The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes

Journal of Biological Chemistry

Volumn 274, Issue 43, 1999, Pages 30468-30473

  Edwards, Kirsten M ^a   Kam, Chih Min ^b   Powers, James C ^b   Trapani, Joseph A ^a  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN; GRANZYME H; SERINE PROTEINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CYTOKINE RELEASE; CYTOPLASM VESICLE; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN TRANSPORT; TARGET CELL;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHYMASES; CHYMOTRYPSIN; CYTOPLASMIC GRANULES; ENDOSOMES; GRANZYMES; HUMANS; JURKAT CELLS; OLIGOPEPTIDES; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SPODOPTERA; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0042377711     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.43.30468     Document Type: Article

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