-
1
-
-
0035923750
-
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
-
Annaert W, Esselens C, Baert V, Boeve C, Snellings G, et al. 2001. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron 32:579-89
-
(2001)
Neuron
, vol.32
, pp. 579-589
-
-
Annaert, W.1
Esselens, C.2
Baert, V.3
Boeve, C.4
Snellings, G.5
-
2
-
-
0032720496
-
Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons
-
Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, et al. 1999. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. J. Cell Bio. 147:277-94
-
(1999)
J. Cell Bio.
, vol.147
, pp. 277-294
-
-
Annaert, W.G.1
Levesque, L.2
Craessaerts, K.3
Dierinck, I.4
Snellings, G.5
-
3
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
Artavanis-Tsakonas S, Rand MD, Lake RJ. 1999. Notch signaling: Cell fate control and signal integration in development. Science 284:770-76
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
4
-
-
0033593027
-
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
-
Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, et al. 1999. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 96:15233-38
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 15233-15238
-
-
Bales, K.R.1
Verina, T.2
Cummins, D.J.3
Du, Y.4
Dodel, R.C.5
-
5
-
-
0035839591
-
Notch1 and amyloid precursor protein are competitive substrates for presenilin 1-dependent gamma-secretase cleavage
-
Berezovska O, Jack C, Deng A, Gastineau N, Rebeck GW, Hyman BT. 2001. Notch1 and amyloid precursor protein are competitive substrates for presenilin 1-dependent gamma-secretase cleavage. J. Biol. Chem. 276:30018-23
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30018-30023
-
-
Berezovska, O.1
Jack, C.2
Deng, A.3
Gastineau, N.4
Rebeck, G.W.5
Hyman, B.T.6
-
6
-
-
0033944273
-
Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservtion of Notch signaling
-
Berezovska O, Jack AC, McLean P, Aster JC, Hicks C, et al. 2000. Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservtion of Notch signaling. J. Neurochem. 75:583-93
-
(2000)
J. Neurochem.
, vol.75
, pp. 583-593
-
-
Berezovska, O.1
Jack, A.C.2
McLean, P.3
Aster, J.C.4
Hicks, C.5
-
7
-
-
0027936599
-
Apolipoprotein E allele epsilon 4 is linked to increased deposition of the amyloid beta-peptide (A-beta) in cases with or without Alzheimer's disease
-
Berr C, Hauw JJ, Delaere P, Duyckaerts C, Amouyel P. 1994. Apolipoprotein E allele epsilon 4 is linked to increased deposition of the amyloid beta-peptide (A-beta) in cases with or without Alzheimer's disease. Neurosci. Lett. 178:221-24
-
(1994)
Neurosci. Lett.
, vol.178
, pp. 221-224
-
-
Berr, C.1
Hauw, J.J.2
Delaere, P.3
Duyckaerts, C.4
Amouyel, P.5
-
8
-
-
0035159765
-
Dancing in the dark? The status of late-onset Alzheimer's disease genetics
-
Bertram L, Tanzi RE. 2001. Dancing in the dark? The status of late-onset Alzheimer's disease genetics. J. Mol. Neurosci. 17:127-36
-
(2001)
J. Mol. Neurosci.
, vol.17
, pp. 127-136
-
-
Bertram, L.1
Tanzi, R.E.2
-
9
-
-
0029311686
-
Coexpression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: Analysis of βAPP processing
-
Biere AL, Ostaszewski B, Zhao H, Gillespie S, Younkin SG, Selkoe DJ. 1995. Coexpression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: Analysis of βAPP processing. Neurobiol. Dis. 2:177-87
-
(1995)
Neurobiol. Dis.
, vol.2
, pp. 177-187
-
-
Biere, A.L.1
Ostaszewski, B.2
Zhao, H.3
Gillespie, S.4
Younkin, S.G.5
Selkoe, D.J.6
-
10
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, et al. 1997. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-45
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
Van Lare, J.3
Lee, M.K.4
Gonzales, V.5
-
11
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, et al. 1996. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17:1005-13
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
-
12
-
-
0027062755
-
Epidemiology of Alzheimer's disease
-
Breteler MM, Claus JJ, van Duijn CM, Launer LJ, Hofman A. 1992. Epidemiology of Alzheimer's disease. Epidemiol. Rev. 14:59-82
-
(1992)
Epidemiol. Rev.
, vol.14
, pp. 59-82
-
-
Breteler, M.M.1
Claus, J.J.2
Van Duijn, C.M.3
Launer, L.J.4
Hofman, A.5
-
13
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown MS, Ye J, Rawson RB, Goldstein JL. 2000. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans. Cell 100:391-98
-
(2000)
Cell
, vol.100
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
14
-
-
0033564771
-
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: Isoform-specific effects on neurodegeneration
-
Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, et al. 1999. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: Isoform-specific effects on neurodegeneration. J. Neurosci. 19:4867-80
-
(1999)
J. Neurosci.
, vol.19
, pp. 4867-4880
-
-
Buttini, M.1
Orth, M.2
Bellosta, S.3
Akeefe, H.4
Pitas, R.E.5
-
15
-
-
14444272986
-
Evidence that tumor necrosis factor alpha-converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
-
Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, et al. 1998. Evidence that tumor necrosis factor alpha-converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273:27765-67
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27765-27767
-
-
Buxbaum, J.D.1
Liu, K.N.2
Luo, Y.3
Slack, J.L.4
Stocking, K.L.5
-
16
-
-
0035816661
-
A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X, Sudhof TC. 2001. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293:115-20
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
17
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, et al. 1998. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J. Biol. Chem. 273:3205-11
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
-
18
-
-
0026745610
-
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
-
Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, et al. 1992. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360:672-74
-
(1992)
Nature
, vol.360
, pp. 672-674
-
-
Citron, M.1
Oltersdorf, T.2
Haass, C.3
McConlogue, L.4
Hung, A.Y.5
-
19
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid βprotein in both transfected cells and transgenic mice
-
Citron M, Westaway D, Xia W, Carlson G, Diehl T, et al. 1997. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid βprotein in both transfected cells and transgenic mice. Nat. Med. 3:67-72
-
(1997)
Nat. Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
-
20
-
-
0034606268
-
Association of a haplotype for tumor necrosis factor in siblings with lateonset Alzheimer disease: The NIMH Alzheimer Disease Genetics Initiative
-
Collins JS, Perry RT, Watson B Jr, Harrell LE, Acton RT, et al. 2000. Association of a haplotype for tumor necrosis factor in siblings with lateonset Alzheimer disease: The NIMH Alzheimer Disease Genetics Initiative. Am. J. Med. Gen. 96:823-30
-
(2000)
Am. J. Med. Gen.
, vol.96
, pp. 823-830
-
-
Collins, J.S.1
Perry, R.T.2
Watson B., Jr.3
Harrell, L.E.4
Acton, R.T.5
-
21
-
-
0028305380
-
Protective effect of apolipoprotein E type 2 allele for late-onset Alzheimer's disease
-
Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, et al. 1994. Protective effect of apolipoprotein E type 2 allele for late-onset Alzheimer's disease. Nat. Genet. 7:180-84
-
(1994)
Nat. Genet.
, vol.7
, pp. 180-184
-
-
Corder, E.H.1
Saunders, A.M.2
Risch, N.J.3
Strittmatter, W.J.4
Schmechel, D.E.5
-
22
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families
-
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC Jr, et al. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families. Science 261:921-23
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell P.C., Jr.5
-
23
-
-
0031958152
-
Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease
-
Cotman CW. 1998. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol. Aging 19:S29-32
-
(1998)
Neurobiol. Aging
, vol.19
-
-
Cotman, C.W.1
-
24
-
-
0035921427
-
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein
-
Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, et al. 2001. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein. J. Cell Bio. 154:731-40
-
(2001)
J. Cell Bio.
, vol.154
, pp. 731-740
-
-
Cupers, P.1
Bentahir, M.2
Craessaerts, K.3
Orlans, I.4
Vanderstichele, H.5
-
25
-
-
0032032019
-
An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos
-
Davis JA, Naruse S, Chen H, Eckman C, Younkin S, et al. 1998. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron 20:603-9
-
(1998)
Neuron
, vol.20
, pp. 603-609
-
-
Davis, J.A.1
Naruse, S.2
Chen, H.3
Eckman, C.4
Younkin, S.5
-
26
-
-
0033926434
-
The number of trait loci in late-onset Alzheimer disease
-
Daw E, Payami H, Nemens EJ, Nochlin D, Bird TD, et al. 2000. The number of trait loci in late-onset Alzheimer disease. Am. J. Hum. Genet. 66:196-204
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 196-204
-
-
Daw, E.1
Payami, H.2
Nemens, E.J.3
Nochlin, D.4
Bird, T.D.5
-
27
-
-
0035421638
-
Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability
-
De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, et al. 2001. Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability. Hum. Mol. Genet. 10:1665-71
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1665-1671
-
-
De Jonghe, C.1
Esselens, C.2
Kumar-Singh, S.3
Craessaerts, K.4
Serneels, S.5
-
28
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, et al. 1999. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518-22
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
-
29
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Gundula G, et al. 1998. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391:387-90
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Gundula, G.5
-
30
-
-
16044366039
-
Increased amyloidβ42(43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, Yu X, Prada C-M, et al. 1996. Increased amyloidβ42(43) in brains of mice expressing mutant presenilin 1. Nature 383:710-13
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.-M.5
-
32
-
-
0034660205
-
Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: Increased toxicity of Dutch-type mutant
-
Eisenhauer PB, Johnson RJ, Wells JM, Davies TA, Fine RE. 2000. Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: Increased toxicity of Dutch-type mutant. J. Neurosci. Res. 60:804-10
-
(2000)
J. Neurosci. Res.
, vol.60
, pp. 804-810
-
-
Eisenhauer, P.B.1
Johnson, R.J.2
Wells, J.M.3
Davies, T.A.4
Fine, R.E.5
-
33
-
-
0033780472
-
Transition-state analogue inhibitors of γ-secretase bind directly to Presenilin-1
-
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, et al. 2000. Transition-state analogue inhibitors of γ-secretase bind directly to Presenilin-1. Nat. Cell Biol. 2:428-34
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 428-434
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
-
34
-
-
0037022644
-
Activity-dependent isolation of the presenilin-gamma-secretase complex reveals nicastrin and a gamma substrate
-
Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, et al. 2002. Activity-dependent isolation of the presenilin-gamma-secretase complex reveals nicastrin and a gamma substrate. Proc. Natl. Acad. Sci. USA 99:2720-25
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 2720-2725
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Ye, W.4
Diehl, T.S.5
-
35
-
-
0028872558
-
Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formarion: Implications for the pathogenesis and treatement of Alzheimer's disease
-
Evans KC, Berger EP, Cho C-G, Weisgraber KH, Lansbury PT Jr. 1995. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formarion: Implications for the pathogenesis and treatement of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 92:763-67
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 763-767
-
-
Evans, K.C.1
Berger, E.P.2
Cho, C.-G.3
Weisgraber, K.H.4
Lansbury P.T., Jr.5
-
36
-
-
0026453127
-
Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein
-
Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, et al. 1992. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry 31:10716-23
-
(1992)
Biochemistry
, vol.31
, pp. 10716-10723
-
-
Fraser, P.E.1
Nguyen, J.T.2
Inouye, H.3
Surewicz, W.K.4
Selkoe, D.J.5
-
37
-
-
0033401526
-
Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
-
Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, et al. 1999. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol. Cell 4:893-902
-
(1999)
Mol. Cell
, vol.4
, pp. 893-902
-
-
Georgakopoulos, A.1
Marambaud, P.2
Efthimiopoulos, S.3
Shioi, J.4
Cui, W.5
-
38
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner GG, Wong CW. 1984. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 122:1131-35
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
39
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner GG, Wong CW. 1984. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120:885-90
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
40
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin M-C, Mullan M, Brown J, Crawford F, et al. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349:704-6
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.-C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
-
41
-
-
0034718203
-
Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease
-
Goedert M, Spillantini MG. 2000. Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. Biochim. Biophys. Acta 1502:110-21
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 110-121
-
-
Goedert, M.1
Spillantini, M.G.2
-
42
-
-
0035943436
-
Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. 2001. Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils. Science 293:1491-95
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
43
-
-
0034080403
-
Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte C, Hepler W, Mickey KM, Priess JR. 2000. Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127:2481-92
-
(2000)
Development
, vol.127
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.M.3
Priess, J.R.4
-
44
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C, Tsunozaki M, Hale VA, Priess JR. 2002. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl. Acad. Sci. USA 99:775-79
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
45
-
-
0028991404
-
Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiopathy
-
Greenberg SM, Rebeck GW, Vonsattel JPG, Gomez-Isla T, Hyman BT. 1995. Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiopathy. Ann. Neurol. 38:254-59
-
(1995)
Ann. Neurol.
, vol.38
, pp. 254-259
-
-
Greenberg, S.M.1
Rebeck, G.W.2
Vonsattel, J.P.G.3
Gomez-Isla, T.4
Hyman, B.T.5
-
46
-
-
0034233382
-
The pervasiveness of interleukin-1 in Alzheimer pathogenesis: A role for specific polymorphisms in disease risk
-
Griffin WS, Nicoll JA, Grimaldi LM, Sheng JG, Mrak RE. 2000. The pervasiveness of interleukin-1 in Alzheimer pathogenesis: A role for specific polymorphisms in disease risk. Exp. Gerontol. 35:481-87
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 481-487
-
-
Griffin, W.S.1
Nicoll, J.A.2
Grimaldi, L.M.3
Sheng, J.G.4
Mrak, R.E.5
-
47
-
-
0028246308
-
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
-
Haass C, Hung AY, Selkoe DJ, Teplow DB. 1994. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. J. Biol. Chem. 269:17741-48
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17741-17748
-
-
Haass, C.1
Hung, A.Y.2
Selkoe, D.J.3
Teplow, D.B.4
-
48
-
-
0026646604
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism
-
Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, et al. 1992. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359:322-25
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
-
49
-
-
0030614627
-
Observation of metastable Abeta amyloid protofibrils by atomic force microscopy
-
Harper JD, Wong SS, Lieber CM, Lansbury PT. 1997. Observation of metastable Abeta amyloid protofibrils by atomic force microscopy. Chem. Biol. 4:119-25
-
(1997)
Chem. Biol.
, vol.4
, pp. 119-125
-
-
Harper, J.D.1
Wong, S.S.2
Lieber, C.M.3
Lansbury, P.T.4
-
50
-
-
0033570337
-
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
-
Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, et al. 1999. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J. Neurosci. 19:8876-84
-
(1999)
J. Neurosci.
, vol.19
, pp. 8876-8884
-
-
Hartley, D.M.1
Walsh, D.M.2
Ye, C.P.3
Diehl, T.4
Vasquez, S.5
-
51
-
-
0034329291
-
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members
-
Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, et al. 2000. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J. Neurosci. 20:7951-63
-
(2000)
J. Neurosci.
, vol.20
, pp. 7951-7963
-
-
Heber, S.1
Herms, J.2
Gajic, V.3
Hainfellner, J.4
Aguzzi, A.5
-
52
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, et al. 1998. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4:97-100
-
(1998)
Nat. Med.
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
Yu, X.4
Benkovic, S.5
-
53
-
-
4243215848
-
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
-
Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, et al. 2000. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 97:2892-97
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 2892-2897
-
-
Holtzman, D.M.1
Bales, K.R.2
Tenkova, T.3
Fagan, A.M.4
Parsadanian, M.5
-
54
-
-
0033559412
-
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease
-
Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, et al. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J. Clin. Invest. 103:R15-21
-
(1999)
J. Clin. Invest.
, vol.103
-
-
Holtzman, D.M.1
Bales, K.R.2
Wu, S.3
Bhat, P.4
Parsadanian, M.5
-
55
-
-
0034702303
-
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
-
Huppert S, Le A, Schroeter E, Mumm J, Saxena M, et al. 2000. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405:966-70
-
(2000)
Nature
, vol.405
, pp. 966-970
-
-
Huppert, S.1
Le, A.2
Schroeter, E.3
Mumm, J.4
Saxena, M.5
-
56
-
-
0034122869
-
Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer's disease
-
Hyman BT, Strickland D, Rebeck GW. 2000. Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer's disease. Arch. Neurol. 57:646-50
-
(2000)
Arch. Neurol.
, vol.57
, pp. 646-650
-
-
Hyman, B.T.1
Strickland, D.2
Rebeck, G.W.3
-
57
-
-
0028169925
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
-
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. 1994. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43). Neuron 13:45-53
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
58
-
-
0027258525
-
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
-
Jarrett JT, Berger EP, Lansbury PT Jr. 1993. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-97
-
(1993)
Biochemistry
, vol.32
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger, E.P.2
Lansbury P.T., Jr.3
-
59
-
-
0030890399
-
Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
-
Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE. 1997. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J. Biol. Chem. 272:11006-10
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11006-11010
-
-
Kim, T.W.1
Pettingell, W.H.2
Hallmark, O.G.3
Moir, R.D.4
Wasco, W.5
Tanzi, R.E.6
-
60
-
-
0035955693
-
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a Notch-like manner
-
Kimberly W, Zheng J, Guenette S, Selkoe D. 2001. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a Notch-like manner. J. Biol. Chem. 276:40288-92
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 40288-40292
-
-
Kimberly, W.1
Zheng, J.2
Guenette, S.3
Selkoe, D.4
-
61
-
-
0000792598
-
The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation
-
Kimberly WT, Xia W, Rahmati R, Wolfe MS, Selkoe DJ. 2000. The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation. J. Biol. Chem. 275:3173-78
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3173-3178
-
-
Kimberly, W.T.1
Xia, W.2
Rahmati, R.3
Wolfe, M.S.4
Selkoe, D.J.5
-
62
-
-
0035831453
-
Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling
-
Kirschenbaum F, Hsu SC, Cordell B, McCarthy JV. 2001. Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling. J. Biol. Chem. 276:7366-75
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7366-7375
-
-
Kirschenbaum, F.1
Hsu, S.C.2
Cordell, B.3
McCarthy, J.V.4
-
63
-
-
0035826909
-
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
-
Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F. 2001. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc. Natl. Acad. Sci. USA 98:5815-20
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5815-5820
-
-
Kojro, E.1
Gimpl, G.2
Lammich, S.3
Marz, W.4
Fahrenholz, F.5
-
64
-
-
0037204122
-
Aph-2/Nicastrin: An essential component of gammasecretase and regulator of Notch signaling and presenilin localization
-
Kopan R, Goate A. 2002. Aph-2/Nicastrin: An essential component of gammasecretase and regulator of Notch signaling and presenilin localization. Neuron 33:321-24
-
(2002)
Neuron
, vol.33
, pp. 321-324
-
-
Kopan, R.1
Goate, A.2
-
65
-
-
0030003538
-
Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
-
Kopan R, Schroeter EH, Weintraub H, Nye JS. 1996. Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl. Acad. Sci. USA 93:1683-88
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1683-1688
-
-
Kopan, R.1
Schroeter, E.H.2
Weintraub, H.3
Nye, J.S.4
-
66
-
-
13344282063
-
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
-
Kovacs DM, Fausett HJ, Page KJ, Kim T-W, Mori RD, et al. 1996. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med. 2:224-29
-
(1996)
Nat. Med.
, vol.2
, pp. 224-229
-
-
Kovacs, D.M.1
Fausett, H.J.2
Page, K.J.3
Kim, T.-W.4
Mori, R.D.5
-
67
-
-
0031017795
-
Light and electron microscopic localization of presenilin-1 in primate brain
-
Lah JJ, Heilman CJ, Nash NR, Rees HD, Yi H, et al. 1997. Light and electron microscopic localization of presenilin-1 in primate brain. J. Neurosci. 17:1971-80
-
(1997)
J. Neurosci.
, vol.17
, pp. 1971-1980
-
-
Lah, J.J.1
Heilman, C.J.2
Nash, N.R.3
Rees, H.D.4
Yi, H.5
-
68
-
-
0034703433
-
The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease
-
Lambert JC, Goumidi L, Vrieze FW, Frigard B, Harris JM, et al. 2000. The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease. Hum. Mol. Genet. 9:2275-80
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2275-2280
-
-
Lambert, J.C.1
Goumidi, L.2
Vrieze, F.W.3
Frigard, B.4
Harris, J.M.5
-
69
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, et al. 1998. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA 95:6448-53
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
-
71
-
-
0030007964
-
Sequence of deposition of heterogeneous amyloid beta-peptides and Apo E in Down syndrome: Implications for initial events in amyloid plaque formation
-
Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. 1996. Sequence of deposition of heterogeneous amyloid beta-peptides and Apo E in Down syndrome: Implications for initial events in amyloid plaque formation. Neurobiol. Dis. 3:16-32
-
(1996)
Neurobiol. Dis.
, vol.3
, pp. 16-32
-
-
Lemere, C.A.1
Blusztajn, J.K.2
Yamaguchi, H.3
Wisniewski, T.4
Saido, T.C.5
Selkoe, D.J.6
-
72
-
-
16044365171
-
The E280A presenilin-1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
-
Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, et al. 1996. The E280A presenilin-1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nat. Med. 2:1146-50
-
(1996)
Nat. Med.
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
Lendon, C.L.4
Ossa, J.5
-
73
-
-
0029906585
-
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
-
Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, et al. 1996. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 93:14940-44
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14940-14944
-
-
Levitan, D.1
Doyle, T.G.2
Brousseau, D.3
Lee, M.K.4
Thinakaran, G.5
-
74
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan D, Greenwald I. 1995. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377:351-54
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
75
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
-
Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, et al. 1990. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 248:1124-26
-
(1990)
Science
, vol.248
, pp. 1124-1126
-
-
Levy, E.1
Carman, M.D.2
Fernandez-Madrid, I.J.3
Power, M.D.4
Lieberburg, I.5
-
76
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, et al. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-77
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
-
77
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, et al. 1995. A familial Alzheimer's disease locus on chromosome 1. Science 269:970-73
-
(1995)
Science
, vol.269
, pp. 970-973
-
-
Levy-Lahad, E.1
Wijsman, E.M.2
Nemens, E.3
Anderson, L.4
Goddard, K.A.5
-
78
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin W, Chisholm L, Corral A, et al. 2001. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293:1487-91
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.3
Chisholm, L.4
Corral, A.5
-
79
-
-
0032499750
-
Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins
-
Li X, Greenwald I. 1998. Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins. Proc. Natl. Acad. Sci. USA 95:7109-14
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7109-7114
-
-
Li, X.1
Greenwald, I.2
-
80
-
-
0034621824
-
Photoactivated γsecretase inhibitors directed to the active site covalently label presenilin 1
-
Li Y-M, Xu M, Lai M-T, Huang Q, Castro JL, et al. 2000. Photoactivated γsecretase inhibitors directed to the active site covalently label presenilin 1. Nature 405:689-94
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.-M.1
Xu, M.2
Lai, M.-T.3
Huang, Q.4
Castro, J.L.5
-
81
-
-
0028172886
-
β-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red
-
Lorenzo A, Yankner B. 1994. β-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. USA 91:12243-47
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.2
-
82
-
-
0026783241
-
Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene
-
Luo L, Tully T, White K. 1992. Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9:595-605
-
(1992)
Neuron
, vol.9
, pp. 595-605
-
-
Luo, L.1
Tully, T.2
White, K.3
-
83
-
-
0028173205
-
The amyloid-associated proteins α 1-antichymotrypsin and apolipoprotein E promote the assembly of the Alzheimer β-protein into filaments
-
Ma J, Yee A, Brewer HB Jr, Das S, Potter H. 1994. The amyloid-associated proteins α 1-antichymotrypsin and apolipoprotein E promote the assembly of the Alzheimer β-protein into filaments. Nature 372:92-94
-
(1994)
Nature
, vol.372
, pp. 92-94
-
-
Ma, J.1
Yee, A.2
Brewer H.B., Jr.3
Das, S.4
Potter, H.5
-
84
-
-
0026570528
-
β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
-
Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. 1992. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:379-89
-
(1992)
J. Neurosci.
, vol.12
, pp. 379-389
-
-
Mattson, M.P.1
Cheng, B.2
Davis, D.3
Bryant, K.4
Lieberburg, I.5
Rydel, R.E.6
-
85
-
-
0034282630
-
Substitutions at codon 22 of Alzheimer's Abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells
-
Miravalle L, Tokuda T, Chiarle R, Giaccone G, Bugiani O, et al. 2000. Substitutions at codon 22 of Alzheimer's Abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells. J. Biol. Chem. 275:27110-16
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27110-27116
-
-
Miravalle, L.1
Tokuda, T.2
Chiarle, R.3
Giaccone, G.4
Bugiani, O.5
-
86
-
-
0035849525
-
Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha-889 * 1 allele
-
Murphy GM Jr, Claassen JD, DeVoss JJ, Pascoe N, Taylor J, et al. 2001. Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha-889 * 1 allele. Neurology 56:1595-97
-
(2001)
Neurology
, vol.56
, pp. 1595-1597
-
-
Murphy G.M., Jr.1
Claassen, J.D.2
DeVoss, J.J.3
Pascoe, N.4
Taylor, J.5
-
87
-
-
0034895326
-
The genetics of late-onset Alzheimer's disease
-
Myers AJ, Goate AM. 2001. The genetics of late-onset Alzheimer's disease. Curr. Opin. Neurol. 14:433-40
-
(2001)
Curr. Opin. Neurol.
, vol.14
, pp. 433-440
-
-
Myers, A.J.1
Goate, A.M.2
-
88
-
-
0025971426
-
Apolipoprotein E immunoreactivity in cerebral deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jacob disease
-
Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. 1991. Apolipoprotein E immunoreactivity in cerebral deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jacob disease. Brain Res. 541:163-66
-
(1991)
Brain Res.
, vol.541
, pp. 163-166
-
-
Namba, Y.1
Tomonaga, M.2
Kawasaki, H.3
Otomo, E.4
Ikeda, K.5
-
89
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, et al. 1998. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21:1213-21
-
(1998)
Neuron
, vol.21
, pp. 1213-1221
-
-
Naruse, S.1
Thinakaran, G.2
Luo, J.J.3
Kusiak, J.W.4
Tomita, T.5
-
90
-
-
0028232662
-
Differential effects of apolipoprotein E3 and E4 on neuronal growth in vitro
-
Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE. 1994. Differential effects of apolipoprotein E3 and E4 on neuronal growth in vitro. Science 264:850-52
-
(1994)
Science
, vol.264
, pp. 850-852
-
-
Nathan, B.P.1
Bellosta, S.2
Sanan, D.A.3
Weisgraber, K.H.4
Mahley, R.W.5
Pitas, R.E.6
-
91
-
-
0035203856
-
Dementia in hereditary cerebral hemorrhage with amyloidosisDutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles
-
Natté R, Maat-Schieman M, Haan J, Bomebroek M, Roos R, Van Duinen S. 2001. Dementia in hereditary cerebral hemorrhage with amyloidosisDutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles. Ann. Neurol. 50:765-72
-
(2001)
Ann. Neurol.
, vol.50
, pp. 765-772
-
-
Natté, R.1
Maat-Schieman, M.2
Haan, J.3
Bomebroek, M.4
Roos, R.5
Van Duinen, S.6
-
92
-
-
0035824391
-
Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
-
Ni CY, Murphy MP, Golde TE, Carpenter G. 2001. Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294:2179-81
-
(2001)
Science
, vol.294
, pp. 2179-2181
-
-
Ni, C.Y.1
Murphy, M.P.2
Golde, T.E.3
Carpenter, G.4
-
93
-
-
17944368176
-
The "Arctic" APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
-
Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, et al. 2001. The "Arctic" APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat. Neurosci. 4:887-93
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Eckman, C.B.3
Condron, M.M.4
Axelman, K.5
-
94
-
-
0028914970
-
Prevalence of Alzheimer's disease and vascular dementia: Association with education. The Rotterdam study
-
Ott A, Breteler MM, van Harskamp F, Claus JJ, van der Cammen TJ, et al. 1995. Prevalence of Alzheimer's disease and vascular dementia: Association with education. The Rotterdam study. Br. Med. J. 310:970-73
-
(1995)
Br. Med. J.
, vol.310
, pp. 970-973
-
-
Ott, A.1
Breteler, M.M.2
Van Harskamp, F.3
Claus, J.J.4
Van der Cammen, T.J.5
-
95
-
-
0031453752
-
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity
-
Perez RG, Zheng H, Van der Ploeg LH, Koo EH. 1997. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J. Neurosci. 17:9407-14
-
(1997)
J. Neurosci.
, vol.17
, pp. 9407-9414
-
-
Perez, R.G.1
Zheng, H.2
Van der Ploeg, L.H.3
Koo, E.H.4
-
97
-
-
0031939059
-
Molecular mapping of Alzheimer-type dementia in Down syndrome
-
Prasher VP, Farrer MJ, Kessling AM, Fisher EM, West RJ, et al. 1998. Molecular mapping of Alzheimer-type dementia in Down syndrome. Ann. Neurol. 43:380-83
-
(1998)
Ann. Neurol.
, vol.43
, pp. 380-383
-
-
Prasher, V.P.1
Farrer, M.J.2
Kessling, A.M.3
Fisher, E.M.4
West, R.J.5
-
98
-
-
0032032847
-
Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression
-
Qian S, Jiang P, Guan XM, Singh G, Trumbauer ME, et al. 1998. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. Neuron 20:611-17
-
(1998)
Neuron
, vol.20
, pp. 611-617
-
-
Qian, S.1
Jiang, P.2
Guan, X.M.3
Singh, G.4
Trumbauer, M.E.5
-
99
-
-
0033579505
-
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of notch
-
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, et al. 1999. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of notch. J. Biol. Chem. 274:36801-7
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 36801-36807
-
-
Ray, W.J.1
Yao, M.2
Mumm, J.3
Schroeter, E.H.4
Saftig, P.5
-
100
-
-
0027374047
-
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
-
Rebeck GW, Reiter JS, Strickland DK, Hyman BT. 1993. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 11:575-80
-
(1993)
Neuron
, vol.11
, pp. 575-580
-
-
Rebeck, G.W.1
Reiter, J.S.2
Strickland, D.K.3
Hyman, B.T.4
-
101
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, et al. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-78
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
-
102
-
-
0030250567
-
Inflammation and Alzheimer's disease pathogenesis
-
Rogers J, Webster S, Lue L-F, Brachova L, Civin WH, et al. 1996. Inflammation and Alzheimer's disease pathogenesis. Neurobiol. Aging 17:681-86
-
(1996)
Neurobiol. Aging
, vol.17
, pp. 681-686
-
-
Rogers, J.1
Webster, S.2
Lue, L.-F.3
Brachova, L.4
Civin, W.H.5
-
103
-
-
0034774969
-
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
-
Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, et al. 2001. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep. 2:835-41
-
(2001)
EMBO Rep.
, vol.2
, pp. 835-841
-
-
Sastre, M.1
Steiner, H.2
Fuchs, K.3
Capell, A.4
Multhaup, G.5
-
104
-
-
0033795279
-
Apolipoprotein E and Alzheimer disease: An update on genetic and functional analyses
-
Saunders AM. 2000. Apolipoprotein E and Alzheimer disease: An update on genetic and functional analyses. J. Neuropathol. Exp. Neurol. 59:751-58
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 751-758
-
-
Saunders, A.M.1
-
105
-
-
0023722957
-
Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease
-
Schellenberg GD, Bird TD, Wijsman EM, Moore DK, Boehnke M, et al. 1988. Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 241:1507-10
-
(1988)
Science
, vol.241
, pp. 1507-1510
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
Moore, D.K.4
Boehnke, M.5
-
106
-
-
0026471656
-
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
-
Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, et al. 1992. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258:668-71
-
(1992)
Science
, vol.258
, pp. 668-671
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
Orr, H.T.4
Anderson, L.5
-
107
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, et al. 1999. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-77
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
-
108
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, et al. 1996. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:864-70
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
-
109
-
-
0027365822
-
Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer's disease
-
Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, et al. 1993. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer's disease. Proc. Natl. Acad. Sci. USA 90:9649-53
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 9649-9653
-
-
Schmechel, D.E.1
Saunders, A.M.2
Strittmatter, W.J.3
Crain, B.J.4
Hulette, C.M.5
-
110
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter EH, Kisslinger JA, Kopan R. 1998. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382-86
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.3
-
111
-
-
0033529331
-
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix
-
Schwarzman AL, Singh N, Tsiper M, Gregori L, Dranovsky A, et al. 1999. Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. Proc. Natl. Acad. Sci. USA 96:7932-37
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7932-7937
-
-
Schwarzman, A.L.1
Singh, N.2
Tsiper, M.3
Gregori, L.4
Dranovsky, A.5
-
112
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe D. 2001. Clearing the brain's amyloid cobwebs. Neuron 32:177-80
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.1
-
113
-
-
0035066332
-
Alzheimer's disease: Genes, proteins and therapies
-
Selkoe DJ. 2001. Alzheimer's disease: Genes, proteins and therapies. Physiol. Rev. 81:742-61
-
(2001)
Physiol. Rev.
, vol.81
, pp. 742-761
-
-
Selkoe, D.J.1
-
114
-
-
0030779784
-
Skeletal and CNS defects in presnilin-1 deficient mice
-
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. 1997. Skeletal and CNS defects in presnilin-1 deficient mice. Cell 89:629-39
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
115
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-60
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
-
116
-
-
0026721943
-
β-amyloid precursor protein cleavage by a membrane-bound protease
-
Sisodia SS. 1992. β-amyloid precursor protein cleavage by a membrane-bound protease. Proc. Natl. Acad. Sci. USA 89:6075-79
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6075-6079
-
-
Sisodia, S.S.1
-
117
-
-
0033536072
-
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
-
Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA. 1999. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc. Natl. Acad. Sci. USA 96:6959-63
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6959-6963
-
-
Song, W.1
Nadeau, P.2
Yuan, M.3
Yang, X.4
Shen, J.5
Yankner, B.A.6
-
118
-
-
0033968306
-
Molecular genetics of Alzheimer's disease
-
St George-Hyslop PH. 2000. Molecular genetics of Alzheimer's disease. Biol. Psychol. 47:183-99
-
(2000)
Biol. Psychol.
, vol.47
, pp. 183-199
-
-
St. George-Hyslop, P.H.1
-
119
-
-
0025179972
-
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
-
FAD Collaborative Study Group
-
St George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, et al. 1990. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. FAD Collaborative Study Group. Nature 347:194-97
-
(1990)
Nature
, vol.347
, pp. 194-197
-
-
St. George-Hyslop, P.H.1
Haines, J.L.2
Farrer, L.A.3
Polinsky, R.4
Van Broeckhoven, C.5
-
120
-
-
0033610863
-
Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation
-
Steiner H, Capell A, Pesold B, Citron M, Kloetzek PM, et al. 1998. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J. Biol. Chem. 273:32322-31
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32322-32331
-
-
Steiner, H.1
Capell, A.2
Pesold, B.3
Citron, M.4
Kloetzek, P.M.5
-
121
-
-
0033778262
-
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
-
Steiner H, Kostka M, Romig H, Basset G, Pesold B, et al. 2000. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat. Cell Biol. 2:848-51
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 848-851
-
-
Steiner, H.1
Kostka, M.2
Romig, H.3
Basset, G.4
Pesold, B.5
-
122
-
-
0033583047
-
The biological and pathological function of the presenilin-1 deltaexon 9 mutation is independent of its defect to undergo proteolytic processing
-
Steiner H, Romig H, Grim MG, Philipp U, Pesold B, et al. 1999. The biological and pathological function of the presenilin-1 deltaexon 9 mutation is independent of its defect to undergo proteolytic processing. J. Biol. Chem. 274:7615-18
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7615-7618
-
-
Steiner, H.1
Romig, H.2
Grim, M.G.3
Philipp, U.4
Pesold, B.5
-
123
-
-
0033517844
-
Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis
-
Steiner H, Romig H, Pesold B, Philipp U, Baader M, et al. 1999. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry 38:14600-5
-
(1999)
Biochemistry
, vol.38
, pp. 14600-14605
-
-
Steiner, H.1
Romig, H.2
Pesold, B.3
Philipp, U.4
Baader, M.5
-
124
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in lateonset familial Alzheimer's disease
-
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, et al. 1993. Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in lateonset familial Alzheimer's disease. Proc. Natl. Acad. Sci. USA 90:1977-81
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
-
125
-
-
0033639117
-
Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
-
Struhl G, Adachi A. 2000. Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. Mol. Cell 6:625-36
-
(2000)
Mol. Cell
, vol.6
, pp. 625-636
-
-
Struhl, G.1
Adachi, A.2
-
126
-
-
0033535508
-
Presenilin is required for activity and nuclear access of Notch in Drosophila
-
Struhl G, Greenwald I. 1999. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398:522-25
-
(1999)
Nature
, vol.398
, pp. 522-525
-
-
Struhl, G.1
Greenwald, I.2
-
127
-
-
0028322017
-
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
-
Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L Jr, et al. 1994. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 264:1336-40
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
Odaka, A.4
Otvos L., Jr.5
-
128
-
-
13344293701
-
Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome
-
Teller JK, Russo C, DeBusk LM, Angelini G, Zaccheo D, et al. 1996. Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome. Nat. Med. 2:93-95
-
(1996)
Nat. Med.
, vol.2
, pp. 93-95
-
-
Teller, J.K.1
Russo, C.2
DeBusk, L.M.3
Angelini, G.4
Zaccheo, D.5
-
129
-
-
15844425969
-
Endoprotreolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, et al. 1996. Endoprotreolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17:181-90
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
-
130
-
-
0030667426
-
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
-
Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, et al. 1997. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J. Biol. Chem. 272:28415-22
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28415-28422
-
-
Thinakaran, G.1
Harris, C.L.2
Ratovitski, T.3
Davenport, F.4
Slunt, H.H.5
-
131
-
-
0031920383
-
Stable association of presenilin derivatives and absence of presenilin interactions with APP
-
Thinakaran G, Regard JB, Bouton CML, Harris CL, Price DL, et al. 1998. Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiol. Dis. 4:438-53
-
(1998)
Neurobiol. Dis.
, vol.4
, pp. 438-453
-
-
Thinakaran, G.1
Regard, J.B.2
Bouton, C.M.L.3
Harris, C.L.4
Price, D.L.5
-
132
-
-
0031056184
-
Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome
-
Tokuda T, Fukushima T, Ikeda S, Sekijima Y, Shoji S, et al. 1997. Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome. Ann. Neurol. 41:271-73
-
(1997)
Ann. Neurol.
, vol.41
, pp. 271-273
-
-
Tokuda, T.1
Fukushima, T.2
Ikeda, S.3
Sekijima, Y.4
Shoji, S.5
-
133
-
-
0032516821
-
Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42
-
Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, et al. 1998. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. J. Biol. Chem. 273:21153-60
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21153-21160
-
-
Tomita, T.1
Tokuhiro, S.2
Hashimoto, T.3
Aiba, K.4
Saido, T.C.5
-
134
-
-
18544410708
-
The plasmin system is induced by and degrades amyloid-beta aggregates
-
Tucker HM, Kihiko M, Caldwell JN, Wright S, Kawarabayashi T, et al. 2000. The plasmin system is induced by and degrades amyloid-beta aggregates. J. Neurosci. 20:3937-46
-
(2000)
J. Neurosci.
, vol.20
, pp. 3937-3946
-
-
Tucker, H.M.1
Kihiko, M.2
Caldwell, J.N.3
Wright, S.4
Kawarabayashi, T.5
-
135
-
-
0025768826
-
Familial aggregation of Alzheimer's disease and related disorders: A collaborative re-analysis of case-control studies
-
EURODEM Risk Factors Research Group
-
van Duijn CM, Clayton D, Chandra V, Fratiglioni L, Graves AB, et al. 1991. Familial aggregation of Alzheimer's disease and related disorders: A collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int. J. Epidemiol. 20:S13-20
-
(1991)
Int. J. Epidemiol.
, vol.20
-
-
Van Duijn, C.M.1
Clayton, D.2
Chandra, V.3
Fratiglioni, L.4
Graves, A.B.5
-
136
-
-
0035980088
-
Pathogenic effects of D23N Iowa mutant amyloid beta-protein
-
Van Nostrand WE, Melchor JP, Cho HS, Greenberg SM, Rebeck GW. 2001. Pathogenic effects of D23N Iowa mutant amyloid beta-protein. J. Biol. Chem. 276:32860-66
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32860-32866
-
-
Van Nostrand, W.E.1
Melchor, J.P.2
Cho, H.S.3
Greenberg, S.M.4
Rebeck, G.W.5
-
137
-
-
0033597195
-
Differential neurotrophic effects of apolipoprotein E in aged transgenic mice
-
Veinbergs I, Mallory M, Mante M, Rockenstein E, Gilbert JR, Masliah E. 1999. Differential neurotrophic effects of apolipoprotein E in aged transgenic mice. Neurosci. Lett. 265:218-22
-
(1999)
Neurosci. Lett.
, vol.265
, pp. 218-222
-
-
Veinbergs, I.1
Mallory, M.2
Mante, M.3
Rockenstein, E.4
Gilbert, J.R.5
Masliah, E.6
-
138
-
-
0037041426
-
Naturally secreted oligomers of amyloid β-protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, et al. 2002. Naturally secreted oligomers of amyloid β-protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-39
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
-
139
-
-
0030799122
-
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate
-
Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB. 1997. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J. Biol. Chem. 272:22364-72
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22364-22372
-
-
Walsh, D.M.1
Lomakin, A.2
Benedek, G.B.3
Condron, M.M.4
Teplow, D.B.5
-
140
-
-
0033951944
-
Toxicity of Dutch (E22Q) and Flemish (A21G) mutant amyloid beta proteins to human cerebral microvessel and aortic smooth muscle cells
-
Wang Z, Natte R, Berliner JA, van Duinen SG, Vinters HV, Rosenblum WI. 2000. Toxicity of Dutch (E22Q) and Flemish (A21G) mutant amyloid beta proteins to human cerebral microvessel and aortic smooth muscle cells. Stroke 31:534-38
-
(2000)
Stroke
, vol.31
, pp. 534-538
-
-
Wang, Z.1
Natte, R.2
Berliner, J.A.3
Van Duinen, S.G.4
Vinters, H.V.5
Rosenblum, W.I.6
-
141
-
-
0031054505
-
Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein
-
Weidemann A, Paliga K, Durrwang U, Czech C, Evin G, et al. 1997. Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein. Nat. Med. 3:328-32
-
(1997)
Nat. Med.
, vol.3
, pp. 328-332
-
-
Weidemann, A.1
Paliga, K.2
Durrwang, U.3
Czech, C.4
Evin, G.5
-
142
-
-
0031915681
-
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity
-
Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. 1998. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. J. Med. Chem. 41:6-9
-
(1998)
J. Med. Chem.
, vol.41
, pp. 6-9
-
-
Wolfe, M.S.1
Citron, M.2
Diehl, T.S.3
Xia, W.4
Donkor, I.O.5
Selkoe, D.J.6
-
143
-
-
0033551099
-
Peptidomimetic probes and molecular modeling suggest Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease
-
Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski BL, et al. 1999. Peptidomimetic probes and molecular modeling suggest Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry 38:4720-27
-
(1999)
Biochemistry
, vol.38
, pp. 4720-4727
-
-
Wolfe, M.S.1
Xia, W.2
Moore, C.L.3
Leatherwood, D.D.4
Ostaszewski, B.L.5
-
144
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and y-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. 1999. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and y-secretase activity. Nature 398:513-17
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
145
-
-
17744401440
-
Presenilin 1 is required for Notch1 and D111 expression in the paraxial mesoderm
-
Wong P, Zhen H, Chen H, Becher MW, Sirinathsinghji DJ, et al. 1997. Presenilin 1 is required for Notch1 and D111 expression in the paraxial mesoderm. Nature 397:288
-
(1997)
Nature
, vol.397
, pp. 288
-
-
Wong, P.1
Zhen, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.5
-
146
-
-
0034255029
-
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
-
Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, et al. 2000. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation. Proc. Natl. Acad. Sci. USA 97:9299-304
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9299-9304
-
-
Xia, W.1
Ray, W.J.2
Ostaszewski, B.L.3
Rahmati, T.4
Kimberly, W.T.5
-
147
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins
-
Xia W, Zhang J, Kholodenko D, Citron, M, Podlisny MB, et al. 1997. Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J. Biol. Chem. 272:7977-82
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
Zhang, J.2
Kholodenko, D.3
Citron, M.4
Podlisny, M.B.5
-
148
-
-
0032564388
-
Presenilin 1 regulates the processing APP C-terminal fragments and the generation of amyloid β-protein in ER and golgi
-
Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, et al. 1998. Presenilin 1 regulates the processing APP C-terminal fragments and the generation of amyloid β-protein in ER and golgi. Biochemistry 37:16465-71
-
(1998)
Biochemistry
, vol.37
, pp. 16465-16471
-
-
Xia, W.1
Zhang, J.2
Ostaszewski, B.L.3
Kimberly, W.T.4
Seubert, P.5
-
149
-
-
0030753089
-
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer's disease
-
Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. 1997. Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 94:8208-13
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8208-8213
-
-
Xia, W.1
Zhang, J.2
Perez, R.3
Koo, E.H.4
Selkoe, D.J.5
-
150
-
-
0033535555
-
Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants
-
Ye Y, Lukinova N, Fortini ME. 1999. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants. Nature 398:525-29
-
(1999)
Nature
, vol.398
, pp. 525-529
-
-
Ye, Y.1
Lukinova, N.2
Fortini, M.E.3
-
151
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, et al. 1998. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J. Biol. Chem. 273:16470-75
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.M.5
-
152
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, et al. 2000. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407:48-54
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
-
153
-
-
0032524865
-
Subcellular distribution and turnover of presenilins in transfected cells
-
Zhang J, Kang DE, Xia W, Okochi M, Mori H, et al. 1998. Subcellular distribution and turnover of presenilins in transfected cells. J. Biol. Chem. 273:12436-42
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12436-12442
-
-
Zhang, J.1
Kang, D.E.2
Xia, W.3
Okochi, M.4
Mori, H.5
-
154
-
-
0028988801
-
Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, et al. 1995. Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525-31
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
Sirinathsinghji, D.J.4
Hopkins, R.5
-
155
-
-
0030788767
-
Presenilin 1 interaction in the brain with a novel member of the Armadillo family
-
Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, et al. 1997. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. NeuroReport 8:2085-90
-
(1997)
NeuroReport
, vol.8
, pp. 2085-2090
-
-
Zhou, J.1
Liyanage, U.2
Medina, M.3
Ho, C.4
Simmons, A.D.5
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