Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: Differential modulation by T helper type 1 and type 2 cells

Journal of Experimental Medicine

Volumn 194, Issue 5, 2001, Pages 657-667

  Medema, J P ^a   Schuurhuis, D H ^a   Rea, D ^a   Van Tongeren, J ^a   De Jong, J ^a   Bres, S A ^a   Laban, S ^a   Toes, R E M ^a   Toebes, M ^a   Schumacher, T N M ^a   Bladergroen, B A ^a   Ossendorp, F ^a   Kummer, J A ^a   Melief, C J M ^a   Offringa, R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD40; CTL; Granzyme; LPS; Survival

Indexed keywords

CD40 ANTIGEN; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL KILLING; CELL MATURATION; CELL PROTECTION; CELL SURVIVAL; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; IMMUNE SYSTEM; IMMUNITY; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL;

ANIMALS; ANTIGENS, CD40; APOPTOSIS; CELLS, CULTURED; DENDRITIC CELLS; FLOW CYTOMETRY; GRANZYMES; HUMANS; KINETICS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, TRANSGENIC; OVALBUMIN; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TH2 CELLS;

EID: 17944376032     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.5.657     Document Type: Article

References (57)

1. Dendritic cells and the control of immunity
2. + T-helper and a T-killer cell
3. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
4. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
5. Leukocyte migration: Scent of the T zone
6. Licence to kill
7. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
8. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells
9. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
10. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
11. Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization
12. Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
13. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis
14. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
15. Granzyme B-mediated cytochrome c release is regulated by the bcl-2 family members bid and Bax
16. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
17. Cytolytic T-cell cytotoxicity is mediated through perform and Fas lytic pathways
18. The CTL's kiss of death
19. The death receptors
20. Perforin and serine esterase expression in stimulated human T cells
21. Differentiation of naive CTL to effector and memory CTL: Correlation of effector function with phenotype and cell division
22. Distinct migration patterns of naive and effector CD8 T cells in the spleen: Correlation with CCR7 receptor expression and chemokine reactivity
23. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
24. The in vivo fate of APCs displaying minor H antigen and/or MHC differences is regulated by CTLs specific for immunodominant class I-associated epitopes
25. + T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity
26. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure
27. + cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent and -dependent stimuli
28. Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells
29. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures
30. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
31. Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset
32. Immune escape of tumors in vivo by expression of cellular FLICE inhibitory protein
33. Enrichment of an antigen-specific T cell response by retroviral transduced human dendritic cells
34. Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes
35. The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites
36. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)
37. The JAM test. A simple assay for DNA fragmentation and cell death
38. Apoptotic DNA fragmentation
39. Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction
40. Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity
41. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
42. Serpins and regulation of cell death
43. Retroviral gene transfer, rapid selection, and maintenance of the immature phenotype in mouse dendritic cells
44. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
45. Interleukin 12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
46. On T cell memory: Arguments for antigen dependence
47. Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells
48. Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein
49. Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA
50. Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
51. Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway
52. Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: Inhibition by bisindolylmaleimide
53. FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and γ irradiation
54. Fas engagement induces the maturation of dendritic cells, the release of interleukin (IL)-1β, and the production of interferon γ in the absence of IL-12 during dendritic cell-T cell cognate interaction: A new role for Fas ligand in inflammatory responses
55. CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells
56. BCL-2 family: Regulators of cell death
57. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor