Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

Cell Death and Differentiation

Volumn 5, Issue 6, 1998, Pages 488-496

  Trapani, Joseph A ^a   Jans, Patricia ^b   Smyth, Mark J ^a   Froelich, Christopher J ^c   Williams, Elizabeth A ^d   Sutton, Vivien R ^a   Jans, David A ^b,e  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

^b Biology and Environment   (Australia)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Caspases; Cytolytic lymphocyte; Granzyme; Nuclear localization; Perforin

Indexed keywords

AZURIN; CYCLIN DEPENDENT KINASE; DEXTRAN; DNA FRAGMENT; FLUORESCEIN ISOTHIOCYANATE; GRANZYME B; PERFORIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DNA CLEAVAGE; LASER MICROSCOPY; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0031847334     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400373     Document Type: Article

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