Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Nature Medicine

Volumn 4, Issue 1, 1998, Pages 97-100

  Holcomb, Leigh ^a   Gordon, Marcia N ^a   Mcgowan, Eileen ^b   Yu, Xin ^b   Benkovic, Stan ^a   Jantzen, Paul ^a   Wright, Kristal ^a   Saad, Irene ^a   Mueller, Ryan ^a   Morgan, Dave ^a   Sanders, Sunny ^b   Zehr, Cindy ^b   O'Campo, Kassandra ^b   Hardy, John ^b   Prada, Cristian Mihail ^b   Eckman, Chris ^b   Younkin, Steve ^b   Hsiao, Karen ^c   Duff, Karen ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISEASE COURSE; GENE MUTATION; HUMAN; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; SENILE PLAQUE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; BRAIN; CEREBRAL CORTEX; CROSSES, GENETIC; GENOTYPE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; POSTURE; PRESENILIN-1; PSYCHOMOTOR PERFORMANCE; REFLEX; SEIZURES;

EID: 0031914718     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0198-097     Document Type: Article

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