Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis

Molecular and Cellular Biology

Volumn 17, Issue 9, 1997, Pages 5067-5076

  Benton, Benjamin K ^a,c   Tinkelenberg, Arthur ^a,d   Gonzalez, Isabel ^b   Cross, Frederick R ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c Cadus Pharmaceutical Corporation   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THREONINE;

ARTICLE; CELL CYCLE G1 PHASE; CHO CELL; CYTOKINESIS; DNA FLANKING REGION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE MUTATION; MAMMAL; MITOSIS; MOLECULAR CLONING; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

MAMMALIA; SACCHAROMYCES CEREVISIAE; TRIXIS;

EID: 0030848931     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.9.5067     Document Type: Article

References (76)

1. Adams, A. E. M., D. I. Johnson, R. M. Longnecker, B. F. Sloat, and J. R. Pringle. 1990. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J. Cell. Biol. 111:131-142.
2. Allen J. B., and S. J. Elledge. 1994. A family of vectors that facilitate transposon and insertional mutagenesis of cloned genes in yeast. Yeast 10:1267-1272.
3. Amon, A., M. Tyers, B. Futcher, and K. Nasmyth. 1993. Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell 74:993-1007.
4. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1987. Current protocols in molecular biology. Wiley Interscience, New York, N.Y.
5. Benton, B., and F. Cross. Unpublished observations.
6. Benton, B. K., A. H. Tinkelenberg, D. Jean, S. D. Plump, and F. R. Cross. 1993. Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast. EMBO J. 12:5267-5275.
7. Brown, J. L., L. Stowers, M. Baer, J. Trejo, S. Coughlin, and J. Chant. 1996. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol. 6:598-605.
8. Burbelo, P. D., D. Drechsel, and A. Hall. 1995. A conserved binding motif defines numerous candidate target proteins for both Cdc42p and Rac GT-Pases. J. Biol. Chem. 270:29071-29074.
9. Chong, L. D., A. Traynor-Kaplan, G. M. Bokoch, and M. A. Schwartz. 1994. The small GTP-binding protein Rho regulates a phosphalidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79:507-513.
10. Chou, M. M., and J. Blenis. 1996. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42p and Rac1. Cell 85:573-583.
11. Christianson, T. W., R. S. Sikorski, M. Dante, J. H. Shero, and P. Hieter. 1992. Multifunctional yeast high-copy-number shuttle vectors. Gene 110: 119-122.
12. Coso, O. A., M. Chiariello, J.-C. Yu, H. Teramoto. P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42p regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146.
13. Cross, F. R. 1990. Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating-pheromone signalling pathway. Mol. Cell. Biol. 10:6482-6490.
14. Cullen, B. R. 1996. HIV-1: is Nef a PAK animal? Curr. Biol. 6:1557-1559.
15. Cvrckova, F., C. De Virgilio, E. Manser, J. R. Pringle, and K. Nasmyth. 1995. Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev. 9:1817-1830.
16. 1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation. EMBO J. 12:5277-5286.
17. Dirick, L., T. Bohm, and K. Nasmyth. 1995. Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14:4803-4813.
18. Dutartre, H., J. Davoust, J.-P. Gorvel, and P. Chavrier. 1996. Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GPTase CDC42Hs. J. Cell Sci. 109:367-377.
19. Epstein, C. B., and F. R. Cross. 1992. CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes Dev. 6:1695-1706.
20. Flanagan, C. A., E. A. Schnieders, A. W. Emerick, R. Kunisawa, A. Admon, and J. Thorner. 1993. Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Science 262:1444-1448.
21. Garcia-Bustos, J. F., F. Marini, I. Stevenson, C. Frei, and M. N. Hall. 1994. PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus. EMBO J. 13:2352-2361.
22. Gibson, T. J., M. Hyvonen, A. Musacchio, M. Saraste, and E. Birney. 1994. PH domain: the first anniversary. Trends Biochem. Sci. 19:349-353.
23. Gonzalez, I., and K. Nasmyth. Unpublished observations.
24. Hall, A. 1994. Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol. 10:31-54.
25. Harlan, J. E., P. J. Hajduk, H. S. Yoon, and S. W. Fesik. 1994. Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371:168-170.
26. Hill, C. S., J. Wynne, and R. Treisman. 1995. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81:1159-1170.
27. Horton, R. M., H. D. Hunt, S. N. Ho, J. K. Pullen, and L. R. Pease. 1989. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77:61-68.
28. Johnson, D. I., and J. R. Pringle. 1990. Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J. Cell. Biol. 111:143-152.
29. Khosravi-Far, R., P. A. Solski, G. J. Clark, M. S. Kinch, and C. J. Der. 1995. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol. 15:6443-6453.
30. Kim, H. B., B. K. Haarer, and J. R. Pringle. 1991. Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: localization of the CDC3 gene product and the timing of events at the budding site. J. Cell Biol. 112:535-544.
31. Knaus, U. G., S. Morris, H.-J. Dong, J. Chernoff, and G. M. Bokoch. 1995. Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science 269:221-223.
32. Kolodziej, P. A., and R. A. Young. 1991. Epitope tagging and protein surveillance. Methods Enzymol. 194:508-519.
33. Larochelle, D. A., K. K. Vithalani, and A. De Lozanne. 1996. A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis. J. Cell Biol. 133:1321-1329.
34. Leberer, E., D. Dignard, D. Harcus, D. Y. Thomas, and M. Whiteway. 1992. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein gamma subunits to downstream signalling components. EMBO J. 11:4815-4824.
35. Leberer, E., C. Wu, T. Leeuw, A. Fourest-Lieuvin, J. E. Segall, and D. Y. Thomas. 1997. Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J. 16:83-97.
36. Lemmon, M. A., K. M. Ferguson and J. Schlessinger. 1996. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85:621-624.
37. 1 cyclins differ in their intrinsic functional specificities. Mol. Cell. Biol. 16: 6794-6803.
38. Lew, D. Personal communication.
39. Longtine, M., and J. Pringle. Personal communication.
40. Longtine, M. S., D. J. DeMarini, M. L. Valencik, O. S. Al-Awar, H. Fares, C. De Virgilio, and J. R. Pringle. 1996. The septins: roles in cytokinesis and other processes. Curr. Opin. Cell Biol. 8:106-119.
41. Lu, X., X. Wu, A. Plemenitas, Y. Haifeng, E. T. Sawai, A. Abo, and B. M. Peterlin. 1996. CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr. Biol. 6:1677-1684.
42. Manser, E., C. Chong, Z.-S. Zhao, T. Leung, G. Michael, C. Hall, and L. Lim. 1995. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem. 270:25070-25078.
43. Manser, E., T. Leung, H. Salihuddin, Z. Zhao, and L. Lim. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367: 40-46.
44. Martin, G. A., G. Bollag, F. McCormick, and A. Abo. 1995. A novel serine/threonine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14:1970-1978.
45. Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147-1157.
46. Musacchio, A., T. Gibson, P. Rice, J. Thompson, and M. Saraste. 1993. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem. Sci. 18:343-348.
47. Nasmyth, K. 1993. Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell Biol. 5:166-179.
48. Nasmyth, K., A. Seddon, and G. Ammerer. 1987. Cell cycle regulation of SWI5 is required for mother-cell-specific HO transcription in yeast. Cell 49:549-558.
49. Nobes, C. D., and A. Hall. 1995. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62.
50. Oehlen, L., and F. Cross. Unpublished observations.
51. 1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycle. Genes Dev. 8:1058-1070.
52. Oehlen, L. J. W. M., J. D. McKinney, and F. R. Cross. 1996. Ste12 and Mcm1 regulate cell cycle-dependent transcription on FAR1. Mol. Cell. Biol. 16: 2830-2837.
53. 1. Science 269:1270-1272.
54. + encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO J. 14:5908-5919.
55. Peppelenbosch, M. P., R.-G. Qiu, A. M. M. de Vries-Smiths, L. G. J. Tertoolen, S. W. de Laat, F. McCormick, A. Hall, M. H. Symons, and J. L. Bos. 1995. Rac mediates growth factor-induced arachiodonic acid release. Cell 81:849-856.
56. Peter, M., A. M. Neiman, H. O. Park, M. Van Lohuizen, and I. Herskowitz. 1996. Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J. 15:7046-7059.
57. Pringle, J. R., and L. H. Hartwell. 1981. The Saccharomyces cerevisiae life cycle, p. 97-142. In J. Strathern, E. W. Jones, and J. R. Broach (ed.), The molecular biology of the yeast Saccharomyces cerevisiae. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
58. Qiu, R.-G., J. Chen, D. Kirn, F. McCormick, and M. Symons. 1995. An essential role for Rac in Ras transformation. Nature 374:457-459.
59. Richardson, H. E., C. Wittenberg, F. Cross, and S. I. Reed. 1989. An essential G1 function for cyclin-like proteins in yeast. Cell 59:1127-1133.
60. Ridley, A. J. 1996. Rho: themes and variations. Curr. Biol. 6:1256-1264.
61. Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers to growth factors. Cell 70:389-399.
62. Ridley, A. J., H. F. Paterson, C. L. Johnston, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
63. Rothstein, R. 1990. Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194:281-301.
64. Sawai, E. T., I. H. Khan, P. M. Montbriand, B. M. Peterlin, C. Cheng-Mayer, and P. A. Luciw. 1996. Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques. Curr. Biol. 6:1519-1527.
65. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast strains designed for efficient manipulations of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
66. Simon, M.-N., C. De Virgilio, B. Souza, J. R. Pringle, A. Abo, and S. I. Reed. 1995. Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway. Nature 376:702-705.
67. Stevenson, B. J., B. Ferguson, C. De Virgilio, E. Bi, J. R. Pringe, G. Ammerer, and G. F. Sprague, Jr. 1995. Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes Dev. 9:2949-2963.
68. Surana, U., A. Amon, C. Dowzer, J. McGrew, B. Byers, and K. Nasmyth. 1993. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J. 12:1969-1978.
69. cdc42/rac-1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets. J. Biol. Chem. 270:26690-26697.
70. 1 cyclins and DNA replication. Mol. Cell. Biol. 15:4291-4302.
71. Wu, C., S.-F. Lee, E. Furmaniak-Kazmierczak, G. P. Cote, D. Y. Thomas, and E. Leberer. 1996. Activation of myosin-I by members of the Ste20p protein kinase family. J. Biol. Chem. 271:31787-31790.
72. Wu, C., M. Whiteway, D. Y. Thomas, and E. Leberer. 1995. Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) from Saccharomyces cerevisiae. J. Biol. Chem. 270:15984-15992.
73. Zhao, Z.-S., T. Leung, E. Manser, and L. Lim. 1995. Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24. Mol. Cell. Biol. 15:5246-5257.
74. Zheng, Y., R. Cerione, and A. Bender. 1994. Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc42 and stimulation of GTPase activity by Bem3. J. Biol. Chem. 269:2369-2372.
75. Ziman, M., J. M. O'Brien, L. A. Ouellette, W. R. Church, and D. I. Johnson. 1991. Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity. Mol. Cell. Biol. 11:3537-3544.
76. Ziman, M., D. Preuss, J. Mulholland, J. M. O'Brien, D. Botstein, and D. I. Johnson. 1993. Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol. Biol. Cell 4:1307-1316.