Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 10, 2001, Pages 5746-5751

  Zhang, Dong ^a   Beresford, Paul J ^a   Greenberg, Arnold H ^a   Lieberman, Judy ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE INHIBITOR; GRANZYME A; GRANZYME B; LAMIN; LAMIN A; LAMIN C; PERFORIN; PROTEIN BCL 2; PROTEINASE; RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GRANULE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR BINDING;

CELL LINE; CELL NUCLEUS; CYTOPLASMIC GRANULES; GRANZYMES; HYDROLYSIS; LAMINS; NUCLEAR PROTEINS; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES, CYTOTOXIC;

ANIMALIA;

EID: 0035826778     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.101329598     Document Type: Article

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