Physiology and pathophysiology of renal aquaporins

Journal of the American Society of Nephrology

Volumn 10, Issue 3, 1999, Pages 647-663

  Nielsen, Søren ^a   Kwon, Tae Hwan ^a   Christensen, Birgitte Mønster ^a   Promeneur, Dominique ^a   Frøkiær, Jørgen ^b   Marples, David ^c  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN; MOZAVAPTAN; VASOPRESSIN;

CONFERENCE PAPER; FLUID BALANCE; IMMUNOELECTRON MICROSCOPY; KIDNEY COLLECTING TUBULE; MEMBRANE CHANNEL; NEPHROGENIC DIABETES INSIPIDUS; NEPHRON; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; WATER ABSORPTION; WATER TRANSPORT;

EID: 0033053453     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (119)

1. Agre P, Preston GM, Smith BL, Jung JS, Raina S, Moon C, Guggino WB, Nielsen S: Aquaporin CHIP: The archetypal molecular water channel. Am J Physiol 265: F463-F476, 1993
2. Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F, Sasaki S: Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature 361: 549-552, 1993
3. Knepper MA: Molecular physiology of urinary concentrating mechanism: Regulation of aquaporin water channels by vasopressin. Am J Physiol 272: F3-F12, 1997
4. Agre P, Bonhivers M, Borgnia MJ: The aquaporins, blueprints for cellular plumbing systems. J Biol Chem 273: 14659-14662, 1998
5. Jung JS, Preston GM, Smith BL, Guggino WB, Agre P: Molecular structure of the water channel through Aquaporin CHIP: The hourglass model. J Biol Chem 269: 14648-14654, 1994
6. Cabiaux V, Oberg KA, Pancoska P, Walz T, Agre P, Engel A: Secondary structures comparison of aquaporin-1 and bacteriorhodopsin: A Fourier transform infrared spectroscopy study of two-dimensional membrane crystals. Biophys J 73: 406-417, 1997
7. Walz T, Hirai T, Murata K, Heymann JB, Mitsuoka K, Fujiyoshi Y, Smith BL, Agre P, Engel A: The three-dimensional structure of aquaporin-1. Nature 387: 624-627, 1997
8. Cheng A, van Hoek AN, Yeager M, Verkman AS, Mitra AK: Three-dimensional organization of a human water channel. Nature 387: 627-630, 1997
9. Yang B, Brown D, Verkman AS: The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells. J Biol Chem 271: 4577-4580, 1996
10. Van Hoek AN, Yang B, Kirmiz S, Brown D: Freeze-fracture analysis of plasma membranes of CHO cells stably expressing aquaporins 1-5. J Membr Biol 165: 243-254, 1998
11. Verbavatz JM, Ma T, Gobin R, Verkman AS: Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4. J Cell Sci 110: 2855-2860, 1997
12. Rash JE, Yasumura T, Hudson CS, Agre P, Nielsen S: Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc Natl Acad Sci USA 95: 11981-11986, 1998
13. Nielsen S, Smith B, Christensen EI, Knepper MA, Agre P: CHIP28 water channels are localized in constitutively water-permeable segments of the nephron. J Cell Biol 120: 371-383, 1993
14. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS: Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem 273: 4296-4299, 1998
15. Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, Verkman AS: Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci USA 95: 9660-9664, 1998
16. Nielsen S, DiGiovanni SR, Christensen EI, Knepper MA, Harris HW: Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proc Natl Acad Sci USA 90: 11663-11667, 1993
17. Kishore BK, Mandon B, Oza NB, DiGiovanni SR, Coleman RA, Ostrowski NL, Wade JB, Knepper MA: Rat renal arcade segment expresses vasopressin-regulated water channel and vasopressin V2 receptor. J Clin Invest 97: 2763-2771, 1996
18. DiGiovanni SR, Nielsen S, Christensen EI, Knepper MA: Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Proc Natl Acad Sci USA 91: 8984-8988, 1994
19. Deen PM, Verdijk MA, Knoers NV: Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science 264: 92-95, 1994
20. Marples D, Christensen S, Christensen EI, Ottosen PD, Nielsen S: Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla. J Clin Invest 95: 1838-1845, 1995
21. Frigeri A, Gropper MA, Turck CW, Verkman AS: Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc Natl Acad Sci USA 92: 4328-4331, 1995
22. Chou CL, Ma T, Yang B, Knepper MA, Verkman AS: Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. Am J Physiol 274: C549-C554, 1998
23. Ishibashi K, Kuwahara M, Gu Y: Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. J Biol Chem 272: 20782-20786, 1997
24. Chevalier J, Bourguet J, Hugon JS: Membrane-associated particles: Distribution in frog urinary bladder epithelium at rest and after oxytocin treatment. Cell Tissue Res 152: 129-140, 1974
25. Kachadorian WA, Levine SD, Wade JB, Di-Scala VA, Hays RM: Relationship of aggregated intramembranous particles to water permeability in vasopressin-treated toad urinary bladder. J Clin Invest 59: 576-581, 1977
26. Humbert F, Montesano R, Grosso A, de-Sousa RC, Orci L: Particle aggregates in plasma and intracellular membranes of toad bladder (granular cell). Experientia 33: 1364-1367, 1977
27. Stetson DL, Wade JB, Giebisch G: Morphologic alterations in the rat medullary collecting duct following potassium depletion. Kidney Int 17: 45-56, 1980
28. Nielsen S, Frøkiær J, Knepper MA: Renal apuapoins: Key roles in water balance and water balance disorders. Curr Opin Nephrol Hypertens 7: 509-516, 1998
29. Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA: Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci USA 92: 1013-1017, 1995
30. Marples D, Knepper MA, Christensen EI, Nielsen S: Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct. Am J Physiol 269: C655-C664, 1995
31. Sabolic I, Katsura T, Verbavatz JM, Brown D: The AQP2 water channel: Effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats. J Membr Biol 143: 165-175, 1995
32. Yamamoto T, Sasaki S, Fushimi K, Ishibashi K, Yaoita E, Kawasaki K, Marumo F, Kihara I: Vasopressin increases AQP-CD water channel in apical membrane of collecting duct principal cells in Brattleboro rats. Am J Physiol 268: C1546-C1551, 1995
33. 2-receptor antagonist on kidney AQP2 expression and subcellular distribution. Am J Physiol 275: F285-F297, 1998
34. Hayashi M, Sasaki S, Tsuganezawa H, Monkawa T, Kitajima W, Konishi K, Fushimi K, Marumo F, Saruta T: Expression and distribution of aquaporin of collecting duct are regulated by vasopressin V2 receptor in rat kidney. J Clin Invest 94: 1778-1783, 1994
35. Saito T, Ishikawa SE, Sasaki S, Fujita N, Fushimi K, Okada K, Takeuchi K, Sakamoto A, Ookawara S, Kaneko T, Marumo F: Alteration in water channel AQP-2 by removal of AVP stimulation in collecting duct cells of dehydrated rats. Am J Physiol 272: F183-F191, 1997
36. Kuwahara M, Fushimi K. Terada Y, Bai L, Marumo F, Sasaki S: cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes. J Biol Chem 270: 10384-10387, 1995
37. Lande MB, Jo I, Zeidel ML, Somers M, Harris HW Jr: Phosphorylation of aquaporin/2 does not alter the membrane water permeability of rat papillary water channel-containing vesicles. J Biol Chem 271: 5552-5557, 1996
38. Katsura T, Ausiello DA, Brown D: Direct demonstration of aquaporin-2 water channel recycling in stably transfected LLC-PK1 epithelial cells. Am J Physiol 270: F548-F553, 1996
39. Katsura T, Gustafson CE, Ausiello DA, Brown D: Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells. Am J Physiol 272: F817-F822, 1997
40. Katsura T, Verbavatz JM, Farinas J, Ma T, Ausiello D, Brown D: Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells. Proc Natl Acad Sci USA 92: 7212-7216, 1995
41. Deen PM, Rijss JP, Mulders SM, Errington RJ, van Baal J, van Os CH: Aquaporin-2 transfection of Madin-Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport. J Am Soc Nephrol 8: 1493-1501, 1997
42. Deen PM, Knoers NV: Physiology and pathophysiology of the aquaporin-2 water channel. Curr Opin Nephrol Hypertens 7: 37-42, 1998
43. Knepper MA, Nielsen S, Chou CL, DiGiovanni SR: Mechanism of vasopressin action in the renal collecting duct. Semin Nephrol 14: 302-321, 1994
44. Kurokawa K, Massry SG: Interaction between catecholamines and vasopressin on renal medullary cyclic AMP of rat. Am J Physiol 225: 825-829, 1973
45. 2. Am J Physiol 240: F311-F318, 1981
46. Dousa TP, Sands H, Hechter O: Cyclic AMP-dependent reversible phosphorylation of renal medullary plasma membrane protein. Endocrinology 91: 757-763, 1972
47. Gapstur SM, Homma S, Dousa TP: cAMP-binding proteins in medullary tubules from rat kidney: Effect of ADH. Am J Physiol 255: F292-F300, 1988
48. Nishimoto G, Zelenina M, Li D, Yasui M, Aperia A, Nielsen S, Nairn AC: Arginine vasopressin stimulates phosphorylation of aquaporin-2 in rat renal tissue. Am J Physiol 1999, in press
49. Wall SM, Han JS, Chou CL, Knepper MA: Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD. Am J Physiol 262: F989-F998, 1992
50. Fushimi K, Sasaki S, Marumo F: Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel. J Biol Chem 272: 14800-14804, 1997
51. 2 receptor antagonist treatment [Abstract]. J Am Soc Nephrol 9: 16A, 1998
52. Zelenina M, Christensen BM, Nielsen S, Aperia A: Prostaglandin E2 interaction with arginine vasopressin (AVP): Effects on aquaporin (AQP) 2 abundance in membrane and the state of AQP2 phosphorylation [Abstract]. J Am Soc Nephrol 9: 29A, 1998
53. Gronbeck L, Marples D, Nielsen S, Christensen S: Mechanism of antidiuresis caused by bendroflumethiazide in conscious rats with diabetes insipidus. Br J Pharmacol 123: 737-745, 1998
54. Phillips ME, Taylor A: Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules. J Physiol Lond 456: 591-608, 1992
55. Phillips ME, Taylor A: Effect of nocodazole on the water permeability response to vasopressin in rabbit collecting tubules perfused in vitro. J Physiol Lond 411: 529-544, 1989
56. Valenti G, Hugon JS, Bourguet J: To what extent is microtubular network involved in antidiuretic response? Am J Physiol 255: F1098-F1106, 1988
57. Achler C, Filmer D, Merte C, Drenckhahn D: Role of microtubules in polarized delivery of apical membrane proteins to the brush border of the intestinal epithelium. J Cell Biol 109: 179-189, 1989
58. Marples D, Turner M, Taylor A: Increase in microtubule content in response to cAMP in rabbit cortical collecting ducts [Abstract]. Kidney Int 47: 662, 1995
59. Marples D, Schroer TA, Ahrens N, Taylor A, Knepper MA, Nielsen S: Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct. Am J Physiol 274: F384-F394, 1998
60. de-Sousa RC, Grosso A: Vanadate blocks cyclic AMP-induced stimulation of sodium and water transport in amphibian epithelia. Nature 279: 803-804, 1979
61. Marples D, Barber B, Taylor A: Effect of a dynein inhibitor on vasopressin action in toad urinary bladder. J Physiol Lond 490: 767-774, 1996
62. Wade JB, Kachadorian WA: Cytochalasin B inhibition of toad bladder apical membrane responses to ADH. Am J Physiol 255: C526-C530, 1988
63. Pearl M, Taylor A: Actin filaments and vasopressin-stimulated water flow in toad urinary bladder. Am J Physiol 245: C28-C39, 1983
64. Kachadorian WA, Ellis SJ, Muller J: Possible roles for microtubules and microfilaments in ADH action on toad urinary bladder. Am J Physiol 236: F14-F20, 1979
65. Muller J, Kachadorian WA: Aggregate-carrying membranes during ADH stimulation and washout in toad bladder. Am J Physiol 247: C90-C98, 1984
66. Pearl M, Taylor A: Role of the cytoskeleton in the control of transcellular water flow by vasopressin in amphibian urinary bladder. Biol Cell 55: 163-172, 1985
67. Ding GH, Franki N, Condeelis J, Hays RM: Vasopressin depolymerizes F-actin in toad bladder epithelial cells. Am J Physiol 260: C9-C16, 1991
68. DiBona DR: Cytoplasmic involvement in ADH-mediated osmosis across toad urinary bladder. Am J Physiol 245: C297-C307, 1983
69. Rothman JE: Mechanisms of intracellular protein transport. Nature 372: 55-63, 1994
70. Nielsen S, Marples D, Birn H, Mohtashami M, Dalby NO, Trimble M, Knepper M: Expression of VAMP-2-like protein in kidney collecting duct intracellular vesicles: Co-localization with aquaporin-2 water channels. J Clin Invest 96: 1834-1844, 1995
71. Franki N, Macaluso F, Gao Y, Hays RM: Vesicle fusion proteins in rat inner medullary collecting duct and amphibian bladder. Am J Physiol 268: 792-797, 1995
72. Jo I, Harris HW, Amedt-Raduege AM, Majewski RR, Hammond TG: Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone (ADH) water channel-containing endosomes in vitro. Proc Natl Acad Sci USA 92: 1876-1880, 1995
73. Mandon B, Chou CL, Nielsen S, Knepper MA: Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: Possible role in aquaporin-2 trafficking. J Clin Invest 98: 906-913, 1996
74. Mandon B, Nielsen S, Kishore BK, Knepper MA: Expression of syntaxins in rat kidney. Am J Physiol 273: F718-F730, 1997
75. Marples D, Christensen BM, Frøkiær J, Knepper MA, Nielsen S: Dehydration reverses vasopressin antagonist-induced diuresis and aquaporin-2 downregulation in rats. Am J Physiol 275: F400-F409, 1998
76. Terris J, Ecelbarger CA, Nielsen S, Knepper MA: Long-term regulation of four renal aquaporins in rats. Am J Physiol 271: F414-F422, 1996
77. Yasui M, Zelenin SM, Celsi G, Aperia A: Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol 272: F443-F450, 1997
78. Hozawa S, Holtzman EJ, Ausiello DA: cAMP motifs regulating transcription in the aquaporin 2 gene. Am J Physiol 270: C1695-C1702, 1996
79. Matsumura Y, Uchida S, Rai T, Sasaki S, Marumo F: Transcriptional regulation of aquaporin-2 water channel gene by cAMP. J Am Soc Nephrol 8: 861-867, 1997
80. Uchida S, Sasaki S, Fushimi K, Marumo F: Isolation of human aquaporin-CD gene. J Biol Chem 269: 23451-23455, 1994
81. Ecelbarger CA, Nielsen S, Olson BR, Murase T, Baker EA, Knepper M, Verbalis JG: Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat. J Clin Invest 99: 1852-1863, 1997
82. Promeneur D, Kwon TH, Christensen BM, Frøkiær J, Knepper MA, Nielsen S: Vasopressin independent regulation of collecting duct AQP2 expression in rat [Abstract]. J Am Soc Nephrol 9: 24A, 1998
83. Kishore BK, Terris JM, Knepper MA: Quantitation of aquaporin-2 abundance in microdissected collecting ducts: Axial distribution and control by AVP. Am J Physiol 271: F62-F70, 1996
84. Bichet DG: Vasopressin receptors in health and disease. Kidney Int 49: 1706-1711, 1996
85. Kanno K, Sasaki S, Hirata Y, Ishikawa S, Fushimi K, Nakanishi S, Bichet DG, Marumo F: Urinary excretion of aquaporin-2 in patients with diabetes insipidus. N Engl J Med 332: 1540-1545, 1995
86. Deen PM, van Aubel RA, van Lieburg AF, van Os CH: Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus. J Am Soc Nephrol 7: 836-841, 1996
87. Elliot S, Goldsmith P, Knepper M, Haughey M, Olson B: Urinary excretion of aquaporin-2 in humans: A potential marker of collecting duct responsiveness to vasopressin. J Am Soc Nephrol 7: 403-409, 1996
88. Frøkiær J, Wen H, Isikay L, Marples D, Knepper MA, Djurhuus JC, Ørskov H, Nielsen S: Aquaporin-2 is excreted in urine by a selective apical pathway different from whole-cell shedding [Abstract]. J Am Soc Nephrol 8: 17A, 1998
89. Marples D, Frøkiær J, Dørup J, Knepper MA, Nielsen S: Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. J Clin Invest 97: 1960-1968, 1996
90. Earm JH, Christensen BM, Frøkiær J, Marples D, Han JS, Knepper MA, Nielsen S: Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats. J Am Soc Nephrol 9: 2181-2193, 1998
91. Sands JM, Flores FX, Kato A: Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats. Am J Physiol 274: F978-F985, 1998
92. Frøkiær J, Marples D, Knepper MA, Nielsen S: Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Am J Physiol 270: F657-F668, 1996
93. Frøkiær J, Kwon TH, Wen JG, Isikay L, Marples D, Djurhuus JC, Knepper MA, Nielsen S: Bilateral ureteral obstruction is associated with long-term downregulation of both aquaporin-1 and aquaporin-2 which parallels the impairment in urinary concentrating capacity [Abstract]. J Am Soc Nephrol 9: 18A, 1998
94. Lavizzo-Mourey RJ: Dehydration in the elderly: A short review. J Natl Med Assoc 79: 1033-1038, 1987
95. Sladek CD, McNeill TH, Gregg CM, Blair ML, Baggs RB: Vasopressin and renin response to dehydration in aged rats. Neurobiol Aging 2: 293-302, 1981
96. Swenson KL, Sands JM, Jacobs JD, Sladek CD: Effect of aging on vasopressin and aquaporin responses to dehydration in Fischer 344-brown-Norway F1 rats. Am J Physiol 273: R35-R40, 1997
97. Sands JM, Naruse M, Jacobs JD, Wilcox JN, Klein JD: Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet. J Clin Invest 97: 2807-2814, 1996
98. Frøkiær J, Christensen BM, Marples D, Djurhuus JC, Jensen UB, Knepper MA, Nielsen S: Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction. Am J Physiol 273: F213-F223, 1997
99. Apostol E, Ecelbarger CA, Terris J, Bradford AD, Andrews P, Knepper MA: Reduced renal medullary water channel expression in puromycin aminonucleoside-induced nephrotic syndrome. J Am Soc Nephrol 8: 15-24, 1997
100. Fernandez-Llama P, Andrews P, Ecelbarger CA, Nielsen S, Knepper M: Concentrating defect in experimental nephrotic syndrone: Altered expression of aquaporins and thick ascending limb Na+ transporters. Kidney Int 54: 170-179, 1998
101. Ecelbarger CA, Chou CL, Lee AJ, DiGiovanni SR, Verbalis JG, Knepper MA: Escape from vasopressin-induced antidiuresis: Role of vasopressin resistance of the collecting duct. Am J Physiol 274: F1161-F1166, 1998
102. Venkatachalam MA, Bernard DB, Donohoe JF, Levinsky NG: Ischemic damage and repair in the rat proximal tubule: Differences among the S1, S2, and S3 segments. Kidney Int 14: 31-49, 1978
103. Brezis M, Rosen S, Silva P, Epstein FH: Selective vulnerability of the medullary thick ascending limb to anoxia in the isolated perfused rat kidney. J Clin Invest 73: 182-190, 1984
104. Fernandez-Llama P, Andrews P, Turner R, Nielsen S, Safirstein RL, Knepper M: Collecting duct aquaporins in non-oliguric ischemic renal injury [Abstract]. J Am Soc Nephrol 9: 576A, 1998
105. Holliday MA, Egan TJ, Morris CR, Jarrah AS, Harrah JL: Pitressin-resistant hyposthenuria in chronic renal disease. Am J Med 42: 378-387, 1967
106. Tannen RL, Regal EM, Dunn MJ, Schrier RW: Vasopressin-resistant hyposthenuria in advanced chronic renal disease. N Engl J Med 280: 1135-1141, 1969
107. Buerkert J, Martin D, Prasad J, Chambless S, Klahr S: Response of deep nephrons and the terminal collecting duct to a reduction in renal mass. Am J Physiol 236: F454-F464, 1979
108. Wilson DR, Sonnenberg H: Medullary collecting duct function in the remnant kidney before and after volume expansion. Kidney Int 15: 487-501, 1979
109. Fine LG, Schlondorff D, Trizna W, Gilbert RM, Bricker NS: Functional profile of the isolated uremic nephron: Impaired water permeability and adenylate cyclase responsiveness of the cortical collecting tubule to vasopressin. J Clin Invest 61: 1519-1527, 1978
110. Teitelbaum I, McGuinness S: Vasopressin resistance in chronic renal failure: Evidence for the role of decreased V2 receptor mRNA. J Clin Invest 96: 378-385, 1995
111. Goldfine ID: Interaction of insulin, polypeptide hormones, and growth factors with intracellular membranes. Biochim Biophys Acta 650: 53-67, 1981
112. Kwon TH, Frøkiær J, Knepper MA, Nielsen S: Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass. Am J Physiol 275: F724-F741, 1998
113. Nielsen S, Terris J, Andersen D, Ecelbarger C, Frøkiær J, Jonassen T, Marples D, Knepper MA, Petersen JS: Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct. Proc Natl Acad Sci USA 94: 5450-5455, 1997
114. Xu DL, Martin PY, Ohara M, St. John J, Pattison T, Meng X, Morris K, Kim JK, Schrier RW: Upregulation of aquaporin-2 water channel expression in chronic heart failure rat. J Clin Invest 99: 1500-1505, 1997
115. Ohara M, Martin PY, Xu DL, St. John J, Pattison TA, Kim JK, Schrier RW: Upregulation of aquaporin 2 water channel expression in pregnant rats. J Clin Invest 101: 1076-1083, 1998
116. Fujita N, Ishikawa SE, Sasaki S, Fujisawa G, Fushimi K, Marumo F, Saito T: Role of water channel AQP-CD in water retention in SIADH and cirrhotic rats. Am J Physiol 269: F926-F931, 1996
117. Asahina Y, Izumi N, Enomoto N, Sasaki S, Fushimi K, Marumo F, Sato C: Increased gene expression of water channel in cirrhotic rat kidneys. Hepatology 21: 169-173, 1995
118. Jonassen T, Nielsen S, Christensen S, Petersen JS: Decreased vasopressin-mediated renal water reabsorption in rats with compensated liver cirrhosis. Am J Physiol 275: F216-F225, 1998
119. Fernandez-Llama P, Jimenez W, Bosch-Marce M, Arroyo V, Nielsen S, Knepper MA: Dysregulation of aquaporin-1 and aquaporin-2 in the kidneys of cirrhotic rats [Abstract]. J Am Soc Nephrol 9: 18a, 1998