and apoptosis
    • Shi L, Kraut RP, Aebersold R, Greenberg AH. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J Exp Med 1992; 175(2):553-66.
    • (1992) J Exp Med , vol.175 , Issue.2 , pp. 553-566
    • Shi, L.1    Kraut, R.P.2    Aebersold, R.3    Greenberg, A.H.4
  • 9
    • 0029914331 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo
    • Kagi D, Ledermann B, Burki K, Zinkernagel RM, Hengartner H. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 1996; 14:207-32.
    • (1996) Annu Rev Immunol , vol.14 , pp. 207-232
    • Kagi, D.1    Ledermann, B.2    Burki, K.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 11
    • 0028257947 scopus 로고
    • Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells
    • Ju ST, Cui H, Panka DJ, Ettinger R, Marshak-Rothstein A. Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells. Proc Natl Acad Sci U S A 1994; 91(10):4185-9.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.10 , pp. 4185-4189
    • Ju, S.T.1    Cui, H.2    Panka, D.J.3    Ettinger, R.4    Marshak-Rothstein, A.5
  • 12
    • 0016345568 scopus 로고
    • Restriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogeneic system
    • Zinkernagel RM, Doherty PC. Restriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogeneic system. Nature 1974; 248:701-2.
    • (1974) Nature , vol.248 , pp. 701-702
    • Zinkernagel, R.M.1    Doherty, P.C.2
  • 13
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: Understanding their relationship
    • Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relationship. Science 1996; 272:54-60.
    • (1996) Science , vol.272 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 14
    • 0038731186 scopus 로고    scopus 로고
    • Delivering the kiss of death
    • Trambas CM, Griffiths GM. Delivering the kiss of death. Nat Immunol 2003; 4(5)399-403.
    • (2003) Nat Immunol , vol.4 , Issue.5 , pp. 399-403
    • Trambas, C.M.1    Griffiths, G.M.2
  • 15
    • 0022362235 scopus 로고
    • The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells
    • Kupfer A, Dennert G, Singer SJ. The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells. J Mol Cell Immunol 1985; 2(1):37-49.
    • (1985) J Mol Cell Immunol , vol.2 , Issue.1 , pp. 37-49
    • Kupfer, A.1    Dennert, G.2    Singer, S.J.3
  • 16
    • 0034022829 scopus 로고    scopus 로고
    • IL-12 enhances IL-2 function by inducing CD25 expression through a p38 mitogen-activated protein kinase pathway
    • Nguyen T, Wang R, Russell JH. IL-12 enhances IL-2 function by inducing CD25 expression through a p38 mitogen-activated protein kinase pathway. Eur J Immunol 2000; 30(5):1445-52.
    • (2000) Eur J Immunol , vol.30 , Issue.5 , pp. 1445-1452
    • Nguyen, T.1    Wang, R.2    Russell, J.H.3
  • 18
    • 0017331287 scopus 로고
    • Antiviral protection by virus-immune cytotoxic T cells: Infected target cells are lysed before infectious virus progeny is assembled
    • Zinkernagel RM, Althage A. Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled. J Exp Med 1977; 145(3):644-51.
    • (1977) J Exp Med , vol.145 , Issue.3 , pp. 644-651
    • Zinkernagel, R.M.1    Althage, A.2
  • 19
    • 0015807492 scopus 로고
    • Cytotoxic lymphocytes in the absence of detectable antibody
    • Berke G, Amos DB. Cytotoxic lymphocytes in the absence of detectable antibody. Nature 1973; 242:237-9.
    • (1973) Nature , vol.242 , pp. 237-239
    • Berke, G.1    Amos, D.B.2
  • 20
    • 0036217977 scopus 로고    scopus 로고
    • Lymphocyte-mediated cytotoxicity
    • Russell JH, Ley TJ. Lymphocyte-mediated cytotoxicity. Annu Rev Immunol 2002; 20:323-70.
    • (2002) Annu Rev Immunol , vol.20 , pp. 323-370
    • Russell, J.H.1    Ley, T.J.2
  • 21
    • 0033975075 scopus 로고    scopus 로고
    • Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system
    • Parra B, Lin MT, Stohlman SA, Bergmann CC, Atkinson R, Hinton DR. Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system. J Virol 2000; 74(5):2447-50.
    • (2000) J Virol , vol.74 , Issue.5 , pp. 2447-2450
    • Parra, B.1    Lin, M.T.2    Stohlman, S.A.3    Bergmann, C.C.4    Atkinson, R.5    Hinton, D.R.6
  • 22
    • 0031307852 scopus 로고    scopus 로고
    • + T cells clear influenza virus by perforin or Fas-dependent processes
    • + T cells clear influenza virus by perforin or Fas-dependent processes. J Immunol 1997; 159(11):5197-200.
    • (1997) J Immunol , vol.159 , Issue.11 , pp. 5197-5200
    • Topham, D.J.1    Tripp, R.A.2    Doherty, P.C.3
  • 23
    • 0029616324 scopus 로고
    • Perforin dependence of natural killer cell-mediated tumor control in vivo
    • van den Broek MF, Kagi D, Zinkernagel RM, Hengartner H. Perforin dependence of natural killer cell-mediated tumor control in vivo. Eur J Immunol 1995; 25(12):3514-6.
    • (1995) Eur J Immunol , vol.25 , Issue.12 , pp. 3514-3516
    • Van Den Broek, M.F.1    Kagi, D.2    Zinkernagel, R.M.3    Hengartner, H.4
  • 25
    • 0042377711 scopus 로고    scopus 로고
    • The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes
    • Edwards KM, Kam CM, Powers JC, Trapani JA. The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. J Biol Chem 1999; 274(43):30468-73.
    • (1999) J Biol Chem , vol.274 , Issue.43 , pp. 30468-30473
    • Edwards, K.M.1    Kam, C.M.2    Powers, J.C.3    Trapani, J.A.4
  • 26
    • 0025598309 scopus 로고
    • Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart
    • Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 1990; 265(36):22348-57.
    • (1990) J Biol Chem , vol.265 , Issue.36 , pp. 22348-22357
    • Urata, H.1    Kinoshita, A.2    Misono, K.S.3    Bumpus, F.M.4    Husain, A.5
  • 27
    • 0035988243 scopus 로고    scopus 로고
    • The genes for perform, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation
    • Kelso A, Costelloe EO, Johnson BJ, Groves P, Buttigieg K, Fitzpatrick DR. The genes for perform, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation. Int Immunol 2002; 14(6):605-13.
    • (2002) Int Immunol , vol.14 , Issue.6 , pp. 605-613
    • Kelso, A.1    Costelloe, E.O.2    Johnson, B.J.3    Groves, P.4    Buttigieg, K.5    Fitzpatrick, D.R.6
  • 28
    • 0036195424 scopus 로고    scopus 로고
    • Cytotoxic cell granule-mediated apoptosis: Perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation
    • Metkar SS, Wang B, Aguilar-Santelises M, Raja SM, Uhlin-Hansen L, Podack E, Trapani JA, Froelich CJ. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity 2002; 16(3):417-28.
    • (2002) Immunity , vol.16 , Issue.3 , pp. 417-428
    • Metkar, S.S.1    Wang, B.2    Aguilar-Santelises, M.3    Raja, S.M.4    Uhlin-Hansen, L.5    Podack, E.6    Trapani, J.A.7    Froelich, C.J.8
  • 29
    • 0037147261 scopus 로고    scopus 로고
    • Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin
    • Raja SM, Wang B, Dantuluri M, Desai UR, Demeler B, Spiegel K, Metkar SS, Froelich CJ. Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. J Biol Chem 2002; 277(51):49523-30.
    • (2002) J Biol Chem , vol.277 , Issue.51 , pp. 49523-49530
    • Raja, S.M.1    Wang, B.2    Dantuluri, M.3    Desai, U.R.4    Demeler, B.5    Spiegel, K.6    Metkar, S.S.7    Froelich, C.J.8
  • 32
    • 0023693490 scopus 로고
    • Homology of perforin to the ninth component of complement (C9)
    • Shinkai Y, Takio K, Okumura K. Homology of perforin to the ninth component of complement (C9). Nature 1988; 334(6182):525-7.
    • (1988) Nature , vol.334 , Issue.6182 , pp. 525-527
    • Shinkai, Y.1    Takio, K.2    Okumura, K.3
  • 33
    • 0022466507 scopus 로고
    • Structural/functional similarity between proteins involved in complement-and cytotoxic T-lymphocyte-mediated cytolysis
    • Tschopp J, Masson D, Stanley KK. Structural/functional similarity between proteins involved in complement-and cytotoxic T-lymphocyte-mediated cytolysis. Nature 1986; 322(6082):831-4.
    • (1986) Nature , vol.322 , Issue.6082 , pp. 831-834
    • Tschopp, J.1    Masson, D.2    Stanley, K.K.3
  • 35
    • 0033499729 scopus 로고    scopus 로고
    • Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin
    • Browne KA, Blink E, Sutton VR, Froelich CJ, Jans DA, Trapani JA. Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol 1999; 19(12):8604-15.
    • (1999) Mol Cell Biol , vol.19 , Issue.12 , pp. 8604-8615
    • Browne, K.A.1    Blink, E.2    Sutton, V.R.3    Froelich, C.J.4    Jans, D.A.5    Trapani, J.A.6
  • 37
    • 0031569218 scopus 로고    scopus 로고
    • Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins
    • Pena SV, Hanson DA, Carr BA, Goralski TJ, Krensky AM. Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins. J Immunol 1997; 158(6):2680-8.
    • (1997) J Immunol , vol.158 , Issue.6 , pp. 2680-2688
    • Pena, S.V.1    Hanson, D.A.2    Carr, B.A.3    Goralski, T.J.4    Krensky, A.M.5
  • 42
    • 0025597939 scopus 로고
    • The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments
    • Burkhardt JK, Hester S, Lapham CK, Argon Y. The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments. J Cell Biol 1990; 111(6 Pt 1):2327-40.
    • (1990) J Cell Biol , vol.111 , Issue.6 PART 1 , pp. 2327-2340
    • Burkhardt, J.K.1    Hester, S.2    Lapham, C.K.3    Argon, Y.4
  • 43
    • 0033587689 scopus 로고    scopus 로고
    • Dipeptidyl peptidase I is required for the processing and activation of granzymes a and B in vivo
    • Pham CT, Ley TJ. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci U S A 1999; 96(15):8627-32.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.15 , pp. 8627-8632
    • Pham, C.T.1    Ley, T.J.2
  • 45
    • 0034745672 scopus 로고    scopus 로고
    • Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy
    • Roberg K. Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy. Lab Invest 2001; 81(2):149-58.
    • (2001) Lab Invest , vol.81 , Issue.2 , pp. 149-158
    • Roberg, K.1
  • 46
    • 0030890614 scopus 로고    scopus 로고
    • Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes
    • Linnevers C, Smeekens SP, Bromme D. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. FEBS Lett 1997; 405(3):253-9.
    • (1997) FEBS Lett , vol.405 , Issue.3 , pp. 253-259
    • Linnevers, C.1    Smeekens, S.P.2    Bromme, D.3
  • 47
    • 0035736259 scopus 로고    scopus 로고
    • Organelle-specific initiation of cell death pathways
    • Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001; 3:E255-63.
    • (2001) Nat Cell Biol , vol.3
    • Ferri, K.F.1    Kroemer, G.2
  • 48
    • 0030044052 scopus 로고    scopus 로고
    • Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis
    • Trapani JA, Browne KA, Smyth MJ, Jans DA. Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis. J Biol Chem 1996; 271(8):4127-33.
    • (1996) J Biol Chem , vol.271 , Issue.8 , pp. 4127-4133
    • Trapani, J.A.1    Browne, K.A.2    Smyth, M.J.3    Jans, D.A.4
  • 49
    • 0032561352 scopus 로고    scopus 로고
    • Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perform are caspase-dependent, but cell death is caspase-independent
    • Trapani JA, Jans DA, Jans PJ, Smyth MJ, Browne KA, Sutton VR. Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perform are caspase-dependent, but cell death is caspase-independent. J Biol Chem 1998; 273(43):27934-8.
    • (1998) J Biol Chem , vol.273 , Issue.43 , pp. 27934-27938
    • Trapani, J.A.1    Jans, D.A.2    Jans, P.J.3    Smyth, M.J.4    Browne, K.A.5    Sutton, V.R.6
  • 50
    • 0031847334 scopus 로고    scopus 로고
    • Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction
    • Trapani JA, Jans P, Smyth MJ, Froelich CJ, Williams EA, Sutton VR, Jans DA. Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Cell Death Differ 1998; 5(6):488-96.
    • (1998) Cell Death Differ , vol.5 , Issue.6 , pp. 488-496
    • Trapani, J.A.1    Jans, P.2    Smyth, M.J.3    Froelich, C.J.4    Williams, E.A.5    Sutton, V.R.6    Jans, D.A.7
  • 51
    • 0025971396 scopus 로고
    • Human and murine cytotoxic T lymphocyte serine proteases: Subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
    • Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC. Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry 1991; 30(8):2217-27.
    • (1991) Biochemistry , vol.30 , Issue.8 , pp. 2217-2227
    • Odake, S.1    Kam, C.M.2    Narasimhan, L.3    Poe, M.4    Blake, J.T.5    Krahenbuhl, O.6    Tschopp, J.7    Powers, J.C.8
  • 52
    • 0030008812 scopus 로고    scopus 로고
    • ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B
    • Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem 1996; 271(28):16720-4.
    • (1996) J Biol Chem , vol.271 , Issue.28 , pp. 16720-16724
    • Duan, H.1    Orth, K.2    Chinnaiyan, A.M.3    Poirier, G.G.4    Froelich, C.J.5    He, W.W.6    Dixit, V.M.7
  • 53
    • 9344261615 scopus 로고    scopus 로고
    • The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism
    • Martin SJ, Amarante-Mendes GP, Shi L, Chuang TH, Casiano CA, O'Brien GA, Fitzgerald P, Tan EM, Bokoch GM, Greenberg AH, Green DR. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. EMBO J 1996; 15(10):2407-16.
    • (1996) EMBO J , vol.15 , Issue.10 , pp. 2407-2416
    • Martin, S.J.1    Amarante-Mendes, G.P.2    Shi, L.3    Chuang, T.H.4    Casiano, C.A.5    O'Brien, G.A.6    Fitzgerald, P.7    Tan, E.M.8    Bokoch, G.M.9    Greenberg, A.H.10    Green, D.R.11
  • 57
    • 0029832173 scopus 로고    scopus 로고
    • Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation
    • Darmon AJ, Ley TJ, Nicholson DW, Bleackley RC. Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation. J Biol Chem 1996; 271(36):21709-12.
    • (1996) J Biol Chem , vol.271 , Issue.36 , pp. 21709-21712
    • Darmon, A.J.1    Ley, T.J.2    Nicholson, D.W.3    Bleackley, R.C.4
  • 58
    • 0033673428 scopus 로고    scopus 로고
    • DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis
    • Thomas DA, Du C, Xu M, Wang X, Ley TJ. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity 2000; 12(6):621-32.
    • (2000) Immunity , vol.12 , Issue.6 , pp. 621-632
    • Thomas, D.A.1    Du, C.2    Xu, M.3    Wang, X.4    Ley, T.J.5
  • 60
    • 0032530361 scopus 로고    scopus 로고
    • Caspase dependence of target cell damage induced by cytotoxic lymphocytes
    • Sarin A, Haddad EK, Henkart PA. Caspase dependence of target cell damage induced by cytotoxic lymphocytes. J Immunol 1998; 161(6):2810-6.
    • (1998) J Immunol , vol.161 , Issue.6 , pp. 2810-2816
    • Sarin, A.1    Haddad, E.K.2    Henkart, P.A.3
  • 61
    • 0028938366 scopus 로고
    • The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity
    • Nakajima H, Golstein P, Henkart PA. The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity. J Exp Med 1995; 181(5):1905-9.
    • (1995) J Exp Med , vol.181 , Issue.5 , pp. 1905-1909
    • Nakajima, H.1    Golstein, P.2    Henkart, P.A.3
  • 62
    • 0034107096 scopus 로고    scopus 로고
    • Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid
    • Barry M, Heibein JA, Pinkoski MJ, Lee SF, Moyer RW, Green DR, Bleackley RC. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. Mol Cell Biol 2000; 20(11):3781-94.
    • (2000) Mol Cell Biol , vol.20 , Issue.11 , pp. 3781-3794
    • Barry, M.1    Heibein, J.A.2    Pinkoski, M.J.3    Lee, S.F.4    Moyer, R.W.5    Green, D.R.6    Bleackley, R.C.7
  • 63
    • 0033521626 scopus 로고    scopus 로고
    • Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis
    • MacDonald G, Shi L, Vande Velde C, Lieberman J, Greenberg AH. Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis. J Exp Med 1999; 189(1):131-44.
    • (1999) J Exp Med , vol.189 , Issue.1 , pp. 131-144
    • MacDonald, G.1    Shi, L.2    Vande Velde, C.3    Lieberman, J.4    Greenberg, A.H.5
  • 64
    • 0034694091 scopus 로고    scopus 로고
    • Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
    • Sutton VR, Davis JE, Cancilla M, Johnstone RW, Ruefli AA, Sedelies K, Browne KA, Trapani JA. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J Exp Med 2000; 192(10):1403-14.
    • (2000) J Exp Med , vol.192 , Issue.10 , pp. 1403-1414
    • Sutton, V.R.1    Davis, J.E.2    Cancilla, M.3    Johnstone, R.W.4    Ruefli, A.A.5    Sedelies, K.6    Browne, K.A.7    Trapani, J.A.8
  • 65
    • 0030916417 scopus 로고    scopus 로고
    • DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
    • Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997; 89(2):175-84.
    • (1997) Cell , vol.89 , Issue.2 , pp. 175-184
    • Liu, X.1    Zou, H.2    Slaughter, C.3    Wang, X.4
  • 66
    • 0032555215 scopus 로고    scopus 로고
    • The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis
    • Liu X, Li P, Widlak P, Zou H, Luo X, Garrard WT, Wang X. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A 1998; 95(15):8461-6.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.15 , pp. 8461-8466
    • Liu, X.1    Li, P.2    Widlak, P.3    Zou, H.4    Luo, X.5    Garrard, W.T.6    Wang, X.7
  • 67
    • 0031888955 scopus 로고    scopus 로고
    • A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
    • Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998; 391(6662):43-50.
    • (1998) Nature , vol.391 , Issue.6662 , pp. 43-50
    • Enari, M.1    Sakahira, H.2    Yokoyama, H.3    Okawa, K.4    Iwamatsu, A.5    Nagata, S.6
  • 68
    • 0031889132 scopus 로고    scopus 로고
    • Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
    • Sakahira H, Enari M, Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 1998; 391(6662):96-9.
    • (1998) Nature , vol.391 , Issue.6662 , pp. 96-99
    • Sakahira, H.1    Enari, M.2    Nagata, S.3
  • 69
    • 0032724653 scopus 로고    scopus 로고
    • Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
    • Wolf BB, Schuler M, Echeverri F, Green DR. Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation. J Biol Chem 1999; 274(43):30651-6.
    • (1999) J Biol Chem , vol.274 , Issue.43 , pp. 30651-30656
    • Wolf, B.B.1    Schuler, M.2    Echeverri, F.3    Green, D.R.4
  • 70
    • 0032514713 scopus 로고    scopus 로고
    • Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45
    • Zhang J, Liu X, Scherer DC, van Kaer L, Wang X, Xu M. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc Natl Acad Sci U S A 1998; 95(21):12480-5.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.21 , pp. 12480-12485
    • Zhang, J.1    Liu, X.2    Scherer, D.C.3    Van Kaer, L.4    Wang, X.5    Xu, M.6
  • 71
    • 0033601251 scopus 로고    scopus 로고
    • DNA fragmentation factor 45-deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells
    • Zhang J, Wang X, Bove KE, Xu M. DNA fragmentation factor 45-deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J Biol Chem 1999; 274(52):37450-4.
    • (1999) J Biol Chem , vol.274 , Issue.52 , pp. 37450-37454
    • Zhang, J.1    Wang, X.2    Bove, K.E.3    Xu, M.4
  • 73
    • 0028917923 scopus 로고
    • Bcl-2 blocks degranulation but not fas-based cell-mediated cytotoxicity
    • Chiu VK, Walsh CM, Liu CC, Reed JC, Clark WR. Bcl-2 blocks degranulation but not fas-based cell-mediated cytotoxicity. J Immunol 1995; 154(5):2023-32.
    • (1995) J Immunol , vol.154 , Issue.5 , pp. 2023-2032
    • Chiu, V.K.1    Walsh, C.M.2    Liu, C.C.3    Reed, J.C.4    Clark, W.R.5
  • 74
    • 0031570536 scopus 로고    scopus 로고
    • Bcl-2 prevents apoptosis induced by perform and granzyme B, but not that mediated by whole cytotoxic lymphocytes
    • Sutton VR, Vaux DL, Trapani JA. Bcl-2 prevents apoptosis induced by perform and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J Immunol 1997; 158(12):5783-90.
    • (1997) J Immunol , vol.158 , Issue.12 , pp. 5783-5790
    • Sutton, V.R.1    Vaux, D.L.2    Trapani, J.A.3
  • 75
    • 0031178835 scopus 로고    scopus 로고
    • Bcl-2 expression in target cells leads to functional inhibition of caspase-3 protease family in human NK and lymphokine-activated killer cell granule-mediated apoptosis
    • Renvoize C, Roger R, Moulian N, Bertoglio J, Breard J. Bcl-2 expression in target cells leads to functional inhibition of caspase-3 protease family in human NK and lymphokine-activated killer cell granule-mediated apoptosis. J Immunol 1997; 159(1):126-34.
    • (1997) J Immunol , vol.159 , Issue.1 , pp. 126-134
    • Renvoize, C.1    Roger, R.2    Moulian, N.3    Bertoglio, J.4    Breard, J.5
  • 76
    • 0033548065 scopus 로고    scopus 로고
    • BCL-2 blocks perforin-induced nudear translocation of granzymes concomitant with protection against the nuclear events of apoptosis
    • Jans DA, Sutton VR, Jans P, Froelich CJ, Trapani JA. BCL-2 blocks perforin-induced nudear translocation of granzymes concomitant with protection against the nuclear events of apoptosis. J Biol Chem 1999; 274(7):3953-61.
    • (1999) J Biol Chem , vol.274 , Issue.7 , pp. 3953-3961
    • Jans, D.A.1    Sutton, V.R.2    Jans, P.3    Froelich, C.J.4    Trapani, J.A.5
  • 77
    • 0033769857 scopus 로고    scopus 로고
    • Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1
    • Davis JE, Sutton VR, Smyth MJ, Trapani JA. Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1. Cell Death Differ 2000; 7(10):973-83.
    • (2000) Cell Death Differ , vol.7 , Issue.10 , pp. 973-983
    • Davis, J.E.1    Sutton, V.R.2    Smyth, M.J.3    Trapani, J.A.4
  • 80
    • 0035831462 scopus 로고    scopus 로고
    • Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition
    • Alimonti JB, Shi L, Baijal PK, Greenberg AH. Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition. J Biol Chem 2001; 276(10):6974-82.
    • (2001) J Biol Chem , vol.276 , Issue.10 , pp. 6974-6982
    • Alimonti, J.B.1    Shi, L.2    Baijal, P.K.3    Greenberg, A.H.4
  • 82
    • 0035910057 scopus 로고    scopus 로고
    • Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
    • Thomas DA, Scorrano L, Putcha GV, Korsmeyer SJ, Ley TJ. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proc Natl Acad Sci U S A 2001; 98(26):14985-90.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.26 , pp. 14985-14990
    • Thomas, D.A.1    Scorrano, L.2    Putcha, G.V.3    Korsmeyer, S.J.4    Ley, T.J.5
  • 84
    • 0348148880 scopus 로고    scopus 로고
    • Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    • Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 2003; 426(6967):671-6.
    • (2003) Nature , vol.426 , Issue.6967 , pp. 671-676
    • Opferman, J.T.1    Letai, A.2    Beard, C.3    Sorcinelli, M.D.4    Ong, C.C.5    Korsmeyer, S.J.6
  • 85
    • 2542501399 scopus 로고    scopus 로고
    • Degradation of Mcl-1 by granzyme B: Implications for Bim-mediated mitochondrial apoptotic events
    • Han J, Goldstein LA, Gastman BR, Froelich CJ, Yin XM, Rabinowich H. Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events. J Biol Chem 2004; 279(21):22020-9.
    • (2004) J Biol Chem , vol.279 , Issue.21 , pp. 22020-22029
    • Han, J.1    Goldstein, L.A.2    Gastman, B.R.3    Froelich, C.J.4    Yin, X.M.5    Rabinowich, H.6
  • 86
    • 18144429102 scopus 로고    scopus 로고
    • Disruption of Mcl-1. Bim complex in granzyme B-mediated mitochondrial apoptosis
    • Han J, Goldstein LA, Gastman BR, Rabinovitz A, Rabinowich H. Disruption of Mcl-1. Bim complex in granzyme B-mediated mitochondrial apoptosis. J Biol Chem 2005; 280(16):16383-92.
    • (2005) J Biol Chem , vol.280 , Issue.16 , pp. 16383-16392
    • Han, J.1    Goldstein, L.A.2    Gastman, B.R.3    Rabinovitz, A.4    Rabinowich, H.5
  • 87
    • 0037451224 scopus 로고    scopus 로고
    • Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis
    • Metkar SS, Wang B, Ebbs ML, Kim JH, Lee YJ, Raja SM, Froelich CJ. Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis. J Cell Biol 2003; 160(6):875-85.
    • (2003) J Cell Biol , vol.160 , Issue.6 , pp. 875-885
    • Metkar, S.S.1    Wang, B.2    Ebbs, M.L.3    Kim, J.H.4    Lee, Y.J.5    Raja, S.M.6    Froelich, C.J.7
  • 88
    • 0022496723 scopus 로고
    • Serine esterase in cytolytic T lymphocytes
    • Pasternack MS, Verret CR, Liu MA, Eisen HN. Serine esterase in cytolytic T lymphocytes. Nature 1986; 322(6081):740-3.
    • (1986) Nature , vol.322 , Issue.6081 , pp. 740-743
    • Pasternack, M.S.1    Verret, C.R.2    Liu, M.A.3    Eisen, H.N.4
  • 89
    • 0021859627 scopus 로고
    • A novel serine esterase expressed by cytotoxic T lymphocytes
    • Pasternack MS, Eisen HN. A novel serine esterase expressed by cytotoxic T lymphocytes. Nature 1985; 314(6013):743-5.
    • (1985) Nature , vol.314 , Issue.6013 , pp. 743-745
    • Pasternack, M.S.1    Eisen, H.N.2
  • 90
    • 0026474805 scopus 로고
    • Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
    • Shi L, Kam CM, Powers JC, Aebersold R, Greenberg AH. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med 1992; 176(6):1521-9.
    • (1992) J Exp Med , vol.176 , Issue.6 , pp. 1521-1529
    • Shi, L.1    Kam, C.M.2    Powers, J.C.3    Aebersold, R.4    Greenberg, A.H.5
  • 91
    • 0033137079 scopus 로고    scopus 로고
    • Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation
    • Beresford PJ, Xia Z, Greenberg AH, Lieberman J. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. Immunity 1999; 10:585-94.
    • (1999) Immunity , vol.10 , pp. 585-594
    • Beresford, P.J.1    Xia, Z.2    Greenberg, A.H.3    Lieberman, J.4
  • 92
    • 0028258577 scopus 로고
    • Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
    • Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 1994; 76:977-87.
    • (1994) Cell , vol.76 , pp. 977-987
    • Heusel, J.W.1    Wesselschmidt, R.L.2    Shresta, S.3    Russell, J.H.4    Ley, T.J.5
  • 93
    • 0037230088 scopus 로고    scopus 로고
    • Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice
    • Zajac AJ, Dye JM, Quinn DG. Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice. Virology 2003; 305(1):1-9.
    • (2003) Virology , vol.305 , Issue.1 , pp. 1-9
    • Zajac, A.J.1    Dye, J.M.2    Quinn, D.G.3
  • 94
    • 0030802988 scopus 로고    scopus 로고
    • Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes
    • Shresta S, Goda P, Wesselschmidt R, Ley TJ. Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. J Biol Chem 1997; 272(32):20236-44.
    • (1997) J Biol Chem , vol.272 , Issue.32 , pp. 20236-20244
    • Shresta, S.1    Goda, P.2    Wesselschmidt, R.3    Ley, T.J.4
  • 95
    • 0032860128 scopus 로고    scopus 로고
    • Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice
    • Wilharm E, Tschopp J, Jenne DE. Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice. FEBS Lett 1999; 459(1):139-42.
    • (1999) FEBS Lett , vol.459 , Issue.1 , pp. 139-142
    • Wilharm, E.1    Tschopp, J.2    Jenne, D.E.3
  • 96
    • 0033986159 scopus 로고    scopus 로고
    • Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice
    • Pereira RA, Simon MM, Simmons A. Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice. J Virol 2000; 74(2):1029-32.
    • (2000) J Virol , vol.74 , Issue.2 , pp. 1029-1032
    • Pereira, R.A.1    Simon, M.M.2    Simmons, A.3
  • 97
    • 0030014911 scopus 로고    scopus 로고
    • Granzyme a is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia
    • Mullbacher A, Ebnet K, Blanden RV, Hla RT, Stehle T, Museteanu C, Simon MM. Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc Natl Acad Sci U S A 1996; 93(12):5783-7.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.12 , pp. 5783-5787
    • Mullbacher, A.1    Ebnet, K.2    Blanden, R.V.3    Hla, R.T.4    Stehle, T.5    Museteanu, C.6    Simon, M.M.7
  • 98
    • 0033136315 scopus 로고    scopus 로고
    • Granzyme a initiates an alternative pathway for granule-mediated apoptosis
    • Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity 1999; 10(5):595-605.
    • (1999) Immunity , vol.10 , Issue.5 , pp. 595-605
    • Shresta, S.1    Graubert, T.A.2    Thomas, D.A.3    Raptis, S.Z.4    Ley, T.J.5
  • 99
    • 8444249247 scopus 로고    scopus 로고
    • Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
    • Pardo J, Bosque A, Brehm R, Wallich R, Naval J, Mullbacher A, Anel A, Simon MM. Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. J Cell Biol 2004; 167(3):457-68.
    • (2004) J Cell Biol , vol.167 , Issue.3 , pp. 457-468
    • Pardo, J.1    Bosque, A.2    Brehm, R.3    Wallich, R.4    Naval, J.5    Mullbacher, A.6    Anel, A.7    Simon, M.M.8
  • 100
    • 15244351845 scopus 로고    scopus 로고
    • Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
    • Martinvalet D, Zhu P, Lieberman J. Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity 2005; 22(3):355-70.
    • (2005) Immunity , vol.22 , Issue.3 , pp. 355-370
    • Martinvalet, D.1    Zhu, P.2    Lieberman, J.3
  • 101
    • 0035900714 scopus 로고    scopus 로고
    • Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
    • Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J Biol Chem 2001; 276(46):43285-93.
    • (2001) J Biol Chem , vol.276 , Issue.46 , pp. 43285-43293
    • Beresford, P.J.1    Zhang, D.2    Oh, D.Y.3    Fan, Z.4    Greer, E.L.5    Russo, M.L.6    Jaju, M.7    Lieberman, J.8
  • 102
    • 0030787867 scopus 로고    scopus 로고
    • Recombinant human granzyme a binds to two putative HLA-associated proteins and cleaves one of them
    • Beresford PJ, Kam CM, Powers JC, Lieberman J. Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them. Proc Natl Acad Sci U S A 1997; 94(17):9285-90.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.17 , pp. 9285-9290
    • Beresford, P.J.1    Kam, C.M.2    Powers, J.C.3    Lieberman, J.4
  • 103
    • 0037423932 scopus 로고    scopus 로고
    • Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor
    • Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 2003; 112(5):659-72.
    • (2003) Cell , vol.112 , Issue.5 , pp. 659-672
    • Fan, Z.1    Beresford, P.J.2    Oh, D.Y.3    Zhang, D.4    Lieberman, J.5
  • 104
    • 0036199666 scopus 로고    scopus 로고
    • HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A
    • Fan Z, Beresford PJ, Zhang D, Lieberman J. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol Cell Biol 2002; 22(8):2810-20.
    • (2002) Mol Cell Biol , vol.22 , Issue.8 , pp. 2810-2820
    • Fan, Z.1    Beresford, P.J.2    Zhang, D.3    Lieberman, J.4
  • 105
    • 0037059740 scopus 로고    scopus 로고
    • NM23-H1 and NM23-H2 repress transcriptional activities of nuclease-hypersensitive elements in the platelet-derived growth factor-A promoter
    • Ma D, Xing Z, Liu B, Pedigo NG, Zimmer SG, Bai Z, Postel EH, Kaetzel DM. NM23-H1 and NM23-H2 repress transcriptional activities of nuclease- hypersensitive elements in the platelet-derived growth factor-A promoter. J Biol Chem 2002; 277 (2):1560-7.
    • (2002) J Biol Chem , vol.277 , Issue.2 , pp. 1560-1567
    • Ma, D.1    Xing, Z.2    Liu, B.3    Pedigo, N.G.4    Zimmer, S.G.5    Bai, Z.6    Postel, E.H.7    Kaetzel, D.M.8
  • 107
    • 0035826778 scopus 로고    scopus 로고
    • Granzymes A and B directly deave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
    • Zhang D, Beresford PJ, Greenberg AH, Lieberman J. Granzymes A and B directly deave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A 2001; 98(10):5746-51.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.10 , pp. 5746-5751
    • Zhang, D.1    Beresford, P.J.2    Greenberg, A.H.3    Lieberman, J.4
  • 110
    • 13544266566 scopus 로고    scopus 로고
    • Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions
    • Revell PA, Grossman WJ, Thomas DA, Cao X, Behl R, Ratner JA, Lu ZH, Ley TJ. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J Immunol 2005; 174(4):2124-31.
    • (2005) J Immunol , vol.174 , Issue.4 , pp. 2124-2131
    • Revell, P.A.1    Grossman, W.J.2    Thomas, D.A.3    Cao, X.4    Behl, R.5    Ratner, J.A.6    Zh, L.7    Ley, T.J.8
  • 112
    • 0022592627 scopus 로고
    • On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell
    • Kupfer A, Singer SJ, Dennert G. On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell. J Exp Med 1986; 163(3):489-98.
    • (1986) J Exp Med , vol.163 , Issue.3 , pp. 489-498
    • Kupfer, A.1    Singer, S.J.2    Dennert, G.3
  • 113
    • 0032100476 scopus 로고    scopus 로고
    • Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perform and granzyme B mobilization by functional ERK2
    • Wei S, Gamero AM, Liu JH, Daulton AA, Valkov NI, Trapani JA, Lamer AC, Weber MJ, Djeu JY. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perform and granzyme B mobilization by functional ERK2. J Exp Med 1998; 187(11):1753-65.
    • (1998) J Exp Med , vol.187 , Issue.11 , pp. 1753-1765
    • Wei, S.1    Gamero, A.M.2    Liu, J.H.3    Daulton, A.A.4    Valkov, N.I.5    Trapani, J.A.6    Lamer, A.C.7    Weber, M.J.8    Djeu, J.Y.9
  • 115
    • 0034330547 scopus 로고    scopus 로고
    • Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells
    • Jiang K, Zhong B, Gilvary DL, Corliss BC, Hong-Geller E, Wei S, Djeu JY. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat Immunol 2000; 1(5):419-25.
    • (2000) Nat Immunol , vol.1 , Issue.5 , pp. 419-425
    • Jiang, K.1    Zhong, B.2    Gilvary, D.L.3    Corliss, B.C.4    Hong-Geller, E.5    Wei, S.6    Djeu, J.Y.7
  • 116
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • Stinchcombe JC, Bossi G, Booth S, Griffiths GM. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 2001; 15(5):751-61.
    • (2001) Immunity , vol.15 , Issue.5 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3    Griffiths, G.M.4
  • 117
    • 0035911150 scopus 로고    scopus 로고
    • Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice
    • Haddad EK, Wu X, Hammer JA, 3rd, Henkart PA. Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice. J Cell Biol 2001; 152(4):835-42.
    • (2001) J Cell Biol , vol.152 , Issue.4 , pp. 835-842
    • Haddad, E.K.1    Wu, X.2    Hammer III, J.A.3    Henkart, P.A.4
  • 120
    • 0035654722 scopus 로고    scopus 로고
    • Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killing
    • Lyubchenko TA, Wurth GA, Zweifach A. Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killing. Immunity 2001; 15(5):847-59.
    • (2001) Immunity , vol.15 , Issue.5 , pp. 847-859
    • Lyubchenko, T.A.1    Wurth, G.A.2    Zweifach, A.3
  • 121
    • 0016597777 scopus 로고
    • Isolation and charcaterization of individual functionally recative cytotoxic T lymphocytes. Conjugation, killing and recycling at the single cell level
    • Zagury D, Bernard J, Thiemess N, Feldman M, Berke G. Isolation and charcaterization of individual functionally recative cytotoxic T lymphocytes. Conjugation, killing and recycling at the single cell level. Eur J Immunol 1975; 5:812-8.
    • (1975) Eur J Immunol , vol.5 , pp. 812-818
    • Zagury, D.1    Bernard, J.2    Thiemess, N.3    Feldman, M.4    Berke, G.5
  • 123
    • 0030892138 scopus 로고    scopus 로고
    • Granzyme B (GraB) autonomously crosses the cell membrane and perform initiates apoptosis and GraB nuclear localization
    • Shi LS, Mai S, Israel S, Browne KA, Trapani JA, Greenberg AH. Granzyme B (GraB) autonomously crosses the cell membrane and perform initiates apoptosis and GraB nuclear localization. J Exp Med 1997; 185:855-66.
    • (1997) J Exp Med , vol.185 , pp. 855-866
    • Shi, L.S.1    Mai, S.2    Israel, S.3    Browne, K.A.4    Trapani, J.A.5    Greenberg, A.H.6
  • 124
    • 0027452741 scopus 로고
    • Granzymes A and B are targeted to the lyric granules of lymphocytes by the mannose-6-phosphate receptor
    • Griffiths GM, Isaaz S. Granzymes A and B are targeted to the lyric granules of lymphocytes by the mannose-6-phosphate receptor. J Cell Biol 1993; 120(4):885-96.
    • (1993) J Cell Biol , vol.120 , Issue.4 , pp. 885-896
    • Griffiths, G.M.1    Isaaz, S.2
  • 127
  • 128
    • 0033555391 scopus 로고    scopus 로고
    • A role for perform in activation-induced T cell death in vivo: Increased expansion of allogeneic perforin-deficient T cells in SCID mice
    • Spaner D, Raju K, Rabinovich B, Miller RG. A role for perform in activation-induced T cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID mice. J Immunol 1999; 162:1192-9.
    • (1999) J Immunol , vol.162 , pp. 1192-1199
    • Spaner, D.1    Raju, K.2    Rabinovich, B.3    Miller, R.G.4
  • 131
    • 0034680811 scopus 로고    scopus 로고
    • Regulation of antigen-specific T cell homeostasis by perform and interferon-γ
    • Badovanic VP, Tvinnereim AR, Harry JT. Regulation of antigen-specific T cell homeostasis by perform and interferon-γ. Science 2000; 290:1354-7.
    • (2000) Science , vol.290 , pp. 1354-1357
    • Badovanic, V.P.1    Tvinnereim, A.R.2    Harry, J.T.3
  • 132
    • 0242417491 scopus 로고    scopus 로고
    • + T Cell expansion and mortality in vaccinated perforin-deficient mice
    • + T Cell expansion and mortality in vaccinated perforin-deficient mice. Immunity 2003; 18:463-74.
    • (2003) Immunity , vol.18 , pp. 463-474
    • Badovinac, V.P.1    Hamilton, S.E.2    Harty, J.T.3
  • 136
    • 0038725690 scopus 로고    scopus 로고
    • The ABCs of granule-mediated cytotoxicity: New weapons in the arsenal
    • Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 2003; 3(5):361-70.
    • (2003) Nat Rev Immunol , vol.3 , Issue.5 , pp. 361-370
    • Lieberman, J.1
  • 140
    • 0037097642 scopus 로고    scopus 로고
    • Synaptic transfer by human gamma delta T cells stimulated with soluble or cellular antigens
    • Espinosa E, Tabiasco J, Hudrisier D, Fournie JJ. Synaptic transfer by human gamma delta T cells stimulated with soluble or cellular antigens. J Immunol 2002; 168(12):6336-43.
    • (2002) J Immunol , vol.168 , Issue.12 , pp. 6336-6343
    • Espinosa, E.1    Tabiasco, J.2    Hudrisier, D.3    Fournie, J.J.4
  • 141
    • 0035942781 scopus 로고    scopus 로고
    • B cells acquire antigen from target cells after synapse formation
    • Batista FD, Iber D, Neuberger MS. B cells acquire antigen from target cells after synapse formation. Nature 2001; 411(6836):489-94.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 489-494
    • Batista, F.D.1    Iber, D.2    Neuberger, M.S.3
  • 143
    • 0037350690 scopus 로고    scopus 로고
    • Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9
    • Chen L, Woo M, Hakem R, Miller RG. Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9. Eur J Immunol 2003; 33(3):769-78.
    • (2003) Eur J Immunol , vol.33 , Issue.3 , pp. 769-778
    • Chen, L.1    Woo, M.2    Hakem, R.3    Miller, R.G.4
  • 144
    • 0028914352 scopus 로고
    • Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway
    • Isaaz S, Baetz K, Olsen K, Podack E, Griffiths GM. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur J Immunol 1995; 25(4):1071-9.
    • (1995) Eur J Immunol , vol.25 , Issue.4 , pp. 1071-1079
    • Isaaz, S.1    Baetz, K.2    Olsen, K.3    Podack, E.4    Griffiths, G.M.5
  • 146
    • 9244226573 scopus 로고    scopus 로고
    • A license to remember
    • Ashton-Rickardt PG. A license to remember. Nat Immunol 2004; 5:1097-8.
    • (2004) Nat Immunol , vol.5 , pp. 1097-1098
    • Ashton-Rickardt, P.G.1
  • 147
    • 0034653828 scopus 로고    scopus 로고
    • CD8+ T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity
    • Hermans IF, Ritchie DS, Yang J, Roberts JM, Ronchese F. CD8+ T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity. J Immunol 2000; 164(6):3095-101.
    • (2000) J Immunol , vol.164 , Issue.6 , pp. 3095-3101
    • Hermans, I.F.1    Ritchie, D.S.2    Yang, J.3    Roberts, J.M.4    Ronchese, F.5
  • 148
    • 0032742010 scopus 로고    scopus 로고
    • The in vivo fate of APCs displaying minor H antigen and/or MHC differences is regulated by CTLs specific for immunodominant class I-associated epitopes
    • Loyer V, Fontaine P, Pion S, Hetu F, Roy DC, Perreault C. The in vivo fate of APCs displaying minor H antigen and/or MHC differences is regulated by CTLs specific for immunodominant class I-associated epitopes. J Immunol 1999; 163(12):6462-7.
    • (1999) J Immunol , vol.163 , Issue.12 , pp. 6462-6467
    • Loyer, V.1    Fontaine, P.2    Pion, S.3    Hetu, F.4    Roy, D.C.5    Perreault, C.6
  • 149
    • 0034975739 scopus 로고    scopus 로고
    • Perforin-independent regulation of dendritic cell homeostasis by CD8(+) T cells in vivo: Implications for adaptive immunotherapy
    • Ludewig B, Bonilla WV, Dumrese T, Odermatt B, Zinkernagel RM, Hengartner H. Perforin-independent regulation of dendritic cell homeostasis by CD8(+) T cells in vivo: implications for adaptive immunotherapy. Eur J Immunol 2001; 31(6):1772-9.
    • (2001) Eur J Immunol , vol.31 , Issue.6 , pp. 1772-1779
    • Ludewig, B.1    Bonilla, W.V.2    Dumrese, T.3    Odermatt, B.4    Zinkernagel, R.M.5    Hengartner, H.6
  • 150
    • 0037136311 scopus 로고    scopus 로고
    • Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
    • Balaji KN, Schaschke N, Machleidt W, Catalfamo M, Henkart PA. Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. J Exp Med 2002; 196(4):493-503.
    • (2002) J Exp Med , vol.196 , Issue.4 , pp. 493-503
    • Balaji, K.N.1    Schaschke, N.2    Machleidt, W.3    Catalfamo, M.4    Henkart, P.A.5
  • 151
    • 2142773262 scopus 로고    scopus 로고
    • Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: A possible mechanism of high dose tolerance
    • Michallet MC, Saltel F, Flacher M, Revillard JP, Genestier L. Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance. J Immunol 2004; 172(9):5405-14.
    • (2004) J Immunol , vol.172 , Issue.9 , pp. 5405-5414
    • Michallet, M.C.1    Saltel, F.2    Flacher, M.3    Revillard, J.P.4    Genestier, L.5
  • 153
    • 0027507325 scopus 로고
    • The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes
    • Dupuis M, Schaerer E, Krause KH, Tschopp J. The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. J Exp Med 1993; 177(1):1-7.
    • (1993) J Exp Med , vol.177 , Issue.1 , pp. 1-7
    • Dupuis, M.1    Schaerer, E.2    Krause, K.H.3    Tschopp, J.4
  • 155
    • 0032468408 scopus 로고    scopus 로고
    • Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model system
    • Fraser SA, Michalak M, Welch WH, Hudig D. Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model system. Biochem Cell Biol 1998; 76(5):881-7.
    • (1998) Biochem Cell Biol , vol.76 , Issue.5 , pp. 881-887
    • Fraser, S.A.1    Michalak, M.2    Welch, W.H.3    Hudig, D.4
  • 156
    • 0034655278 scopus 로고    scopus 로고
    • Perform lytic activity is controlled by calreticulin
    • Fraser SA, Karimi R, Michalak M, Hudig D. Perform lytic activity is controlled by calreticulin. J Immunol 2000; 164(8):4150-5.
    • (2000) J Immunol , vol.164 , Issue.8 , pp. 4150-4155
    • Fraser, S.A.1    Karimi, R.2    Michalak, M.3    Hudig, D.4
  • 158
    • 0027393310 scopus 로고
    • The ovalbumm family of serpin protiens
    • Remold-O'Donnell E. The ovalbumm family of serpin protiens. FEBS Lett 1993; 315:105-9.
    • (1993) FEBS Lett , vol.315 , pp. 105-109
    • Remold-O'Donnell, E.1
  • 159
    • 0029914132 scopus 로고    scopus 로고
    • A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
    • Sun J, Bird CH, Sutton V, McDonald L, Coughlin PB, De Jong TA, Trapani JA, Bird PI. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J Biol Chem 1996; 271(44):27802-9.
    • (1996) J Biol Chem , vol.271 , Issue.44 , pp. 27802-27809
    • Sun, J.1    Bird, C.H.2    Sutton, V.3    McDonald, L.4    Coughlin, P.B.5    De Jong, T.A.6    Trapani, J.A.7    Bird, P.I.8
  • 160
    • 0031008162 scopus 로고    scopus 로고
    • A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)
    • Sun J, Ooms L, Bird CH, Sutton VR, Trapani JA, Bird PI. A new family of
    • (1997) J Biol Chem , vol.272 , Issue.24 , pp. 15434-15441
    • Sun, J.1    Ooms, L.2    Ch, B.3    Sutton, V.R.4    Trapani, J.A.5    Bird, P.I.6
  • 161
    • 0034932940 scopus 로고    scopus 로고
    • Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1
    • Bird CH, Blink EJ, Hirst CE, Buzza MS, Steele PM, Sun J, Jans DA, Bird CH. Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1. Mol Cell Biol 2001; 21:5396-407.
    • (2001) Mol Cell Biol , vol.21 , pp. 5396-5407
    • Bird, C.H.1    Blink, E.J.2    Hirst, C.E.3    Buzza, M.S.4    Steele, P.M.5    Sun, J.6    Jans, D.A.7    Bird, C.H.8
  • 162
    • 0037438474 scopus 로고    scopus 로고
    • The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency
    • Hirst CE, Buzza MS, Bird CH, Warren HS, Cameron PU, Zhang M, Ashton-Rickardt PG, Bird PI. The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol 2003; 170:805-15.
    • (2003) J Immunol , vol.170 , pp. 805-815
    • Hirst, C.E.1    Buzza, M.S.2    Bird, C.H.3    Warren, H.S.4    Cameron, P.U.5    Zhang, M.6    Ashton-Rickardt, P.G.7    Bird, P.I.8
  • 164
    • 0037174880 scopus 로고    scopus 로고
    • Modulators of inflammation use nuclear factor-kappa B and activator protein-1 sites to induce the caspase-1 and granzyme B inhibitor, proteinase inhibitor 9
    • Kannan-Thulasiraman P, Shapiro DJ. Modulators of inflammation use nuclear factor-kappa B and activator protein-1 sites to induce the caspase-1 and granzyme B inhibitor, proteinase inhibitor 9. J Biol Chem 2002; 277(43):41230-9.
    • (2002) J Biol Chem , vol.277 , Issue.43 , pp. 41230-41239
    • Kannan-Thulasiraman, P.1    Shapiro, D.J.2
  • 167
    • 0028955325 scopus 로고
    • Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A
    • Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GS. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J Biol Chem 1995; 270:10377-9.
    • (1995) J Biol Chem , vol.270 , pp. 10377-10379
    • Quan, L.T.1    Caputo, A.2    Bleackley, R.C.3    Pickup, D.J.4    Salvesen, G.S.5
  • 168
    • 0030977847 scopus 로고    scopus 로고
    • Target protease specificity of the viral serpin CrmA: Analysis of five caspases
    • Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS. Target protease specificity of the viral serpin CrmA: analysis of five caspases. J Biol Chem 1997; 272:7797-800.
    • (1997) J Biol Chem , vol.272 , pp. 7797-7800
    • Zhou, Q.1    Snipas, S.2    Orth, K.3    Muzio, M.4    Dixit, V.M.5    Salvesen, G.S.6
  • 169
    • 0029808217 scopus 로고    scopus 로고
    • Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein
    • Macen JL, Garner RS, Musy PY, Brooks MA, Turner PC, Moyer RW, McFadden G, Bleackley RC. Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein. Proc Natl Acad Sci U S A 1996; 93(17):9108-13.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.17 , pp. 9108-9113
    • Macen, J.L.1    Garner, R.S.2    Musy, P.Y.3    Brooks, M.A.4    Turner, P.C.5    Moyer, R.W.6    McFadden, G.7    Bleackley, R.C.8
  • 170
    • 0028873964 scopus 로고
    • Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product
    • Tewari M, Dixit VM. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 1995; 270:3255-60.
    • (1995) J Biol Chem , vol.270 , pp. 3255-3260
    • Tewari, M.1    Dixit, V.M.2
  • 171
    • 0036095702 scopus 로고    scopus 로고
    • Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: A novel protective mechanism for tumor cells to circumvent the immune system?
    • Bladergroen BA, Meijer CJ, ten Berge RL, Hack CE, Muris JJ, Dukers DF, Chott A, Kazama Y, Oudejans JJ, van Berkum O, Kummer JA. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? Blood 2002; 99(1):232-7.
    • (2002) Blood , vol.99 , Issue.1 , pp. 232-237
    • Bladergroen, B.A.1    Meijer, C.J.2    Ten Berge, R.L.3    Hack, C.E.4    Muris, J.J.5    Dukers, D.F.6    Chott, A.7    Kazama, Y.8    Oudejans, J.J.9    Van Berkum, O.10    Kummer, J.A.11
  • 172
    • 9144247731 scopus 로고    scopus 로고
    • The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias
    • Classen CF, Ushmorov A, Bird P, Debatin KM. The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias. Haematologica 2004; 89(11):1314-21.
    • (2004) Haematologica , vol.89 , Issue.11 , pp. 1314-1321
    • Classen, C.F.1    Ushmorov, A.2    Bird, P.3    Debatin, K.M.4
  • 174
    • 0033981007 scopus 로고    scopus 로고
    • Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation
    • Jenkins D, Seth R, Kummer JA, Scott BB, Hawkey CJ, Robins RA. Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation. J Pathol 2000; 190(2):184-9.
    • (2000) J Pathol , vol.190 , Issue.2 , pp. 184-189
    • Jenkins, D.1    Seth, R.2    Kummer, J.A.3    Scott, B.B.4    Hawkey, C.J.5    Robins, R.A.6
  • 175
    • 12344299197 scopus 로고    scopus 로고
    • + T lymphocytes expressing perform and granzyme B correlates with disease activity in patients with systemic lupus erythematosus
    • + T lymphocytes expressing perform and granzyme B correlates with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 2005; 52(1):201-11.
    • (2005) Arthritis Rheum , vol.52 , Issue.1 , pp. 201-211
    • Blanco, P.1    Pitard, V.2    Viallard, J.F.3    Taupin, J.L.4    Pellegrin, J.L.5    Moreau, J.F.6
  • 176
    • 0032895417 scopus 로고    scopus 로고
    • The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)
    • Tak PP, Spaeny-Dekking L, Kraan MC, Breedveld FC, Froelich CJ, Hack CE. The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA). Clin Exp Immunol 1999; 116(2):366-70.
    • (1999) Clin Exp Immunol , vol.116 , Issue.2 , pp. 366-370
    • Tak, P.P.1    Spaeny-Dekking, L.2    Kraan, M.C.3    Breedveld, F.C.4    Froelich, C.J.5    Hack, C.E.6
  • 177
    • 0030823702 scopus 로고    scopus 로고
    • Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
    • Graubert TA, DiPersio JF, Russell JH, Ley TJ. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 1997; 100(4):904-11.
    • (1997) J Clin Invest , vol.100 , Issue.4 , pp. 904-911
    • Graubert, T.A.1    DiPersio, J.F.2    Russell, J.H.3    Ley, T.J.4
  • 178
    • 4644372395 scopus 로고    scopus 로고
    • Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: A potential mechanism for stable renal function in patients with subclinical rejection
    • Rowshani AT, Florquin S, Bemelman F, Kummer JA, Hack CE, Ten Berge IJ. Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection. Kidney Int 2004; 66(4):1417-22.
    • (2004) Kidney Int , vol.66 , Issue.4 , pp. 1417-1422
    • Rowshani, A.T.1    Florquin, S.2    Bemelman, F.3    Kummer, J.A.4    Hack, C.E.5    Ten Berge, I.J.6


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