Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p

Molecular and Cellular Biology

Volumn 19, Issue 8, 1999, Pages 5474-5485

  Rep, Martijn ^a   Reiser, Vladimír ^b   Gartner, Ulrike ^b   Thevelein, Johan M ^a   Hohmann, Stefan ^a,c   Ammerer, Gustav ^b   Ruis, Helmut ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR FACTOR;

ARTICLE; GENE EXPRESSION REGULATION; NONHUMAN; OSMOLALITY; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 0032814143     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.8.5474     Document Type: Article

References (61)

1. Albertyn, J., S. Hohmann, J. M. Thevelein, and B. A. Prior. 1994. GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway. Mol. Cell. Biol. 14:4135-4144.
2. Ansell, R., K. Granath, S. Hohmann, J. Thevelein, and L. Adler. 1997. The two isoenzymes for yeast NAD-dependent glycerol 3-phosphate dehydrogenase, encoded by GPD1 and GPD2, have distinct roles in osmoadaption and redox regulation. EMBO J. 16:2179-2187.
3. Baker, H. 1991. GCR1 of Saccharomyces cerevisiae encodes a DNA binding protein whose binding is abolished by mutations in CTTCC sequence motif. Proc. Natl. Acad. Sci. USA 88:9443-9447.
4. Baker, H. 1986. Glycolytic gene expression in Saccharomyces cerevisiae: nucleotide sequence of GCR1, null mutants, and evidence for expression. Mol. Cell. Biol. 6:3774-3784.
5. Breeden, L., and K. Nasmyth. 1985. Regulation of the yeast HO gene. Cold Spring Harbor Symp. Quant. Biol. 50:643-650.
6. Brewster, J. L., T. de Valoir, N. D. Dwyer, E. Winter, and M. C. Gustin. 1993. An osmosensing signal transduction pathway in yeast. Science 259:1760-1763.
7. Chambers, A., E. A. Packham, and I. R. Graham. 1995. Control of glycolytic gene expression in the budding yeast (Saccharomyces cerevisiae). Curr. Genet. 29:1-9.
8. Clifton, D., and D. G. Frankel. 1981. The gcr (glycolysis regulation) mutation of Saccharomyces cerevisiae. J. Biol. Chem. 256:13074-13078.
9. Cyrcková, F., C. de Virgilio, E. Manser, J. R. Pringle, and K. Nasmyth. 1995. Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev. 9:1817-1830.
10. de Winde, J. H., M. Crauwels, S. Hohmann, J. M. Thevelein, and J. Winderickx. 1996. Differential requirement of the yeast sugar kinases for sugar sensing in the establishment of the catabolite repressed state. Eur. J. Biochem. 241:633-643.
11. Drazinic, C. M., J. B. Smerage, M. C. Lopez, and H. V. Baker. 1996. Activation mechanism of the multifunctional transcription factor repressor-activator protein 1 (Rap1p). Mol. Cell. Biol. 16:3187-3196.
12. Eide, D., and L. Guarente. 1992. Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae. J. Gen. Microbiol. 138:347-354.
13. Eriksson, P., L. Adler, and A. Blomberg. 1997. Ph.D. thesis. Gothenburg University, Gothenburg, Sweden.
14. Estruch, F., and M. Carlson. 1990. Increased dosage of the MSN1 gene restores invertase expression in yeast mutants defective in the SNF1 protein kinase. Nucleic Acids Res. 11:6959-6964.
15. Estruch, F., and M. Carlson. 1993. Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol. Cell. Biol. 13:3872-3881.
16. Ferrigno, P., F. Posas, D. Koepp, H. Saito, and P. A. Silver. 1998. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J. 17:5606-5614.
17. Gaits, F., G. Degols, K. Shiozaki, and P. Russell. 1998. Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/ Sty1 stress-activated kinase in fission yeast. Genes Dev. 12:1464-1473.
18. Görner, W., E. Durchschlag, M. T. Martinez-Pastor, F. Estruch, G. Ammerer, B. Hamilton, H. Ruis, and C. Schüller. 1998. Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 12:586-597.
19. Gustin, M. C., J. Albertyn, M. Alexander, and K. Davenport. 1998. MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62:1264-1300.
20. Hirayama, T., T. Maeda, H. Saito, and K. Shinozaki. 1995. Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae. Mol. Gen. Genet. 249:127-138.
21. Hohmann, S. 1997. Shaping up: the response of yeast to osmotic stress, p. 101-145. In S. Hohmann and W. H. Mager (ed.), Yeast stress responses. R.G. Landes, Austin, Tex.
22. Huie, M. A., and H. V. Baker. 1996. DNA-binding properties of the yeast transcriptional activator, Gcr1p. Yeast 12:307-317.
23. Hule, M. A., E., W. Scott, C. M. Drazinic, M. C. Lopez, I. K. Hornstra, T. P. Yang, and H. V. Baker. 1992. Characterization of the DNA-binding activity of GCR1: in vivo evidence for two GCR1-binding sites in the upstream activating sequence of TPI of Saccharomyces cerevisiae. Mol. Cell. Biol. 12:2690-2700.
24. Jacoby, T., H. Flanagan, A. Faykin, A. G. Seto, C. Mattison, and I. Ota. 1997. Two protein tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen activated protein kinase, Hog1. J. Biol. Chem. 272:17749-17755.
25. James, P., J. Halladay, and E. A. Craig. 1996. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144:1425-1436.
26. Lambrechts, M. G., F. F. Bauer, J. Marmur, and I. S. Pretorius. 1996. Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc. Natl. Acad. Sci. USA 93:8419-8424.
27. Lambrechts, M. G., P. Sollitti, J. Marmur, and I. S. Pretorius. 1996. A multicopy suppressor gene, MSS10, restores STA2 expression in Saccharomyces cerevisiae strains containing the STA10 repressor gene. Curr. Genet. 29:523-529.
28. Lindquist, S., and G. Kim. 1996. Heat-shock protein 104 expression is sufficient for thermotolerance in yeast. Proc. Natl. Acad. Sci. USA 93:5301-5306.
29. Luyten, K., J. Albertyn, W. F. Skibbe, B. A. Prior, J. Ramos, J. Thevelein, and S. Hohmann. 1995. Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J. 14:1360-1371.
30. Maeda, T., M. Takekawa, and H. Saito. 1995. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269:554-558.
31. Maeda, T., S. M. Wurgler-Murphy, and H. Saito. 1994. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369:242-245.
32. Manivasakam, P., S. C. Weber, J. McElver, and R. H. Schiestl. 1995. Microhomology mediated PCR targeting in Saccharomyces cerevisiae. Nucleic Acids Res. 23:2799-2800.
33. Marchler, G., C. Schüller, G. Adam, and H. Ruis. 1993. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J. 12:1997-2003.
34. Márquez, J. A., A. Pascual-Ahuir, M. Proft, and R. Serrano. 1998. The Ssn6-Tup1 represser complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG-dependent and -independent genes. EMBO J. 17:2543-2553.
35. Martinez-Pastor, M. T., G. Marchler, C. Schüller, A. Marchler-Bauer, H. Ruis, and F. Estruch. 1996. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress-response element (STRE). EMBO J. 15:2227-2235.
36. Norbeck, J., A. K. Påhlman, N. Akhtar, A. Blomberg, and L. Adler. 1996. Purification and characterization of two isoenzymes of DL-glycerol 3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing MAP kinase signal transduction pathway. J. Biol. Chem. 271:13875-13881.
37. Posas, F., and H. Saito. 1998. Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator. EMBO J. 17:1385-1394.
38. Posas, F., and H. Saito. 1997. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 76:1702-1705.
39. Posas, F., M. Takekawa, and H. Saito. 1998. Signal transduction by MAP kinase cascades in budding yeast. Curr. Opin. Microbiol. 1:175-182.
40. Posas, F., E. A. Witten, and H. Saito. 1998. Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway. Mol. Cell. Biol. 18:5788-5796.
41. Posas, F., S. M. Wurgler-Murphy, T. Maeda, E. A. Witten, T. C. Thai, and H. Saito. 1996. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell 86:865-875.
42. Proft, M., and R. Serrano. 1999. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation. Mol. Cell. Biol. 19:537-546.
43. Reiser, V., H. Ruis, and G. Ammerer. 1999. Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell 10:1147-1161.
44. Rep, M., J. Albertyn, J. M. Thevelein, B. A. Prior, and S. Hohmann. 1999. Different signalling pathways contribute to the control of GPD1 expression by osmotic stress in Saccharomyces cerevisiae. Microbiology 145:715-727.
45. Rep, M., J. M. Thevelein, and S. Hohmann. 1999. The role of ATF-like transcription factors in yeast osmoadaptation. Unpublished results.
46. Rose, M. D., F. Winston, and P. Hieter. 1990. Methods in yeast genetics. A laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
47. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
48. Schmitt, A. P., and K. McEntee. 1996. Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93:5777-5782.
49. Schüller, G., J. L. Brewster, M. R. Alexander, M. C. Gustin, and H. Ruis. 1994. The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. EMBO J. 13:4382-4389.
50. Schüller, H. J., A. Hahn, F. Troster, A. Schutz, and E. Schweizer. 1992. Coordinate genetic control of yeast fatty acid synthase genes FAS1 and FAS2 by an upstream activation site common to genes involved in membrane lipid biosynthesis. EMBO J. 11:107-114.
51. Siderius, M., E. Rots, and W. H. Mager. 1997. High-osmolarity signalling in Saccharomyces cerevisiae is modulated in a carbon-source-dependent fashion. Microbiology 143:3241-3250.
52. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
53. Tamás, M. J., K. Luyten, F. C. W. Sutherland, A. Hernandez, J. Albertyn, H. Valadi, H. Li, B. A. Prior, S. G. Kilian, J. Ramos, L. Gustafsson, J. M. Thevelein, and S. Hohmann. 1999. Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol. Microbiol. 31:1087-1104.
54. Thomas, B. J., and R. J. Rothstein. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619-630.
55. Toone, W. M., and N. Jones. 1998. Stress-activated signalling pathways in yeast. Genes Cells 3:485-498.
56. Tornow, J., X. Zeng, W. Gao, and G. M. Santangelo. 1993. GCR1, a transcriptional activator in Saccharomyces cerevisiae, complexes with RAP1 and can function without its DNA binding domain. EMBO J. 12:2431-2437.
57. Varela, J. C. S., U. M. Praekelt, P. A. Meacock, R. J. Planta, and W. H. Mager. 1995. The Saccharomyces cerevisiae HSP12 gene is activated by the high-osmolarity glycerol pathway and negatively regulated by protein kinase A. Mol. Cell. Biol. 15:6232-6245.
58. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
59. Wach, A., A. Brachat, R. Pohlmann, and P. Philippsen. 1994. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10:1793-1808.
60. Wurgler-Murphy, S. M., T. Maeda, E. A. Witten, and H. Saito. 1997. Regulation of the Saccharomyces cerevisiae Hog1 mitogen-activated protein kinase by the Ptp2 and Ptp3 protein tyrosine phosphatases. Mol. Cell. Biol. 17:1289-1297.
61. Zachariae, W., and K. Nasmyth. Unpublished results.