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Volumn 3, Issue 1, 1996, Pages 16-32

Sequence of deposition of heterogeneous amyloid β-peptides and APO E in down syndrome: Implications for initial events in amyloid plaque formation

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E;

EID: 0030007964     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1996.0003     Document Type: Article
Times cited : (490)

References (50)
  • 1
    • 0027936599 scopus 로고
    • Apolipoprotein E allele e4 is linked to increased deposition of the amyloid β-peptide (A-β) in cases with or without Alzheimer's disease
    • Berr, C., Hauw, J.-J., Delaere, P., Duyckaerts, C., & Amouyel, P. (1994) Apolipoprotein E allele e4 is linked to increased deposition of the amyloid β-peptide (A-β) in cases with or without Alzheimer's disease. Neurosci. Lett. 178, 221-224.
    • (1994) Neurosci. Lett. , vol.178 , pp. 221-224
    • Berr, C.1    Hauw, J.-J.2    Delaere, P.3    Duyckaerts, C.4    Amouyel, P.5
  • 3
    • 0028872558 scopus 로고
    • Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease
    • Evans, K. C., Berger, E. P., Cho, C-G., Weisgraber, K. H., & Lansbury, P. T., Jr. (1995) Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease. Proc. Natl. Acad. Sci. USA 92, 763-767.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 763-767
    • Evans, K.C.1    Berger, E.P.2    Cho, C.-G.3    Weisgraber, K.H.4    Lansbury P.T., Jr.5
  • 4
    • 0028171110 scopus 로고
    • Nonfibrillar β-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer's disease
    • Frackowiak, J., Zoltowska, A., & Wisniewski, H. M. (1994) Nonfibrillar β-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 53, 637-645.
    • (1994) J. Neuropathol. Exp. Neurol. , vol.53 , pp. 637-645
    • Frackowiak, J.1    Zoltowska, A.2    Wisniewski, H.M.3
  • 5
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner, G. G., & Wong, C. W. (1984) Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890.
    • (1984) Biochem. Biophys. Res. Commun. , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 6
    • 0023037536 scopus 로고
    • Isolation and partial characterization of neurofibrillary tangles and amyloid plaque cores in Alzheimer's disease: Immunohistological studies
    • Gorevic, P., Goni, F., Pons-Estel, B., Alvarez, F., Peress, R., & Frangione, B. (1986) Isolation and partial characterization of neurofibrillary tangles and amyloid plaque cores in Alzheimer's disease: Immunohistological studies. J. Neuropathol. Exp. Neurol. 45, 647-664.
    • (1986) J. Neuropathol. Exp. Neurol. , vol.45 , pp. 647-664
    • Gorevic, P.1    Goni, F.2    Pons-Estel, B.3    Alvarez, F.4    Peress, R.5    Frangione, B.6
  • 7
    • 0028179341 scopus 로고
    • Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer's disease
    • Gowing, E., Roher, A. E., Woods, A. S., Cotter, R. J., Chaney, M., Little, S. P., & Ball, M. J. (1994) Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer's disease. J. Biol. Chem. 269, 10987-10990.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10987-10990
    • Gowing, E.1    Roher, A.E.2    Woods, A.S.3    Cotter, R.J.4    Chaney, M.5    Little, S.P.6    Ball, M.J.7
  • 8
    • 0028915895 scopus 로고
    • Amyloid β protein (Aβ) in Alzheimer's disease brain: Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Aβ40 or Aβ42(43)
    • Gravina, S. A., Ho, L., Eckman, C. B., Long, K. E., Otvos, L. J., Younkin, L. H., Suzuki, N., & Younkin, S. G. (1995) Amyloid β protein (Aβ) in Alzheimer's disease brain: Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Aβ40 or Aβ42(43). J. Biol. Chem. 270, 7013-7016.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7013-7016
    • Gravina, S.A.1    Ho, L.2    Eckman, C.B.3    Long, K.E.4    Otvos, L.J.5    Younkin, L.H.6    Suzuki, N.7    Younkin, S.G.8
  • 11
    • 0028246308 scopus 로고
    • Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor
    • Haass, C., Hung, A. Y., Selkoe, D. J., & Teplow, D. B. (1994a) Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor. J. Biol. Chem. 269, 17741-17748.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17741-17748
    • Haass, C.1    Hung, A.Y.2    Selkoe, D.J.3    Teplow, D.B.4
  • 12
    • 0028181256 scopus 로고
    • Polarized secretion of β-amyloid precursor protein and amyloid β-peptide in MDCK cells
    • Haass, C., Koo, E. H., Teplow, D. B., & Selkoe, D. J. (1994b) Polarized secretion of β-amyloid precursor protein and amyloid β-peptide in MDCK cells. Proc. Natl. Acad. Sci. USA 91, 1564-1568.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1564-1568
    • Haass, C.1    Koo, E.H.2    Teplow, D.B.3    Selkoe, D.J.4
  • 13
    • 0026101636 scopus 로고
    • Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease
    • Hilbich, C., Kisters-Woike, B., Reed, J., Masters, C. L., & Beyreuther, K. (1991) Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease. J. Mol. Biol. 218, 149-163.
    • (1991) J. Mol. Biol. , vol.218 , pp. 149-163
    • Hilbich, C.1    Kisters-Woike, B.2    Reed, J.3    Masters, C.L.4    Beyreuther, K.5
  • 14
    • 0028948391 scopus 로고
    • Age-related distribution of neuropathological changes in the cerebral cortex of patients with Down's syndrome
    • Hof, P. R., Bouras, C., Perl, D. P., Sparks, L., Mehta, N., & Morrison, J. H. (1995) Age-related distribution of neuropathological changes in the cerebral cortex of patients with Down's syndrome. Arch. Neurol. 52, 379-391.
    • (1995) Arch. Neurol. , vol.52 , pp. 379-391
    • Hof, P.R.1    Bouras, C.2    Perl, D.P.3    Sparks, L.4    Mehta, N.5    Morrison, J.H.6
  • 15
    • 0027490070 scopus 로고
    • The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution
    • Hyman, B. T., Marzloff, K., & Arriagada, P. V. (1993) The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J. Neuropathol. Exp. Neurol. 52, 594-600.
    • (1993) J. Neuropathol. Exp. Neurol. , vol.52 , pp. 594-600
    • Hyman, B.T.1    Marzloff, K.2    Arriagada, P.V.3
  • 16
    • 0028899724 scopus 로고
    • Quantitative analysis of senile plaques in Alzheimer's disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)
    • Hyman, B. T., West, H. L., Rebeck, G. W., Buldyrev, S. V., Mantegna, R. N., Ukleja, M., Havlin, S., & Stanley, H. E. (1995) Quantitative analysis of senile plaques in Alzheimer's disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proc. Natl. Acad. Sci. USA 92, 3586-3590.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3586-3590
    • Hyman, B.T.1    West, H.L.2    Rebeck, G.W.3    Buldyrev, S.V.4    Mantegna, R.N.5    Ukleja, M.6    Havlin, S.7    Stanley, H.E.8
  • 17
    • 0028919919 scopus 로고
    • Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome
    • Iwatsubo, T., Mann, D. M., Odaka, A., Suzuki, N., & Ihara, Y. (1995) Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome. Ann. Neurol. 37, 294-299.
    • (1995) Ann. Neurol. , vol.37 , pp. 294-299
    • Iwatsubo, T.1    Mann, D.M.2    Odaka, A.3    Suzuki, N.4    Ihara, Y.5
  • 18
    • 0028169925 scopus 로고
    • Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
    • Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, H., & Ihara, Y. (1994) Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43). Neuron 13, 45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, H.5    Ihara, Y.6
  • 19
    • 0027258525 scopus 로고
    • The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • Jarrett, J. T., Berger, E. P., & Lansbury, P. T., Jr. (1993) The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease. Biochemistry 32, 4693-4697.
    • (1993) Biochemistry , vol.32 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury P.T., Jr.3
  • 20
    • 0023607396 scopus 로고
    • Tau epitopes are incorporated into a range of lesions in Alzheimer's disease
    • Joachim, C., Morris, J., Selkoe, D., & Kosik, K. (1987) Tau epitopes are incorporated into a range of lesions in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 46, 611-622.
    • (1987) J. Neuropathol. Exp. Neurol. , vol.46 , pp. 611-622
    • Joachim, C.1    Morris, J.2    Selkoe, D.3    Kosik, K.4
  • 21
    • 0024232950 scopus 로고
    • Protein chemical and immunocytochemical studies of meningovascular β-amyloid protein in Alzheimer's disease and normal aging
    • Joachim, C. L., Duffy, L. K., Morris, J. H., & Selkoe, D. J. (1988) Protein chemical and immunocytochemical studies of meningovascular β-amyloid protein in Alzheimer's disease and normal aging. Brain Res. 474, 100-111.
    • (1988) Brain Res. , vol.474 , pp. 100-111
    • Joachim, C.L.1    Duffy, L.K.2    Morris, J.H.3    Selkoe, D.J.4
  • 22
    • 0028856744 scopus 로고
    • Apolipoprotein E genotype and cerebral amyloid angiopathy
    • Kalaria, R. N., & Premkumar, D. R. D. (1995) Apolipoprotein E genotype and cerebral amyloid angiopathy. Lancet 346, 1424.
    • (1995) Lancet , vol.346 , pp. 1424
    • Kalaria, R.N.1    Premkumar, D.R.D.2
  • 23
    • 0028173205 scopus 로고
    • The amyloid-associated proteins al-antichymotrypsin and apolipoprotein E promote the assembly of the Alzheimer's β-protein into filaments
    • Ma, J., Yee, A., Brewer, H. B., Jr., Das, S., & Potter, H. (1994) The amyloid-associated proteins al-antichymotrypsin and apolipoprotein E promote the assembly of the Alzheimer's β-protein into filaments. Nature 372, 92-94.
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer H.B., Jr.3    Das, S.4    Potter, H.5
  • 24
    • 0002732445 scopus 로고
    • Neuropathology of organic brain syndromes associated with aging
    • Plenum, New York
    • Malamud, N. (1972) Neuropathology of Organic Brain Syndromes Associated with Aging. Aging and the Brain: Advances in Behavioral Biology, Vol. 3, pp. 63-87. Plenum, New York.
    • (1972) Aging and the Brain: Advances in Behavioral Biology , vol.3 , pp. 63-87
    • Malamud, N.1
  • 26
    • 0027184611 scopus 로고
    • Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
    • Miller, D. L., Papayannopoulos, I. A., Styles, J., & Bobin, S. A. (1993) Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch. Biochem. Biophys. 301, 41-52.
    • (1993) Arch. Biochem. Biophys. , vol.301 , pp. 41-52
    • Miller, D.L.1    Papayannopoulos, I.A.2    Styles, J.3    Bobin, S.A.4
  • 27
    • 0026794746 scopus 로고
    • Mass spectrometry of purified amyloid β protein in Alzheimer's disease
    • Mori, H., Takio, K., Ogawara, M., & Selkoe, D. J. (1992) Mass spectrometry of purified amyloid β protein in Alzheimer's disease. J. Biol. Chem. 267, 17082-17086.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17082-17086
    • Mori, H.1    Takio, K.2    Ogawara, M.3    Selkoe, D.J.4
  • 29
    • 0025971426 scopus 로고
    • Apolipoprotein E immunoreactivity in cerebral deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jacob disease
    • Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) Apolipoprotein E immunoreactivity in cerebral deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jacob disease. Brain Res. 541, 163-166.
    • (1991) Brain Res. , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 30
    • 0028986690 scopus 로고
    • Apolipoprotein E E4 allele is associated with deposition of amyloid β-protein following head injury
    • Nicoll, J. A. R., Roberts, G. W., & Graham, D. I. (1995) Apolipoprotein E E4 allele is associated with deposition of amyloid β-protein following head injury. Nature Med. 1, 135-137.
    • (1995) Nature Med. , vol.1 , pp. 135-137
    • Nicoll, J.A.R.1    Roberts, G.W.2    Graham, D.I.3
  • 33
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer's disease: Alelic variation and receptor interactions
    • Rebeck, G. W., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) Apolipoprotein E in sporadic Alzheimer's disease: Alelic variation and receptor interactions. Neuron 11, 575-580.
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 35
    • 0001861571 scopus 로고
    • Quantitative analysis of β-amyloid deposition in Down's syndrome using computerized image analysis
    • Royston, M. C., Kodical, N. S., Mann, D. M. A., Groom, K., Landon, M., & Roberts, G. W. (1994) Quantitative analysis of β-amyloid deposition in Down's syndrome using computerized image analysis. Neurodegeneration 3, 43-51.
    • (1994) Neurodegeneration , vol.3 , pp. 43-51
    • Royston, M.C.1    Kodical, N.S.2    Mann, D.M.A.3    Groom, K.4    Landon, M.5    Roberts, G.W.6
  • 37
    • 0028278366 scopus 로고
    • Spatial resolution of the primary β-amyloidogenic process induced in postischemic hippocampus
    • Saido, T. C., Yokota, M., Maruyama, K., Yamao-Hariguaya, Tani, E., Ihara, Y., & Kawashima, S. (1994) Spatial resolution of the primary β-amyloidogenic process induced in postischemic hippocampus. J. Biol. Chem. 269, 15253-15257.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15253-15257
    • Saido, T.C.1    Yokota, M.2    Maruyama, K.3    Yamao-Hariguaya4    Tani, E.5    Ihara, Y.6    Kawashima, S.7
  • 40
    • 0022654027 scopus 로고
    • Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease
    • Selkoe, D. J., Abraham, C. R., Podlisny, M. B., & Duffy, L. K. (1986) Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J. Neurochem. 146, 1820-1834.
    • (1986) J. Neurochem. , vol.146 , pp. 1820-1834
    • Selkoe, D.J.1    Abraham, C.R.2    Podlisny, M.B.3    Duffy, L.K.4
  • 41
    • 0028979854 scopus 로고
    • Amyloid β-proteins 1-40 and 1-42(43) in the soluble fraction of extra- and intracranial blood vessels
    • Shinkai, Y., Yoshimura, M., Ito, Y., Odaka, A., Suzuki, N., Yanagisawa, K., & Ihara, Y. (1995) Amyloid β-proteins 1-40 and 1-42(43) in the soluble fraction of extra- and intracranial blood vessels. Ann. Neurol. 38, 421-428.
    • (1995) Ann. Neurol. , vol.38 , pp. 421-428
    • Shinkai, Y.1    Yoshimura, M.2    Ito, Y.3    Odaka, A.4    Suzuki, N.5    Yanagisawa, K.6    Ihara, Y.7
  • 43
    • 0027956675 scopus 로고
    • High tissue content of soluble β1-40 is linked to cerebral amyloid angiopathy
    • Suzuki, N., Iwatsubo, T., Odaka, A., Ishibashi, Y., Kitada, C., & Ihara, Y. (1994) High tissue content of soluble β1-40 is linked to cerebral amyloid angiopathy. Am. J. Pathol. 145, 452-460.
    • (1994) Am. J. Pathol. , vol.145 , pp. 452-460
    • Suzuki, N.1    Iwatsubo, T.2    Odaka, A.3    Ishibashi, Y.4    Kitada, C.5    Ihara, Y.6
  • 44
    • 0021956826 scopus 로고
    • Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
    • Wisniewski, K., Wisniewski, H., & Wen, G. (1985) Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 17, 278-282.
    • (1985) Ann. Neurol. , vol.17 , pp. 278-282
    • Wisniewski, K.1    Wisniewski, H.2    Wen, G.3
  • 45
    • 0026542786 scopus 로고
    • Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid
    • Wisniewski, T., & Frangione, B. (1992) Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci. Lett. 135, 235-238.
    • (1992) Neurosci. Lett. , vol.135 , pp. 235-238
    • Wisniewski, T.1    Frangione, B.2
  • 46
    • 0027970307 scopus 로고
    • Acceleration of Alzheimer's fibril formation by Apolipoprotein E in vitro
    • Wisniewski, T., Castano, E. M., Golabek, A., Vogel, T., & Frangione, B. (1994) Acceleration of Alzheimer's fibril formation by Apolipoprotein E in vitro. Am. J. Pathol. 145, 1030-1035.
    • (1994) Am. J. Pathol. , vol.145 , pp. 1030-1035
    • Wisniewski, T.1    Castano, E.M.2    Golabek, A.3    Vogel, T.4    Frangione, B.5
  • 47
    • 0028952332 scopus 로고
    • The influence of Apolipoprotein E isotypes on Alzheimer's disease pathology in 40 cases of Down's syndrome
    • Wisniewski, T., Morelli, L., Wegiel, J., Levy, E., Wisniewski, H., & Frangione, B. (1995) The influence of Apolipoprotein E isotypes on Alzheimer's disease pathology in 40 cases of Down's syndrome. Ann. Neurol. 37, 136-138.
    • (1995) Ann. Neurol. , vol.37 , pp. 136-138
    • Wisniewski, T.1    Morelli, L.2    Wegiel, J.3    Levy, E.4    Wisniewski, H.5    Frangione, B.6
  • 48
    • 0030033057 scopus 로고    scopus 로고
    • Amyloid β 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs
    • Wisniewski, T., Lalowski, M., Bobik, M., Russell, M., Strosznajder, J., & Frangione, B. (1996) Amyloid β 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs. Biochem. J. 313 (Part 2), 575-580.
    • (1996) Biochem. J. , vol.313 , Issue.2 PART , pp. 575-580
    • Wisniewski, T.1    Lalowski, M.2    Bobik, M.3    Russell, M.4    Strosznajder, J.5    Frangione, B.6
  • 49
    • 0029167555 scopus 로고
    • Immunohistochemical analysis of COOH-termini of amyloid beta protein (Aβ) using end-specific antisera for Aβ40 and Aβ42 in Alzheimer's disease and normal aging
    • Yamaguchi, H., Sugiahra, S., Ishiguro, K., Takashima, A., & Hirai, S. (1995) Immunohistochemical analysis of COOH-termini of amyloid beta protein (Aβ) using end-specific antisera for Aβ40 and Aβ42 in Alzheimer's disease and normal aging. Amyloid: Int. J. Clin. Invest. 2, 7-16.
    • (1995) Amyloid: Int. J. Clin. Invest. , vol.2 , pp. 7-16
    • Yamaguchi, H.1    Sugiahra, S.2    Ishiguro, K.3    Takashima, A.4    Hirai, S.5
  • 50
    • 0028080483 scopus 로고
    • Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precede the Alzheimer β-amyloid deposition
    • Yamaguchi, H., Ishiguro, K., Sugihara, S., Nakazato, Y., Kawarabayashi, T., Sun, X., & Hirai, S. (1994) Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precede the Alzheimer β-amyloid deposition. Acta Neuropathol. 88, 413-419.
    • (1994) Acta Neuropathol. , vol.88 , pp. 413-419
    • Yamaguchi, H.1    Ishiguro, K.2    Sugihara, S.3    Nakazato, Y.4    Kawarabayashi, T.5    Sun, X.6    Hirai, S.7


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