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Control of cell lineage-specific development and transcription by bHLH-PAS proteins
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A general review of bHLH-PAS proteins focusing predominantly on the role of Drosophila bHLH-PAS proteins in controlling development.
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Crews ST Control of cell lineage-specific development and transcription by bHLH-PAS proteins. Genes Dev. 12:1998;607-620. A general review of bHLH-PAS proteins focusing predominantly on the role of Drosophila bHLH-PAS proteins in controlling development.
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Molecular bases for circadian clocks
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This article reviews the molecular control of circadian rhythms in fungi, plants, insects, and mammals, and describes the roles of bHLH-PAS proteins in rhythm gene regulation.
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Dunlap JC Molecular bases for circadian clocks. Cell. 96:1999;271-290. This article reviews the molecular control of circadian rhythms in fungi, plants, insects, and mammals, and describes the roles of bHLH-PAS proteins in rhythm gene regulation.
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0029110488
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1.4 Å structure of photoactive yellow protein, a cytosolic photoreceptor: Unusual fold, active site, and chromophore
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Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain
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Cabral, J.H.1
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A review of PAS protein structure with an emphasis on the oxygen-sensing FixL PAS protein.
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Pellequer J-L, Brudler R, Getzoff ED Biological sensors: more than one way to sense oxygen. Curr Biol. 9:1999;416-4180. A review of PAS protein structure with an emphasis on the oxygen-sensing FixL PAS protein.
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Pellequer, J.-L.1
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Getzoff, E.D.3
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0032568630
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Photoactive yellow protein: A structural prototype for the three-dimensional fold of the PAS domain superfamily
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The authors of this report used the structure of PYP to model a PAS domain of the Arnt bHLH-PAS protein. The conclusion is that the structure of the Arnt PAS-B domain strongly resembles PYP and it is likely that all PAS domains will have a similar structure. This prediction has, so far, concurred with the structures of FixL and HERG. The authors make testable predictions regarding sequences potentially used for bHLH-PAS protein heterodimerization and other ligand and protein interactions.
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Pellequer J-L, Wager-Smith KA, Kay SA, Getzoff ED Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily. Proc Natl Acad Sci USA. 95:1998;5884-5890. The authors of this report used the structure of PYP to model a PAS domain of the Arnt bHLH-PAS protein. The conclusion is that the structure of the Arnt PAS-B domain strongly resembles PYP and it is likely that all PAS domains will have a similar structure. This prediction has, so far, concurred with the structures of FixL and HERG. The authors make testable predictions regarding sequences potentially used for bHLH-PAS protein heterodimerization and other ligand and protein interactions.
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Proc Natl Acad Sci USA
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Pellequer, J.-L.1
Wager-Smith, K.A.2
Kay, S.A.3
Getzoff, E.D.4
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0032190614
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This article and [12] are general reviews regarding recent work on the physiological and developmental roles of mammalian hypoxia-inducible transcription factors.
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2 homeostasis. Curr Opin Genet Dev. 8:1998;588-594. This article and [12] are general reviews regarding recent work on the physiological and developmental roles of mammalian hypoxia-inducible transcription factors.
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Semenza, G.L.1
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The hypoxic response: Huffing and HIFing
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Guillemin, K.1
Krasnow, M.A.2
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0031020884
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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
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Tian H, McKnight SL, Russell DW Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11:1997;72-82.
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Tian, H.1
McKnight, S.L.2
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0031733828
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Molecular characterization and chromosomal localization of a third a-class hypoxia inducible factor subunit, HIF3α
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Bradfield, C.A.5
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16
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12644279862
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Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system
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Zhou Y-D, Barnard M, Tian H, Ring H, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci USA. 94:1997;713-718.
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Proc Natl Acad Sci USA
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Zhou, Y.-D.1
Barnard, M.2
Tian, H.3
Ring, H.4
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Shelton, J.6
Richardson, J.7
Russell, D.W.8
McKnight, S.L.9
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17
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0030887045
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Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
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Hogenesch JB, Chan WK, Kackiw VH, Brown RC, Gu Y-Z, Pray-Grant M, Perdew GH, Bradfield CA Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem. 272:1997;8581-8593.
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Hogenesch, J.B.1
Chan, W.K.2
Kackiw, V.H.3
Brown, R.C.4
Gu, Y.-Z.5
Pray-Grant, M.6
Perdew, G.H.7
Bradfield, C.A.8
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18
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0032581410
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Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1α, HLF, and Clock
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Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1α, HLF, and Clock. Biochem Biophys Res Commun. 248:1998;789-794.
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Takahata, S.1
Sogawa, K.2
Kobayashi, A.3
Ema, M.4
Mimura, J.5
Ozaki, N.6
Fujii-Kuriyama, Y.7
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19
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0032510778
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The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
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Hogenesch JB, Gu Y-Z, Jain S, Bradfield CA The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci USA. 95:1998;5474-5479.
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Hogenesch, J.B.1
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15444342958
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Iyer, N.V.1
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Wenger, R.H.6
Gassmann, M.7
Gerhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
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22
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0032581277
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Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
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••] describe the initial phenotypic analyses of mouse knockouts of the HIF-1α gene and its developmental roles.
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••] describe the initial phenotypic analyses of mouse knockouts of the HIF-1α gene and its developmental roles.
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Nature
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Carmeliet, P.1
Dor, Y.2
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Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
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23
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0030943461
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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
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Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature. 386:1997;403-407.
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Maltepe, E.1
Schmidt, J.V.2
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Bradfield, C.A.4
Simon, M.C.5
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17544384815
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ARNT-deficient mice and placental differentiation
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Kozak KR, Abbott B, Hankinson O ARNT-deficient mice and placental differentiation. Dev Biol. 191:1997;297-305.
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Kozak, K.R.1
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Hankinson, O.3
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0033562569
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Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
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This report provide a detailed examination of mesenchymal cell death in HIF-1α mouse knockouts. The surprising conclusion is that defective vascularization associated with mesenchymal cell death is not caused by an absence of VEGF. In contrast, the authors report increased levels of VEGF in HIF-1α mutant mice, although levels in the mesenchymal cells were not directly examined.
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Kotch LE, Iyer NV, Laughner E, Semenza GL Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol. 209:1999;254-267. This report provide a detailed examination of mesenchymal cell death in HIF-1α mouse knockouts. The surprising conclusion is that defective vascularization associated with mesenchymal cell death is not caused by an absence of VEGF. In contrast, the authors report increased levels of VEGF in HIF-1α mutant mice, although levels in the mesenchymal cells were not directly examined.
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Kotch, L.E.1
Iyer, N.V.2
Laughner, E.3
Semenza, G.L.4
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0032528023
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112K deletion
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This report demonstrates that a deletion of the Arnt2 locus is viable. The only phenotypes observed were defects in the thymus.
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112K deletion. Genomics. 51:1998;223-232. This report demonstrates that a deletion of the Arnt2 locus is viable. The only phenotypes observed were defects in the thymus.
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Genomics
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Wines, M.E.1
Tiffany, A.M.2
Holdener, B.C.3
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0343920277
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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
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Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt Cet al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 380:1996;435-439.
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Carmeliet, P.1
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Gertsenstein, M.6
Fahrig, M.7
Vandenhoeck, A.8
Harpal, K.9
Eberhardt, C.10
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28
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0030004485
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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
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Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MW Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 380:1996;439-442.
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Ferrara, N.1
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Powell-Braxton, L.7
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Moore, M.W.9
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0032213236
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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
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An elegant paper describing mouse knockout of the EPAS1 gene. EPAS1 mice die late in embryogenesis from cardiac failure. EPAS1 functions during embryogenesis in the Organ of Zuckerkandl by controlling the hypoxia-regulated release of catecholamines. This neurotransmitter controls fetal heart beat.
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Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12:1998;3320-3324. An elegant paper describing mouse knockout of the EPAS1 gene. EPAS1 mice die late in embryogenesis from cardiac failure. EPAS1 functions during embryogenesis in the Organ of Zuckerkandl by controlling the hypoxia-regulated release of catecholamines. This neurotransmitter controls fetal heart beat.
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Genes Dev
, vol.12
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Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
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0030739531
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Behavioral and electrophysiologic responses of Drosophila melanogaster to prolonged periods of anoxia
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Krishnan SN, Sun Y, Mohsenin A, Wyman RJ, Haddad GG Behavioral and electrophysiologic responses of Drosophila melanogaster to prolonged periods of anoxia. J Insect Physiol. 43:1997;203-210.
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Krishnan, S.N.1
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Growth and regeneration in the tracheal system of an insect, Rhodnius prolixus (Hemiptera)
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0030025172
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Trachealess encodes a bHLH-PAS protein and is a master regulator gene in the Drosophila tracheal system
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0030700310
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Sonnenfeld M, Ward M, Nystrom G, Mosher J, Stahl S, Crews S The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. Development. 124:1997;4583-4594.
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0031834240
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Regulation of Drosophila bHLH PAS protein cellular localization during embryogenesis
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In the absence of other bHLH-PAS partner proteins, Tango is cytoplasmic; however, it is nuclear in cells that express Sim and Trh, which are dimerization partners of Tango. When either sim or trh are ectopically expressed, their products and Tango are nuclear. This suggests a model in which Sim/Trh forms a heterodimer with Tango in the cytoplasm and the complex translocates into the nucleus. The paper argues against ligand-driven nuclear translocation of Sim and Trh.
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Ward MP, Mosher JT, Crews ST Regulation of Drosophila bHLH PAS protein cellular localization during embryogenesis. Development. 125:1998;1599-1608. In the absence of other bHLH-PAS partner proteins, Tango is cytoplasmic; however, it is nuclear in cells that express Sim and Trh, which are dimerization partners of Tango. When either sim or trh are ectopically expressed, their products and Tango are nuclear. This suggests a model in which Sim/Trh forms a heterodimer with Tango in the cytoplasm and the complex translocates into the nucleus. The paper argues against ligand-driven nuclear translocation of Sim and Trh.
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Ohshiro T, Saigo K Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea. Development. 124:1997;3975-3986.
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Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-1 binding sites
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0030012683
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The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human Hypoxia-inducible factor 1α and Drosophila Single-minded
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Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: Functional evidence for homology with mammalian HIF-1α
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2-sensitive regulation. This region is functionally analogous to the mammalian HIF protein hypoxia responsive domain-1 and suggests that Drosophila Similar is an insect HIF.
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2-sensitive regulation. This region is functionally analogous to the mammalian HIF protein hypoxia responsive domain-1 and suggests that Drosophila Similar is an insect HIF.
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0030155492
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Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome
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0032532480
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Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
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In this study, the authors generated murine knockouts of the Sim1 gene, demonstrating that the PVN, SON, and aPV nuclei of the hypothalamus failed to form and that expression of genes in those lineages was altered. Evidence is provided for transcriptional regulatory hierarchy between Sim1 and Brain-2, which is conserved between their fly homologs sim and drifter [45], respectively.
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Michaud JL, Rosenquist T, May NR, Fan C-M Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev. 12:1998;3264-3275. In this study, the authors generated murine knockouts of the Sim1 gene, demonstrating that the PVN, SON, and aPV nuclei of the hypothalamus failed to form and that expression of genes in those lineages was altered. Evidence is provided for transcriptional regulatory hierarchy between Sim1 and Brain-2, which is conserved between their fly homologs sim and drifter [45], respectively.
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Michaud, J.L.1
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0028221381
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