B cells acquire antigen from target cells after synapse formation

Nature

Volumn 411, Issue 6836, 2001, Pages 489-494

  Batista, F D ^a   Iber, D ^a   Neuberger, M S ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOLOGICAL MEMBRANES; ENZYMES;

SOLUBLE ANTIGENS;

CELLS;

CD45 ANTIGEN; EPITOPE; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL INTERACTION; CONTROLLED STUDY; DOWN REGULATION; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; SYNAPSE; T LYMPHOCYTE; TARGET CELL;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, SURFACE; B-LYMPHOCYTES; CELL COMMUNICATION; CELL LINE; ENDOCYTOSIS; HUMANS; MICE; MICE, TRANSGENIC; MURAMIDASE; RECEPTORS, ANTIGEN, B-CELL;

ANIMALIA;

EID: 0035942781     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35078099     Document Type: Article

References (30)

1. Antigen-specific interaction between T and B cells
2. The follicular dendritic cell: Its role in antigen presentation in the generation of immunological memory
3. Follicular dendritic cells as accessory cells
4. Follicular dendritic cells help resting B cells to become effective antigen-presenting cells: Induction of B7/BB1 and upregulation of major histocompatibility complex class II molecules
5. Monomeric and oligomeric complexes of the B cell antigen receptor
6. Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody
7. Capping and the lymphocyte: Models for membrane reorganisation
8. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting
9. Entry of B cell receptor into signaling domains is inhibited in tolerant B cells
10. Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
11. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
12. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
13. Low affinity interaction of human and rat T cell adhesion molecule CD2 with its ligands aligns adhering membranes to achieve high physiological affinity
14. B cells are exquisitely sensitive to central tolerance and receptor editing by ultralow affinity, membrane-bound antigen
15. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
16. Three-dimensional segregation of supramolecular activation clusters in T cells
17. A receptor/cytoskeletal movement triggered by costimulation during T cell activation
18. The immunological synapse: A molecular machine controlling T cell activation
19. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
20. The bride of sevenless and sevenless interaction: Internalization of a transmembrane ligand
21. TCR-mediated internalization of peptide-MHC complexes acquired by T cells
22. T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells
23. B cells extract and present immobilized antigen: Implications for affinity discrimination
24. Anti-immunoglobulin augments the B-cell antigen-presentation function independently of internalization of receptor-antigen complex
25. Signals from the B lymphocyte antigen receptor regulate MHC class II containing late endosomes
26. Efficient presentation of multivalent antigens targeted to various cell surface molecules of dendritic cells and surface Ig of antigen-specific B cells
27. Transformation of growth factor-dependent myeloid stem cells with retroviral vectors carrying c-myc
28. Peripheral deletion of self-reactive B cells
29. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
30. Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: Importance depends on the nature of the antigen-antibody interaction