Metabolic surprises in Saccharomyces cerevisiae during adaptation to saline conditions: Questions, some answers and a model

FEMS Microbiology Letters

Volumn 182, Issue 1, 2000, Pages 1-8

  Blomberg, Anders ^a  

^a Microbiol Lundberg Lab G   (Sweden)

Author keywords

Futile cycles; Glycerol; Osmoregulation; Trehalose; Yeast

Indexed keywords

GLYCEROL; SODIUM CHLORIDE; TREHALOSE;

ADAPTATION; ARTICLE; GENE EXPRESSION; GLYCOLYSIS; METABOLISM; MODEL; NONHUMAN; OSMOREGULATION; OSMOTIC STRESS; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ADAPTATION, PHYSIOLOGICAL; OSMOLAR CONCENTRATION; SACCHAROMYCES CEREVISIAE; SODIUM CHLORIDE; WATER-ELECTROLYTE BALANCE;

SACCHAROMYCES CEREVISIAE;

EID: 0033987099     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(99)00531-5     Document Type: Article

References (47)

1. Brown A.D. Compatible solute and extreme water stress in eukaryotic micro-organisms. Adv. Microb. Phys. 17:1978;181-242.
2. Blomberg A., Adler L. Physiology of osmotolerance in fungi. Adv. Microb. Phys. 33:1992;145-212.
3. Varela J.C.S., Mager W.H. Response of Saccharomyces cerevisiae to changes in external osmolarity. Microbiology. 142:1996;721-731.
4. Hohmann, S. (1997) Shaping up: the response of yeast to osmotic stress. In: Yeast Stress Responses (Hohmann, S. et al., Eds.), pp. 101-146. Springer, New York.
5. Gustin M.C., Albertyn J., Alexander M., Davenport K. MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62:1998;1264-1300.
6. Bonhivers M., Carbrey J.M., Gould S.J., Agre P. Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains. J. Biol. Chem. 273:1998;27565-27572.
7. Blomberg A. The osmotic hypersensitivity of the yeast Saccharomyces cerevisiae is strain and growth media dependent: quantitative aspects of the phenomenon. Yeast. 13:1997;529-539.
8. Blomberg A., Larsson C., Gustafsson L. Microcalorimetric monitoring of growth of Saccharomyces cerevisiae: Osmotolerance in relation to physiological state. J. Bacteriol. 170:1988;4562-4568.
9. Serrano, R., Marquez, J.A. and Rios, G. (1997) Crucial factors in salt stress tolerance. In: Yeast Stress Responses (Hohmann, S. et al., Eds.), pp. 147-170. Springer, New York.
10. Prior C., Potier S., Souciet J.L., Sychrova H. Characterization of the NHA1 gene encoding a Na+/H+-antiporter of the yeast Saccharomyces cerevisiae. FEBS Lett. 387:1996;89-93.
11. Adler L., Blomberg A., Nilsson A. Glycerol metabolism and osmoregulation in the salt-tolerant yeast Debaryomyces hansenii. J. Bacteriol. 162:1985;300-306.
12. Luyten K., Albertyn J., Skibbe W.F., Prior B.A., Ramos J., Thevelein J.M., Hohmann S. FPS1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J. 14:1995;1360-1371.
13. +) in acquired osmotolerance of Saccharomyces cerevisiae. J. Bacteriol. 171:1989;1087-1092.
14. +) complements an osmosensitive mutant of Saccharomyces cerevisiae. Mol. Microbiol. 10:1993;1101-1111.
15. Albertyn J., Hohmann S., Thevelein J.M., Prior B.A. GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high osmolarity glycerol response pathway. Mol. Cell. Biol. 14:1994;4135-4144.
16. +) in Saccharomyces cerevisiae, and its comparison with GPD1. Mol. Microbiol. 17:1995;95-107.
17. Norbeck J., Blomberg A. Two-dimensional electrophoretic separation of yeast proteins using a non-linear wide range (pH 3-10) immobilized pH gradient in the first dimension; reproducibility and evidence for isoelectric focusing of alkaline (pI7) proteins. Yeast. 13:1997;529-539.
18. Blomberg A. Global changes in protein synthesis during adaptation to 0.7 M NaCl medium of Saccharomyces cerevisiae. J. Bacteriol. 177:1995;3563-3572.
19. Norbeck J., Påhlmann A.-K., Akhtar N., Blomberg A., Adler L. Purification and characterization of two isoenzymes of DL-glycerol 3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 271:1996;13875-13883.
20. Hirayama T., Maeda T., Saito H., Shinozaki K. Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae. Mol. Gen. Genet. 249:1995;127-138.
21. Norbeck J., Blomberg A. Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M sodium chloride: Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway. J. Biol. Chem. 272:1997;5544-5554.
22. Kato N., Yoshikawa H., Tanaka K., Shimao M., Sakazawa C. Dihydroxyacetone kinase from a methylotrophic yeast, Hansenula polymorpha CBS 4732. Arch. Microbiol. 150:1988;155-159.
23. van Zyl P.J., Prior B.A., Kilian S.G. Regulation of glycerol metabolism in Zygosaccharomyces rouxii in response to osmotic stress. Appl. Microbiol. Biotechnol. 36:1991;369-374.
24. 13C nuclear magnetic resonance spectroscopic analysis of acyclic polyol and trehalose accumulation by several yeast species in response to salt stress. FEMS Microbiol. Lett. 82:1991;163.
25. Parrou J.L., Teste M.-A., Francois J. Effects of various types of stress on the metabolism of reserve carbohydratesin Saccharomyces cerevisiae: genetic evidence for a stress-induced recycling of glycogen and trehalose. Microbiology. 143:1997;1891-1900.
26. Singer M.A., Lindquist S. Multiple effects of trehalose on protein folding in vitro and in vivo. Mol. Cell. 1:1998;639-648.
27. Allison S.D., Chang B., Randolph T.W., Carpenter J.F. Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding. Arch. Biochem. Biophys. 356:1999;289-298.
28. Crowe J.H., Crowe L.M., Chapman D. Preservation of membranes in anhydrobiotic organisms: the role of trehalose. Science. 223:1984;701-703.
29. Ölz R., Larsson K., Adler L., Gustafsson L. Energy flux and osmoregulation of Saccharomyces cerevisiae grown in chemostat under NaCl stress. J. Bacteriol. 175:1993;2205-2213.
30. Winderickx J.H.d.W.J., Crauwels M., Hino A., Hohmann S., Van Dijck P., Thevelein J.M. Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: novel variations of STRE-mediated transcription control? Mol. Gen. Genet. 252:1996;470-482.
31. Akhtar N., Blomberg A., Adler L. Osmoregulation and protein expression in a pbs2Δ mutant of Saccharomyces cerevisiae during adaptation to hypersaline stress. FEBS Lett. 403:1997;173-180.
32. Norbeck, J. and Blomberg, A. (1999) The level of cAMP dependent protein kinase A activity strongly affects osmotolerance and osmo instigated gene expression changes in Saccharomyces cerevisiae. Yeast, in press.
33. Godon C., Lagniel G., Lee J., Buhler J.-M., Kieffer S., Perrot M., Boucherie H., Toledano M.B., Labarre J. The H2O2 stimulon in Saccharomyces cerevisiae. J. Biol. Chem. 273:1998;22480-22489.
34. Blazquez M.A., Lagunas R., Gancedo C., Gancedo J.M. Trehalose-6-phosphate, a new regulator of yeast glycolysis that inhibits hexokinases. FEBS Lett. 329:1993;51-54.
35. Teusink B., Walsh M.C., van Dam K., Westerhoff H.V. The danger of metabolic pathways with turbo design. TIBS. 23:1998;162-169.
36. Neves M.J., Hohmann S., Bell W., Dumortier F., Luyten K., Ramos J., Cobbaert P., de Koning W., Kaneva Z., Thevelein J.M. Control of glucose influx into glycolysis and pleiotropic effects studied in different isogenic sets of Saccharomyces cerevisiae mutants in trehalose biosynthesis. Curr. Genet. 27:1995;110-122.
37. Jong A., Yeh Y., Ma J.J. Characteristics, substrate analysis, and intracellular location of Saccharomyces cerevisiae UMP kinase. Arch. Biochem. Biophys. 304:1993;197-204.
38. Van Aelst T., Hohmann S., Zimmermann F.K., Jans A.W.H., Thevelein J.M. A yeast homologue of the bovine lens fibre MIP gene family complements the growth defect of a Saccharomyces cerevisiae mutant on fermentable sugars but not its defect in glucose-induced RAS-mediated cAMP signalling. EMBO J. 10:1991;2095-2104.
39. Hohmann S., Neves M.J., de Koning W., Alijo R., Ramos J., Thevelein J.M. The growth and signalling defects of the ggs1 (fdp1/byp1) deletion mutant on glucose are suppressed by a deletion of the gene encoding hexokinase PII. Curr. Genet. 23:1993;281-289.
40. Jennings D.H., Burke R.M. Compatible solutes - the mycological dimension and their role as physiological buffering agents. N. Phytol. 116:1990;277.
41. Hottiger T., Schmutz P., Wiemken A. Heat-induced accumulation and cycling of trehalose in Saccharomyces cerevisiae. J. Bacteriol. 169:1987;5518-5522.
42. Zähringer H., Burgert M., Holzer H., Nwaka S. Neutral trehalase Nth1p of Saccharomyces cerevisiae encoded by the NTH1 gene is a multiple stress responsive protein. FEBS Lett. 412:1997;615-620.
43. Jelinsky S.A., Samson L.D. Global responses of Saccharomyces cerevisiae to an alkylating agent. Proc. Natl. Acad. Sci. USA. 96:1999;1486-1491.
44. Timasheff S.N. Solvent stabilization of protein structure. Methods Mol. Biol. 40:1995;253-269.
45. de Winde, J.H., Thevelein, J.M. and Winderickx, J. (1997) From feast to famine: asaptation to nutrient depletion in yeast. In: Yeast Stress Responses (Hohmann, S. et al., Eds.), pp. 7-52. Springer, New York.
46. McAlister L., Holland M.J. Isolation and characterization of yeast strains carrying mutations in the glyceraldehyde-3-phosphate dehydrogenase genes. J. Biol. Chem. 260:1985;15013-15018.
47. DeRisi J.L., Lyer V.R., Brown P.O. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science. 278:1997;680-686.