Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation

Journal of Clinical Investigation

Volumn 100, Issue 4, 1997, Pages 904-911

  Graubert, Timothy A ^a   DiPersio, John F ^a   Russell, John H ^b   Ley, Timothy J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Fas; Graft versus host disease; Granzyme B; Hematopoiesis; Perforin

Indexed keywords

FAS ANTIGEN; GRANZYME B; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; GRAFT VERSUS HOST REACTION; HEMATOPOIESIS; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030823702     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119606     Document Type: Article

References (53)

1. Rodt, H., S. Thierfelder, and M. Eulitz. 1974. Anti-lymphocyte antibodies and marrow transplantation. III. Effect of heterologous anti-brain antibodies on acute secondary disease in mice. Eur. J. Immunol. 4:25-29.
2. Martin, P.J., J.A. Hansen, C.D. Buckner, J.E. Sanders, H.J. Deeg, P. Stewart, F.R. Appelbaum, R. Clift, A. Fefer, R.P. Witherspoon, et al. 1985. Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts. Blood. 66:664-672.
3. Goldman, J.M., R.P. Gale, M.M. Horowitz, J.C. Biggs, R.E. Champlin, E. Gluckman, R.G. Hoffmann, S.J. Jacobsen, A.M. Marmont, P.B. McGlave, et al. 1988. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion. Ann. Intern. Med. 108:806-814.
4. Korngold, R., and J. Sprent. 1985. Surface markers of T cells causing lethal graft-versus-host disease to class I vs class II H-2 differences. J. Immunol. 135:3004-3010.
5. Sprent, J., M. Schaefer, D. Lo, and R. Korngold. 1986. Properties of purified T cell subsets: In vivo responses to Class I vs. Class II H-2 differences. J. Exp. Med. 163:998-1011.
6. Podack, E.R., J.D. Young, and Z.A. Cohn. 1985. Isolation and biochemical and functional characterization of perform 1 from cytolytic T-cell granules. Proc. Natl. Acad. Sci. USA. 82:8629-8633.
7. Podack, E.R., and G. Dennert. 1983. Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells. Nature (Lond.). 302: 442-445.
8. Duke, R.C., P.M. Persechini, S. Chang, C.C. Liu, J.J. Cohen, and J.D. Young. 1989. Purified perform induces target cell lysis but not DNA fragmentation. J. Exp. Med. 170:1451-1456.
9. Shi, L., R.P. Kraut, R. Aebersold, and A.H. Greenberg. 1992. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175:553-566.
10. Shiver, J.W., L. Su, and P.A. Henkart. 1992. Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A. Cell. 71:315-322.
11. Hayes, M.P., G.A. Berrebi, and P.A. Henkart. 1989. Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A. J. Exp. Med. 170:933-946.
12. Nakajima, H., H.L. Park, and P.A. Henkart. 1995. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J. Exp. Med. 181:1037-1046.
13. Shi, L., C.M. Kam, J.C. Powers, R. Aebersold, and A.H. Greenberg. 1992. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J. Exp. Med. 176:1521-1529.
14. Kagi, D., B. Ledermann, K. Burki , P. Seiler, B. Odermatt, K.J. Olsen, E.R. Podack, R.M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (Lond.). 369:31-37.
15. Walsh, C.M., M. Matloubian, C.C. Liu, R. Ueda, C.G. Kurahara, J.L. Christensen, M.T.F. Huang, J.D. Young, R. Ahmed, and W.R. Clark. 1994. Immune function in mice lacking the perform gene. Proc. Natl. Acad. Sci. USA. 91: 10854-10858.
16. Kojima, H., N. Shinohara, S. Hanaoka, Y. Someya-Shirota, Y. Takagaki, H. Ohno, T. Saito, T. Katayama, H. Yagita, K. Okumura, et al. 1994. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity. 1:357-364.
17. Lowin, B., F. Beermann, A. Schmidt, and J. Tschopp. 1994. A null mutation in the perforin gene impairs cytolytic T lymphocyte-and natural killer cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA. 91:11571-11575.
18. Heusel, J.W., R.L. Wesselschmidt, S. Shresta, J.H. Russell, and T.J. Ley. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 76:977-987.
19. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S.I. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 66: 233-243.
20. Chinnaiyan, A.M., K. O'Rourke, M. Tewari, and V.M. Dixit. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 81:505-512.
21. Stanger, B.Z., P. Leder, T.H. Lee, E. Kim, and B. Seed. 1995. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell. 81:513-523.
22. Hsu, H., J. Xiong, and D.V. Goeddel. 1995. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell. 81:495-504.
23. Boldin, M.P., E.E. Varfolomeev, Z. Pancer, I.L. Mett, J.H. Camonis, and D. Wallach. 1995. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem. 270:7795-7798.
24. Cleveland, J.L., and J.N. Ihle. 1995. Contenders in FasL/TNF death signaling. Cell. 81:479-482.
25. Cohen, P.L., and R.A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243-269.
26. Takahashi, T., M. Tanaka, C.I. Brannan, N.A. Jenkins, N.G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 76:969-976.
27. Russell, J.H., and R. Wang. 1993. Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells. Eur. J. Immunol. 23:2379-2382.
28. Hanabuchi, S., M. Koyanagi, A. Kawasaki, N. Shinohara, A. Matsuzawa, Y. Nishimura, Y. Kobayashi, S. Yonehara, H. Yagita, and K. Okumura, 1994. Fas and its ligand in a general mechanism of T-cell mediated cytotoxicity. Proc. Natl. Acad. Sci. USA. 91:4930-4934.
29. + T cell-mediated cytotoxicity. J. Immunol. 152:1127-1133.
30. + cytotoxic T cells. Proc Natl. Acad. Sci. USA. 91:4185-4189.
31. Braun, M.Y., B. Lowin, L. French, H. Acha-Orbea, and J. Tschopp. 1996. Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their ability to induce lethal acute graft-versus-host disease. J. Exp. Med. 183:657-661.
32. Baker, M.B., N.H. Altman, E.R. Podack, and R.B. Levy. 1996. The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice. J. Exp. Med. 183:2645-2656.
33. Graubert, T.A., J.H. Russell, and T.J. Ley. 1996. The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection. Blood. 87:1232-1237.
34. Ebnet, K., J.C. Tapia, U. Hurtenbach, M.D. Kramer, and M.M. Simon. 1991. In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C. Int. Immunol. 3: 9-19.
35. Prendergast, J.A., C.D. Helgason, and R.C. Bleackley. 1992. Quantitative polymerase chain reaction analysis of cytotoxic cell proteinase gene transcripts in T cells. J. Biol. Chem. 267:5090-5095.
36. + peripheral blood progenitor cells mobilized by chemotherapy and granulocyte colony-stimulating factor. Blood. 86:3500-3506.
37. Hampson, I.N., M.A. Cross, C.M. Heyworth, L. Fairbairn, E. Spooncer, G.J. Cowling, and T.M. Dexter. 1992. Expression and downregulation of cytotoxic cell protease 1 or granzyme B transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines. Blood. 80:3097-3105.
38. Shresta, S., J.H. Russell, and T.J. Ley. 1997. Mechanisms responsible for granzyme B-independent cytotoxicity. Blood. 89:4085-4091.
39. Hanson, R.D., and T.J. Ley. 1990. Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes. Mol. Cell. Biol. 10:5655-5662.
40. Brunet, J.F., F. Denizot, M. Suzan, W. Haas, J.M. Mencia-Huerta, G. Berke, M.F. Luciani, and P. Golstein. 1987. CTLA-1 and CTLA-3 serine esterase transcripts are detected mostly in cytotoxic T cells, but not only and not always. J. Immunol. 138:4102-4105.
41. Liu, C.C., S. Rafii, A. Granelli-Piperno, J.A. Trapani, and J.D. Young. 1989. Perforin and serine esterase gene expression in stimulated human T cells. J. Exp. Med. 170:2105-2118.
42. Ley, T.J., K.A. Maloney, J.I. Gordon, and A.L. Schwartz. 1989. Globin gene expression in erythroid human fetal liver cells. J. Clin. Invest. 83:1032-1038.
43. Krause, D.S., T. Ito, M.J. Fackler, O.M. Smith, M.I. Collector, S.J. Sharkis, and W.S. May. 1994. Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells. Blood. 84:691-701.
44. Shresta, S., D.M. MacIvor, J.W. Heusel, J.H. Russell, and T.J. Ley. 1995. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc. Natl. Acad. Sci. USA. 92:5679-5683.
45. Kagi, D., F. Vignaux, B. Ledermann, K. Burki, V. Depraetere, S. Nagata, H. Hengartner, and P. Golstein. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (Wash. DC). 265:528-530.
46. Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature (Lond.). 370:650-652.
47. Vignaux, F., and P. Golstein. 1994. Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: a regulatory pathway? Eur. J. Immunol. 24:923-927.
48. Bellgrau, D., D. Gold, H. Selawry, J. Moore, A. Franzusoff, and R.C. Duke. 1995. A role for CD95 ligand in preventing graft rejection. Nature (Lond.). 377:630-632.
49. Griffith, T.S., T. Brunner, S.M. Fletcher, D.R. Green, and T.A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science (Wash. DC). 270:1189-1192.
50. Abbas, A.K. 1996. Die and let live: eliminating dangerous lymphocytes. Cell. 84:655-657.
51. Ferrara, J.L.M. 1993. Cytokine dysregulation as a mechanism of graft versus host disease. Curr. Opin. Immunol. 5:794-799.
52. Ebnet, K., M. Hausmann, F. Lehmann-Grube, A. Mullbacher, M. Kopf, M. Lamers, and M.M. Simon. 1995. Granzyme A - deficient mice retain potent cell-mediated cytotoxicity. EMBO (Eur. Mol. Biol. Organ) J. 14:4230-4239.
53. Du, Z., C. Ricordi, E. Podack, and R.L. Pastori. 1996. A Hammerhead rihozyme that cleaves perforin and Fas-ligand RNAs in vitro. Biochem. Biophys. Res. Commun. 226:595-600.