The immunological synapse of CTL contains a secretory domain and membrane bridges

Immunity

Volumn 15, Issue 5, 2001, Pages 751-761

  Stinchcombe, Jane C ^a   Bossi, Giovanna ^a   Booth, Sarah ^a   Griffiths, Gillian M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CELL MEMBRANE MARKER; MEMBRANE PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CONTACT; CELL DEATH; CELL INTERACTION; CELL MEMBRANE; CELL SEPARATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ELECTRON MICROSCOPY; EXOCYTOSIS; IMMUNE RESPONSE; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECRETION; PROTEIN TRANSPORT; SYNAPSE; TARGET CELL;

EID: 0035655587     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00234-5     Document Type: Article

References (36)

1. Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis
2. B cells acquire antigen from target cells after synapse formation
3. Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells
4. The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments
5. Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells. I. Hypertrophy and change of orientation of the Golgi apparatus
6. Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells. II. Morphogenesis of secretory granules and intracellular vacuoles
7. Proteases and cell-mediated cytotoxicity
8. The immunological synapse: Required for T cell receptor signalling or directing T cell effector function?
9. The human natural killer cell immune synapse
10. The immunological synapse
11. Information transfer at the immunological synapse
12. The T cell-specific serine proteinase TSP-1 is associated with cytoplasmic granules of cytolytic T lymphocytes
13. Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells
14. The immunological synapse: A molecular machine controlling T cell activation
15. TCR-mediated internalization of peptide-MHC complexes acquired by T cells
16. Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner
17. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway
18. Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells
19. Cell biology of cytotoxic and helper T cell functions: Immunofluorescence microscopic studies of single cells and cell couples
20. The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells
21. On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell
22. Perforin and granzymes: Crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity
23. Microcinematographic and electron microscopic analysis of target cell lysis induced by cytotoxic T lymphocytes
24. Three-dimensional segregation of supramolecular activation clusters in T cells
25. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
26. L is for lytic granules: Lysosomes that kill
27. Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes
28. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
29. Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets
30. Cytotoxic T lymphocyte sequential killing of immobilized allogeneic tumor target cells measured by time-lapse microcinematography
31. The mechanism of T cell mediated cytotoxicity. II. Morphological studies of cell death by time-lapse microcinematography
32. The mechanism of T-cell mediated cytotoxicity. VI. T-cell projections and their role in target cell killing
33. Cytotoxic T lymphocytes as a model system for studying secretory lysosome biogenesis
34. Rab27a is required for regulated secretion in cytotoxic T lymphocytes
35. Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography
36. Isolation and characterisation of individual functionally reactive cytotoxic T lymphocytes: Conjugation, killing and recycling at the single cell level