A role for perforin in downregulating T-cell responses during chronic viral infection

Journal of Virology

Volumn 73, Issue 3, 1999, Pages 2527-2536

  Matloubian, Mehrdad ^b   Suresh, M ^a   Glass, Alison ^b   Galvan, Marisa ^b   Chow, Kit ^b   Whitmire, Jason K ^a   Walsh, Craig M ^b   Clark, William R ^b   Ahmed, Rafi ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; PERFORIN; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CHRONIC DISEASE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; IMMUNOPATHOGENESIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION;

EID: 0032980707     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.3.2527-2536.1999     Document Type: Article

References (61)

1. Adachi, M., S. Suematsu, T. Kondo, J. Ogasawara, T. Tanaka, N. Yoshida, and S. Nagata. 1995. Targeted mutation in the Fas gene causes hyperplasia in the peripheral lymphoid organs and liver. Nat. Genet. 11:294-299.
2. Adachi, M., S. Suematsu, T. Suda, D. Watanabe, H. Fukuyama, J. Ogasawara, T. Tanaka, Y. Yoshida, and S. Nagata. 1996. Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc. Natl. Acad. Sci. USA 93:2131-2136.
3. Ahmed, R, A. Salmi,L. D. Butler, J. M. Chiller, and M. B. A. Oldslone. 1984, Selection of genetic varians of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160:521-540.
4. Asano, M. S., and R. Ahmed. 1995. Immune conflicts in lymphocytic choriomeningitis virus Springer Semin. Immunopathol. 17:247-259.
5. Berke, G. 1991. Lymphocyte-triggered internal target disintegrations. Immunol. Today 12:396-399.
6. Berke, G. 1994. The binding and lysis of target cells by cytotoxic T lymphocytes: molecular and cellular aspects. Annu. Rev. lmmunol. 12:735-773.
7. L. Immunity 3:87-98.
8. Burns, J., K. Littlefield, J. Gill, and J. Trotter. 1991. Autoantigen-induced self-lysis of human myelin protein-specific T lymphocytes, J. Neuroimmunol. 35:227-236.
9. Clark, W. R., C. M. Walsh, A. A. Glass, F. Hayashi, M. Matloubian, and R. Ahmed. 1995. Molecular pathways of CTL-mediated cytotoxicity. lmmunol. Rev. 146:33-44.
10. Cohen, P. L., and R. A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. lmmunol. 9:243-269.
11. Czerkinsky, C. C., L. A. Nilsson, H. Nygren, O. Ouchterlony, and A. Tarkowski. 1983. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J. Immunol. Methods 65:109-121.
12. Dhein, J., H. Walczak, C. Baumler, K. Debatin, and P. H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1 (Fas/CD95). Nature 343:438-441.
13. Di Virgilio, F., P. Pizzo, P. Zanovello, V. Bronte, and D. Collavo. 1990. Extracellular ATP as a possible mediator of cell-mediated cytotoxicity. Immunol. Today 11:274-276.
14. + T cell deletion. Immunity 3:321-333.
15. Dohlsten, M., M. Bjorklund, A. Sundstedt, G. Hedlund, D. Samson, and T. Kalland. 1993. Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor Vβ3 transgenic mice. Immunology 79:520-527.
16. Filipini, A., R. A. Traffs, and M. V. Sitovsky. 1990. Extracellular ATP in T-lymphocyte activation: possible role in effector functions. Proc. Natl. Acad. Sci. USA 87:8267-8271.
17. Golstein, P. 1974. Sensitivity of cytotoxic T cells to T cell-mediated cytotoxicity. Nature 252:81-83.
18. Henkart, P. A. 1996. ICE family proteases: mediators of all apoptotic death? Immunity 4:195-201.
19. Heusel, J. W., R. L. Wesselschmidt, S. Shresta, J. H. Russell, and T. J. Ley. 1994. Cytotoxic lymphocytes require Granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76:977-987.
20. + T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur. J. Immunol. 24:3068-3072.
21. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37.
22. Kagi, D., B. Ledermann, K. Burki, R. M. Zinkernagel, and H. Hengartner. 1996. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14:207-232.
23. + T lymphocytes. J. Immunol. 146:3242-3249.
24. + lymph node T cells from lpr mice generate CD4-CD8-B220+TcR-beta low cells. J. Immunol. 153:3948-3955.
25. Lenardo, M. J. 1996. Fas and the art of lymphocyte maintenance. J. Exp. Med. 183:721-724.
26. Liu, C. C., M. Steffen, F. King, and J. D. Young. 1987. Identification, isolation, and characterization of a novel cytotoxin in murine cytolytic lymphocytes. Cell 51:393-403.
27. Liu, C., C. M. Walsh, and J. D. Young. 1995. Perform: structure and function. Immunol. Today 16:194-201.
28. Los, M., M. van de Craen, L. C. Penning, H. Schenk, M. Westendorp, P. Baeuerle, W. Droge, P. H. Krammer, W. Fiers, and K. Schulze-Osthoff. 1995. Requirement of an ICE/CED-3 protease for Fas/Apo-1-mediated apoptosis. Nature 375:81-83.
29. Lynch, D. H, F. Ramsdell, and M. R. Alderson. 1995. Fas and FasL in the homeostatic regulation of immune responses. Immunol. Today 16:569-574.
30. Lynch, D. H., M. L, Watson, M. R. Alderson, P. R. Baum, R. E. Miller, T. Tough, M. Givson, T. Davis-Smith, C. A. Smith, K. Hunter, D. Bhat, W. Din, R. G. Goodwill, and M. F. Seldin. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1:131-136.
31. Maldonado, M. A., R. A. Eisenberg, E. Roper, P. L. Cohen, and B. L. Kotzen. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility coupled class I. J. Exp. Med. 181:641-648.
32. Matloubian, M., T. Somsundaram, S. R. Kohlekar, R. Selvakumar, and R. Ahmed. 1990. Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to prsist in adult mice. J. Exp. Med. 172:1043-1048.
33. + cytotoxic T-cell responses during chronic viral infection J. Virol. 68:8056-8063.
34. Matloubian, M., S. R. Kohlekar, T. Somasundaram, and R. Ahmed. 1993. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 67:7340-7349.
35. McCormack, J. E., J. E. Callahan, J. Kappler, and P. C. Marrack. 1993 Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J. Immunol. 150:3785-3792.
36. Moskophidis, D., F. Lethner, H. Pircher, and R. M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature (London) 362:758-761.
37. Nagata, S., and P. Golstein. 1995. The Fas death factor. Science 267:1449-1456.
38. Ojcius, D. M., S. Jrang, P. M. Persechini, P. A. Detmers, and J. D. Young. 1991. Cytoplasts from cytotoxic T lymphocytes are resistant to perforinmediated lysis. Mol. Immunol. 28:1011-1018.
39. Orange, J. S., T. P. Salazar-Mather, S. M. Opal, R. L. Spencer, A. H. Miller, B. S. McEwen, and C. B. Biron. 1995. Mechanism of interleukin 12-mediated toxicities during experimental viral infections. J. Exp. Med. 181:901-914.
40. Peng, S. L., J. Moslehi, M. E. Robert, and J. Croft. 1998. Perforin protects against autoimmunity in lupus-prone mice. J. Immunol. 160:652-660.
41. Rabinovitch, P. S., R. M. Torres, and D. Engel. 1986. Simultaneous cell cycle analysis and two-color surface immunofluorescence using 7-amino-actinomycin D and single laser activation: application to study of cell activation and the cell cycle of murine Ly-1 B cells. J. Immunol. 136:2769-2775.
42. Radvanyi, L. G., G. B. Mills, and R. G. Miller. 1993 Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death. J. Immunol. 150:5704-5715.
43. Riddell, S. R., and P. D. Greenberg. 1995. Principles for adoptive T cell therapy of human viral diseases. Annu. Rev. Immunol. 13:545-586.
44. Russell, J. H., B. Rush, C. Weaver, and R. Wang. 1993. Mature T cells of autoimmune Lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA 90:4409-4413.
45. + T cells limits their cytokine synthesis and proliferation. J. Exp. Med. 184:1543-1547.
46. Shen, H., M. K. Slifka, M. Matloubian, E. R. Jensen, R. Ahmed, and J. F. Miller. 1995. Recombinant Listeria monocylogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity. Proc. Natl. Acad. Sci. USA 92:3987-3991.
47. Shresta, S, J. W. Heusel, D. M. Macivor, R. L. Wesselschmidt, J. H. Russell, and T. J. Ley. 1995. Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis. Immunol. Rev. 146:211-221.
48. Singer, G. G., and A. K. Abbas. 1994. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365-371.
49. Suhrbier, A., S. R. Burrows, A. Fervan, M. F. Laven, G. D. Baxter, and D. J. Moss. 1993. Peptide epitope-induced apoptosis of human cytotoxic T lymphocytes. Implication for peripheral T cell deletion and peptide vaccination. J. Immunol. 150:2169-2178.
50. Taguchi, T., J. R. McGhee, R. L. Coffman, K. W. Beagley, J. H. Eldridge, K. Takatsu, and H. Kiyono. 1990. Detection of individual mouse spleen T cells producing IFN-γ and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J. Immunol. Methods 128:65-73.
51. Takahashi, T., M. Tanaka, C. L. Brannon, N. A. Jenkins, N. A. Copeland, T. Sude, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice caused by a point mutation in the Fas ligand. Cell 76:969-976.
52. Thompson, C. B., T. Lindsten, J. A. Ledbutler, S. L. Kunkel, H. A. Young, S. A. Emerson, J. M. Leiden, and C. H. June. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA 86:1333-1337.
53. Tian, Q., M. Streuli, H. Saito, S. F. Schlossman, and P. Anderson. 1991. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. Cell 67:629-639.
54. Tschopp, J., and M. Nabholz. 1990. Perforin-mediated target cell lysis by cytotoxic T lymphocytes. Annu. Rev. Immunol. 8:279-302.
55. Vermes, I., C. Haanen, H. Steffens-Nakken, and C. Reutelingsperger. 1995. A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein-labelled annexin V. J. Immunol. Methods 184:39-51.
56. + cytolytic T lymphocytes. Proc. Natl. Acad. Sci. USA 87:9015-9019.
57. Walsh, C. M., M. Matloubian, C. C. Liu, R. Ueda, C. G. Kurahara, J. L. Christensen, M. T. Huang, J. D. Young, R. Ahmed, and W. R. Clark. 1994. Immune function in mice lacking the perform gene. Proc. Natl. Acad. Sci. USA 91:10854-10858.
58. Watanabe-Fukanuga, R., C. I. Brannon, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that initiate apoptosis. Nature 356:314-317.
59. Wesselborg, S., O. Janssen, and D. Kabelitz. 1993. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. J. Immunol. 150:4338-4345.
60. + human cytotoxic T-cell clones. Blood 81:1527-1534.
61. Zheng, L., G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377:348-351.