Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perforin and granzyme B mobilization by functional ERK2

Journal of Experimental Medicine

Volumn 187, Issue 11, 1998, Pages 1753-1763

  Wei, Sheng ^a   Gamero, Ana M ^a   Liu, Jin Hong ^a   Daulton, Angela A ^a   Valkov, Nichola I ^a   Trapani, Joseph A ^b   Larner, Andrew C ^c   Weber, Michael J ^d   Djeu, Julie Y ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b AUSTIN RESEARCH INSTITUTE   (Australia)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Granzyme B; Mitogen activated protein kinase; Natural killer cell; Perforin; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GRANZYME B; MITOGEN ACTIVATED PROTEIN KINASE; PERFORIN;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CELL GRANULE; CROSS LINKING; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; ENZYME REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KILLER CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TARGET CELL;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CYTOTOXICITY TESTS, IMMUNOLOGIC; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; GRANZYMES; HL-60 CELLS; HUMANS; JURKAT CELLS; KILLER CELLS, NATURAL; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; PORE FORMING CYTOTOXIC PROTEINS; SERINE ENDOPEPTIDASES; TRANSFECTION; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0032100476     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.11.1753     Document Type: Article

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