Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system

Journal of Virology

Volumn 74, Issue 5, 2000, Pages 2447-2450

  Parra, Beatriz ^a   Lin, Mark T ^a   Stohlman, Stephen A ^a   Bergmann, Cornelia C ^a   Atkinson, Roscoe ^a   Hinton, David R ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; LIGAND; PERFORIN;

ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CLEARANCE; CONTROLLED STUDY; CYTOTOXICITY; HEPATITIS VIRUS; HISTOPATHOLOGY; KINETICS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; VIREMIA; VIRUS ENCEPHALITIS; VIRUS REPLICATION;

ANIMALS; ANTIGENS, CD95; BRAIN; CELL LINE; CENTRAL NERVOUS SYSTEM INFECTIONS; CORONAVIRUS INFECTIONS; FAS LIGAND PROTEIN; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MURINE HEPATITIS VIRUS; PORE FORMING CYTOTOXIC PROTEINS; SPINAL CORD;

EID: 0033975075     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.5.2447-2450.2000     Document Type: Article

References (22)

1. Alderson, M. R., T. W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K. A. Schooley, R. G. Goodwin, C. A. Smith, F. Ramsdell, and D. H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71-77.
2. Biron, C. A. 1994. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr. Opin. Immunol. 6:530-538.
3. b-restricted cytotoxic T cell response. J. Gen. Virol. 77:315-325.
4. + T cells during viral persistence in the central nervous system. J. Immunol. 163:3379-3387.
5. Bonetti, B., J. Pohl, Y.-L. Gao, and C. S. Raine. 1997. Cell death during autoimmune demyelination: effector but not target cells are eliminated by apoptosis. J. Immunol. 159:5733-5741.
6. Dowling, P., G. Shang, S. Raval, J. Menonna, S. Cook, and W. Husar. 1996. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain. J. Exp. Med. 184:1513-1518.
7. D'Souza, S. D., B. Bonnetti, V. Balasingam, N. R. Cashman, P. A. Barker, A. B. Troutt, C. S. Raine, and J. P. Antel. 1996. Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J. Exp. Med. 184:2361-2370.
8. Fleming, J. O., M. D. Trousdale, F. A. K. el-Zaatari, S. A. Stohlman, and L. P. Weiner. 1986. Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies. J. Virol. 58:869-875.
9. Fleming, J. O., S. A. Stohlman, R. C. Harmon, M. M. C. Lai, J. A. Frelinger, and L. P. Weiner. 1983. Antigenic relationship of murine coronavirus: analysis using monoclonal antibodies to JHM (MHV-4) virus. Virology 131:296-307.
10. Henkart, P. A. 1994. Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules. Immunity 1:343-346.
11. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37.
12. Kagi, D., F. Vignaux, B. Ledermann, K. Burki, V. Depraetere, S. Nagata, et al. 1994. Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science 265:528-530.
13. Kagi, D., P. Seiler, P. Pavlovic, B. Ledermann, K. Burki, R. M. Zinkernagel, and H. Hengatner. 1995. The roles of perforin and fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur. J. Immunol. 25:3256-3262.
14. Lin, M. T., S. A. Stohlman, and D. R. Hinton. 1997. Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis. J. Virol. 71:383-391.
15. Lohman, B. L., E. S. Razvi, and R. M. Welsh. 1996. T-lymphocyte down-regulation after acute viral infection is not dependent on CD95(Fas) receptor-ligand interactions. J. Virol. 70:8199-8203.
16. Parra, B., D. R. Hinton, N. W. Marten, C. C. Bergmann, M. T. Lin, C. S. Yang, and S. A. Stohlman. 1999. IFN-γ is required for viral clearance from central nervous system oligodendroglia. J. Immunol. 162:1641-1647.
17. 2+-independent T-cell mediated cytotoxicity. J. Exp. Med. 177:195-200.
18. Ruby, J., and I. Ramshaw. 1991. The antiviral activity of immune CD8+ T cells is dependent on interferon-γ. Lymphokine Cytokine Res. 10:353-358.
19. Sabelko, K. A., K. A. Kelly, M. H. Nahm, A. H. Cross, and J. H. Russell. 1997. Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyelitis, but are not essential for immune privilege in the central nervous system. J. Immunol. 159:3096-3099.
20. Stohlman, S. A., C. C. Bergmann, R. C. van der Veen, and D. R. Hinton. 1995. Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from oligodendroglia. J. Virol. 69:684-694.
21. + T cells clear influenza virus by perforin or Fas-dependent processes. J. Immunol. 159: 5197-5200.
22. Waldner, H., R. A. Sobel, E. Howard, and V. K. Kuchroo. 1997. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. J. Immunol. 159:3100-3103.