-
1
-
-
0036595397
-
Cytotoxic T lymphocytes: All roads lead to death
-
Barry, M., and R.C. Bleackley. 2002. Cytotoxic T lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2:401-409.
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 401-409
-
-
Barry, M.1
Bleackley, R.C.2
-
2
-
-
0034107096
-
Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid
-
Barry, M., J.A. Heibein, M.J. Pinkoski, S.F. Lee, R.W. Moyer, D.R. Green, and R.C. Bleackley. 2000. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. Mol. Cell Biol. 20:3781-3794.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 3781-3794
-
-
Barry, M.1
Heibein, J.A.2
Pinkoski, M.J.3
Lee, S.F.4
Moyer, R.W.5
Green, D.R.6
Bleackley, R.C.7
-
3
-
-
0032516910
-
The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor
-
Blanchard, F., S. Raher, L. Duplomb, P. Vusio, V. Pitard, J.L. Taupin, J.F. Moreau, B. Hoflack, S. Minvielle, Y. Jacques, and A. Godard. 1998. The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor. J. Biol. Chem. 273:20886-20893.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 20886-20893
-
-
Blanchard, F.1
Raher, S.2
Duplomb, L.3
Vusio, P.4
Pitard, V.5
Taupin, J.L.6
Moreau, J.F.7
Hoflack, B.8
Minvielle, S.9
Jacques, Y.10
Godard, A.11
-
4
-
-
0033499729
-
Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin
-
Browne, K.A., E. Blink, V.R. Surron, C.J. Froelich, D.A. Jans, and J.A. Trapani. 1999. Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol. Cell Biol. 19:8604-8615.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 8604-8615
-
-
Browne, K.A.1
Blink, E.2
Surron, V.R.3
Froelich, C.J.4
Jans, D.A.5
Trapani, J.A.6
-
5
-
-
0030716258
-
Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas
-
Chappell, S.A., T. Walsh, R.A. Walker, and J.A. Shaw. 1997. Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas. Br. J. Cancer. 76:1558-1561.
-
(1997)
Br. J. Cancer
, vol.76
, pp. 1558-1561
-
-
Chappell, S.A.1
Walsh, T.2
Walker, R.A.3
Shaw, J.A.4
-
6
-
-
0028036513
-
Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
-
Damke, H., T. Baba, D.E. Warnock, and S.L. Schmid. 1994. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J. Cell Biol. 127:915-934.
-
(1994)
J. Cell Biol.
, vol.127
, pp. 915-934
-
-
Damke, H.1
Baba, T.2
Warnock, D.E.3
Schmid, S.L.4
-
7
-
-
0029134736
-
Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin
-
Damke, H., T. Baba, A.M. van der Bliek, and S.L. Schmid. 1995. Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J. Cell Biol. 131:69-80.
-
(1995)
J. Cell Biol.
, vol.131
, pp. 69-80
-
-
Damke, H.1
Baba, T.2
Van Der Bliek, A.M.3
Schmid, S.L.4
-
8
-
-
0028804071
-
M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
-
De Souza, A.T., G.R. Hankins, M.K. Washington, T.C. Orton, and R.L. Jirtle. 1995. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat. Genet. 11:447-449.
-
(1995)
Nat. Genet.
, vol.11
, pp. 447-449
-
-
De Souza, A.T.1
Hankins, G.R.2
Washington, M.K.3
Orton, T.C.4
Jirtle, R.L.5
-
9
-
-
10544252275
-
New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
-
Froelich, C.J., K. Orth, J. Turbov, P. Seth, R. Gottlieb, B. Babior, G.M. Shah, R.C. Bleackley, V.M. Dixit, and W. Hanna. 1996. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J. Biol. Chem. 271:29073-29079.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 29073-29079
-
-
Froelich, C.J.1
Orth, K.2
Turbov, J.3
Seth, P.4
Gottlieb, R.5
Babior, B.6
Shah, G.M.7
Bleackley, R.C.8
Dixit, V.M.9
Hanna, W.10
-
10
-
-
0027452741
-
Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor
-
Griffiths, G.M., and S. Isaaz. 1993. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. J. Cell Biol. 120:885-896.
-
(1993)
J. Cell Biol.
, vol.120
, pp. 885-896
-
-
Griffiths, G.M.1
Isaaz, S.2
-
11
-
-
0034694083
-
Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax
-
Heibein, J.A., I.S. Goping, M. Barry, M.J. Pinkoski, G.C. Shore, D.R. Green, and R.C. Bleackley. 2000. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. J. Exp. Med. 192:1391-1402.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1391-1402
-
-
Heibein, J.A.1
Goping, I.S.2
Barry, M.3
Pinkoski, M.J.4
Shore, G.C.5
Green, D.R.6
Bleackley, R.C.7
-
12
-
-
0028258577
-
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
-
Heusel, J.W., R.L. Wesselschmidt, S. Shresta, J.H. Russell, and T.J. Ley. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 76:977-987.
-
(1994)
Cell
, vol.76
, pp. 977-987
-
-
Heusel, J.W.1
Wesselschmidt, R.L.2
Shresta, S.3
Russell, J.H.4
Ley, T.J.5
-
13
-
-
0028802362
-
The regulation of protein transport to the nucleus by phosphorylation
-
Jans, D.A. 1995. The regulation of protein transport to the nucleus by phosphorylation. Biochem. J. 311:705-716.
-
(1995)
Biochem. J.
, vol.311
, pp. 705-716
-
-
Jans, D.A.1
-
14
-
-
0029844220
-
Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro
-
Jans, D.A., P. Jans, L.J. Briggs, V. Sutton, and J.A. Trapani. 1996. Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro. J. Biol. Chem. 271:30781-30789.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 30781-30789
-
-
Jans, D.A.1
Jans, P.2
Briggs, L.J.3
Sutton, V.4
Trapani, J.A.5
-
15
-
-
0024592869
-
Interactions of recombinant and platelet transforming growth factor-beta 1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor
-
Kovacina, K.S., G. Steele-Perkins, A.F. Purchio, M. Lioubin, K. Miyazono, C.H. Heldin, and R.A. Roth. 1989. Interactions of recombinant and platelet transforming growth factor-beta 1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor. Biochem. Biophys. Res. Commun. 160:393-403.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.160
, pp. 393-403
-
-
Kovacina, K.S.1
Steele-Perkins, G.2
Purchio, A.F.3
Lioubin, M.4
Miyazono, K.5
Heldin, C.H.6
Roth, R.A.7
-
16
-
-
0026329715
-
Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma
-
Morita, R., S. Saito, J. Ishikawa, O. Ogawa, O. Yoshida, K. Yamakawa, and Y. Nakamura. 1991. Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma. Cancer Res. 51:5817-5820.
-
(1991)
Cancer Res.
, vol.51
, pp. 5817-5820
-
-
Morita, R.1
Saito, S.2
Ishikawa, J.3
Ogawa, O.4
Yoshida, O.5
Yamakawa, K.6
Nakamura, Y.7
-
17
-
-
0034721646
-
Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
-
Motyka, B., G. Korbutt, M.J. Pinkoski, J.A. Heibein, A. Caputo, M. Hobman, M. Barry, I. Shostak, T. Sawchuk, C.F. Holmes, et al. 2000. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell. 103:491-500.
-
(2000)
Cell
, vol.103
, pp. 491-500
-
-
Motyka, B.1
Korbutt, G.2
Pinkoski, M.J.3
Heibein, J.A.4
Caputo, A.5
Hobman, M.6
Barry, M.7
Shostak, I.8
Sawchuk, T.9
Holmes, C.F.10
-
18
-
-
0033598718
-
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
-
Mullbacher, A., P. Waring, R. Tha Hla, T. Tran, S. Chin, T. Stehle, C. Museteanu, and M.M. Simon. 1999. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. USA. 96:13950-13955.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13950-13955
-
-
Mullbacher, A.1
Waring, P.2
Tha Hla, R.3
Tran, T.4
Chin, S.5
Stehle, T.6
Museteanu, C.7
Simon, M.M.8
-
19
-
-
0025240143
-
Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells
-
Nolan, C.M., J.W. Kyle, H. Watanabe, and W.S. Sly. 1990. Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells. Cell Regul. 1:197-213.
-
(1990)
Cell Regul.
, vol.1
, pp. 197-213
-
-
Nolan, C.M.1
Kyle, J.W.2
Watanabe, H.3
Sly, W.S.4
-
20
-
-
0025971396
-
Human and murine cytotoxic T lymphocyte serine proteases: Subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
-
Odake, S., C.M. Kam, L. Narasimhan, M. Poe, J.T. Blake, O. Krahenbuhl, J. Tschopp, and J.C. Powers. 1991. Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry. 30:2217-2227.
-
(1991)
Biochemistry
, vol.30
, pp. 2217-2227
-
-
Odake, S.1
Kam, C.M.2
Narasimhan, L.3
Poe, M.4
Blake, J.T.5
Krahenbuhl, O.6
Tschopp, J.7
Powers, J.C.8
-
21
-
-
0022982169
-
The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand
-
Oka, Y., and M.P. Czech. 1986. The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand. J. Biol. Chem. 261:9090-9093.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 9090-9093
-
-
Oka, Y.1
Czech, M.P.2
-
22
-
-
0025258892
-
Clarhrin, adaptors, and sorting
-
Pearse, B.M., and M.S. Robinson. 1990. Clarhrin, adaptors, and sorting. Annu. Rev. Cell Biol. 6:151-171.
-
(1990)
Annu. Rev. Cell Biol.
, vol.6
, pp. 151-171
-
-
Pearse, B.M.1
Robinson, M.S.2
-
23
-
-
0032147225
-
Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis
-
Pinkoski, M.J., M. Hobman, J.A. Heibein, K. Tomaselli, F. Li, P. Seth, C.J. Froelich, and R.C. Bleackley. 1998. Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 92:1044-1054.
-
(1998)
Blood
, vol.92
, pp. 1044-1054
-
-
Pinkoski, M.J.1
Hobman, M.2
Heibein, J.A.3
Tomaselli, K.4
Li, F.5
Seth, P.6
Froelich, C.J.7
Bleackley, R.C.8
-
24
-
-
0026532606
-
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
-
Shi, L., R.P. Kraut, R. Aebersold, and A.H. Greenberg. 1992. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175:553-566.
-
(1992)
J. Exp. Med.
, vol.175
, pp. 553-566
-
-
Shi, L.1
Kraut, R.P.2
Aebersold, R.3
Greenberg, A.H.4
-
25
-
-
0030892138
-
Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization
-
Shi, L., S. Mai, S. Israels, K. Browne, J.A. Trapani, and A.H. Greenberg. 1997. Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization. J. Exp. Med. 185:855-866.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 855-866
-
-
Shi, L.1
Mai, S.2
Israels, S.3
Browne, K.4
Trapani, J.A.5
Greenberg, A.H.6
-
26
-
-
0031570536
-
Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes
-
Sutton, V.R., D.L. Vaux, and J.A. Trapani. 1997. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J. Immunol. 158:5783-5790.
-
(1997)
J. Immunol.
, vol.158
, pp. 5783-5790
-
-
Sutton, V.R.1
Vaux, D.L.2
Trapani, J.A.3
-
27
-
-
0034694091
-
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
-
Sutton, V.R., J.E. Davis, M. Cancilla, R.W. Johnstone, A.A. Ruefli, K. Sedelies, K.A. Browne, and J.A. Trapani. 2000. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J. Exp. Med. 192:1403-1414.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1403-1414
-
-
Sutton, V.R.1
Davis, J.E.2
Cancilla, M.3
Johnstone, R.W.4
Ruefli, A.A.5
Sedelies, K.6
Browne, K.A.7
Trapani, J.A.8
-
28
-
-
0033673428
-
DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis
-
Thomas, D.A., C. Du, M. Xu, X. Wang, and T.J. Ley. 2000. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity. 12:621-632.
-
(2000)
Immunity
, vol.12
, pp. 621-632
-
-
Thomas, D.A.1
Du, C.2
Xu, M.3
Wang, X.4
Ley, T.J.5
-
29
-
-
0035910057
-
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
-
Thomas, D.A., L. Scorrano, G.V. Putcha, S.J. Korsmeyer, and T.J. Ley. 2001. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proc. Natl. Acad. Sci. USA. 98:14985-14990.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14985-14990
-
-
Thomas, D.A.1
Scorrano, L.2
Putcha, G.V.3
Korsmeyer, S.J.4
Ley, T.J.5
-
30
-
-
0036779576
-
Functional significance of the perforin/granzyme cell death pathway
-
Trapani, J.A., and M.J. Smyth. 2002. Functional significance of the perforin/ granzyme cell death pathway. Nat. Rev. Imunol. 2:735-747.
-
(2002)
Nat. Rev. Imunol.
, vol.2
, pp. 735-747
-
-
Trapani, J.A.1
Smyth, M.J.2
-
31
-
-
0027166202
-
Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody
-
Trapani, J.A., K.A. Browne, M. Dawson, and M.J. Smyth. 1993. Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody. Biochem. Biophys. Res. Commun. 195:910-920.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.195
, pp. 910-920
-
-
Trapani, J.A.1
Browne, K.A.2
Dawson, M.3
Smyth, M.J.4
-
32
-
-
0030044052
-
Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis
-
Trapani, J.A., K.A. Browne, M.J. Smyth, and D.A. Jans. 1996. Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis. J. Biol. Chem. 271:4127-4133.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4127-4133
-
-
Trapani, J.A.1
Browne, K.A.2
Smyth, M.J.3
Jans, D.A.4
-
33
-
-
0032561352
-
Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent
-
Trapani, J.A., D.A. Jans, P.J. Jans, M.J. Smyth, K.A. Browne, and V.R. Sutton. 1998. Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J. Biol. Chem. 273:27934-27938.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27934-27938
-
-
Trapani, J.A.1
Jans, D.A.2
Jans, P.J.3
Smyth, M.J.4
Browne, K.A.5
Sutton, V.R.6
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