A novel mechanism for protein delivery: Granzyme B undergoes electrostatic exchange from serglycin to target cells

Journal of Biological Chemistry

Volumn 280, Issue 21, 2005, Pages 20752-20761

  Raja, Srikumar M ^a   Metkar, Sunil S ^a   Höning, Stefan ^c   Wang, Baikun ^a   Russin, William A ^b   Pipalia, Nina H ^e   Menaa, Cheikh ^a   Belting, Mattias ^f   Cao, Xuefang ^d   Dressel, Ralf ^c   Froelich, Christopher J ^a  

^a EVANSTON NORTHWESTERN HEALTHCARE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d USA   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOASSAY; CELLS; ELECTROSTATICS;

ELECTROSTATIC TRANSFER; GRANZYME B; MOLECULAR INTERACTION; PROTEIN DELIVERY;

PROTEINS;

CELL SURFACE PROTEIN; GLYCOSAMINOGLYCAN POLYSULFATE; GRANZYME B; PROTEOGLYCAN; SERGLYCAN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SURFACE; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME IMMOBILIZATION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TARGET CELL;

ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CHO CELLS; CRICETINAE; ELECTROSTATICS; FLOW CYTOMETRY; GLYCOSAMINOGLYCANS; GRANZYMES; HL-60 CELLS; HUMANS; JURKAT CELLS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PROTEOGLYCANS; RECEPTORS, ANTIGEN, T-CELL; SERINE ENDOPEPTIDASES; SULFATES; T-LYMPHOCYTES, CYTOTOXIC; VESICULAR TRANSPORT PROTEINS;

EID: 20144380101     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501181200     Document Type: Article

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