Light and electron microscopic localization of presenilin-1 in primate brain

Journal of Neuroscience

Volumn 17, Issue 6, 1997, Pages 1971-1980

  Lah, James J ^a   Heilman, Craig J ^a   Nash, Norman R ^a   Rees, Howard D ^a   Yi, Hong ^a   Counts, Scott E ^a   Levey, Allan I ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; coated vesicles; electron microscopy; endoplasmic reticulum; immunocytochemistry; intermediate compartment; monoclonal antibody; presenilin; transport vesicles

Indexed keywords

BRAIN PROTEIN; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 14; ENDOPLASMIC RETICULUM; GENETIC LINKAGE; GOLGI COMPLEX; HUMAN; IMMUNOCYTOCHEMISTRY; MONKEY; NONHUMAN; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SPECIES DIFFERENCE; TISSUE DISTRIBUTION;

EID: 0031017795     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-06-01971.1997     Document Type: Article

References (41)

1. Anwar R, Moynihan T, Ardley H, Brindle N, Coletta P, Cairns N, Markham A, Robinson P (1996) Molecular analysis of the presenilin 1 (S182) gene in "sporadic" cases of Alzheimer's disease: identification and characterization of unusual splice variants. J Neurochem 66:1774-1777.
2. Aridor M, Bannykh S, Rowe T, Balch W (1995) Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport. J Cell Biol 131:875-893.
3. Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada C-M, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17:1005-1013.
4. Broadwell R, Cataldo A (1984) The neuronal endoplasmic reticulum: its cytochemistry and contribution to the endomembrane system. II. Axons and terminals. J Comp Neurol 230:231-248.
5. Chartier-Harlin MC, Crawford F, Houlden H, Warren A, Hughes D, Fidani L, Goate A, Rossor M, Roques P, Hardy J, Mullan M (1991) Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 353:844-846.
6. Clark R, Hutton M, Fuldncr F, Froelich S, Karran E, Talbot C, Crook R, Lendon C, Prihar GCH, Korenblat K, Martinez A, Wragg M, Busfield F, Behrens M, Myers A, Norton J, Morris J, Mehta N, Pearson C, Lincoln S, Baker M, Duff K, Zehr C, Perez-Tur J, Houlden H, Ruiz A, Ossa J, Lopera F, Arcos M, Madrigal L, Collinge J, Humphreys C, Ashworth A, Sarner S, Fox N, Harvey R, Kennedy A, Roques P, Cline R, Philips C, Venter J, Forsell L, Axelman K, Lilius L, Johnston J, Cowburn R, Viitanen M, Winblad B, Kosik K, Haltia M, Poyhonen M, Dickson D, Mann D, Neary D, Snowden J, Lantos P, Lannfelt L, Rossor M, Roberts G, Adams M, Hardy J, Goate A (1995) The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat Genet 11:219-222.
7. Cook D, Sung J, Golde T, Felsenstein K, Wojczyk B, Tanzi R, Trajanowski J, Lee V-Y, Doms R (1996) Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc Natl Acad Sci USA 93:9223-9228.
8. Duff K, Eckman C, Zehr C, Yu X, Prada C-M, Perez-Tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S (1996) Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383:710-713.
9. Elder G, Tezapsidis N, Carter J, Shioi J, Bouras C, Li H-C, Johnston J, Efthimiopoulos S, Friedrich VLJ, Robakis N (1996) Identification and neuron-specific expression of the S182/presenilin I protein in human and rodent brains. J Neurosci Res 45:308-320.
10. Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Guiffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Paricak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349:704-706.
11. Gray E, Whittaker V (1962) The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization and centrifugation. J Anat 96:79-87.
12. Hauri H, Schweizer A (1992) The endoplasmic reticulum-Golgi intermediate compartment. Curr Opin Cell Biol 4:600-608.
13. Hof P, Cox K, Morrison J (1990) Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease. I. Superior frontal and inferior temporal cortex. J Comp Neurol 301:44-54.
14. Kovacs D, Fausett H, Page K, Kim T-W, Moir R, Merriam D, Hollister R, Hallmark O, Mancini R, Felsenstein K, Hyman B, Tanzi R, Wasco W (1996) Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med 2:224-229.
15. Krijnse-Locker J, Parton R, Fuller S, Griffiths G, Dotti C (1995) The organization of the endoplasmic reticulum and intermediate compartment in cultured rat hippocampal neurons. Mol Biol Cell 6:1315-1332.
16. L'Hernault S, Arduengo P (1992) Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions. J Cell Biol 119:55-68.
17. Levey A, Kitt C, Simonds W, Price D, Brann M (1991) Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11:3218-3226.
18. Levey A, Heilman C, Lah J, Nash N, Rees H, Wakai M, Mirra S, Rye D, Nochlin D, Bird T, Mufson E (1997) Presenilin-1 protein expression in familial and sporadic Alzheimer's disease. Ann Neurol, in press.
19. Levitan D, Greenwald I (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377:351-354.
20. Levy-Lahad E, Wasco W, Poorkaj P, Romano D, Oshima J, Pettingell W, Yu C, Jondro P, Schmidt S, Wang K, Crowley A, Fu Y, Guenette S, Galas D, Nemens E, Wijsman E, Bird T, Schellenberg G, Tanzi R (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-977.
21. Martins R, Turner B, Carroll R, Sweeney D, Kim K, Wisniewski H, Blass J, Gibson G, Gandy S (1995) High levels of amyloid-β protein from S182 (Glu246) familial Alzheimer's cells. NeuroReport 7:217-220.
22. Mercken M, Takahashi H, Honda T, Sato K, Murayama M, Nakazato Y, Noguchi K, Imahori K, Takashima A (1996) Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: evidence that Alzheimer mutations affect proteolytic processing. FEBS Lett 389:297-303.
23. Moussaoui S, Czech C, Pradier L, Blanchard V, Bonici B, Gohin M, Imperato A, Revah F (1996) Immunohistochemical analysis of presenilin-1 expression in the mouse brain. FEBS Lett 383:219-222.
24. Murrell J, Farlow M, Ghetti B, Benson MD (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254:97-99.
25. Rexach M, Latterich M, Schekman R (1994) Characteristics of endoplasmic reticulum-derived transport vesicles. J Cell Biol 5:1133-1148.
26. Rogaev E, Sherrington R, Rogaeva E, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, Mar L, Sorbi S, Nacmias B, Placentini S, Amaducci L, Chumakov I, Cohen D, Lannfelt L, Fraser P, Rommens J, George-Hyslop PS (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-778.
27. Rothman J, Wieland F (1996) Protein sorting by transport vesicles. Science 272:227-234.
28. Sahara N, Yahagi Y, Takagi H, Kondo T, Okochi M, Usami M, Shirasawa T, Mori H (1996) Identification and characterization of presenilin I-467, I-463, and I-374. FEBS Lett 381:7-11.
29. Satoh T, Ross C, Villa A, Supattapone S, Pozzan T, Snyder S, Meldolesi J (1990) The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. J Cell Biol 111:615-624.
30. Schekman R, Orci L (1996) Coat proteins and vesicle budding. Science 271:1526-1533.
31. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird T, Hardy J, Hutton M, Kukul W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2:864-870.
32. Sherrington R, Rogaev E, Liang Y, Rogaeva E, Levesque G, Ikeda M, Chl H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin J-F, Bruni A, Montesi M, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Pollnsky R, Wasco W, Silva HD, Haines J, Pericak-Vance M, Tanzi R, Roses A, Fraser P, Rommens J, George-Hyslop PS (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.
33. Smith DB, Johnson KS (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40.
34. Suzuki T, Nishiyama K, Murayama S, Yamamoto A, Sato S, Kanazawa I, Sakaki Y (1996) Regional and cellular presenilin 1 gene expression in human and rat tissues. Biochem Biophys Res Commun 219:708-713.
35. Takahashi H, Murayama M, Takashima A, Mercken M, Nakazato Y, Noguchi K, Imahori K (1996) Molecular cloning and expression of the rat homologue of presenilin-1. Neurosci Lett 206:113-116.
36. 2+-ATPase, and calsequestrin. J Neurosci 12:489-505.
37. Terasaki M, Slater N, Fein A, Schmidek A, Reese T (1994) Continuous network of endoplasmic reticulum in cerebellar Purkinje neurons. Proc Natl Acad Sci USA 91:7510-7514.
38. Terry R, Peck A, DeTeresa R, Schecter R, Horoupian D (1981) Some morphometric aspects of the brain in senile dementia of the Alzheimer's type. Ann Neurol 10:184-192.
39. Thinakaran G, Borchelt D, Lee M, Slunt H, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Gandy S, Levey A, Jenkins N, Copeland N, Price D, Sisodia S (1996) Endoproteolysis of presenilin 1 and regulated accumulation of processed derivatives in vivo. Neuron 17:181-190.
40. Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR (1981) Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 10:122-126.
41. r 38,000 characteristic of presynaptic vesicles. Cell 41:1017-1028.