Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress

EMBO Journal

Volumn 20, Issue 5, 2001, Pages 1123-1133

  Proft, Markus ^a   Pascual Ahuir, Amparo ^a   De Nadal, Eulàlia ^b   Arĩo, Joaquin ^c   Serrano, Ramón ^b   Posas, Francesc ^c  

^a Ciudad Politécnica de la Innovación   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Hog1; Mitogen activated protein kinase; Signal transduction; Sko1; Stress response

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SKO 1; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE ACTIVITY; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE INDUCTION; GENE MUTATION; NONHUMAN; OSMOLARITY; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPRESSOR GENE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, REPORTER; IMMUNOBLOTTING; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; OSMOTIC PRESSURE; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; RESPONSE ELEMENTS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE PROTEINS; YEASTS;

EID: 0035282906     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.5.1123     Document Type: Article

References (30)

1. Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1
2. PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae
3. An osmosensing signal transduction pathway in yeast
4. Two differentially regulated mRNAs with different 5′-ends encode secreted and intracellular forms of yeast invertase
5. The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae
6. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin β homologs NMD5 and XPO1
7. Cloning vectors for the synthesis of epitope-tagged, truncated and chimeric proteins in Saccharomyces cerevisiae
8. Three genes whose expression is induced by stress in Saccharomyces cerevisiae
9. Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress
10. A novel and conserved salt induced protein is an important determinant of salt-tolerance in yeast
11. Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity
12. MAP kinase pathways in the yeast Saccharomyces cerevisiae
13. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt 1 repressor
14. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor
15. Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast
16. The Ssn6-Tup1 repressor complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG-dependent and independent genes
17. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)
18. Transcriptional regulation by cyclic AMP
19. Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription
20. Sko1 p-repressor and Gcn4p-activator antagonistically modulate stress-regulated transcription in S. cerevisiae
21. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 'two-component' osmosensor
22. The transcriptional response of yeast to saline stress
23. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1 confers HOG-dependent osmotic regulation
24. Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae
25. Related osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p
26. The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes
27. Mitogen-activated protein kinase pathways
28. Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae
29. Use of polymerase chain reaction epitope tagging for protein tagging in S. cerevisiae
30. ACR1, a yeast ATF/CREB repressor