Sensors of extracellular nutrients in Saccharomyces cerevisiae

Current Genetics

Volumn 40, Issue 2, 2001, Pages 91-109

  Forsberg, H ^a   Ljungdahl, P O ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

Fungal proteins; Metabolite transport proteins; Nutrient sensing; Signal transduction

Indexed keywords

AMINO ACID; AMMONIA; CARRIER PROTEIN; CELL RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCOSE; LIGAND; MEP2P PROTEIN; RGT2P PROTEIN; SNF3P PROTEIN; SSY1P PROTEIN; UNCLASSIFIED DRUG;

ADAPTATION; CELL MEMBRANE; CONTROLLED STUDY; ENVIRONMENT; EUKARYOTE; EXTRACELLULAR SPACE; FUNGUS GROWTH; INFORMATION; MAMMAL CELL; METABOLISM; MONITORING; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SACCHAROMYCES CEREVISIAE; SENSOR; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; YEAST;

AMINO ACIDS; BACTERIA; CARBON; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CELL DIVISION; GENE EXPRESSION REGULATION, FUNGAL; GLUCOSE; MEMBRANE PROTEINS; MONOSACCHARIDE TRANSPORT PROTEINS; NITROGEN; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0034799351     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940100244     Document Type: Review

References (148)

1. A recognition component of the ubiquitin system is required for peptide transport in Saccharomyces cerevisiae
2. An overview of membrane transport proteins in Saccharomyces cerevisiae
3. Phospholipase C binds to the receptor-like GPR1 protein and controls pseudohyphal differentiation in Saccharomyces cerevisiae
4. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
5. In vivo half-life of a protein is a function of its amino-terminal residue
6. SUT2, a putative sucrose sensor in sieve elements
7. PTR3, a novel gene mediating amino acid-inducible regulation of peptide transport in Saccharomyces cerevisiae
8. Inhibition of pathogenicity of the rice blast fungus by Saccharomyces cerevisiae alpha-factor
9. Genetic analysis of the signalling pathway activated by external amino acids in Saccharomyces cerevisiae
10. Ubiquitin and the SCF(Grr1) ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae
11. The SNF3 gene is required for high-affinity glucose transport in Saccharomyces cerevisiae
12. A mutation affecting carbon catabolite repression suppresses growth defects in pyruvate carboxylase mutants from Saccharomyces cerevisiae
13. The molecular genetics of hexose transport in yeast
14. The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor
15. Glucose repression in yeast
16. The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein
17. Bg1F, the sensor of the E. coli bgl system, uses the same site to phosphorylate both a sugar and a regulatory protein
18. Computer-assisted nonlinear regression analysis of the multicomponent glucose uptake kinetics of Saccharomyces cerevisiae
19. The C-terminal domain of Snf3p is sufficient to complement the growth defect of snf3 null mutations in Saccharomyces cerevisiae: SNF3 functions in glucose recognition
20. Ammonia regulation of amino acid permeases in Saccharomyces cerevisiae
21. Glucose depletion causes haploid invasive growth in yeast
22. Regulatory circuit for response of nitrogen catabolic gene expression to the GLN3 and DAL80 proteins and nitrogen catabolic repression in Saccharomyces cerevisiae
23. Regulation of expression of the amino acid transporter gene BAP3 in Saccharomyces cerevisiae
24. Stp1p, Stp2p and Abf1p are involved in regulation of expression of the amino acid transporter gene BAP3 of Saccharomyces cerevisiae
25. ABF1 binding sites in yeast RNA polymerase genes
26. Amino acids induce expression of BAP2, a branched-chain amino acid permease in Saccharomyces cerevisiae
27. The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae
28. The C terminus of the Saccharomyces cerevisiae alpha-factor receptor contributes to the formation of preactivation complexes with its cognate G protein
29. Methylamine/ammonia uptake systems in Saccharomyces cerevisiae: Multiplicity and regulation
30. Integration of the multiple controls regulating the expression of the arginase gene CAR1 of Saccharomyces cerevisiae in response to different nitrogen signals: Role of G1n3p, ArgRp-Mcm1p, and Ume6p
31. Non specific induction of arginase in Saccharomyces cerevisiae
32. A two-component signal transduction system essential for growth of Bacillus subtilis: Implications for anti-infective therapy
33. Two-component signal transduction in Bacillus subtilis: How one organism sees its world
34. Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids
35. The role of the plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids
36. Suppressors of ssy1 and ptr3 null mutations define novel Amino Acid Sensor Independent (ASI) genes in Saccharomyces cerevisiae
37. The mutation DGT1-1 decreases glucose transport and alleviates carbon catabolite repression in Saccharomyces cerevisiae
38. Yeast carbon catabolite repression
39. Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein
40. Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib
41. A method for determining the in vivo topology of yeast polytopic membrane proteins demonstrates that Gap1p fully integrates into the membrane independently of Shr3p
42. Shr3p mediates specific COPII coatomer-cargo interactions required for the packaging of amino acid permeases into ER-derived transport vesicles
43. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS
44. BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiae
45. Amino acid transporters in yeast: Structure, function and regulation
46. The large intracytoplasmic loop of the glucose transporter GLUT2 is involved in glucose signaling in hepatic cells
47. Multiplicity and regulation of genes encoding peptide transporters in Saccharomyces cerevisiae
48. Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae
49. Translational control of GCN4: An in vivo barometer of initiation-factor activity
50. Two-component and phosphorelay signal transduction
51. Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe
52. Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence
53. Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae
54. SacY, a transcriptional anti-terminator from Bacillus subtilis, is regulated by phosphorylation in vivo
55. Amino acid signaling in Saccharomyces cerevisiae: A permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a permease
56. Regulation of dipeptide transport in Saccharomyces cerevisiae by micromolar amino acid concentrations
57. Isolation and characterization of S. cerevisiae mutants deficient in amino acid-inducible peptide transport
58. GAP1, the general amino acid permease gene of Saccharomyces cerevisiae. Nucleotide sequence, protein similarity with the other bakers yeast amino acid permeases, and nitrogen catabolite repression
59. Nitrogen catabolite regulation of proline permease in Saccharomyces cerevisiae. Cloning of the PUT4 gene and study of PUT4 RNA levels in wild-type and mutant strains
60. Two glucose sensing/signaling pathways stimulate glucose-induced inactivation of maltose permease in Saccharomyces
61. Feasting, fasting and fermenting. Glucose sensing in yeast and other cells
62. Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast
63. Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids
64. Regulated degradation of the transcription factor Gcn4
65. A Saccharomyces cerevisiae G protein-coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose
66. The hexose transporter family of Saccharomyces cerevisiae
67. The HXT2 gene of Saccharomyces cerevisiae is required for high-affinity glucose transport
68. How do yeast cells sense glucose?
69. Gpa2p, a G-protein α-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism
70. Meiosis and sporulation in Saccharomyces cerevisiae
71. Mth1 receives the signal given by the glucose sensors Snf3 and Rgt2 in Saccharomyces cerevisiae
72. Cell cycle control in Saccharomyces cerevisiae
73. The HXT1 gene product of Saccharomyces cerevisiae is a new member of the family of hexose transporters
74. A novel signal transduction pathway in Saccharomyces cerevisiae defined by Snf3-regulated expression of HXT6
75. SHR3: A novel component of the secretory pathway specifically required for the localization of amino acid permeases in yeast
76. Nonfilamentous C. albicans mutants are avirulent
77. Yeast pseudohyphal growth is regulated by GPA2, a G protein α homolog
78. The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae
79. The G protein-coupled receptor Gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae
80. Mutants of Neurospora crassa that alter gene expression and conidia development
81. Rco-3, a gene involved in glucose transport and conidiation in Neurospora crassa
82. Regulation of nitrogen utilization
83. In vivo N-glycosylation of the Mep2 high-affinity ammonium transporter of Saccharomyces cerevisiae reveals an extracytosolic N-terminus
84. Cloning and expression of the MEP1 gene encoding an ammonium transporter in Saccharomyces cerevisiae
85. A family of ammonium transporters in Saccharomyces cerevisiae
86. Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant
87. Glucose-6-phosphate transporter and receptor functions of the glucose-6-phosphatase system analyzed from a consensus defined by multiple alignments
88. Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex
89. Pseudohyphal development of Saccharomyces cerevisiae
90. Transmembrane segment 5 of the Glut1 glucose transporter is an amphipathic helix that forms part of the sugar permeation pathway
91. Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae
92. Null mutations in the SNF3 gene of Saccharomyces cerevisiae cause a different phenotype than do previously isolated missense mutations
93. Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae
94. Transcriptional regulation of the Saccharomyces cerevisiae amino acid permease gene BAP2
95. Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: Involvement of two hexose transporters
96. Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose
97. Function and regulation of yeast hexose transporters
98. Glucose uptake and catabolite repression in dominant HTR1 mutants of Saccharomyces cerevisiae
99. Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression
100. Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription
101. Glucose sensing and signaling by two glucose receptors in the yeast
102. Comparison of thermosensitive alleles of the CDC25 gene involved in the cAMP metabolism of Saccharomyces cerevisiae
103. The Saccharomyces cerevisiae cell cycle
104. Characteristics of galactose transport in Saccharomyces cerevisiae cells and reconstituted lipid vesicles
105. Amino acid uptake in Saccharomyces cerevisiae, substrate specificity and regulation of the permeases
106. Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae
107. Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae
108. Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux
109. Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their relation to the triggering mechanisms of glucose repression
110. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: Mating and invasive growth
111. Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p
112. Glucose-induced cAMP signalling in yeast requires both a G protein-coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process
113. The role of hexose transport and phosphorylation in cAMP signalling in the yeast Saccharomyces cerevisiae
114. Glucose-sensing mechanisms in eukaryotic cells
115. Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae
116. Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake
117. Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae
118. The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine
119. The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast
120. Function of the cytosolic N-terminus of sucrose transporter AtSUT2 in substrate affinity
121. The role of ammonia metabolism in nitrogen catabolite repression in Saccharomyces cerevisiae
122. Genomic exploration of the hemiascomycetous yeasts: 1. A set of yeast species for molecular evolution studies
123. A co-activator of nitrogen-regulated transcription in Saccharomyces cerevisiae
124. Transcriptional and post-transcriptional regulation of the general amino acid permease of Saccharomyces cerevisiae
125. Cloning and sequencing of the Saccharomyces cerevisiae gene LYP1 coding for a lysine-specific permease
126. APL1, a yeast gene encoding a putative permease for basic amino acids
127. GPR1 regulates filamentous growth through FLO11 in yeast Saccharomyces cerevisiae
128. The histidine permease gene (HIP1) of Saccharomyces cerevisiae
129. High-copy suppression of glucose transport defects by HXT4 and regulatory elements in the promoters of the HXT genes in Saccharomyces cerevisiae
130. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae
131. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells
132. STD1 (MSN3) interacts directly with the TATA-binding protein and modulates transcription of the SUC2 gene of Saccharomyces cerevisiae
133. GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae
134. Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway
135. The SKS1 gene of Saccharomyces cerevisiae is required for long-term adaptation of snf3 null strains to low glucose
136. The N-end rule: Functions, mysteries, uses
137. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2
138. Isolation of a yeast gene involved in species-specific pre-tRNA processing
139. Glucose monitoring in fission yeast via the Gpa2 G-alpha, the Git5 G-beta and the Git3 putative glucose receptor
140. Characterization of amino acid pools in the vacuolar compartment of Saccharomyces cerevisiae
141. SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis
142. Plugging it in: Signaling circuits and the yeast cell cycle
143. The histidine kinase domain of UhpB inhibits UhpA action at the Escherichia coli uhpT promoter
144. MAP kinase and cAMP signaling regulate infection structure formation and pathogenic growth in the rice blast fungus Magnaporthe grisea
145. GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p G-alpha subunit and functions in a Ras-independent pathway
146. Gpr1p, a putative G protein-coupled receptor, regulates glucose-dependent cellular cAMP level in yeast Saccharomyces cerevisiae
147. GNP1, the high-affinity glutamine permease of S. cerevisiae