Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice

Immunity

Volumn 18, Issue 4, 2003, Pages 463-474

  Badovinac, Vladimir P ^a   Hamilton, Sara E ^a   Harty, John T ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON ANTIBODY; PERFORIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CYTOKINE PRODUCTION; CYTOTOXICITY; KNOCKOUT MOUSE; LISTERIA; LYMPHOCYTE DEPLETION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOID TISSUE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VACCINATION; VIRUS INFECTION; VIRUS RECOMBINANT;

EID: 0242417491     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(03)00079-7     Document Type: Article

References (52)

1. Altman J.D., Moss P., Goulder P., Barouch D.H., McHeyzer W.M., Bell J.I., McMichael A.J., Davis M.M. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:1996;94-96.
2. Badovinac V.P., Harty J.T. Intracellular staining for TNF and IFN-gamma detects different frequencies of antigen-specific CD8(+) T cells. J. Immunol. Methods. 238:2000;107-117.
3. Badovinac V.P., Corbin G.A., Harty J.T. Cutting edge. OFF cycling of TNF production by antigen-specific CD8(+) T cells is antigen independent J. Immunol. 165:2000;5387-5391. a.
4. Badovinac V.P., Tvinnereim A.R., Harty J.T. Regulation of antigen-specific CD8(+) T cell homeostasis by perforin and interferon-gamma. Science. 290:2000;1354-1357. b.
5. Badovinac V.P., Porter B.B., Harty J.T. Programmed contraction of CD8(+) T cells after infection. Nat. Immunol. 3:2002;619-626.
6. Bevan M.J., Fink P.J. The CD8 response on autopilot. Nat. Immunol. 2:2001;381-382.
7. Binder D., van den Broek M.F., Kagi D., Bluethmann H., Fehr J., Hengartner H., Zinkernagel R.M. Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus. J. Exp. Med. 187:1998;1903-1920.
8. Blattman J.N., Antia R., Sourdive D.J., Wang X., Kaech S.M., Murali-Krishna K., Altman J.D., Ahmed R. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 195:2002;657-664.
9. Brundage R.A., Smith G.A., Camilli A., Theriot J.A., Portnoy D.A. Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells. Proc. Natl. Acad. Sci. USA. 90:1993;11890-11894.
10. Busch D.H., Kerksiek K.M., Pamer E.G. Differing roles of inflammation and antigen in T cell proliferation and memory generation. J. Immunol. 164:2000;4063-4070.
11. + T cells during an acute virus infection. Immunity. 8:1998;167-175.
12. de Saint Basile G., Fischer A. The role of cytotoxicity in lymphocyte homeostasis. Curr. Opin. Immunol. 13:2001;549-554.
13. Fulginiti V.A., Eller J.J., Downie A.W., Kempe C.H. Altered reactivity to measles virus. Atypical measles in children previously immunized with inactivated measles virus vaccines. JAMA. 202:1967;1075-1080.
14. Gallimore A., Glithero A., Godkin A., Tissot A.C., Pluckthun A., Elliott T., Hengartner H., Zinkernagel R. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I peptide complexes. J. Exp. Med. 187:1998;1383-1393.
15. Goldrath A.W., Bevan M.J. Selecting and maintaining a diverse T-cell repertoire. Nature. 402:1999;255-262.
16. Grayson J.M., Harrington L.E., Lanier J.G., Wherry E.J., Ahmed R. Differential sensitivity of naive and memory CD8(+) T cells to apoptosis in vivo. J. Immunol. 169:2002;3760-3770.
17. Hamilton S.E., Harty J.T. Quantitation of CD8(+) T cell expansion, memory, and protective immunity after immunization with peptide-coated dendritic cells. J. Immunol. 169:2002;4936-4944.
18. Harty J.T., Bevan M.J. Specific immunity to Listeria monocytogenes in the absence of IFN γ Immunity. 3:1995;109-117.
19. Harty J.T., Pamer E.G. CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection. J. Immunol. 154:1995;4642-4650.
20. Harty J.T., Badovinac V.P. Influence of effector molecules on the CD8(+) T cell response to infection. Curr. Opin. Immunol. 14:2002;360-365.
21. Harty J.T., Tvinnereim A.R., White D.W. CD8(+) T cell effector mechanisms in resistance to infection. Annu. Rev. Immunol. 18:2000;275-308.
22. Homann D., Teyton L., Oldstone M.B. Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory. Nat. Med. 7:2001;913-919.
23. Jensen E.R., Glass A.A., Clark W.R., Wing E.J., Miller J.F., Gregory S.H. Fas (CD95)-dependent cell-mediated immunity to Listeria monocytogenes. Infect. Immun. 66:1998;4143-4150.
24. Kaech S.M., Ahmed R. Memory CD8+ T cell differentiation. initial antigen encounter triggers a developmental program in naive cells Nat. Immunol. 2:2001;415-422.
25. Kagi D., Ledermann B., Burki K., Seiler P., Odermatt B., Olsen K.J., Podack E.R., Zinkernagel R.M., Hensgartner H. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 369:1994;31-37.
26. Kagi D., Ledermann B., Burki K., Zinkernagel R.M., Hengartner H. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis. Annu. Rev. Immunol. 14:1996;207-232.
27. Kagi D., Odermatt B., Mak T.W. Homeostatic regulation of CD8+ T cells by perforin. Eur. J. Immunol. 29:1999;3262-3272.
28. Kim H.W., Canchola J.G., Brandt C.D., Pyles G., Chanock R.M., Jensen K., Parrott R.H. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 89:1969;422-434.
29. Marshall D.R., Turner S.J., Belz G.T., Wingo S., Andreansky S., Sangster M.Y., Riberdy J.M., Liu T., Tan M., Doherty P.C. Measuring the diaspora for virus-specific CD8+ T cells. Proc. Natl. Acad. Sci. USA. 98:2001;6313-6318.
30. Masopust D., Vezys V., Marzo A.L., Lefrancois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science. 291:2001;2413-2417.
31. Matloubian M., Suresh M., Glass A., Galvan M., Chow K., Whitmire J.K., Walsh C.M., Clark W.R., Ahmed R. A role for perforin in downregulating T-cell responses during chronic viral infection. J. Virol. 73:1999;2527-2536.
32. Mercado R., Vijh S., Allen S.E., Kerksiek D., Pilip I.M., Pamer E.G. Early programming of T cell populations responding to bacterial infection. J. Immunol. 165:2000;6833-6839.
33. Murali-Krishna K., Altman J.D., Suresh M., Sourdive D.J., Zajac A.J., Miller J.D., Slansky J., Ahmed R. Counting antigen-specific CD8 T cells. a reevaluation of bystander activation during viral infection Immunity. 8:1998;177-187.
34. Oehen S., Ohashi P.S., Aichele P., Burki K., Hengartner H., Zinkernagel R.M. Vaccination or tolerance to prevent diabetes. Eur. J. Immunol. 22:1992;3149-3153.
35. Pamer E.G., Harty J.T., Bevan M.J. Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature. 353:1991;852-855.
36. Shen H., Miller J.F., Fan X., Kolwyck D., Ahmed R., Harty J.T. Compartmentalization of bacterial antigens. differential effects on priming of CD8 T cells and protective immunity Cell. 92:1998;535-545.
37. Slifka M.K., Whitton J.L. Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers. J. Immunol. 164:2000;208-216. a.
38. Slifka M.K., Whitton J.L. Antigen-specific regulation of T cell-mediated cytokine production. Immunity. 12:2000;451-457. b.
39. Slifka M.K., Rodriguez F., Whitton J.L. Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells. Nature. 401:1999;76-79.
40. Smelt S.C., Borrow P., Kunz S., Cao W., Tishon A., Lewicki H., Campbell K.P., Oldstone M.B. Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics. J. Virol. 75:2001;448-457.
41. Spaner D., Kaliannan R., Rabinovich B., Miller R.G. A role for perforin in activation-induced T cell death in vivo. increased expansion of allogeneic perforin-deficient T cell in SCID mice J. Immunol. 162:1999;1192-1199.
42. Spielman J., Lee R.K., Podack E.R. Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis. J. Immunol. 161:1998;7063-7070.
43. Stepp S.E., Dufourcq L.R., Le D.F., Bhawan S., Certain S., Mathew P.A., Henter J.I., Bennett M., Fischer A., Saint B.G., Kumar V. Perforin gene defects in familiar hemophagocytic lymphohistiocytosis. Science. 286:1999;1957-1959.
44. Trapani J.A., Smyth M.J. Functional significance of perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2:2002;735-747.
45. Tvinnereim A.R., Hamilton S.E., Harty J.T. CD8(+)-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection. Infect. Immun. 70:2002;153-162.
46. van der Most R.G., Sette A., Oseroff C., Alexander J., Murali-Krishna K., Lau L.L., Southwood S., Sidney J., Chesnut R.W., Matloubian M., Ahmed R. Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J. Immunol. 157:1996;5543-5554.
47. van Stipdonk M.J., Lemmens E.E., Schoenberger S.P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2:2001;423-429.
48. Walsh C.M., Matloubian M., Liu C.C., Ueda R., Kurahara C.G., Christensen J.L., Huang M.T., Young J.D., Ahmed R., Clark W.R. Immune function in mice lacking the perforin gene. Proc. Natl. Acad. Sci. USA. 91:1994;10854-10858.
49. White D.W., Harty J.T. Perforin-deficient CD8+ T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha. J. Immunol. 160:1998;898-905.
50. White D.W., MacNeil A., Busch D.H., Pilip I.M., Pamer E.G., Harty J.T. Perforin-deficient CD8+ T cells. in vivo priming and antigen-specific immunity against Listeria monocytogenes J. Immunol. 162:1999;980-988.
51. White D.W., Badovinac V.P., Kollias G., Harty J.T. Cutting edge. antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice J. Immunol. 165:2000;5-9.
52. Zajac A.J., Blattman J.N., Murali-Krishna K., Sourdive D.J., Suresh M., Altman J.D., Ahmed R. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188:1998;2205-2213.