The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites

Journal of Immunology

Volumn 166, Issue 5, 2001, Pages 3218-3225

  Bladergroen, B A ^a   Strik, M C M ^a   Bovenschen, N ^a   Van Berkum, O ^a   Scheffer, G L ^a   Meijer, C J L M ^a   Hack, C E ^a   Kummer, J A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B; MONOCLONAL ANTIBODY; SERINE PROTEINASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DEGRANULATION; DENDRITIC CELL; ENDOTHELIUM CELL; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; LYMPHOID ORGAN; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

EID: 0035284891     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.5.3218     Document Type: Article

References (27)

1. Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity
2. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin
3. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
4. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
5. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
6. Inhibition of death receptor signals by cellular FLIP
7. Expression of Fas and Fas ligand in the testes and testicular germ cell tumors: An immunohistochemical study
8. Fas ligand-induced apoptosis as a mechanism of immune privilege
9. Serpins and regulation of cell death
10. Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor α-induced apoptosis: Evidence for an alternate biological function
11. Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
12. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
13. SV40-transformed simian cells support the replication of early SV40 mutants
14. Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood
15. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors
16. Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies
17. Proteinase inhibitor 6 cannot be secreted, which suggests it is a new type of cellular serpin
18. The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G
19. Structure and function of plasminogen activator inhibitor-2: An intracellular serine proteinase inhibitor modulating apoptosis
20. Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface
21. Inhibition of neutrophil elastase by recombinant human proteinase inhibitor 9
22. Caspase-1 (interleukin-1β-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9
23. The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1β-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
24. Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway
25. Extracellular granzymes A and B in humans: Detection of native species during CTL responses in vitro and in vivo
26. Apoptosis of human endometrium mediated by perforin and granzyme B of NK cells and cytotoxic T lymphocytes
27. Expression of Fas-ligand in first trimester and term human placental villi