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Volumn 9, Issue 5, 1999, Pages 580-587

Remembrance of things PAS: Regulation of development by bHLH-PAS proteins

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; HELIX LOOP HELIX PROTEIN; OXYGEN; TOXIN;

EID: 0032872915     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)00003-9     Document Type: Review
Times cited : (163)

References (58)
  • 1
    • 0032030839 scopus 로고    scopus 로고
    • Control of cell lineage-specific development and transcription by bHLH-PAS proteins
    • A general review of bHLH-PAS proteins focusing predominantly on the role of Drosophila bHLH-PAS proteins in controlling development.
    • Crews ST Control of cell lineage-specific development and transcription by bHLH-PAS proteins. Genes Dev. 12:1998;607-620. A general review of bHLH-PAS proteins focusing predominantly on the role of Drosophila bHLH-PAS proteins in controlling development.
    • (1998) Genes Dev , vol.12 , pp. 607-620
    • Crews, S.T.1
  • 2
    • 0029582690 scopus 로고
    • Atypical phytochrome gene structure in the green alga Mesotaenium caldariorum
    • Lagarias DM, Wu S-H, Lagarias JC Atypical phytochrome gene structure in the green alga Mesotaenium caldariorum. Plant Mol Biol. 29:1995;1127-1142.
    • (1995) Plant Mol Biol , vol.29 , pp. 1127-1142
    • Lagarias, D.M.1    Wu, S.-H.2    Lagarias, J.C.3
  • 3
    • 0030884102 scopus 로고    scopus 로고
    • PAS domain S-boxes in Archae, Bacteria and sensors for oxygen and redox
    • Zhulin IB, Taylor BL, Dixon R PAS domain S-boxes in Archae, Bacteria and sensors for oxygen and redox. Trends Biochem Sci. 22:1997;331-333.
    • (1997) Trends Biochem Sci , vol.22 , pp. 331-333
    • Zhulin, I.B.1    Taylor, B.L.2    Dixon, R.3
  • 4
    • 0031262875 scopus 로고    scopus 로고
    • PAS: A multifunctional domain family comes to light
    • Ponting CP, Aravind L PAS: a multifunctional domain family comes to light. Curr Biol. 7:1997;674-677.
    • (1997) Curr Biol , vol.7 , pp. 674-677
    • Ponting, C.P.1    Aravind, L.2
  • 5
    • 0033593306 scopus 로고    scopus 로고
    • Molecular bases for circadian clocks
    • This article reviews the molecular control of circadian rhythms in fungi, plants, insects, and mammals, and describes the roles of bHLH-PAS proteins in rhythm gene regulation.
    • Dunlap JC Molecular bases for circadian clocks. Cell. 96:1999;271-290. This article reviews the molecular control of circadian rhythms in fungi, plants, insects, and mammals, and describes the roles of bHLH-PAS proteins in rhythm gene regulation.
    • (1999) Cell , vol.96 , pp. 271-290
    • Dunlap, J.C.1
  • 6
    • 0029110488 scopus 로고
    • 1.4 Å structure of photoactive yellow protein, a cytosolic photoreceptor: Unusual fold, active site, and chromophore
    • Borgstahl GEO, Williams DR, Getzoff ED 1.4 Å structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore. Biochemistry. 34:1995;6278-6287.
    • (1995) Biochemistry , vol.34 , pp. 6278-6287
    • Borgstahl, G.E.O.1    Williams, D.R.2    Getzoff, E.D.3
  • 8
    • 0032567106 scopus 로고    scopus 로고
    • Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain
    • •] strongly support the notion that there is a common structure to the PAS domain.
    • •] strongly support the notion that there is a common structure to the PAS domain.
    • (1998) Cell , vol.95 , pp. 649-655
    • Cabral, J.H.1    Lee, A.2    Cohen, S.L.3    Chait, B.T.4    Li, M.5    Mackinnon, R.6
  • 9
    • 0033519628 scopus 로고    scopus 로고
    • Biological sensors: More than one way to sense oxygen
    • A review of PAS protein structure with an emphasis on the oxygen-sensing FixL PAS protein.
    • Pellequer J-L, Brudler R, Getzoff ED Biological sensors: more than one way to sense oxygen. Curr Biol. 9:1999;416-4180. A review of PAS protein structure with an emphasis on the oxygen-sensing FixL PAS protein.
    • (1999) Curr Biol , vol.9 , pp. 416-4180
    • Pellequer, J.-L.1    Brudler, R.2    Getzoff, E.D.3
  • 10
    • 0032568630 scopus 로고    scopus 로고
    • Photoactive yellow protein: A structural prototype for the three-dimensional fold of the PAS domain superfamily
    • The authors of this report used the structure of PYP to model a PAS domain of the Arnt bHLH-PAS protein. The conclusion is that the structure of the Arnt PAS-B domain strongly resembles PYP and it is likely that all PAS domains will have a similar structure. This prediction has, so far, concurred with the structures of FixL and HERG. The authors make testable predictions regarding sequences potentially used for bHLH-PAS protein heterodimerization and other ligand and protein interactions.
    • Pellequer J-L, Wager-Smith KA, Kay SA, Getzoff ED Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily. Proc Natl Acad Sci USA. 95:1998;5884-5890. The authors of this report used the structure of PYP to model a PAS domain of the Arnt bHLH-PAS protein. The conclusion is that the structure of the Arnt PAS-B domain strongly resembles PYP and it is likely that all PAS domains will have a similar structure. This prediction has, so far, concurred with the structures of FixL and HERG. The authors make testable predictions regarding sequences potentially used for bHLH-PAS protein heterodimerization and other ligand and protein interactions.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5884-5890
    • Pellequer, J.-L.1    Wager-Smith, K.A.2    Kay, S.A.3    Getzoff, E.D.4
  • 11
    • 0032190614 scopus 로고    scopus 로고
    • 2 homeostasis
    • This article and [12] are general reviews regarding recent work on the physiological and developmental roles of mammalian hypoxia-inducible transcription factors.
    • 2 homeostasis. Curr Opin Genet Dev. 8:1998;588-594. This article and [12] are general reviews regarding recent work on the physiological and developmental roles of mammalian hypoxia-inducible transcription factors.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 588-594
    • Semenza, G.L.1
  • 12
    • 0030963616 scopus 로고    scopus 로고
    • The hypoxic response: Huffing and HIFing
    • Guillemin K, Krasnow MA The hypoxic response: huffing and HIFing. Cell. 89:1997;9-12.
    • (1997) Cell , vol.89 , pp. 9-12
    • Guillemin, K.1    Krasnow, M.A.2
  • 14
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11:1997;72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 15
    • 0031733828 scopus 로고    scopus 로고
    • Molecular characterization and chromosomal localization of a third a-class hypoxia inducible factor subunit, HIF3α
    • Gu Y-Z, Moran SM, Hogenesch JB, Wartman L, Bradfield CA Molecular characterization and chromosomal localization of a third a-class hypoxia inducible factor subunit, HIF3α Gene Expression. 7:1998;205-213.
    • (1998) Gene Expression , vol.7 , pp. 205-213
    • Gu, Y.-Z.1    Moran, S.M.2    Hogenesch, J.B.3    Wartman, L.4    Bradfield, C.A.5
  • 17
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
    • Hogenesch JB, Chan WK, Kackiw VH, Brown RC, Gu Y-Z, Pray-Grant M, Perdew GH, Bradfield CA Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem. 272:1997;8581-8593.
    • (1997) J Biol Chem , vol.272 , pp. 8581-8593
    • Hogenesch, J.B.1    Chan, W.K.2    Kackiw, V.H.3    Brown, R.C.4    Gu, Y.-Z.5    Pray-Grant, M.6    Perdew, G.H.7    Bradfield, C.A.8
  • 19
    • 0032510778 scopus 로고    scopus 로고
    • The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
    • Hogenesch JB, Gu Y-Z, Jain S, Bradfield CA The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci USA. 95:1998;5474-5479.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5474-5479
    • Hogenesch, J.B.1    Gu, Y.-Z.2    Jain, S.3    Bradfield, C.A.4
  • 23
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature. 386:1997;403-407.
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3    Bradfield, C.A.4    Simon, M.C.5
  • 24
    • 17544384815 scopus 로고    scopus 로고
    • ARNT-deficient mice and placental differentiation
    • Kozak KR, Abbott B, Hankinson O ARNT-deficient mice and placental differentiation. Dev Biol. 191:1997;297-305.
    • (1997) Dev Biol , vol.191 , pp. 297-305
    • Kozak, K.R.1    Abbott, B.2    Hankinson, O.3
  • 25
    • 0033562569 scopus 로고    scopus 로고
    • Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    • This report provide a detailed examination of mesenchymal cell death in HIF-1α mouse knockouts. The surprising conclusion is that defective vascularization associated with mesenchymal cell death is not caused by an absence of VEGF. In contrast, the authors report increased levels of VEGF in HIF-1α mutant mice, although levels in the mesenchymal cells were not directly examined.
    • Kotch LE, Iyer NV, Laughner E, Semenza GL Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol. 209:1999;254-267. This report provide a detailed examination of mesenchymal cell death in HIF-1α mouse knockouts. The surprising conclusion is that defective vascularization associated with mesenchymal cell death is not caused by an absence of VEGF. In contrast, the authors report increased levels of VEGF in HIF-1α mutant mice, although levels in the mesenchymal cells were not directly examined.
    • (1999) Dev Biol , vol.209 , pp. 254-267
    • Kotch, L.E.1    Iyer, N.V.2    Laughner, E.3    Semenza, G.L.4
  • 26
    • 0032528023 scopus 로고    scopus 로고
    • 112K deletion
    • This report demonstrates that a deletion of the Arnt2 locus is viable. The only phenotypes observed were defects in the thymus.
    • 112K deletion. Genomics. 51:1998;223-232. This report demonstrates that a deletion of the Arnt2 locus is viable. The only phenotypes observed were defects in the thymus.
    • (1998) Genomics , vol.51 , pp. 223-232
    • Wines, M.E.1    Tiffany, A.M.2    Holdener, B.C.3
  • 29
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • An elegant paper describing mouse knockout of the EPAS1 gene. EPAS1 mice die late in embryogenesis from cardiac failure. EPAS1 functions during embryogenesis in the Organ of Zuckerkandl by controlling the hypoxia-regulated release of catecholamines. This neurotransmitter controls fetal heart beat.
    • Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12:1998;3320-3324. An elegant paper describing mouse knockout of the EPAS1 gene. EPAS1 mice die late in embryogenesis from cardiac failure. EPAS1 functions during embryogenesis in the Organ of Zuckerkandl by controlling the hypoxia-regulated release of catecholamines. This neurotransmitter controls fetal heart beat.
    • (1998) Genes Dev , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 30
    • 0030739531 scopus 로고    scopus 로고
    • Behavioral and electrophysiologic responses of Drosophila melanogaster to prolonged periods of anoxia
    • Krishnan SN, Sun Y, Mohsenin A, Wyman RJ, Haddad GG Behavioral and electrophysiologic responses of Drosophila melanogaster to prolonged periods of anoxia. J Insect Physiol. 43:1997;203-210.
    • (1997) J Insect Physiol , vol.43 , pp. 203-210
    • Krishnan, S.N.1    Sun, Y.2    Mohsenin, A.3    Wyman, R.J.4    Haddad, G.G.5
  • 31
    • 0000994370 scopus 로고
    • Growth and regeneration in the tracheal system of an insect, Rhodnius prolixus (Hemiptera)
    • Wigglesworth VB Growth and regeneration in the tracheal system of an insect, Rhodnius prolixus (Hemiptera). Q J Microsc Sci. 95:1954;115-137.
    • (1954) Q J Microsc Sci , vol.95 , pp. 115-137
    • Wigglesworth, V.B.1
  • 32
    • 0030923034 scopus 로고    scopus 로고
    • Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster
    • Ma E, Haddad GG Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster. Mol Brain Res. 46:1997;325-328.
    • (1997) Mol Brain Res , vol.46 , pp. 325-328
    • Ma, E.1    Haddad, G.G.2
  • 33
    • 0030025172 scopus 로고    scopus 로고
    • Trachealess encodes a bHLH-PAS protein and is a master regulator gene in the Drosophila tracheal system
    • Wilk R, Weizman I, Glazer L, Shilo B-Z trachealess encodes a bHLH-PAS protein and is a master regulator gene in the Drosophila tracheal system. Genes Dev. 10:1996;93-102.
    • (1996) Genes Dev , vol.10 , pp. 93-102
    • Wilk, R.1    Weizman, I.2    Glazer, L.3    Shilo, B.-Z.4
  • 34
    • 0030049584 scopus 로고    scopus 로고
    • Tubulogenesis in Drosophila: A requirement for the trachealess gene product
    • Isaac DD, Andrew DJ Tubulogenesis in Drosophila: a requirement for the trachealess gene product. Genes Dev. 10:1996;103-117.
    • (1996) Genes Dev , vol.10 , pp. 103-117
    • Isaac, D.D.1    Andrew, D.J.2
  • 35
    • 0030700310 scopus 로고    scopus 로고
    • The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development
    • Sonnenfeld M, Ward M, Nystrom G, Mosher J, Stahl S, Crews S The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. Development. 124:1997;4583-4594.
    • (1997) Development , vol.124 , pp. 4583-4594
    • Sonnenfeld, M.1    Ward, M.2    Nystrom, G.3    Mosher, J.4    Stahl, S.5    Crews, S.6
  • 36
    • 0031834240 scopus 로고    scopus 로고
    • Regulation of Drosophila bHLH PAS protein cellular localization during embryogenesis
    • In the absence of other bHLH-PAS partner proteins, Tango is cytoplasmic; however, it is nuclear in cells that express Sim and Trh, which are dimerization partners of Tango. When either sim or trh are ectopically expressed, their products and Tango are nuclear. This suggests a model in which Sim/Trh forms a heterodimer with Tango in the cytoplasm and the complex translocates into the nucleus. The paper argues against ligand-driven nuclear translocation of Sim and Trh.
    • Ward MP, Mosher JT, Crews ST Regulation of Drosophila bHLH PAS protein cellular localization during embryogenesis. Development. 125:1998;1599-1608. In the absence of other bHLH-PAS partner proteins, Tango is cytoplasmic; however, it is nuclear in cells that express Sim and Trh, which are dimerization partners of Tango. When either sim or trh are ectopically expressed, their products and Tango are nuclear. This suggests a model in which Sim/Trh forms a heterodimer with Tango in the cytoplasm and the complex translocates into the nucleus. The paper argues against ligand-driven nuclear translocation of Sim and Trh.
    • (1998) Development , vol.125 , pp. 1599-1608
    • Ward, M.P.1    Mosher, J.T.2    Crews, S.T.3
  • 37
    • 0030812569 scopus 로고    scopus 로고
    • Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea
    • Ohshiro T, Saigo K Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea. Development. 124:1997;3975-3986.
    • (1997) Development , vol.124 , pp. 3975-3986
    • Ohshiro, T.1    Saigo, K.2
  • 38
    • 0029891739 scopus 로고    scopus 로고
    • Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-1 binding sites
    • Nagao M, Ebert BL, Ratcliffe PJ, Pugh CW Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-1 binding sites. FEBS Lett. 387:1996;161-166.
    • (1996) FEBS Lett , vol.387 , pp. 161-166
    • Nagao, M.1    Ebert, B.L.2    Ratcliffe, P.J.3    Pugh, C.W.4
  • 39
    • 0030012683 scopus 로고    scopus 로고
    • The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human Hypoxia-inducible factor 1α and Drosophila Single-minded
    • Nambu JR, Chen W, Hu S, Crews ST The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human Hypoxia-inducible factor 1α and Drosophila Single-minded. Gene. 172:1996;249-254.
    • (1996) Gene , vol.172 , pp. 249-254
    • Nambu, J.R.1    Chen, W.2    Hu, S.3    Crews, S.T.4
  • 40
    • 0032575669 scopus 로고    scopus 로고
    • Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: Functional evidence for homology with mammalian HIF-1α
    • 2-sensitive regulation. This region is functionally analogous to the mammalian HIF protein hypoxia responsive domain-1 and suggests that Drosophila Similar is an insect HIF.
    • 2-sensitive regulation. This region is functionally analogous to the mammalian HIF protein hypoxia responsive domain-1 and suggests that Drosophila Similar is an insect HIF.
    • (1998) Biochem Biophys Res Comm , vol.249 , pp. 811-816
    • Bacon, N.C.M.1    Wappner, P.2    O'Rourke, J.F.3    Bartlett, S.M.4    Shilo, B.5    Pugh, C.W.6    Ratcliffe, P.J.7
  • 41
    • 0030750422 scopus 로고    scopus 로고
    • Single-minded - two genes, three chromosomes
    • Michaud J, Fan C-M Single-minded - two genes, three chromosomes. Genome Research. 7:1997;569-571.
    • (1997) Genome Research , vol.7 , pp. 569-571
    • Michaud, J.1    Fan, C.-M.2
  • 43
    • 0032532480 scopus 로고    scopus 로고
    • Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
    • In this study, the authors generated murine knockouts of the Sim1 gene, demonstrating that the PVN, SON, and aPV nuclei of the hypothalamus failed to form and that expression of genes in those lineages was altered. Evidence is provided for transcriptional regulatory hierarchy between Sim1 and Brain-2, which is conserved between their fly homologs sim and drifter [45], respectively.
    • Michaud JL, Rosenquist T, May NR, Fan C-M Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev. 12:1998;3264-3275. In this study, the authors generated murine knockouts of the Sim1 gene, demonstrating that the PVN, SON, and aPV nuclei of the hypothalamus failed to form and that expression of genes in those lineages was altered. Evidence is provided for transcriptional regulatory hierarchy between Sim1 and Brain-2, which is conserved between their fly homologs sim and drifter [45], respectively.
    • (1998) Genes Dev , vol.12 , pp. 3264-3275
    • Michaud, J.L.1    Rosenquist, T.2    May, N.R.3    Fan, C.-M.4
  • 45
    • 0028817312 scopus 로고
    • Drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia
    • Anderson MG, Perkins GL, Chittick P, Shrigley RJ, Johnson WA drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia. Genes Dev. 9:1995;123-137.
    • (1995) Genes Dev , vol.9 , pp. 123-137
    • Anderson, M.G.1    Perkins, G.L.2    Chittick, P.3    Shrigley, R.J.4    Johnson, W.A.5
  • 46
    • 0033534628 scopus 로고    scopus 로고
    • A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
    • Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell. 96:1999;57-68.
    • (1999) Cell , vol.96 , pp. 57-68
    • Jin, X.1    Shearman, L.P.2    Weaver, D.R.3    Zylka, M.J.4    De Vries, G.J.5    Reppert, S.M.6
  • 47
    • 0028172292 scopus 로고
    • Control of CNS midline transcription by asymmetric E-box elements: Similarity to xenobiotic responsive regulation
    • Wharton JKA, Franks RG, Kasai Y, Crews ST Control of CNS midline transcription by asymmetric E-box elements: similarity to xenobiotic responsive regulation. Development. 120:1994;3563-3569.
    • (1994) Development , vol.120 , pp. 3563-3569
    • Wharton, J.K.A.1    Franks, R.G.2    Kasai, Y.3    Crews, S.T.4
  • 48
    • 0008258998 scopus 로고    scopus 로고
    • The Drosophila SOX-domain protein Dichaete is required for the development of the central nervous system midline
    • Provides genetic evidence that the Drosophila Dichaete SOX domain transcription factor interacts genetically with the Drifter POU domain protein to control midline glial expression. In combination with [47], these results suggest that slit midline glial transcription is regulated combinatorially by Sim, Tango, Dichaete, and Drifter.
    • Sanchez-Soriano N, Russell S The Drosophila SOX-domain protein Dichaete is required for the development of the central nervous system midline. Development. 125:1998;3989-3996. Provides genetic evidence that the Drosophila Dichaete SOX domain transcription factor interacts genetically with the Drifter POU domain protein to control midline glial expression. In combination with [47], these results suggest that slit midline glial transcription is regulated combinatorially by Sim, Tango, Dichaete, and Drifter.
    • (1998) Development , vol.125 , pp. 3989-3996
    • Sanchez-Soriano, N.1    Russell, S.2
  • 49
    • 0033560895 scopus 로고    scopus 로고
    • Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
    • A demonstration that vertebrate Nkx2.2 regulates neuronal identity in the spinal cord and controls Sim1 expression.
    • Briscoe J, Sussel L, Hartigan-O'Connor D, Jessell TM, Rubenstein JLR, Ericson J Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 398:1999;622-627. A demonstration that vertebrate Nkx2.2 regulates neuronal identity in the spinal cord and controls Sim1 expression.
    • (1999) Nature , vol.398 , pp. 622-627
    • Briscoe, J.1    Sussel, L.2    Hartigan-O'Connor, D.3    Jessell, T.M.4    Rubenstein, J.L.R.5    Ericson, J.6
  • 50
    • 0028822316 scopus 로고
    • Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryos
    • Mellerick DM, Nirenberg M Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryos. Dev Biol. 171:1995;306-316.
    • (1995) Dev Biol , vol.171 , pp. 306-316
    • Mellerick, D.M.1    Nirenberg, M.2
  • 51
    • 0003133553 scopus 로고    scopus 로고
    • Alternate function of the single-minded and rhomboid genes in development of the Drosophila ventral neuroectoderm
    • Xiao H, Hrdlicka LA, Nambu JR Alternate function of the single-minded and rhomboid genes in development of the Drosophila ventral neuroectoderm. Mech Dev. 58:1996;65-74.
    • (1996) Mech Dev , vol.58 , pp. 65-74
    • Xiao, H.1    Hrdlicka, L.A.2    Nambu, J.R.3
  • 52
    • 0030888748 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated signal transduction
    • Rowlands JC, Gustafsson J-A Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol. 27:1997;109-134.
    • (1997) Crit Rev Toxicol , vol.27 , pp. 109-134
    • Rowlands, J.C.1    Gustafsson, J.-A.2
  • 53
    • 0028334079 scopus 로고
    • Photoaffinity labeling of the Ah receptor: Phylogenetic survey of diverse vertebrate and invertebrate species
    • Hahn ME, Poland A, Glover E, Stegement JJ Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species. Arch Biochem Biophys. 310:1994;218-228.
    • (1994) Arch Biochem Biophys , vol.310 , pp. 218-228
    • Hahn, M.E.1    Poland, A.2    Glover, E.3    Stegement, J.J.4
  • 54
    • 0032079316 scopus 로고    scopus 로고
    • Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor
    • Comprehensive molecular genetic analysis of the Drosophila spineless gene demonstrates that it is homologous to vertebrate Ahr. Although highly related by sequence identity, insect Ss is a developmental regulatory protein and vertebrate Ahr is a physiological regulator.
    • Duncan DM, Burgess EA, Duncan I Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor. Genes Dev. 12:1998;1290-1303. Comprehensive molecular genetic analysis of the Drosophila spineless gene demonstrates that it is homologous to vertebrate Ahr. Although highly related by sequence identity, insect Ss is a developmental regulatory protein and vertebrate Ahr is a physiological regulator.
    • (1998) Genes Dev , vol.12 , pp. 1290-1303
    • Duncan, D.M.1    Burgess, E.A.2    Duncan, I.3
  • 55
    • 0032539796 scopus 로고    scopus 로고
    • Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator
    • The authors identify Ahr and Arnt homologs in C. elegans, indicating that bHLH-PAS proteins are highly conserved from worm to human. They further show that dimerization, interaction with Hsp90, and DNA binding properties of C. elegans AHR are similar to mammalian AHR. Studies in yeast suggest that a post-translational process is required for nuclear localization or transcriptional activation, but that activation does not involve dioxin binding.
    • Powell-Coffman JA, Bradfield CA, Wood WB Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator. Proc Natl Acad Sci USA. 95:1998;2844-2849. The authors identify Ahr and Arnt homologs in C. elegans, indicating that bHLH-PAS proteins are highly conserved from worm to human. They further show that dimerization, interaction with Hsp90, and DNA binding properties of C. elegans AHR are similar to mammalian AHR. Studies in yeast suggest that a post-translational process is required for nuclear localization or transcriptional activation, but that activation does not involve dioxin binding.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2844-2849
    • Powell-Coffman, J.A.1    Bradfield, C.A.2    Wood, W.B.3
  • 56
    • 0032872580 scopus 로고    scopus 로고
    • The Drosophila Spineless-Aristapedia and Tango bHLH-PAS proteins interact to control antennal and tarsal development
    • Demonstrates that Drosophila Ss and Tango function as heterodimers in vivo. Provides evidence that Ss function is not controlled by binding of an exogenous ligand, but is controlled by cell-specific ss expression. This differs from vertebrate Ahr, the function funtion which is ligand-dependent.
    • Emmons R, Duncan D, Estes P, Mosher J, Sonnenfeld Ward M, Duncan I, Crews S The Drosophila Spineless-Aristapedia and Tango bHLH-PAS proteins interact to control antennal and tarsal development. Development. 26:1999;3937-3945. Demonstrates that Drosophila Ss and Tango function as heterodimers in vivo. Provides evidence that Ss function is not controlled by binding of an exogenous ligand, but is controlled by cell-specific ss expression. This differs from vertebrate Ahr, the function funtion which is ligand-dependent.
    • (1999) Development , vol.26 , pp. 3937-3945
    • Emmons, R.1    Duncan, D.2    Estes, P.3    Mosher, J.4    Sonnenfeld Ward, M.5    Duncan, I.6    Crews, S.7
  • 58
    • 0030015421 scopus 로고    scopus 로고
    • Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development
    • Schmidt JV, Su GH-T, Reddy JK, Simon MC, Bradfield CA Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci USA. 93:1996;6731-6736.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6731-6736
    • Schmidt, J.V.1    Su, G.-T.2    Reddy, J.K.3    Simon, M.C.4    Bradfield, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.