Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

Genes and Development

Volumn 15, Issue 9, 2001, Pages 1078-1092

  Chi, Yong ^a   Huddleston, Michael J ^b   Zhang, Xiaolong ^b   Young, Richard A ^c   Annan, Roland S ^b   Carr, Steven A ^b   Deshaies, Raymond J ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Kin28; Mass spectrometry; Mediator; Msn5; Phosphopeptide; SCF

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE; PROTEIN MSN2; RNA POLYMERASE II; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GCN4; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE EXPRESSION; GENE REPRESSION; HEAT STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; YEAST;

AMINO ACIDS; CELL NUCLEUS; CULTURE MEDIA; CYCLIN-DEPENDENT KINASES; DNA-BINDING PROTEINS; FUNGAL PROTEINS; MUTATION; PEPTIDE SYNTHASES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; UBIQUITINS; YEASTS;

SACCHAROMYCETALES;

EID: 0035339092     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.867501     Document Type: Article

References (43)

1. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
2. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
3. Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae
4. Genetics of transcriptional regulation in yeast: Connections to the RNA polymerase II CTD
5. Selective detection and sequencing of phosphopeptides at the femtomole level by mass spectrometry
6. Ubiquitin-mediated proteolysis: Biological regulation via destruction
7. SCF and cullin/RING H2-based ubiquitin ligases
8. The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast
9. Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis
10. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
11. Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity
12. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast
13. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases
14. General and pathway-specific regulatory mechanisms controlling the synthesis of amino acid biosynthetic enzymes in Saccharomyces cerevisiae
15. GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8
16. Dissecting the regulatory circuitry of a eukaryotic genome
17. Selective detection of phosphopeptides in complex mixtures by electrospray LC-MS
18. The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
19. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
20. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
21. Regulated degradation of the transcription factor Gcn4
22. A kinase-cyclin pair in the RNA polymerase II holoenzyme
23. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)
24. Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex
25. Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo
26. RNA polymerase II holoenzymes and subcomplexes
27. Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator
28. Biological role of the general control of amino acid biosynthesis in Saccharomyces cerevisiae
29. Phosphorylation of sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation
30. Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast
31. Combinatorial control in ubiquitin-dependent proteolysis: Don't Skp the F-box hypothesis
32. Immunofluorescence methods for yeast
33. Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae
34. Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae
35. 1 to S transition in S. cerevisiae
36. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
37. Getting started with yeast
38. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
39. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
40. 1-CDK required for its degradation and entry into S phase
41. Ubiquitination of cell cycle regulatory proteins in yeast extract
42. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities
43. Identification of phosphorylation sites in proteins separated by polyacrylamide gel electrophoresis