The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)

Clinical and Experimental Immunology

Volumn 116, Issue 2, 1999, Pages 366-370

  Tak, Paul P ^e   Spaeny Dekking, L ^a,b   Kraan, M C ^f   Breedveld, F C ^f   Froelich, C J ^d   Hack, C E ^a,c  

^a CENTRAL LABORATORY   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d NORTHWESTERN UNIVERSITY   (United States)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f NONE

Author keywords

Cytotoxic cells; Granzymes; Osteoarthritis; Reactive arthritis; Rheumatoid arthritis

Indexed keywords

GRANZYME A; GRANZYME B;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

ADULT; AGED; ARTHRITIS, RHEUMATOID; FEMALE; GRANZYMES; HUMANS; MALE; MIDDLE AGED; SERINE ENDOPEPTIDASES; SYNOVIAL FLUID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032895417     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00881.x     Document Type: Article

References (39)

1. 1 Tak PP, Smeets TJM, Daha MR et al. Analysis of the synovial cellular infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum 1997; 40:217-25.
2. 2 Tak PP, Kummer JA, Hack CE et al. Granzyme positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue. Arthritis Rheum 1994; 37:1735-43.
3. 3 Griffiths GM, Isaaz S. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. J Cell Biol 1993; 120:885-96.
4. 4 Froelich CJ, Dixit VM, Yang XH, Yang X. Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today 1998; 19:30-36.
5. 5 Liu CC, Young LHY, Young JDE. Mechanisms of disease: lymphocyte-mediated cytolysis and disease. N Engl J Med 1996; 335:1651-9.
6. 6 Kummer JA, Tak PP, Brinkman B et al. Expression of granzymes A and B in synovial tissue from patients with rheumatoid arthritis and osteoarthritis. Clin Immunol Immunopathol 1994; 73:88-95.
7. 7 Muller-Ladner U, Kriegsmann J, Tschopp J, Gay RE, Gay S. Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis. Arthritis Rheum 1995; 38:477-84.
8. 8 Smeets TJM, Dolhain RJEM, Breedveld FC, Tak PP. Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis. J Pathol 1998; 186:75-81.
9. 9 Griffiths GM, Alpert S, Lambert E, McGuire J, Weissman IL. Perforin and granzyme A expression identifying cytolytic lymphocytes in rheumatoid arthritis. Proc Natl Acad Sci USA 1992; 89:549-53.
10. 10 Young LH, Joag SV, Lin PY et al. Expression of cytolytic mediators by synovial fluid lymphocytes in rheumatoid arthritis. Am J Pathol 1992; 140:1261-8.
11. 11 Takayama H, Trenn G, Humphrey W Jr, Bluestone JA, Henkart PA, Sitkovsky MV. Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes. J Immunol 1987; 138:566-9.
12. 12 Spaeny-Dekking EHA, Hanna WL, Wolbink AM et al. Extracellular granzymes A and B in man: detection of native species during CTL responses in vitro and in vivo. J Immunol 1998; 160:3610-6.
13. 13 Sower I.E, Froelich CJ, Allegretto N, Rose PM, Hanna WD, Klimpel GR. Extracellular activities of human granzyme A - monocyte activation by granzyme A versus alpha-thrombin. J Immunol 1996; 156:2585-90.
14. 14 Sower LE, Klimpel GR, Hanna W, Froelich CJ. Extracellular activities of human granzymes. I. Granzyme A induces IL-6 and IL-8 production in fibroblast and epithelial cell lines. Cell Immunol 1996; 171:159-63.
15. 15 Simon MM, Simon HG, Fruth U, Epplen J, Muller-Hermelink HK, Kramer MD. Cloned cytolytic T-effector cells and their malignant variants produce an extracellular matrix degrading trypsin-like proteinase. Immunol 1987; 60:219-30.
16. 16 Froelich CJ, Zhang X, Turbov J, Hudig D, Winkler U, Hanna WL. Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes. J Immunol 1993; 151:7161-71.
17. 17 Ronday HK, Tak PP, Bank R et al. Granzyme B degrades cartilage matrix in vitro and is present at the pannus-cartilage junction. Arthritis Rheum 1997; 40:S75.
18. 18 Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31:315-24.
19. 19 Altman R, Asch ES, Bloch DA et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Arthritis Rheum 1986; 29:1039-49.
20. 20 Heesemann J, Eggers C, Schroder J. Serological diagnosis of yersiniosis by immunoblot technique using virulence-associated antigen of enteropathogenic Yersiniae. Contrib Microbiol Immunol 1987; 9:285-9.
21. 21 Tak PP, Visser LG, Hoogkamp Korstanje JA et al. Unusual manifestations of Yersinia enterocolitica infections diagnosed using novel methods. Clin Infect Dis 1992; 15:645-9.
22. 22 Ritchie DM, Boyle JA, McInnes JM et al. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med 1968; 37:303-406.
23. 23 Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 1997; 24:365-71.
24. 24 Mullbacher A, Ebnet K, Blanden RV et al. Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc Natl Acad Sci USA 1996; 93:5783-7.
25. 25 Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 1994; 76:977-87.
26. 26 Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid arthritis synovium. J Clin Invest 1995; 96:1631-8.
27. 27 Tak PP, Firestein GS. Apoptosis in rheumatoid arthritis. In: Winkler JD, ed. Apoptosis and inflammation Basel: Birkhäuser Publishing Ltd, 1999: in press.
28. 28 Firestein GS, Echeverri F, Yeo M, Zvainer NJ, Green DR. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc Natl Acad Sci USA 1997; 94:10895-900.
29. 29 Berke G. The Fas-based mechanism of lymphocytotoxicity. Hum Immunol 1997; 54:1-7.
30. 30 Talanian RV, Yang XH, Turbov J et al. Granule-mediated killing: pathways tor granzyme B-initiated apoptosis. J Exp Med 1997; 186:1323-31.
31. 31 Medema JP, Toes REM, Scaffidi C et al. Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis. Eur J Immunol 1997; 27:3492-8.
32. 32 Peng SL, Moslehi J, Robert ME, Craft J. Perforin protects against autoimmunity in lupus-prone mice. J Immunol 1998; 160:652-60.
33. 33 Isaaz S, Baetz K, Olsen K, Podack E, Griffiths GM. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, refilling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur J Immunol 1995; 25:1071-9.
34. 34 Simon MM, Kramer MD, Prester M, Gay S. Mouse T-cell associated serine proteinase I degrades collagen type IV: a structural basis for the migration of lymphocytes through vascular basement membranes. Immunol 1991; 73:117-9.
35. 35 Chu CQ, Field M, Allard S, Abney E, Feldmann M, Maini RN. Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair. Br J Rheumatol 1992; 31:653-61.
36. 36 Rathanaswami P, Hachicha M, Wong WL, Schall TJ, McColl SR. Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on interleukin-8 gene expression in synovial fibroblasts. Evidence that interleukin-8 is the major neutrophil-activating chemokine released in response to monokine activation. Arthritis Rheum 1993; 36:1295-304.
37. 37 Koch AE, Kunkel SL, Stricter RM. Cytokines in rheumatoid arthritis. J Invest Med 1995; 43:28-38.
38. 38 Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996; 14:397-440.
39. 39 Ebnet K, Hausmann M, Lehmann-Grube F et al. Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J 1995; 14:4230-9.