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Volumn 185, Issue 5, 1997, Pages 855-866

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B; PERFORIN;

EID: 0030892138     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.5.855     Document Type: Article
Times cited : (202)

References (43)
  • 2
    • 0027937745 scopus 로고
    • Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
    • Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature (Lond.). 370:650-652.
    • (1994) Nature (Lond.) , vol.370 , pp. 650-652
    • Lowin, B.1    Hahne, M.2    Mattmann, C.3    Tschopp, J.4
  • 6
    • 0026474805 scopus 로고
    • Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinctsubstrate and target cell interactions
    • Shi, L., C.M. Kam, J.C. Powers, R. Aebersold, and A.H. Greenberg. 1992. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinctsubstrate and target cell interactions. J. Exp. Med. 176: 1521-1529.
    • (1992) J. Exp. Med. , vol.176 , pp. 1521-1529
    • Shi, L.1    Kam, C.M.2    Powers, J.C.3    Aebersold, R.4    Greenberg, A.H.5
  • 7
    • 0026532606 scopus 로고
    • A natural killer cell granule protein that induces DNA fragmentation and apoptosis
    • Shi, L., R.P. Kraut, R. Aebersold, and A.H. Greenberg. 1992. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175:553-566.
    • (1992) J. Exp. Med. , vol.175 , pp. 553-566
    • Shi, L.1    Kraut, R.P.2    Aebersold, R.3    Greenberg, A.H.4
  • 8
    • 0028967988 scopus 로고
    • Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin
    • Nakajima, H., H.L. Park, and P.A. Henkart. 1995. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J. Exp. Med. 181:1037-1046.
    • (1995) J. Exp. Med. , vol.181 , pp. 1037-1046
    • Nakajima, H.1    Park, H.L.2    Henkart, P.A.3
  • 9
    • 0028258577 scopus 로고
    • Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis inallogeneic target cells
    • Heusel, J.W., R.L. Wesselschmidt, S. Shresta, J. H. Russell, and T.J. Ley. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis inallogeneic target cells. Cell. 76:977-987.
    • (1994) Cell , vol.76 , pp. 977-987
    • Heusel, J.W.1    Wesselschmidt, R.L.2    Shresta, S.3    Russell, J.H.4    Ley, T.J.5
  • 10
    • 0022444350 scopus 로고
    • The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: Structural, immunological and functional similarities
    • Young, J.D.-E., Z.A. Cohn, and E.R. Podack. 1986. The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological and functional similarities. Science (Wash. DC). 233: 184-190.
    • (1986) Science (Wash. DC) , vol.233 , pp. 184-190
    • Young, J.D.-E.1    Cohn, Z.A.2    Podack, E.R.3
  • 13
    • 0025962661 scopus 로고
    • Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity
    • Poe, M., J.T. Blake, D.A. Boulton, M. Gammon, N.H. Sigal, J.K. Wu, and H.J. Zweerink. 1991. Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. J. Biol. Chem. 266:98-103.
    • (1991) J. Biol. Chem. , vol.266 , pp. 98-103
    • Poe, M.1    Blake, J.T.2    Boulton, D.A.3    Gammon, M.4    Sigal, N.H.5    Wu, J.K.6    Zweerink, H.J.7
  • 14
    • 0029125701 scopus 로고
    • Protease activation during apoptosis: Death by a thousand cuts?
    • Martin, S.J., and D.R. Green. 1995. Protease activation during apoptosis: death by a thousand cuts?. Cell. 82:349-352.
    • (1995) Cell , vol.82 , pp. 349-352
    • Martin, S.J.1    Green, D.R.2
  • 16
    • 0029099845 scopus 로고
    • Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
    • Darmon, A.J., D.W. Nicholson, and R.C. Bleackley. 1995. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature (Lond.). 377:446-448.
    • (1995) Nature (Lond.) , vol.377 , pp. 446-448
    • Darmon, A.J.1    Nicholson, D.W.2    Bleackley, R.C.3
  • 20
    • 0030011398 scopus 로고    scopus 로고
    • Involvement of MACH, a novel MORT1/ FADD-interacting protease, in Fas/APO-1- And TNF receptor-induced cell death
    • Boldin, M.P., T.M. Goncharov, Y.V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/ FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 85:803-815.
    • (1996) Cell , vol.85 , pp. 803-815
    • Boldin, M.P.1    Goncharov, T.M.2    Goltsev, Y.V.3    Wallach, D.4
  • 22
    • 0030008812 scopus 로고    scopus 로고
    • ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B
    • Duan, H.J., K. Orth, A.M. Chinnaiyan, G.G. Poirier, C.J. Froelich, W.W. He, and V.M. Dixit. 1996. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271: 16720-16724.
    • (1996) J. Biol. Chem. , vol.271 , pp. 16720-16724
    • Duan, H.J.1    Orth, K.2    Chinnaiyan, A.M.3    Poirier, G.G.4    Froelich, C.J.5    He, W.W.6    Dixit, V.M.7
  • 23
    • 8044237448 scopus 로고    scopus 로고
    • Identification and characterization of ICH-3, a member of the ICE/Ced-3 family and an upstream regulator of ICE
    • Wang, W., M. Miura, Y.-K. Jung, H. Ahu, V. Gagliardini, L. Shi, A.H. Greenberg, and J. Yuan. 1996. Identification and characterization of ICH-3, a member of the ICE/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 271:5112-5117.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5112-5117
    • Wang, W.1    Miura, M.2    Jung, Y.-K.3    Ahu, H.4    Gagliardini, V.5    Shi, L.6    Greenberg, A.H.7    Yuan, J.8
  • 26
    • 0028984948 scopus 로고
    • Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
    • Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld et al. 1995. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell. 80:401-411.
    • (1995) Cell , vol.80 , pp. 401-411
    • Li, P.1    Allen, H.2    Banerjee, S.3    Franklin, S.4    Herzog, L.5    Johnston, C.6    McDowell, J.7    Paskind, M.8    Rodman, L.9    Salfeld, J.10
  • 27
    • 0030044052 scopus 로고    scopus 로고
    • Localization of granzyme B in the nucleus - A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis
    • Trapani, J.A., K.A. Browne, M.J. Smyth, and D.A. Jans. 1996. Localization of granzyme B in the nucleus - A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis. Biol. Chem. 271:4127-4133.
    • (1996) Biol. Chem. , vol.271 , pp. 4127-4133
    • Trapani, J.A.1    Browne, K.A.2    Smyth, M.J.3    Jans, D.A.4
  • 28
    • 0027166202 scopus 로고
    • Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody
    • Trapani, J.A., K.A. Browne, M. Dawson, and M.J. Smyth. 1993. Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody. Biochem. Biophys. Res. Commun. 195:910-920.
    • (1993) Biochem. Biophys. Res. Commun. , vol.195 , pp. 910-920
    • Trapani, J.A.1    Browne, K.A.2    Dawson, M.3    Smyth, M.J.4
  • 29
    • 0018891631 scopus 로고
    • Mechanism of action of cytochasin B on actin
    • MacLean-Fletcher, S., and T. D. Pollard. 1980. Mechanism of action of cytochasin B on actin. Cell. 20:329-341.
    • (1980) Cell , vol.20 , pp. 329-341
    • MacLean-Fletcher, S.1    Pollard, T.D.2
  • 30
    • 0022308091 scopus 로고
    • Mechanism of lymphocyte-mediated cytotoxicity
    • Henkart, P.A. 1985. Mechanism of lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 3:31-58.
    • (1985) Annu. Rev. Immunol. , vol.3 , pp. 31-58
    • Henkart, P.A.1
  • 31
    • 0025230476 scopus 로고
    • Pertbrin-mediated target cell lysis by cytolytic T lymphocytes
    • Tschopp, J., and M. Nabholz. 1990. Pertbrin-mediated target cell lysis by cytolytic T lymphocytes. Annu. Rev. Immunol. 8: 279-302.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 279-302
    • Tschopp, J.1    Nabholz, M.2
  • 32
    • 0024567524 scopus 로고
    • Structure and function of the family of proteoglycans that reside in the secretory granzules of natural killer cells and othr effector cells of the immune system
    • Stevens, R.L., M.M. Kamada, and W.E. Serafin. 1989. Structure and function of the family of proteoglycans that reside in the secretory granzules of natural killer cells and othr effector cells of the immune system. Curr. Topics Microbiol. Immunol. 140:93-108.
    • (1989) Curr. Topics Microbiol. Immunol. , vol.140 , pp. 93-108
    • Stevens, R.L.1    Kamada, M.M.2    Serafin, W.E.3
  • 34
    • 0029890823 scopus 로고    scopus 로고
    • Apopain/CPP32 cleaves proteins that are essential for cellular repair: A fundamental principle of apoptotic death
    • Casciola-Rosen, L., D.W. Nicholson, T. Chong, K.R. Rowan, N.A. Thornberry, D.K. Miller, and A. Rosen. 1996. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J. Exp. Med. 183:1957-1964.
    • (1996) J. Exp. Med. , vol.183 , pp. 1957-1964
    • Casciola-Rosen, L.1    Nicholson, D.W.2    Chong, T.3    Rowan, K.R.4    Thornberry, N.A.5    Miller, D.K.6    Rosen, A.7
  • 35
    • 0028938366 scopus 로고
    • The target cell nucleus is not required for cell-mediated granzyme or Fas-based cytoroxidty
    • Nakajima, H., P. Golstein, and P.A. Henkart. 1995. The target cell nucleus is not required for cell-mediated granzyme or Fas-based cytoroxidty. J. Exp. Med. 181:1905-1909.
    • (1995) J. Exp. Med. , vol.181 , pp. 1905-1909
    • Nakajima, H.1    Golstein, P.2    Henkart, P.A.3
  • 36
    • 0029066661 scopus 로고
    • Expression of recombinant human granzymc B: A processing and activation role for dipeptidyl peptidase I
    • Smyth, M.J., M.J. McGuire, and K.Y.T. Thia. 1995. Expression of recombinant human granzymc B: A processing and activation role for dipeptidyl peptidase I. J. Immunol. 154: 6299-6305.
    • (1995) J. Immunol. , vol.154 , pp. 6299-6305
    • Smyth, M.J.1    McGuire, M.J.2    Thia, K.Y.T.3
  • 37
    • 0028955325 scopus 로고
    • Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A
    • Quan, L.T., A. Caputo, R.C. Bleackley, D.J. Pickup, and G.S. Salvesen. 1995. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J. Biol. Chem. 270: 10377-10379.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10377-10379
    • Quan, L.T.1    Caputo, A.2    Bleackley, R.C.3    Pickup, D.J.4    Salvesen, G.S.5
  • 38
    • 0021183979 scopus 로고
    • Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors
    • Henkart, P.A., P.J. Millard, C.W. Reynolds, and M.P. Henkart. 1984. Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors. J. Exp. Med. 160:75-93.
    • (1984) J. Exp. Med. , vol.160 , pp. 75-93
    • Henkart, P.A.1    Millard, P.J.2    Reynolds, C.W.3    Henkart, M.P.4
  • 39
    • 0021270576 scopus 로고
    • Cytolytic T cell granules: Isolation, structural, and biochemical, and functional characterization
    • Podack, E.R., and PJ. Konigsberg. 1984. Cytolytic T cell granules: isolation, structural, and biochemical, and functional characterization. J.Exp. Med. 160:695-710.
    • (1984) J.Exp. Med. , vol.160 , pp. 695-710
    • Podack, E.R.1    Konigsberg, P.J.2
  • 40
    • 0022497854 scopus 로고
    • Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer cell activity
    • Young, J.D.-E., H. Hengartner, E.R. Podack, and Z.A. Cohn. 1986. Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer cell activity. Cell. 44:849-859.
    • (1986) Cell , vol.44 , pp. 849-859
    • Young, J.D.-E.1    Hengartner, H.2    Podack, E.R.3    Cohn, Z.A.4
  • 41
    • 0022178185 scopus 로고
    • Cytotoxic granules from natural killer cells: Specificity of granules and insertion of channels of defined size into target membrane
    • Craido, M., C.G. Lindstrom, and G. Dennert. 1985. Cytotoxic granules from natural killer cells: specificity of granules and insertion of channels of defined size into target membrane. J. Immunol. 135:4245-4251.
    • (1985) J. Immunol. , vol.135 , pp. 4245-4251
    • Craido, M.1    Lindstrom, C.G.2    Dennert, G.3
  • 42
    • 0026060951 scopus 로고
    • Functional size of complement and perform pores compared by confocal laser scanning microscopy and fluorescence microphotolysis
    • Sauer, H., L. Pratsch, J. Tschopp, S. Bhakdi, and R. Peters. 1991. Functional size of complement and perform pores compared by confocal laser scanning microscopy and fluorescence microphotolysis. Biochim. Biophys. Acta. 1063:137-146.
    • (1991) Biochim. Biophys. Acta , vol.1063 , pp. 137-146
    • Sauer, H.1    Pratsch, L.2    Tschopp, J.3    Bhakdi, S.4    Peters, R.5
  • 43
    • 0023689857 scopus 로고
    • Cell damage by cytolysin. Spontaneous recovery and reversible inhibition by divalent cations
    • Bashford, C.L., G. Menestrina, P.A. Henkart, and C.A. Pasternak. 1988. Cell damage by cytolysin. Spontaneous recovery and reversible inhibition by divalent cations. J. Immunol. 141:3965-3974.
    • (1988) J. Immunol. , vol.141 , pp. 3965-3974
    • Bashford, C.L.1    Menestrina, G.2    Henkart, P.A.3    Pasternak, C.A.4


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