Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity

Genes and Development

Volumn 12, Issue 4, 1998, Pages 586-597

  Görner, Wolfram ^a   Durchschlag, Erich ^a   Martinez Pastor, Maria Teresa ^b   Estruch, Francisco ^b   Ammerer, Gustav ^a   Hamilton, Barbara ^a   Ruis, Helmut ^a   Schüller, Christoph ^a  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

Author keywords

Msn2p; Msn4p; Nuclear localization; Protein kinase A; STRE; Stress; Yeast

Indexed keywords

ALANINE; ALCOHOL; ASPARTIC ACID; CARBON; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTEINE; HISTIDINE; HYBRID PROTEIN; SERINE; SORBIC ACID; ZINC FINGER PROTEIN; DNA BINDING PROTEIN; FUNGAL DNA; FUNGAL PROTEIN; MSN2 PROTEIN, S CEREVISIAE; MSN4 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; HEAT SHOCK; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STARVATION; STRESS; AMINO ACID SEQUENCE; BINDING SITE; CELL COMPARTMENTALIZATION; COMPARATIVE STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; SIGNAL TRANSDUCTION; TIME; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; CELL NUCLEUS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTEINE; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HISTIDINE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0032518996     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.4.586     Document Type: Article

References (33)

1. Baldwin, A.S., Jr. 1996. The NF-kappa B and I kappa B proteins: New discoveries and insights. Annu. Rev. Immunol. 14: 649-683.
2. Baroni, M.D., P. Monti, G. Marconi, and L. Alberghina. 1992. cAMP-mediated increase in the critical cell size required for the G1 to S transition in Saccharomyces cerevisiae. Exp. Cell Res. 201: 299-306.
3. Baroni, M.D., P. Monti, and L. Alberghina. 1994. Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast. Nature 371: 339-342.
4. Beals, C.R., C.M. Sheridan, C.W. Turck, P. Gardner, and G.R. Crabtree. 1997. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275: 1930-1933.
5. Brewster, J.L., T. de Valoir, N.D. Dwyer, E. Winter, and M.C. Gustin. 1993. An osmosensing signal transduction pathway in yeast. Science 259: 1760-1763.
6. Boy-Marcotte, E., D. Tadi, M. Perrot, H. Boucherie, and M. Jacquet. 1996. High cAMP levels antagonize the reprogramming of gene expression that occurs at the diauxic shift in Saccharomyces cerevisiae. Microbiology 142: 459-467.
7. Cameron, S., L. Levin, M. Zoller, and M. Wigler. 1988. cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell 53: 555-566.
8. Chen, R.-H., C. Sarniecki, and J. Blenis. 1992. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol. Cell. Biol. 12: 915-927.
9. DeVit, M.J., J.A. Waddle, and M. Johnston. 1997. Regulated nuclear translocation of the Mig1 glucose repressor. Mol. Biol. Cell 8: 1603-1618.
10. De Winde, J.H., J.M. Thevelein, and J. Winderickx. 1997. From feast to famine: Adaptation to nutrient depletion in yeast. In Yeast stress responses (ed. S. Hohmann and W.H. Mager ), pp. 7-52. Landes, Austin, TX.
11. Estruch, F. and M. Carlson. 1993. Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 3872-3881.
12. Gietz, R.D. and A. Sugino. 1988. New yeast - Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74: 527-534.
13. Görlich, D. and I.W. Mattaj. 1996. Nucleocytoplasmic transport. Science 271: 1513-1518.
14. Hubler, L., J. Bradshaw-Rouse, and W. Heideman. 1993. Connections between the Ras-cyclic AMP pathway and G1 cyclin expression in the budding yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 6274-6282.
15. Jans, D.A. 1995. The regulation of protein transport to the nucleus by phosphorylation. Biochem. J. 311: 705-716.
16. Koch, C., A. Schleiffer, G. Ammerer, and K. Nasmyth. 1996. Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2. Genes & Dev. 10: 129-141.
17. Kuge, S., N. Jones, and A. Nomoto. 1997. Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J. 16: 1710-1720.
18. Marchler, G., C. Schüller, G. Adam, and H. Ruis. 1993. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J. 12: 1997-2003.
19. Martinez-Pastor, M.T., G. Marchler, C. Schüller, A. Marchler-Bauer, H. Ruis, and F. Estruch. 1996. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). EMBO J. 15: 2227-2235.
20. Nasmyth, K., G. Adolf, D. Lydall, and A. Seddon. 1990. The identification of a second cell cycle control on the HO promoter in yeast: cell cycle regulation of SW15 nuclear entry. Cell 62: 631-647.
21. Nigg, E.A. 1997. Nucleocytoplasmic transport: Signals, mechanisms and regulation. Nature 386: 779-783.
22. O'Neill, E.M., A. Kaffman, R.J. Jolly, and E.K. O'Shea. 1996. Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex. Science 271: 209-212.
23. Piatti, S., T. Böhm, J.H. Cocker, J.F.X. Diffley, and K. Nasmyth. 1996. Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes & Dev. 10: 1516-1531.
24. Ruis, H. 1997. Yeast stress responses: Achievements, goals and a look beyond yeast. In Yeast stress responses (ed. S. Hohmann and W.H. Mager), pp. 231-247. Landes, Austin, TX.
25. Ruis, H. and C. Schüller. 1995. Stress signaling in yeast, BioEssays 17: 959-965.
26. Schmitt, A.P. and K. McEntee. 1996. Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 93: 5777-5782.
27. Schüller, C., J.L. Brewster, M.R. Alexander, M.C. Gustin, and H. Ruis. 1994. The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. EMBO J. 13: 4382-4389.
28. Shin, D.-Y., K. Matsumoto, H. Iida, I. Uno, and T. Ishikawa. 1987. Heat shock response of Saccharomyces cerevisiae mutants altered in cAMP-dependent protein phosphorylation. Mol. Cell. Biol. 7: 244-250.
29. Siebenlist, U., K. Brown, and G. Franzoso. 1995. NF-κB: A mediator of pathogen and stress responses. In Inducible gene expression, Vol.1, Environmental stresses and nutrients (ed. P. Baeuerle), pp. 93-142. Birkhäuser, Boston, MA.
30. Siderius, M. and W.H. Mager. 1997. General stress response: In search of a common denominator. In Yeast stress responses (ed. S. Hohmann and W.H. Mager), pp. 213-230. Landes, Austin, TX.
31. Sikorski, R.S. and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
32. Thevelein, J.M. 1994. Signal transduction in yeast. Yeast 10: 1753-1790.
33. Tokiwa, G., M. Tyers, T. Volpe, and B. Futcher. 1994. Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast. Nature 371: 342-345.