A role for perforin in activation-induced T cell death in vivo: Increased expansion of allogeneic perforin-deficient T cells in SCID mice

Journal of Immunology

Volumn 162, Issue 2, 1999, Pages 1192-1199

  Spaner, David ^a,b   Raju, Kaliannan ^a   Rabinovich, Brian ^a   Miller, Richard G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PERFORIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ARTICLE; CELL DEATH; CELL KILLING; COMBINED IMMUNODEFICIENCY; EFFECTOR CELL; EXOCYTOSIS; GENETIC RECOMBINATION; GRAFT VERSUS HOST REACTION; GRANULE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; T LYMPHOCYTE ACTIVATION; TARGET CELL;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD95; APOPTOSIS; CELL DIFFERENTIATION; CYTOKINES; ISOANTIGENS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE TRANSFUSION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; PORE FORMING CYTOTOXIC PROTEINS; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 0033555391     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Rocha, B., A. A. Freitas, and A. A. Coutinho. 1983. Population dynamics of T lymphocytes: renewal rate and expansion in the peripheral lymphoid organs. J. Immunol. 131:2158.
2. Ferrara, J. L., K. R. Cooke, L. Pan, and W. Krenger. 1996. The immunopathophysiology of acute graft-versus-host-disease. Stem Cells 14:473.
3. Russell, J. H. 1995. Activation-induced death of mature T cells in the regulation of immune responses. Curr. Opin. Immunol. 7:382.
4. Gruss, H. J., and S. K. Dower. 1995. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood 85:3378.
5. Shi, L., W. K. Nishioka, J. Th'ng, E. M. Bradbury, D. W. Litchfield, and A. H. Greenberg. 1994. Premature p34cdc2 activation required for apoptosis. Science 263:1143.
6. Zheng, L., G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo, 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377:348.
7. Pfeffer, K., T. Matsuyama, T. M. Kundig, A. Wakeham, K. Kishihara, A. Shahinian, K. Wiegmann, P. S. Ohashi, M. Kronke, and T. W. Mak. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73:457.
8. Spaner, D. E., K Raju, L. Radvanyi, Y. P. Lin, and R. G. Miller. 1998. A role for perforin in activation induced cell death. J. Immunol. 160:2655.
9. Kagi, D., B. Ledermann, K. Burki, R. M. Zinkernagel, and H. Hengartner. 1996. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14:207.
10. Podack, E. R. 1995. Execution and suicide: cytotoxic lymphocytes enforce draconian laws through separate molecular pathways. Curr. Opin. Immunol. 7:11.
11. Evans, C. A., P. J. Owen-Lynch, A. D. Whetton, and C. Dive. 1993. Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells. Cancer Res. 53:1735.
12. Griffiths, G. M., and Y. Argon. 1995. Structure and biogenesis of lytic granules. Curr. Top. Microbiol. Immunol. 198:39.
13. Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353:858.
14. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
15. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
16. Unkeless, J. C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580.
17. Gross, J. A., E. Callas, and J. P. Allison. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149:380.
18. Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Andersson, G. J. Gleich, and J. E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5.
19. Ware, C. F., N. J. Donato, and K. Dorshkind. 1985. Human, rat or mouse hybridomas secrete high levels of monoclonal antibodies following transplantation into mice with severe combined immunodeficiency disease (SCID). J. Immunol. Methods 85:353.
20. Karasuyama, H., N. Tohyama, and T. Tada. 1989. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J. Exp. Med. 169:13.
21. Radvanyi, L. G., G. B. Mills, and R. G. Miller. 1993. Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death. J. Immunol. 150:5704.
22. Ferrick, D. A., M. D. Schrenzel, T. Mulvania, B. Hsieh, W. G. Ferlin, and H. Lepper. 1995. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature 373:255.
23. Spaner, D. 1995. Studies on γδ-T cell activation in vivo. Doctoral Dissertation, University of Toronto, Toronto, Canada.
24. Phillips, R. A., and D. E. Spaner. 1991. The scid mouse: mutation in a DNA repair gene creates recipients useful for studies on stem cells, lymphocyte development and graft-versus-host disease. Immunol. Rev. 124:63.
25. Kyburz, D., D. E. Speiser, T. Aebischer, H. Hengartner, and R. M. Zinkernagel. 1993. Virus-specific cytotoxic T cell-mediated lysis of lymphocytes in vitro and in vivo. J. Immunol. 150:5051.
26. 9)n. J. Exp. Med. 151:1452.
27. Kundig, T. M., M. F. Bachmann, C. DiPaolo, J. J. Simard, M. Battegay, H. Lother, A. Gessner, K. Kuhlcke, P. S. Ohashi, and H. Hengartner. 1995. Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 268: 1343.
28. + T cells expressing Vβ8 TCR: a role of the Qa-I molecule. Immunity 2:185.
29. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
30. Carter, L. L., and R. W. Dutton. 1995. Relative perform- and Fas-mediated lysis in T1 and T2 CD8 effector populations. J. Immunol. 155:1028.
31. Razvi, E. S., and R. M. Welsh. 1993. Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency. J. Virol. 67:5754.
32. Katsikis, P. D., M. E. Garcia-Ojeda, E. S. Wunderlich, C. A. Smith, H. Yagita, K. Okumura, N. Kayagaki, M. Alderson, and L. A. Herzenberg. 1996. Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals. Int. Immunol. 8:1311.
33. Gougeon, M. L., and L. Montagnier. 1993. Apoptosis in AIDS [published erratum appears in Science 1993 Jun 18;260(5115):1709]. Science 260:1269.
34. Martin, S. J., C. P. Reutelingsperger, A. J. McGahon, J. A. Rader, R. C. van Schie, D. M. LaFace, and D. R. Green. 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182:1545.
35. Lynch, D. H., F. Ramsdell, and M. R. Anderson. 1995. Fas and FasL in the homeostalic regulation of immune responses. Immunol. Today 16:569.
36. Shi, Y., J. M. Glynn, L. J. Guilbert, T. G. Cotter, R. P. Bissonnette, and D. R. Green. 1992. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257:212.
37. Radvanyi, L. G., Y. Shi, H. Vaziri, A. Sharma, R. Dhala, G. B. Mills, and R. G. Miller. 1996. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. J. Immunol. 156:1788.
38. Carter, L. L., and R. W. Dutton. 1996. Type 1 and type 2: a fundamental dichotomy for all T-cell subsets. Curr. Opin. Immunol. 8:336.
39. Ko, L. J., and C. Prives. 1996. p53: puzzle and paradigm. Genes Dev. 10:1054.
40. Canman, C. E., T. M. Gilmer, S. B. Coutts, and M. B. Kastan. 1995. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev. 9:600.
41. Radvanyi, L. G., Y. Shi, G. B. Mills, and R. G. Miller. 1996. Cell cycle progression out of G1 sensitizes primary-cultured nontransformed T cells to TCR-mediated apoptosis. Cell Immunol. 170:260.
42. Mogil, R. J., L. Radvanyi, R. Gonzalez-Quintial, R. Miller, G. Mills, A. N. Theofilopoulos, and D. R. Green. 1995. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int. Immunol. 7:1451.
43. Biron, C. A., K. F. Pedersen, and R. M. Welsh. 1987. Aberrant T cells in beige mutant mice. J. Immunol. 138:2050.
44. Isaaz, S., K. Baetz, K. Olsen, E. Podack, and G. M. Griffiths. 1995. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur. J. Immunol. 25:1071.
45. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 349:245.
46. + T cells. Int. Immunol. 4:599.
47. Spaner, D., K. Migita, A. Ochi, J. Shannon, R. G. Miller, P. Pereira, S. Tonegawa, and R. A. Phillips. 1993. γδ T cells differentiate into a functional but nonproliferative state during a normal immune response. Proc. Natl. Acad. Sci. USA 90: 8415.
48. 4 integrin expression. Int. Immunol. 8:707.
49. Bosma, M. J., and A. M. Carroll. 1991. The SCID mouse mutant: definition, characterization, and potential uses. Annu. Rev. Immunol. 9:323.
50. Johnston, C. J., B. Piedboeuf, P. Rubin, J. P. Williams, R. Baggs, and J. N. Finkelstein. 1996. Early and persistent alterations in the expression of interleukin-1α, interleukin-1β and tumor necrosis factor α mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat. Res. 145:762.
51. Darzynkiewicz, Z., S. Bruno, G. Del Bino, W. Gorczyca, M. A. Hotz, P. Lassota, and F. Traganos. 1992. Features of apoptotic cells measured by flow cytometry. Cytometry 13:795.
52. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.