Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

Biochemistry

Volumn 38, Issue 44, 1999, Pages 14600-14605

  Steiner, Harald ^a,e   Romig, Helmut ^b   Pesold, Brigitte ^a   Philipp, Uwe ^b   Baader, Miriam ^a   Citron, Martin ^c   Loetscher, Hansruedi ^d   Jacobsen, Helmut ^d   Haass, Christian ^a,e  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c AMGEN INC   (United States)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; GENE MUTATION; HUMAN; HUMAN CELL; KNOCKOUT GENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SENILE PLAQUE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; BINDING SITES; CELL LINE; DNA, COMPLEMENTARY; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; MUTATION; POINT MUTATION; PRESENILIN-1; TRANSFECTION;

EID: 0033517844     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9914210     Document Type: Article

References (43)

1. Selkoe, D. J. (1996) J. Biol. Chem. 271, 18295-18298.
2. Price, D., and Sisodia, S. (1998) Annu. Rev. Neurosci. 21, 479-505.
3. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390.
4. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517.
5. Steiner, H., Duff, K., Capell, A., Romig, H., Grim, G., Lincoln, S., Hardy, J., Yu, X., Picciano, M., Fechteler, K., Citron, M., Kopan, R., Pesold, B., Keck, S., Baader, M., Tomita, T., Iwatsubo, T., Baumeister, B., and Haass, C. (1999) J. Biol. Chem. 274, 28669-28673.
6. Leimer, U., Lun, K., Romig, H., Walter, J., Grünberg, J., Brand, M., and Haass, C. (1999) Biochemistry 38, 13602-13609.
7. Brockhaus, M., Loetscher, H., Jacobsen, H., Baumeister, R., Zweckbronner, I., Jakubek, C., Grünberg, J., and Haass, C. (1998) NeuroReport 9, 1481-1486.
8. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1998) Nature 398, 518-522.
9. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190.
10. Seeger, M., Nordstedt, C., Petanceska, S., Kovacs, D. M., Gouras, G. K., Hahne, S., Fraser, P., Levesque, L., Czernik, A. J., St. George-Hyslop, P., Sisodia, S. S., Thinakaran, G., Tanzi, R., Greengard, P., and Gandy, S. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 5090-5094.
11. Capell, A., Grünberg, J., Pesold, B., Diehlmann, A., Citron, M., Nixon, R., Beyreuther, K., Selkoe, D. J., and Haass, C. (1998) J. Biol. Chem. 273, 3205-3211.
12. Thinakaran, G., Regard, J. B., Bouton, C. M. L., Harris, C. L., Sabo, S., Price, D. L., Borchelt, D. R., and Sisodia, S. S. (1998) Neurobiol. Dis. 4, 438-453.
13. Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., St. George-Hyslop, P. H., and Fraser, P. (1998) J. Biol. Chem. 273, 16470-16475.
14. Saura, C. A., Tomita, T., Davenport, F., Harris, C. L., Iwatsubo, T., and Thinakaran, G. (1999) J. Biol. Chem. 274, 13818-13823.
15. Citron, M., Eckman, C. B., Diehl, T. S., Corcoran, C., Ostazewski, B. L., Xia, W., St. George Hyslop, P., Younkin, S. G., and Selkoe, D. J. (1998) Neurobiol. Dis. 5, 107-116.
16. Tomita, T., Tokuhiro, S., Hashimoto, T., Aiba, K., Saido, T. C., Maruyama, K., and Iwatsubo, T. (1998) J. Biol. Chem. 273, 21153-21160.
17. Steiner, H., Capell, A., Pesold, B., Citron, M., Kloetzel, P.-M., Selkoe, D., Romig, H., Mendia, K., and Haass, C. (1998) J. Biol. Chem. 273, 32322-32331.
18. Podlisny, M., Citron, M., Amarante, P., Sherrington, R., Xia, W., Zhang, J., Diehl, T., Levesque, G., Fraser, P., Haass, C., Koo, E., Seubert, P., St. George-Hyslop, P., Teplow, D., and Selkoe, D. (1997) Neurobiol. Dis. 3, 325-337.
19. Ratovitski, T., Slunt, H. H., Thinakaran, G., Price, D. L., Sisodia, S. S., and Borchelt, D. R. (1997) J. Biol. Chem. 272, 24536-24541.
20. Zhang, J., Kang, D. E., Xia, W., Okochi, M., Mori, H., Selkoe, D. J., and Koo, E. H. (1998) J. Biol. Chem. 273, 12436-12442.
21. Kim, T.-W., Pettingell, W., Hallmark, O., Moir, R., Wasco, W., and Tanzi, R. (1997) J. Biol. Chem. 272, 11006-11010.
22. Marambaud, P., Ancolio, K., Lopez-Perez, E., and Checler, F. (1998) Mol. Med. 4, 147-157.
23. Kim, T.-W., Pettingell, W. H., Jung, Y.-K., Kovacs, D. M., and Tanzi, R. E. (1997) Science 277, 373-376.
24. Grünberg, J., Walter, J., Loetscher, H., Deuschle, U., Jacobsen, H., and Haass, C. (1998) Biochemistry 37, 2263-2270.
25. Loetscher, H., Deuschle, U., Brockhaus, M., Reinhardt, D., Nelboeck, P., Mous, J., Grünberg, J., Haass, C., and Jacobsen, H. (1997) J. Biol. Chem. 272, 20655-20659.
26. Vito, P., Ghayur, T., and D'Adamio, L. (1997) J. Biol. Chem. 272, 28315-28320.
27. Lee, M. L., Borchelt, D. R., Kim, G., Thinakaran, G., Slunt, H., Ratovitski, T., Martin, L. J., Kittur, A., Gandy, S., Levey, A., Jenkins, N., Copeland, N., Price, D. L., and Sisodia, S. (1997) Nat. Med. 3, 756-760.
28. Mercken, M., Takahashi, H., Honda, T., Sato, K., Murayama, M., Nakazato, Y., Noguchi, K., Imahori, K., and Takashima, A. (1996) FEBS Lett. 389, 297-303.
29. Murayama, O., Honda, T., and Mercken, M. (1997) Neurosci. Lett. 229, 61-64.
30. Takahashi, H., Mercken, M., Honda, T., Saito, Y., Murayama, M., Song, S., and Takashima, A. (1999) Neurosci. Lett. 260, 121-124.
31. Citron, M., Oltersdorf, T., Haass, C., McConlogue, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., and Selkoe, D. J. (1992) Nature 360, 672-674.
32. Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T. S., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., Kholodenko, D., Motter, R., Sherrington, R., Perry, B., Yao, H., Strome, R., Lieberburg, I., Rommens, J., Kim, S., Schenk, D., Fraser, P., St. George-Hyslop, P., and Selkoe, D. J. (1997) Nat. Med. 3, 67-72.
33. Walter, J., Grünberg, J., Capell, A., Pesold, B., Schindzielorz, A., Citron, M., Mendla, K., St. George-Hyslop, P., Multhaup, G., Selkoe, D. J., and Haass, C. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 5349-5354.
34. Steiner, H., Romig, H., Grim, M. G., Philipp, U., Pesold, B., Citron, M., Baumeister, R., and Haass, C. (1999) J. Biol. Chem. 274, 7615-7618.
35. Wild-Bode, C., Yamazaki, T., Capell, A., Leimer, U., Steiner, H., Ihara, Y., and Haass, C. (1997) J. Biol. Chem. 272, 16085-16088.
36. Podlisny, M. B., Tolan, D., and Selkoe, D. J. (1991) Am. J. Pathol. 138, 1423-1435.
37. Wisniewski, T., Dowjat, W. K., Permanne, B., Palha, J., Kumar, A., Gallo, G., and Frangione, B. (1997) Am. J. Pathol. 151, 601-610.
38. Shirotani, K., Takahashi, K., and Tabira, T. (1999) Neurosci. Lett. 262, 37-40.
39. Shirotani, K., Takahashi, K., Ozawa, K., Kunishita, T., and Tabira, T. (1997) Biochem. Biophys. Res. Commun. 240, 728-731.
40. Tischer, E., and Cordell, B. (1996) J. Biol. Chem. 271, 21914-21919.
41. Murphy, M. P., Hickman, L. J., Eckman, C. B., Uljon, S. N., Wang, R., and Golde, T. E. (1999) J. Biol. Chem. 274, 11914-11923.
42. Lichtenthaler, S. F., Wang, R., Grimm, H., Uljon, S. N., Masters, C. L., and Beyreuther, K. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 3053-3058.
43. Haass, C., and Mandelkow, E. (1999) Trends Cell Biol. 9, 241-244.