New paradigm for lymphocyte granule-mediated cytotoxicity: Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis

Journal of Biological Chemistry

Volumn 271, Issue 46, 1996, Pages 29073-29079

  Froelich, Christopher J ^a,g   Orth, Kim ^b   Turbov, Jane ^a   Seth, Prem ^c   Gottlieb, Roberta ^d   Babior, Bernard ^d   Shah, Girish M ^e   Bleackley, R Christopher ^f   Dixit, Vishva M ^b   Hanna, William ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITÉ LAVAL   (Canada)

^f UNIVERSITY OF ALBERTA   (Canada)

^g EVANSTON HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; DNA FRAGMENT; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PERFORIN; SERINE PROTEINASE;

ACIDIFICATION; ADENOVIRUS; ARTICLE; BINDING SITE; CELL DEATH; CELL GRANULE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME BINDING; HUMAN; HUMAN CELL; INTERNALIZATION; LEUKEMIA CELL LINE; LYMPHOCYTE; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; TARGET CELL;

APOPTOSIS; CYTOPLASMIC GRANULES; CYTOTOXICITY, IMMUNOLOGIC; ENDOCYTOSIS; GRANZYMES; HUMANS; JURKAT CELLS; LYMPHOCYTES; SERINE ENDOPEPTIDASES;

ADENOVIRIDAE;

EID: 10544252275     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.46.29073     Document Type: Article

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